听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览Molecular Cancer期刊下所有文献
  • Circular RNA circSDHC serves as a sponge for miR-127-3p to promote the proliferation and metastasis of renal cell carcinoma via the CDKN3/E2F1 axis.

    abstract:BACKGROUND:There is increasing evidence that circular RNAs (circRNAs) have significant regulatory roles in cancer development and progression; however, the expression patterns and biological functions of circRNAs in renal cell carcinoma (RCC) remain largely elusive. METHOD:Bioinformatics methods were applied to screen...

    journal_title:Molecular cancer

    pub_type: 杂志文章

    doi:10.1186/s12943-021-01314-w

    authors: Cen J,Liang Y,Huang Y,Pan Y,Shu G,Zheng Z,Liao X,Zhou M,Chen D,Fang Y,Chen W,Luo J,Zhang J

    更新日期:2021-01-20 00:00:00

  • The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity.

    abstract:BACKGROUND:The IκB kinase (IKK) complex, comprising the two enzymes IKKα and IKKβ, is the main activator of the inflammatory transcription factor NF-κB, which is constitutively active in many cancers. While several connections between NF-κB signaling and the oncogene c-Myc have been shown, functional links between the ...

    journal_title:Molecular cancer

    pub_type: 杂志文章

    doi:10.1186/s12943-021-01308-8

    authors: Moser B,Hochreiter B,Basílio J,Gleitsmann V,Panhuber A,Pardo-Garcia A,Hoesel B,Salzmann M,Resch U,Noreen M,Schmid JA

    更新日期:2021-01-18 00:00:00

  • Circular RNAs in body fluids as cancer biomarkers: the new frontier of liquid biopsies.

    abstract::Cancer is a leading cause of death worldwide, particularly because of its high mortality rate in patients who are diagnosed at late stages. Conventional biomarkers originating from blood are widely used for cancer diagnosis, but their low sensitivity and specificity limit their widespread application in cancer screeni...

    journal_title:Molecular cancer

    pub_type: 杂志文章,评审

    doi:10.1186/s12943-020-01298-z

    authors: Wang S,Zhang K,Tan S,Xin J,Yuan Q,Xu H,Xu X,Liang Q,Christiani DC,Wang M,Liu L,Du M

    更新日期:2021-01-11 00:00:00

  • Circular RNA: metabolism, functions and interactions with proteins.

    abstract::Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammals. Important advances have been made in the biogenesis, regulation, localization, degradation and modification of circRNAs. CircRNAs exert biological functions by acting as tra...

    journal_title:Molecular cancer

    pub_type: 杂志文章,评审

    doi:10.1186/s12943-020-01286-3

    authors: Zhou WY,Cai ZR,Liu J,Wang DS,Ju HQ,Xu RH

    更新日期:2020-12-14 00:00:00

  • circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway.

    abstract:BACKGROUND:Laryngeal squamous cell carcinoma (LSCC) is the second most common malignant tumor in head and neck. Autophagy and circular RNAs (circRNAs) play critical roles in cancer progression and chemoresistance. However, the function and mechanism of circRNA in autophagy regulation of LSCC remain unclear. METHODS:Th...

    journal_title:Molecular cancer

    pub_type: 杂志文章

    doi:10.1186/s12943-020-01279-2

    authors: Gao W,Guo H,Niu M,Zheng X,Zhang Y,Xue X,Bo Y,Guan X,Li Z,Guo Y,He L,Zhang Y,Li L,Cao J,Wu Y

    更新日期:2020-11-24 00:00:00

  • Circular HER2 RNA positive triple negative breast cancer is sensitive to Pertuzumab.

    abstract:BACKGROUND:Triple negative breast cancer (TNBC) remains the most challenging breast cancer subtype so far. Specific therapeutic approaches have rarely achieved clinical improvements in treatment of TNBC patients and effective molecular biomarkers are largely unknown. METHODS:We used paired TNBC samples and high throug...

