Abstract:
:Anti-endothelial cell antibodies (AECA) represent a heterogeneous family of autoantibodies directed against structural endothelial proteins, as well as antigens adhering to endothelial cells. Although AECA immunoassays still show a high-interlaboratory variability, several findings suggest a pathogenic role of these autoantibodies in diseases characterized by endothelial damage. In this chapter, we analyze the knowledge about AECA prevalence, clinical relevance, and their pathogenic role in autoimmune diseases focusing in particular on systemic lupus erythematosus, antiphospholipid syndrome, systemic sclerosis (SSc), and systemic vasculitis.
journal_name
Adv Clin Chemjournal_title
Advances in clinical chemistryauthors
Alessandri C,Bombardieri M,Valesini Gdoi
10.1016/s0065-2423(06)42008-4subject
Has Abstractpub_date
2006-01-01 00:00:00pages
297-326eissn
0065-2423issn
2162-9471journal_volume
42pub_type
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