解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:There is increasing evidence that circular RNAs (circRNAs) have significant regulatory roles in cancer development and progression; however, the expression patterns and biological functions of circRNAs in renal cell carcinoma (RCC) remain largely elusive. METHOD:Bioinformatics methods were applied to screen...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-021-01314-w
更新日期:2021-01-20 00:00:00
abstract:BACKGROUND:The IκB kinase (IKK) complex, comprising the two enzymes IKKα and IKKβ, is the main activator of the inflammatory transcription factor NF-κB, which is constitutively active in many cancers. While several connections between NF-κB signaling and the oncogene c-Myc have been shown, functional links between the ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-021-01308-8
更新日期:2021-01-18 00:00:00
abstract::Cancer is a leading cause of death worldwide, particularly because of its high mortality rate in patients who are diagnosed at late stages. Conventional biomarkers originating from blood are widely used for cancer diagnosis, but their low sensitivity and specificity limit their widespread application in cancer screeni...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-020-01298-z
更新日期:2021-01-11 00:00:00
abstract::Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammals. Important advances have been made in the biogenesis, regulation, localization, degradation and modification of circRNAs. CircRNAs exert biological functions by acting as tra...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-020-01286-3
更新日期:2020-12-14 00:00:00
abstract:BACKGROUND:Laryngeal squamous cell carcinoma (LSCC) is the second most common malignant tumor in head and neck. Autophagy and circular RNAs (circRNAs) play critical roles in cancer progression and chemoresistance. However, the function and mechanism of circRNA in autophagy regulation of LSCC remain unclear. METHODS:Th...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-020-01279-2
更新日期:2020-11-24 00:00:00
abstract:BACKGROUND:Triple negative breast cancer (TNBC) remains the most challenging breast cancer subtype so far. Specific therapeutic approaches have rarely achieved clinical improvements in treatment of TNBC patients and effective molecular biomarkers are largely unknown. METHODS:We used paired TNBC samples and high throug...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-020-01259-6
更新日期:2020-09-11 00:00:00
abstract::An amendment to this paper has been published and can be accessed via the original article. ...
journal_title:Molecular cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12943-020-01252-z
更新日期:2020-09-09 00:00:00
abstract::At the moment, pancreatic cancer is among the deadliest gastrointestinal diseases, and pancreatic cancer growth is a complex biological process that is based on different kinds of genes. Exosomes are extracellular vesicles containing microRNAs (miRNAs), messenger RNA (mRNA), and proteins, they act as the most prominen...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-020-01245-y
更新日期:2020-08-27 00:00:00
abstract:BACKGROUND:Deregulated circular RNAs (circRNAs) are associated with the development of cancer and therapy resistance. However, functional research of circRNAs mostly focus on potential miRNA or protein binding and more potential regulation of circRNA on host gene DNA in cancers are yet to be inspected. METHOD:We perfo...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-020-01246-x
更新日期:2020-08-24 00:00:00
abstract::This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1186/s12943-015-0389-y. ...
journal_title:Molecular cancer
pub_type: 杂志文章,撤回出版物
doi:10.1186/s12943-020-01242-1
更新日期:2020-08-15 00:00:00
abstract:BACKGROUND:Long non-coding RNAs (lncRNAs) have been identified as important epigenetic regulators that play critical roles in human cancers. However, the regulatory functions of lncRNAs in tumorigenesis remains to be elucidated. Here, we aimed to investigate the molecular mechanisms and potential clinical application o...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-020-01232-3
更新日期:2020-07-15 00:00:00
abstract:BACKGROUND:Increasing evidence supports the role of small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs) as master gene regulators at the epigenetic modification level. However, the underlying mechanism of these functional ncRNAs in colorectal cancer (CRC) has not been well investigated. METHODS:The dysre...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-020-01201-w
更新日期:2020-05-22 00:00:00
abstract:BACKGROUND:Estrogen receptor-positive (ER+) breast cancers represent approximately two-thirds of all breast cancers and have a sustained risk of late disease recurrence. Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors have shown significant efficacy in ER+ breast cancer. However, their effects are still limited by ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-020-01210-9
更新日期:2020-05-11 00:00:00
abstract::seRNA is a noncoding RNA (ncRNA) transcribed from active super-enhancer (SE), through which SE exerts biological functions and participates in various physiological and pathological processes. seRNA recruits cofactor, RNA polymerase II and mediator to constitute and stabilize chromatin loop SE and promoter region, whi...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-020-01195-5
更新日期:2020-04-11 00:00:00
abstract:BACKGROUND:Although both circular RNAs (circRNAs) and autophagy are associated with the function of breast cancer (BC), whether circRNAs regulate BC progression via autophagy remains unknown. In this study, we aim to explore the regulatory mechanisms and the clinical significance of autophagy-associated circRNAs in BC....