    journal_title:Molecular cancer

    pub_type: 杂志文章

    doi:10.1186/s12943-020-01259-6

    authors: Li J,Ma M,Yang X,Zhang M,Luo J,Zhou H,Huang N,Xiao F,Lai B,Lv W,Zhang N

    更新日期:2020-09-11 00:00:00

  • Correction to: CircPSMC3 suppresses the proliferation and metastasis of gastric cancer by acting as a competitive endogenous RNA through sponging miR-296-5p.

    abstract::An amendment to this paper has been published and can be accessed via the original article. ...

    journal_title:Molecular cancer

    pub_type: 杂志文章,已发布勘误

    doi:10.1186/s12943-020-01252-z

    authors: Rong D,Lu C,Zhang B,Fu K,Zhao S,Tang W,Cao H

    更新日期:2020-09-09 00:00:00

  • The involvement of exosomes in the diagnosis and treatment of pancreatic cancer.

    abstract::At the moment, pancreatic cancer is among the deadliest gastrointestinal diseases, and pancreatic cancer growth is a complex biological process that is based on different kinds of genes. Exosomes are extracellular vesicles containing microRNAs (miRNAs), messenger RNA (mRNA), and proteins, they act as the most prominen...

    journal_title:Molecular cancer

    pub_type: 杂志文章,评审

    doi:10.1186/s12943-020-01245-y

    authors: Ariston Gabriel AN,Wang F,Jiao Q,Yvette U,Yang X,Al-Ameri SA,Du L,Wang YS,Wang C

    更新日期:2020-08-27 00:00:00

  • CircRNA inhibits DNA damage repair by interacting with host gene.

    abstract:BACKGROUND:Deregulated circular RNAs (circRNAs) are associated with the development of cancer and therapy resistance. However, functional research of circRNAs mostly focus on potential miRNA or protein binding and more potential regulation of circRNA on host gene DNA in cancers are yet to be inspected. METHOD:We perfo...

    journal_title:Molecular cancer

    pub_type: 杂志文章

    doi:10.1186/s12943-020-01246-x

    authors: Xu X,Zhang J,Tian Y,Gao Y,Dong X,Chen W,Yuan X,Yin W,Xu J,Chen K,He C,Wei L

    更新日期:2020-08-24 00:00:00

  • Retraction Note: HGF and TGFβ1 differently influenced Wwox regulatory function on Twist program for mesenchymal-epithelial transition in bone metastatic versus parental breast carcinoma cells.

    abstract::This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1186/s12943-015-0389-y. ...

    journal_title:Molecular cancer

    pub_type: 杂志文章,撤回出版物

    doi:10.1186/s12943-020-01242-1

    authors: Bendinelli P,Maroni P,Matteucci E,Desiderio MA

    更新日期:2020-08-15 00:00:00

  • A novel LncRNA transcript, RBAT1, accelerates tumorigenesis through interacting with HNRNPL and cis-activating E2F3.

    abstract:BACKGROUND:Long non-coding RNAs (lncRNAs) have been identified as important epigenetic regulators that play critical roles in human cancers. However, the regulatory functions of lncRNAs in tumorigenesis remains to be elucidated. Here, we aimed to investigate the molecular mechanisms and potential clinical application o...

    journal_title:Molecular cancer

    pub_type: 杂志文章

    doi:10.1186/s12943-020-01232-3

    authors: He X,Chai P,Li F,Zhang L,Zhou C,Yuan X,Li Y,Yang J,Luo Y,Ge S,Zhang H,Jia R,Fan X

    更新日期:2020-07-15 00:00:00

  • Long noncoding RNA ZFAS1 promoting small nucleolar RNA-mediated 2'-O-methylation via NOP58 recruitment in colorectal cancer.

    abstract:BACKGROUND:Increasing evidence supports the role of small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs) as master gene regulators at the epigenetic modification level. However, the underlying mechanism of these functional ncRNAs in colorectal cancer (CRC) has not been well investigated. METHODS:The dysre...

