Abstract：
:During winter hibernation, small mammals fall into long periods of deep cold torpor where metabolic rate is suppressed by > 90% and core body temperature can fall to near 0 degrees C. Studies with hibernators illustrate the molecular regulatory mechanisms that coordinate the suppression of metabolic functions during torpor, reprioritize energy use, and preserve/stabilize macromolecules to support long-term viability during cold torpor. This review explores mechanisms including posttranslational modification of proteins, differential regulation of enzymes, global suppression of transcription and translation including a role for microRNA, torpor-responsive gene expression, signal transduction, and regulation of transcription factors. The molecular basis of natural torpor in hibernating mammals offers models and applications that are relevant to issues in clinical science including hypothermia and ischemia resistance, inducible torpor, organ preservation, and atrophy resistance.
journal_name
Adv Clin Chemjournal_title
Advances in clinical chemistryauthors
Storey KB,Storey JMsubject
Has Abstractpub_date
2010-01-01 00:00:00pages
77-108eissn
0065-2423issn
2162-9471journal_volume
52pub_type
杂志文章,评审abstract：:Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease occurs in significant percentage of general population. NAFLD is closely associated with entire spectrum of metabolic-related disorders including diabetes, obesity, and cardiovascular diseases. Considering several similar pathways underpinning metabol...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2016.10.002
更新日期：2017-01-01 00:00:00
abstract：:Marine organisms are a rich source of sulfated polysaccharides with unique structures. Fucosylated chondroitin sulfate (FucCS) from the sea cucumber Ludwigothurea grisea and sulfated galactan from the red alga Botryocladia occidentalis are one of these unusual molecules. Besides their uncommon structures, they also ex...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章
doi：10.1016/b978-0-12-800096-0.00007-x
更新日期：2013-01-01 00:00:00
abstract：:The abnormal breakdown of circulating red blood cells (RBCs), also known as hemolysis, is a significant clinical issue that can present as a primary disorder or arise secondary to another disease process. The evaluation for pathologic hemolysis (and the establishment of a hemolytic disorder) is heavily dependent on as...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2018.12.006
更新日期：2019-01-01 00:00:00
abstract：:Endogenous prostaglandins (PGs) play an important role in modulating the mucosal integrity and various functions of the alimentary tract, and E type PGs are most effective in these actions. PGE2 protects against acid reflux esophagitis and affords gastric cytoprotection against ethanol and indomethacin. These effects ...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/s0065-2423(10)51005-9
更新日期：2010-01-01 00:00:00
abstract：:Mechanisms postulated to link folate and B12 metabolism with cancer, including genome-wide hypomethylation, gene-specific promoter hypermethylation, and DNA uracil misincorporation, have been observed in prostate tumor cells. However, epidemiological studies of prostate cancer risk, based on dietary intakes and blood ...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/b978-0-12-407681-5.00001-5
更新日期：2013-01-01 00:00:00
abstract：:Sepsis is the primary cause of death in the intensive care unit. The prevention of sepsis complications requires an early and accurate diagnosis as well as the appropriate mon itoring. A deep knowledge of the immunologic basis of sepsis is essential to better understand the scope of incorporating a new marker into cli...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/b978-0-12-800141-7.00002-4
更新日期：2014-01-01 00:00:00
abstract：:Since the discovery of group-specific component and its polymorphism by Hirschfeld in 1959, research has put spotlight on this multifunctional transport protein (vitamin D binding protein, DBP). Besides the transport of vitamin D metabolites, DBP is a plasma glycoprotein with many important functions, including seques...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/b978-0-12-800094-6.00001-7
更新日期：2014-01-01 00:00:00
abstract：:This monograph on the clinical chemistry of vitamin B12 reviews the literature on daily requirements, methods for measurement, the effects of drugs on vitamin B12 metabolism absorption, pregnancy, clinical conditions associated with vitamin B12 deficiency, errors of metabolism, and reactions to vitamin therapy. Altho...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/s0065-2423(08)60273-5
更新日期：1985-01-01 00:00:00