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-020-01152-2
更新日期:2020-03-25 00:00:00
abstract:BACKGROUND:The epigenetic regulation of immune response has been demonstrated in recent studies. Nonetheless, potential roles of RNA N6-methyladenosine (m6A) modification in tumor microenvironment (TME) cell infiltration remain unknown. METHODS:We comprehensively evaluated the m6A modification patterns of 1938 gastric...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-020-01170-0
更新日期:2020-03-12 00:00:00
abstract:BACKGROUND:The poor prognosis of esophageal squamous cell carcinoma (ESCC) highlights the need for novel strategies against this disease. Our previous study suggested the involvement of CCL2 and tumor associated macrophages (TAMs) in esophageal carcinogenesis. Despite the recognition of TAMs as a promising target for c...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-020-01165-x
更新日期:2020-02-27 00:00:00
abstract::After the publication of this work [1], an error was found in Fig. 1b. As described in the Results section that circ0084003 has 13 exons, it should be formed by 5-17 (13exons) exons, authors have described "formed by 5-19 exons". The authors extend their apology for the mistake caused by their action. With that mistak...
journal_title:Molecular cancer
pub_type: 已发布勘误
doi:10.1186/s12943-020-1131-y
更新日期:2020-02-01 00:00:00
abstract::Since the publication of this work [1] and in response to a recent query that was brought to our attention in relation to the Western Blot in Figure 1(C) for NP2, protein lysates prepared around the same time as those presented in the manuscript in question, were run by SDS-PAGE under similar experimental conditions a...
journal_title:Molecular cancer
pub_type: 已发布勘误
doi:10.1186/s12943-020-1142-8
更新日期:2020-01-27 00:00:00
abstract:BACKGROUND:Interferon alpha (IFNα) is a well-established regulator of immunosuppression in head and neck squamous cell carcinoma (HNSCC), while the role of long noncoding RNAs (lncRNAs) in immunosuppression remains largely unknown. METHODS:Differentially expressed lncRNAs were screened under IFNα stimulation using lnc...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-019-1123-y
更新日期:2020-01-06 00:00:00
abstract:BACKGROUND:N6-methyladenosine (m6A) emerges as one of the most important modification of RNA. Bladder cancer is a common cancer type in developed countries, and hundreds of thousands of bladder cancer patients die every year. MATERIALS AND METHODS:There are various cells in bladder tumor bulk, and a small population c...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-019-1084-1
更新日期:2019-11-25 00:00:00
abstract:BACKGROUND:Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic secretome delivering and trafficking for long-distance cell-to-cell communication. This stu...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-019-1077-0
更新日期:2019-11-07 00:00:00
abstract:BACKGROUND:As an important means of communication, exosomes play an important role in the development of hepatocellular carcinoma (HCC). METHODS:Bioinformatics analysis, dual-luciferase reporter assays, methylation-specific quantitative PCR, and ChIP-PCR analysis were used to gain insight into the underlying mechanism...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-019-1075-2
更新日期:2019-10-27 00:00:00
abstract:BACKGROUND:As one of the most frequent chemical modifications in eukaryotic mRNAs, N6-methyladenosine (m6A) modification exerts important effects on mRNA stability, splicing, and translation. Recently, the regulatory role of m6A in tumorigenesis has been increasingly recognized. However, dysregulation of m6A and its fu...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-019-1065-4
更新日期:2019-10-13 00:00:00
abstract::Cancer has become a major health issue worldwide, contributing to a high mortality rate. Tumor metastasis is attributed to the death of most patients. Epithelial-to-mesenchymal transition (EMT) plays a vital role in inducing metastasis. During EMT, epithelial cells lose their characteristics, such as cell-to-cell adhe...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-019-1071-6
更新日期:2019-09-16 00:00:00
abstract:BACKGROUND:Emerging studies suggest that long non-coding RNAs (lncRNAs) play crucial roles in colorectal cancer (CRC). Here, we report a lncRNA, SATB2-AS1, which is specifically expressed in colorectal tissue and is significantly reduced in CRC. We systematically elucidated its functions and possible molecular mechanis...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-019-1063-6
更新日期:2019-09-06 00:00:00
abstract::Chimeric antigen receptor T (CAR-T) cell therapy is an emerging and effective cancer immunotherapy. Especially in hematological malignancies, CAR-T cells have achieved exciting results. Two Anti-CD19 CAR-T therapies have been approved for the treatment of CD19-positive leukemia or lymphoma. However, the application of...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-019-1057-4
更新日期:2019-08-20 00:00:00
abstract:BACKGROUND:METTL3 is known to be involved in all stages in the life cycle of RNA. It affects the tumor formation by the regulation the m6A modification in the mRNAs of critical oncogenes or tumor suppressors. In bladder cancer, METTL3 could promote the bladder cancer progression via AFF4/NF-κB/MYC signaling network by ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-019-1036-9