    journal_title:Molecular cancer

    pub_type: 杂志文章

    doi:10.1186/s12943-020-01201-w

    authors: Wu H,Qin W,Lu S,Wang X,Zhang J,Sun T,Hu X,Li Y,Chen Q,Wang Y,Zhao H,Piao H,Zhang R,Wei M

    更新日期:2020-05-22 00:00:00

  • LncRNA TROJAN promotes proliferation and resistance to CDK4/6 inhibitor via CDK2 transcriptional activation in ER+ breast cancer.

    abstract:BACKGROUND:Estrogen receptor-positive (ER+) breast cancers represent approximately two-thirds of all breast cancers and have a sustained risk of late disease recurrence. Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors have shown significant efficacy in ER+ breast cancer. However, their effects are still limited by ...

    journal_title:Molecular cancer

    pub_type: 杂志文章

    doi:10.1186/s12943-020-01210-9

    authors: Jin X,Ge LP,Li DQ,Shao ZM,Di GH,Xu XE,Jiang YZ

    更新日期:2020-05-11 00:00:00

  • Oncogenic seRNA functional activation: a novel mechanism of tumorigenesis.

    abstract::seRNA is a noncoding RNA (ncRNA) transcribed from active super-enhancer (SE), through which SE exerts biological functions and participates in various physiological and pathological processes. seRNA recruits cofactor, RNA polymerase II and mediator to constitute and stabilize chromatin loop SE and promoter region, whi...

    journal_title:Molecular cancer

    pub_type: 杂志文章,评审

    doi:10.1186/s12943-020-01195-5

    authors: Tan Y,Li Y,Tang F

    更新日期:2020-04-11 00:00:00

  • Autophagy-associated circRNA circCDYL augments autophagy and promotes breast cancer progression.

    abstract:BACKGROUND:Although both circular RNAs (circRNAs) and autophagy are associated with the function of breast cancer (BC), whether circRNAs regulate BC progression via autophagy remains unknown. In this study, we aim to explore the regulatory mechanisms and the clinical significance of autophagy-associated circRNAs in BC....

    journal_title:Molecular cancer

    pub_type: 杂志文章

    doi:10.1186/s12943-020-01152-2

    authors: Liang G,Ling Y,Mehrpour M,Saw PE,Liu Z,Tan W,Tian Z,Zhong W,Lin W,Luo Q,Lin Q,Li Q,Zhou Y,Hamai A,Codogno P,Li J,Song E,Gong C

    更新日期:2020-03-25 00:00:00

  • m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer.

    abstract:BACKGROUND:The epigenetic regulation of immune response has been demonstrated in recent studies. Nonetheless, potential roles of RNA N6-methyladenosine (m6A) modification in tumor microenvironment (TME) cell infiltration remain unknown. METHODS:We comprehensively evaluated the m6A modification patterns of 1938 gastric...

    journal_title:Molecular cancer

    pub_type: 杂志文章

    doi:10.1186/s12943-020-01170-0

    authors: Zhang B,Wu Q,Li B,Wang D,Wang L,Zhou YL

    更新日期:2020-03-12 00:00:00

  • CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis.

    abstract:BACKGROUND:The poor prognosis of esophageal squamous cell carcinoma (ESCC) highlights the need for novel strategies against this disease. Our previous study suggested the involvement of CCL2 and tumor associated macrophages (TAMs) in esophageal carcinogenesis. Despite the recognition of TAMs as a promising target for c...

    journal_title:Molecular cancer

    pub_type: 杂志文章

    doi:10.1186/s12943-020-01165-x

    authors: Yang H,Zhang Q,Xu M,Wang L,Chen X,Feng Y,Li Y,Zhang X,Cui W,Jia X

    更新日期:2020-02-27 00:00:00

  • Correction to: Circular RNA circFGFR1 promotes progression and anti-PD-1 resistance by sponging miR-381-3p in non-small cell lung cancer cells.