abstract：:The generation of bulky DNA adducts consists of conjugates formed between large reactive electrophiles and DNA-binding sites. The term "bulky DNA adducts" comes from early experiments that employed a 32P-DNA postlabeling approach. This technique has long been used to elucidate the association between adducts and carci...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2017.01.006
更新日期：2017-01-01 00:00:00
abstract：:Metabolomics is the quantitative analysis of a large number of low molecular weight metabolites that are intermediate or final products of all the metabolic pathways in a living organism. Any metabolic profiles detectable in a human biological fluid are caused by the interaction between gene expression and the environ...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2015.12.006
更新日期：2016-01-01 00:00:00
abstract：:Multidrug resistance represents a major obstacle in the successful therapy of neoplastic diseases. Studies have demonstrated that this form of drug resistance occurs in cultured tumor cell lines as well as in human cancers. P-glycoprotein appears to play an important role in such cells by acting as an energy-dependent...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/s0065-2423(08)60332-7
更新日期：1994-01-01 00:00:00
abstract：:Biomarkers are increasingly employed in empirical studies of human populations to understand physiological processes that change with age, diseases whose onset appears linked to age, and the aging process itself. In this chapter, we describe some of the most commonly used biomarkers in population aging research, inclu...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/s0065-2423(08)00405-8
更新日期：2008-01-01 00:00:00
abstract：:In addition to their historical role, autoantibodies appear promising as biomarkers to facilitate diagnosis, improve patient outcome and decrease mortality in cancer. Autoantibodies may also be useful in the identification of subjects at risk for cancer, that is, those bearing premalignant changes. Numerous studies ha...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/b978-0-12-800263-6.00005-7
更新日期：2014-01-01 00:00:00
abstract：:Aggressive behavior exerts an enormous impact on society remaining among the main causes of worldwide premature death. Effective primary interventions, relying on predictive models of aggression that show adequate sensitivity and specificity are currently lacking. One strategy to increase the accuracy and precision of...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2019.07.004
更新日期：2019-01-01 00:00:00
abstract：:Nonalcoholic fatty liver disease (NAFLD), the most common liver disorder worldwide, encompasses a spectrum of abnormal liver histology ranging from simple steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis. Population studies show that NAFLD is strongly associated with insulin resistance, obesity, type 2 d...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/b978-0-12-407680-8.00004-x
更新日期：2013-01-01 00:00:00
abstract：:Deregulated DNA replication occurs in cancer where it contributes to genomic instability. This process is a target of cytotoxic therapies. Chemotherapies exploit high DNA replication in cancer cells by modifying the DNA template or by inhibiting vital enzymatic activities that lead to slowing or stalling replication f...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2014.12.003
更新日期：2015-01-01 00:00:00
abstract：:There is now substantial evidence for the role of cyclooxygenase (COX)-2 in causation and prevention of cancer. Selective COX-2 inhibitors (coxibs) were considered attractive candidate chemoprevention agents; however, concerns over the toxicity of systemic selective inhibition have cast some doubt on COX-2 inhibition ...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：
更新日期：2007-01-01 00:00:00
abstract：:Malignant pleural mesothelioma (MPM) is an extremely aggressive tumor which develops in the epithelial lining of the lungs. Exposure to asbestos is the most influential risk factor for developing this disease. Despite recent advances in the treatment of other types of cancer, patients with mesothelioma currently face ...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：
更新日期：2012-01-01 00:00:00
abstract：:Circular RNAs (circRNAs) are covalently circularized RNA moieties that despite being relatively abundant were only recently identified and have only begun to be investigated within the last couple of years. Even though there are many thousands of genes that appear capable of producing circRNAs, and the fact that many ...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章
doi：10.1016/bs.acc.2020.02.008
更新日期：2020-01-01 00:00:00