更新日期:2019-06-22 00:00:00
abstract:BACKGROUND:Changes in glycogen metabolism is an essential feature among the various metabolic adaptations used by cancer cells to adjust to the conditions imposed by the tumor microenvironment. Our previous study showed that glycogen branching enzyme (GBE1) is downstream of the HIF1 pathway in hypoxia-conditioned lung ...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-019-1027-x
更新日期:2019-06-20 00:00:00
abstract::Autophagy is a highly conserved catabolic process that mediates degradation of pernicious or dysfunctional cellular components, such as invasive pathogens, senescent proteins, and organelles. It can promote or suppress tumor development, so it is a "double-edged sword" in tumors that depends on the cell and tissue typ...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-019-1030-2
更新日期:2019-05-24 00:00:00
abstract::Cells respond to hypoxia by shifting cellular processes from general housekeeping functions to activating specialized hypoxia-response pathways. Oxygen plays an important role in generating ATP to maintain a productive rate of protein synthesis in normoxia. In hypoxia, the rate of the canonical protein synthesis pathw...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-019-0968-4
更新日期:2019-03-30 00:00:00
abstract::Increasing evidence indicates that the ability of cancer cells to convey biological information to recipient cells within the tumor microenvironment (TME) is crucial for tumor progression. Microvesicles (MVs) are heterogenous vesicles formed by budding of the cellular membrane, which are secreted in larger amounts by ...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-019-0973-7
更新日期:2019-03-30 00:00:00
abstract::Although solid tumors comprise malignant cells, they also contain many different non-malignant cell types in their micro-environment. The cellular components of the tumor stroma consist of immune and endothelial cells combined with a heterogeneous population of stromal cells which include cancer-associated fibroblasts...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-019-0960-z
更新日期:2019-03-30 00:00:00
abstract:BACKGROUND:Though esophageal cancer is three to four times more common among males than females worldwide, this type of cancer still ranks in the top incidence among women, even more than the female specific cancer types. The occurrence is currently attributed to extrinsic factors, including tobacco use and alcohol con...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-019-0949-7
更新日期:2019-02-08 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with high morbidity and mortality worldwide. To date, limited therapeutic achievements targeting cell proliferation and related mechanisms has led researchers to focus on the microenvironment where pancreatic cancers develop. The anomalous proliferation ...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-018-0927-5
更新日期:2019-01-21 00:00:00
abstract:BACKGROUND:Breast cancer is one of the most common malignancies and the major cause of cancer-related death in women. Although the importance of PIWI-interacting RNAs (piRNAs) in cancer has been increasingly recognized, few studies have been explored the functional mechanism of piRNAs in breast cancer development and p...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-019-0940-3
更新日期:2019-01-12 00:00:00
abstract:BACKGROUND:In recent years, circular RNAs (circRNAs), a new star of non-coding RNA, have been emerged as vital regulators and gained much attention for involvement of initiation and progression of diverse kinds of human diseases, especially cancer. However, regulatory role, clinical significance and underlying mechanis...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-018-0933-7
更新日期:2019-01-08 00:00:00
abstract:BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies. Neovascularization during tumorigenesis supplies oxygen and nutrients to proliferative tumor cells, and serves as a conduit for migration. Targeting oncogenes involved in angiogenesis is needed to treat organ-confined and local...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-018-0930-x
更新日期:2019-01-04 00:00:00
abstract:BACKGROUND:Cellular senescence is a state of irreversible cell growth arrest and senescence cells permanently lose proliferation potential. Induction of cellular senescence might be a novel therapy for cancer cells. TRIB2 has been reported to participate in regulating proliferation and drug resistance of various cancer...
journal_title:Molecular cancer
pub_type: 杂志文章
doi:10.1186/s12943-018-0922-x
更新日期:2018-12-12 00:00:00
abstract::Recent studies have shown that on one hand, tumors need to obtain a sufficient energy supply, and on the other hand they must evade the body's immune surveillance. Because of their metabolic reprogramming characteristics, tumors can modify the physicochemical properties of the microenvironment, which in turn affects t...
journal_title:Molecular cancer
pub_type: 杂志文章,评审
doi:10.1186/s12943-018-0913-y
更新日期:2018-11-26 00:00:00