    abstract::After the publication of this work [1], an error was found in Fig. 1b. As described in the Results section that circ0084003 has 13 exons, it should be formed by 5-17 (13exons) exons, authors have described "formed by 5-19 exons". The authors extend their apology for the mistake caused by their action. With that mistak...

    journal_title:Molecular cancer

    pub_type: 已发布勘误

    doi:10.1186/s12943-020-1131-y

    authors: Zhang PF,Pei X,Li KS,Jin LN,Wang F,Wu J,Zhang XM

    更新日期:2020-02-01 00:00:00

  • Correction to: Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer.

    abstract::Since the publication of this work [1] and in response to a recent query that was brought to our attention in relation to the Western Blot in Figure 1(C) for NP2, protein lysates prepared around the same time as those presented in the manuscript in question, were run by SDS-PAGE under similar experimental conditions a...

    journal_title:Molecular cancer

    pub_type: 已发布勘误

    doi:10.1186/s12943-020-1142-8

    authors: Barr MP,Gray SG,Gately K,Hams E,Fallon PG,Davies AM,Richard DJ,Pidgeon GP,O'Byrne KJ

    更新日期:2020-01-27 00:00:00

  • A novel IFNα-induced long noncoding RNA negatively regulates immunosuppression by interrupting H3K27 acetylation in head and neck squamous cell carcinoma.

    abstract:BACKGROUND:Interferon alpha (IFNα) is a well-established regulator of immunosuppression in head and neck squamous cell carcinoma (HNSCC), while the role of long noncoding RNAs (lncRNAs) in immunosuppression remains largely unknown. METHODS:Differentially expressed lncRNAs were screened under IFNα stimulation using lnc...

    journal_title:Molecular cancer

    pub_type: 杂志文章

    doi:10.1186/s12943-019-1123-y

    authors: Ma H,Chang H,Yang W,Lu Y,Hu J,Jin S

    更新日期:2020-01-06 00:00:00

  • Mettl14 inhibits bladder TIC self-renewal and bladder tumorigenesis through N6-methyladenosine of Notch1.

    abstract:BACKGROUND:N6-methyladenosine (m6A) emerges as one of the most important modification of RNA. Bladder cancer is a common cancer type in developed countries, and hundreds of thousands of bladder cancer patients die every year. MATERIALS AND METHODS:There are various cells in bladder tumor bulk, and a small population c...

    journal_title:Molecular cancer

    pub_type: 杂志文章

    doi:10.1186/s12943-019-1084-1

    authors: Gu C,Wang Z,Zhou N,Li G,Kou Y,Luo Y,Wang Y,Yang J,Tian F

    更新日期:2019-11-25 00:00:00

  • ASPH-notch Axis guided Exosomal delivery of Prometastatic Secretome renders breast Cancer multi-organ metastasis.

    abstract:BACKGROUND:Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic secretome delivering and trafficking for long-distance cell-to-cell communication. This stu...

    journal_title:Molecular cancer

    pub_type: 杂志文章

    doi:10.1186/s12943-019-1077-0

    authors: Lin Q,Chen X,Meng F,Ogawa K,Li M,Song R,Zhang S,Zhang Z,Kong X,Xu Q,He F,Bai X,Sun B,Hung MC,Liu L,Wands J,Dong X

    更新日期:2019-11-07 00:00:00

  • Exosomal miR-21 regulates the TETs/PTENp1/PTEN pathway to promote hepatocellular carcinoma growth.

    abstract:BACKGROUND:As an important means of communication, exosomes play an important role in the development of hepatocellular carcinoma (HCC). METHODS:Bioinformatics analysis, dual-luciferase reporter assays, methylation-specific quantitative PCR, and ChIP-PCR analysis were used to gain insight into the underlying mechanism...

    journal_title:Molecular cancer

    pub_type: 杂志文章

    doi:10.1186/s12943-019-1075-2

    authors: Cao LQ,Yang XW,Chen YB,Zhang DW,Jiang XF,Xue P

    更新日期:2019-10-27 00:00:00

  • METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer.