abstract：:The application of simple, cost-effective, rapid, and accurate diagnostic technologies for detection and identification of cardiac and cancer biomarkers has been a central point in the clinical area. Biosensors have been recognized as efficient alternatives for the diagnostics of various diseases due to their specific...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2015.10.004
更新日期：2016-01-01 00:00:00
abstract：:Cataract is a major cause of blindness worldwide. It is characterized by lens opacification and is accompanied by extensive posttranslational modifications (PTMs) in various proteins. PTMs play an essential role in lens opacification. Several PTMs have been described in proteins isolated from relatively old human lens...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2018.05.005
更新日期：2018-01-01 00:00:00
abstract：:Laboratory testing for drugs of abuse has become standard practice in many settings both forensic and clinical. Urine is the predominant specimen, but other specimens are possible including hair, nails, sweat, and oral fluid. Point-of-care test kits provide for rapid analysis at the site where specimens are collected ...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章
doi：10.1016/bs.acc.2016.11.003
更新日期：2017-01-01 00:00:00
abstract：:Microfluidics is an emerging field in diagnostics that allows for extremely precise fluid control and manipulation, enabling rapid and high-throughput sample processing in integrated micro-scale medical systems. These platforms are well-suited for both standard clinical settings and point-of-care applications. The uni...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2019.08.001
更新日期：2020-01-01 00:00:00
abstract：:The primary role of the clinical laboratory is to report accurate results for diagnosis of disease and management of illnesses. This goal has, to a large extent been achieved for routine biochemical tests, but not for immunoassays which remained susceptible to interference from endogenous immunoglobulin antibodies, ca...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/b978-0-12-801401-1.00007-4
更新日期：2014-01-01 00:00:00
abstract：:Specific nucleic acid detection in vitro or in vivo has become increasingly important in the discovery of genetic diseases, diagnosing pathogen infection and monitoring disease treatment. One challenge, however, is that the amount of target nucleic acid in specimens is limited. Furthermore, direct sensing methods are ...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2019.03.002
更新日期：2019-01-01 00:00:00
abstract：:The recent development and introduction into clinical and laboratory practice of the novel highly sensitive cardiac troponin assays has contributed to improve the diagnosis and risk stratification of patients presenting with suspected myocardial injury and acute coronary syndrome at the emergency department (ED). The ...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：
更新日期：2012-01-01 00:00:00
abstract：:Metaproteomics, as a subfield of proteomics, has quickly emerged as a pivotal tool for global characterization of a microbiome system at a functional level. It has been increasingly applied in studying human digestive and metabolic diseases, and provides information-rich data to identify the dysbiosis of human gut mic...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2019.12.002
更新日期：2020-01-01 00:00:00
abstract：:Hypoxemia (systemic oxygen desaturation) marks the presence, risk, and progression of many diseases. Episodic or nocturnal hypoxemia can be challenging to detect and quantify. A sensitive, specific, and convenient marker of recent oxygen desaturation represents an unmet medical need. Observations of acclimatization to...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/bs.acc.2017.06.002
更新日期：2017-01-01 00:00:00
abstract：:This chapter summarizes progress in several approaches and devices that will improve and augment existing diagnostic techniques. The term bionanotechnology has been used to describe the science that supports the construction of nanoscale bioassemblies. In each of the present applications to diagnostics, bionanotechnol...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/S0065-2423(05)41002-1
更新日期：2006-01-01 00:00:00
abstract：:Due to its importance both in the clearance of pathogens that contribute as rheumatic etiological agents and in the disposal of apoptotic bodies and potential autoimmune initiators, deficiencies of the components of the lectin pathway of complement have been found to increase susceptibility and modulate the severity o...
journal_title：Advances in clinical chemistry
pub_type： 杂志文章,评审
doi：10.1016/b978-0-12-394317-0.00012-1
更新日期：2012-01-01 00:00:00