    abstract:BACKGROUND:As one of the most frequent chemical modifications in eukaryotic mRNAs, N6-methyladenosine (m6A) modification exerts important effects on mRNA stability, splicing, and translation. Recently, the regulatory role of m6A in tumorigenesis has been increasingly recognized. However, dysregulation of m6A and its fu...

    journal_title:Molecular cancer

    pub_type: 杂志文章

    doi:10.1186/s12943-019-1065-4

    authors: Yue B,Song C,Yang L,Cui R,Cheng X,Zhang Z,Zhao G

    更新日期:2019-10-13 00:00:00

  • Functional roles of circular RNAs during epithelial-to-mesenchymal transition.

    abstract::Cancer has become a major health issue worldwide, contributing to a high mortality rate. Tumor metastasis is attributed to the death of most patients. Epithelial-to-mesenchymal transition (EMT) plays a vital role in inducing metastasis. During EMT, epithelial cells lose their characteristics, such as cell-to-cell adhe...

    journal_title:Molecular cancer

    pub_type: 杂志文章,评审

    doi:10.1186/s12943-019-1071-6

    authors: Shang BQ,Li ML,Quan HY,Hou PF,Li ZW,Chu SF,Zheng JN,Bai J

    更新日期:2019-09-16 00:00:00

  • LncRNA SATB2-AS1 inhibits tumor metastasis and affects the tumor immune cell microenvironment in colorectal cancer by regulating SATB2.

    abstract:BACKGROUND:Emerging studies suggest that long non-coding RNAs (lncRNAs) play crucial roles in colorectal cancer (CRC). Here, we report a lncRNA, SATB2-AS1, which is specifically expressed in colorectal tissue and is significantly reduced in CRC. We systematically elucidated its functions and possible molecular mechanis...

    journal_title:Molecular cancer

    pub_type: 杂志文章

    doi:10.1186/s12943-019-1063-6

    authors: Xu M,Xu X,Pan B,Chen X,Lin K,Zeng K,Liu X,Xu T,Sun L,Qin J,He B,Pan Y,Sun H,Wang S

    更新日期:2019-09-06 00:00:00

  • Next generation chimeric antigen receptor T cells: safety strategies to overcome toxicity.

    abstract::Chimeric antigen receptor T (CAR-T) cell therapy is an emerging and effective cancer immunotherapy. Especially in hematological malignancies, CAR-T cells have achieved exciting results. Two Anti-CD19 CAR-T therapies have been approved for the treatment of CD19-positive leukemia or lymphoma. However, the application of...

    journal_title:Molecular cancer

    pub_type: 杂志文章,评审

    doi:10.1186/s12943-019-1057-4

    authors: Yu S,Yi M,Qin S,Wu K

    更新日期:2019-08-20 00:00:00

  • METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner.

    abstract:BACKGROUND:METTL3 is known to be involved in all stages in the life cycle of RNA. It affects the tumor formation by the regulation the m6A modification in the mRNAs of critical oncogenes or tumor suppressors. In bladder cancer, METTL3 could promote the bladder cancer progression via AFF4/NF-κB/MYC signaling network by ...

    journal_title:Molecular cancer

    pub_type: 杂志文章

    doi:10.1186/s12943-019-1036-9

    authors: Han J,Wang JZ,Yang X,Yu H,Zhou R,Lu HC,Yuan WB,Lu JC,Zhou ZJ,Lu Q,Wei JF,Yang H

    更新日期:2019-06-22 00:00:00

  • Lung adenocarcinoma-intrinsic GBE1 signaling inhibits anti-tumor immunity.

    abstract:BACKGROUND:Changes in glycogen metabolism is an essential feature among the various metabolic adaptations used by cancer cells to adjust to the conditions imposed by the tumor microenvironment. Our previous study showed that glycogen branching enzyme (GBE1) is downstream of the HIF1 pathway in hypoxia-conditioned lung ...

    journal_title:Molecular cancer

    pub_type: 杂志文章

    doi:10.1186/s12943-019-1027-x

    authors: Li L,Yang L,Cheng S,Fan Z,Shen Z,Xue W,Zheng Y,Li F,Wang D,Zhang K,Lian J,Wang D,Zhu Z,Zhao J,Zhang Y

    更新日期:2019-06-20 00:00:00

  • Crosstalk between autophagy and epithelial-mesenchymal transition and its application in cancer therapy.

    abstract::Autophagy is a highly conserved catabolic process that mediates degradation of pernicious or dysfunctional cellular components, such as invasive pathogens, senescent proteins, and organelles. It can promote or suppress tumor development, so it is a "double-edged sword" in tumors that depends on the cell and tissue typ...

    journal_title:Molecular cancer

    pub_type: 杂志文章,评审

    doi:10.1186/s12943-019-1030-2

    authors: Chen HT,Liu H,Mao MJ,Tan Y,Mo XQ,Meng XJ,Cao MT,Zhong CY,Liu Y,Shan H,Jiang GM

    更新日期:2019-05-24 00:00:00

  • mRNA-to-protein translation in hypoxia.

    abstract::Cells respond to hypoxia by shifting cellular processes from general housekeeping functions to activating specialized hypoxia-response pathways. Oxygen plays an important role in generating ATP to maintain a productive rate of protein synthesis in normoxia. In hypoxia, the rate of the canonical protein synthesis pathw...

    journal_title:Molecular cancer

    pub_type: 杂志文章,评审

    doi:10.1186/s12943-019-0968-4

    authors: Chee NT,Lohse I,Brothers SP

    更新日期:2019-03-30 00:00:00

  • Microvesicles and chemokines in tumor microenvironment: mediators of intercellular communications in tumor progression.

    abstract::Increasing evidence indicates that the ability of cancer cells to convey biological information to recipient cells within the tumor microenvironment (TME) is crucial for tumor progression. Microvesicles (MVs) are heterogenous vesicles formed by budding of the cellular membrane, which are secreted in larger amounts by ...

    journal_title:Molecular cancer

    pub_type: 杂志文章,评审

    doi:10.1186/s12943-019-0973-7

    authors: Bian X,Xiao YT,Wu T,Yao M,Du L,Ren S,Wang J

    更新日期:2019-03-30 00:00:00

  • Recent advances in understanding tumor stroma-mediated chemoresistance in breast cancer.

    abstract::Although solid tumors comprise malignant cells, they also contain many different non-malignant cell types in their micro-environment. The cellular components of the tumor stroma consist of immune and endothelial cells combined with a heterogeneous population of stromal cells which include cancer-associated fibroblasts...

    journal_title:Molecular cancer

    pub_type: 杂志文章,评审

    doi:10.1186/s12943-019-0960-z

    authors: Plava J,Cihova M,Burikova M,Matuskova M,Kucerova L,Miklikova S

    更新日期:2019-03-30 00:00:00

  • Exosomal FMR1-AS1 facilitates maintaining cancer stem-like cell dynamic equilibrium via TLR7/NFκB/c-Myc signaling in female esophageal carcinoma.

    abstract:BACKGROUND:Though esophageal cancer is three to four times more common among males than females worldwide, this type of cancer still ranks in the top incidence among women, even more than the female specific cancer types. The occurrence is currently attributed to extrinsic factors, including tobacco use and alcohol con...

    journal_title:Molecular cancer

    pub_type: 杂志文章

    doi:10.1186/s12943-019-0949-7

    authors: Li W,Zhang L,Guo B,Deng J,Wu S,Li F,Wang Y,Lu J,Zhou Y

    更新日期:2019-02-08 00:00:00

  • Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis.

    abstract::Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with high morbidity and mortality worldwide. To date, limited therapeutic achievements targeting cell proliferation and related mechanisms has led researchers to focus on the microenvironment where pancreatic cancers develop. The anomalous proliferation ...

    journal_title:Molecular cancer

    pub_type: 杂志文章,评审

    doi:10.1186/s12943-018-0927-5

    authors: Thomas D,Radhakrishnan P

    更新日期:2019-01-21 00:00:00

  • PIWI-interacting RNA-36712 restrains breast cancer progression and chemoresistance by interaction with SEPW1 pseudogene SEPW1P RNA.

    abstract:BACKGROUND:Breast cancer is one of the most common malignancies and the major cause of cancer-related death in women. Although the importance of PIWI-interacting RNAs (piRNAs) in cancer has been increasingly recognized, few studies have been explored the functional mechanism of piRNAs in breast cancer development and p...

    journal_title:Molecular cancer

    pub_type: 杂志文章

    doi:10.1186/s12943-019-0940-3

    authors: Tan L,Mai D,Zhang B,Jiang X,Zhang J,Bai R,Ye Y,Li M,Pan L,Su J,Zheng Y,Liu Z,Zuo Z,Zhao Q,Li X,Huang X,Yang J,Tan W,Zheng J,Lin D

    更新日期:2019-01-12 00:00:00

  • The circRNA circAGFG1 acts as a sponge of miR-195-5p to promote triple-negative breast cancer progression through regulating CCNE1 expression.

    abstract:BACKGROUND:In recent years, circular RNAs (circRNAs), a new star of non-coding RNA, have been emerged as vital regulators and gained much attention for involvement of initiation and progression of diverse kinds of human diseases, especially cancer. However, regulatory role, clinical significance and underlying mechanis...

    journal_title:Molecular cancer

    pub_type: 杂志文章

    doi:10.1186/s12943-018-0933-7

    authors: Yang R,Xing L,Zheng X,Sun Y,Wang X,Chen J

    更新日期:2019-01-08 00:00:00

  • Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/ Bcl-2 expression.

    abstract:BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies. Neovascularization during tumorigenesis supplies oxygen and nutrients to proliferative tumor cells, and serves as a conduit for migration. Targeting oncogenes involved in angiogenesis is needed to treat organ-confined and local...

    journal_title:Molecular cancer

    pub_type: 杂志文章

    doi:10.1186/s12943-018-0930-x

    authors: Chen Y,Wang D,Peng H,Chen X,Han X,Yu J,Wang W,Liang L,Liu Z,Zheng Y,Hu J,Yang L,Li J,Zhou H,Cui X,Li F

    更新日期:2019-01-04 00:00:00

  • TRIB2 functions as novel oncogene in colorectal cancer by blocking cellular senescence through AP4/p21 signaling.

    abstract:BACKGROUND:Cellular senescence is a state of irreversible cell growth arrest and senescence cells permanently lose proliferation potential. Induction of cellular senescence might be a novel therapy for cancer cells. TRIB2 has been reported to participate in regulating proliferation and drug resistance of various cancer...

    journal_title:Molecular cancer

    pub_type: 杂志文章

    doi:10.1186/s12943-018-0922-x

    authors: Hou Z,Guo K,Sun X,Hu F,Chen Q,Luo X,Wang G,Hu J,Sun L

    更新日期:2018-12-12 00:00:00

  • Effects of tumor metabolic microenvironment on regulatory T cells.

    abstract::Recent studies have shown that on one hand, tumors need to obtain a sufficient energy supply, and on the other hand they must evade the body's immune surveillance. Because of their metabolic reprogramming characteristics, tumors can modify the physicochemical properties of the microenvironment, which in turn affects t...

    journal_title:Molecular cancer

    pub_type: 杂志文章,评审

    doi:10.1186/s12943-018-0913-y

    authors: Wang YA,Li XL,Mo YZ,Fan CM,Tang L,Xiong F,Guo C,Xiang B,Zhou M,Ma J,Huang X,Wu X,Li Y,Li GY,Zeng ZY,Xiong W

    更新日期:2018-11-26 00:00:00

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