abstract：: Background: The photo reflection method (PRM) is used to measure light reflected from particles released from dry powder inhalers (DPIs). This simple method depicts time trajectories of released drugs; however, it underestimates the number of particles at high peak inhalat...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Kondo T,Hibino M,Tanigaki T,Tajiri S,Horiuchi S

更新日期：2020-11-04 00:00:00

abstract：: Background: Many countries have introduced a compulsory use of community masks for certain public areas during the SARS-CoV-2 pandemic. Different manufacturers offer reusable community masks in large quantities. The efficacy of these masks, however, is unknown. ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Maurer L,Peris D,Kerl J,Guenther F,Koehler D,Dellweg D

更新日期：2020-09-23 00:00:00

abstract：:The success of inhalation therapy is not only dependent upon the pharmacology of the drugs being inhaled but also upon the site and extent of deposition in the respiratory tract. Similarly, the toxicity of environmental and industrial particulate matter is affected not only by the nature of the dust but also by the am...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Darquenne C

更新日期：2020-08-01 00:00:00

abstract：: Background: Salvia miltiorrhiza polyphenolic acid (SMPA) is effective in the treatment of cardiovascular diseases and currently it is administered orally or intravenously. However, SMPA is poorly absorbed orally and quickly eliminated in vivo. A long-term frequent intraveno...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Lu P,Xing Y,Peng H,Liu Z,Zhou QT,Xue Z,Ma Z,Kebebe D,Zhang B,Liu H

更新日期：2020-04-01 00:00:00

abstract：: Background: Many substances used in inhalation research are water soluble and can be administered as nebulized solutions. Typical examples are therapeutic, small-molecular agents, or macromolecules. Another category is a number of water-soluble agents used for airway diagn...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Gerde P,Nowenwik M,Sjöberg CO,Selg E

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Predicting local lung tissue pharmacodynamic (PD) responses of inhaled drugs is a longstanding challenge related to the lack of experimental techniques to determine local free drug concentrations. This has prompted the use of physiologically based pharmacokinetic (PBPK) modeling to potentially predict local ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Boger E,Fridén M

更新日期：2019-02-01 00:00:00

abstract：: Background: Inhalation of medications is the cornerstone in the treatment of patients with lung diseases. A variety of inhalation devices exists and each device has specific requirements to achieve optimum inhalation of the drug. The goal of this study was to establish a c...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Pohlmann G,Hohlfeld JM,Haidl P,Pankalla J,Cloes RM

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Vitamin A (VA) is crucial for lung growth and development. In premature infants, inadequate VA levels are associated with an increased risk of bronchopulmonary dysplasia (BPD). Intramuscular VA supplementation has been shown to decrease the incidence of BPD, but is not widely used in the clinical setting due...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Wahl HB,Hütten MC,Monz D,Tutdibi E,Ophelders D,Nikiforou M,Tschernig T,Gortner L,Nohr D,Biesalski HK,Kramer BW

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Secondary lung infections are the primary cause of morbidity associated with cystic fibrosis lung disease. Aerosolized antibiotic inhalation is potentially advantageous but has limited effectiveness due to altered airway aerodynamics and deposition patterns that limit drug access to infected regions. One pot...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Iasella SV,Stetten AZ,Corcoran TE,Garoff S,Przybycien TM,Tilton RD

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Remote inhaler monitoring is an emerging technology that enables the healthcare team to monitor the time and location of a patient's inhaler use. We assessed the feasibility of remote inhaler monitoring for chronic obstructive pulmonary disease (COPD) patients and the pattern of albuterol inhaler use associa...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Sumino K,Locke ER,Magzamen S,Gylys-Colwell I,Humblet O,Nguyen HQ,Thomas RM,Fan VS

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Preclinical evaluation of new chemical entities (NCEs) designed to be administered by inhalation route requires lung administration to rodents, especially in the discovery phase. Different administration methods have been used until now, but more efforts are required to obtain controlled and reproducible lun...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Fioni A,Selg E,Cenacchi V,Acevedo F,Brogin G,Gerde P,Puccini P

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Model predictions of regional deposition in the respiratory tract are useful in assessing factors that influence the effectiveness of aerosol delivery. Regional deposition models have previously been coupled with models of mucous production and clearance to estimate initial concentrations of drug deposited i...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Martin AR,Finlay WH

更新日期：2018-02-01 00:00:00

abstract：:The available toxicity data of benzalkonium chloride (BKC) clearly shows that it is toxic; however, the weight of evidence favors the view that at doses encountered in nasally and orally inhaled pharmaceutical preparations it is well tolerated. The adverse toxicological data predominantly come from in vitro and animal...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Johnson NF

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:The delivery of antitubercular drugs through direct lung targeting can lead to reduction in the dose as well as side effects of the drug. In the present investigation, carrier (lactose)-based dry-powder inhaler of rifampicin was prepared to achieve direct targeting of the drug into the lungs. METHODS:The dr...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Rawal T,Kremer L,Halloum I,Butani S

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:The unit dose dry powder inhaler (UD-DPI) is being considered as an alternative inhaler platform that, if developed, has the potential to improve access to inhaled respiratory medicines in developing countries. AIM:This study compared the systemic exposure of fluticasone furoate after delivery from the UD-D...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Mehta R,Moore A,Riddell K,Joshi S,Chan R

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Researchers, using checklists, have identified that 30%-90% of patients make errors in inhaler use. It is not certain whether these errors affect the delivery of medication. We have developed an electronic monitor (INCA™) that records audio each time an inhaler is used, providing objective information on inh...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Sulaiman I,Seheult J,Sadasivuni N,MacHale E,Killane I,Giannoutsos S,Cushen B,Mokoka MC,Bhreathnach AS,Boland F,Reilly RB,Costello RW

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:The effectiveness of metered-dose inhalers (MDIs) in delivering medication to the lungs highly depends on its correct usage technique. Current guidelines state optimal technique for high lung deposition should include a slow inhalation (>5 seconds) at an inspiratory flow rate of 30 L/min and inhaler actuatio...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Biswas R,Hanania NA,Sabharwal A

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Mechanically ventilated patients commonly suffer from ventilator-associated pneumonia, hypoxemia, and other lower respiratory tract infection as a result of pathogen colonization and poor sputum clearance. Consequently, there is a high rate of morbidity and mortality in these patients. Dry powder mannitol in...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Feng B,Tang P,Leung SS,Dhanani J,Chan HK

更新日期：2017-04-01 00:00:00

abstract：:Upper respiratory tract infections (URTIs), primarily acute rhinopharyngitis, tonsillitis, adenoiditis, and rhinosinusitis (RS), are major causes of morbidity in both children and adults of any age. In addition to the frequent occurrence of related medical problems and the associated socioeconomic costs, URTIs have a ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Esposito S,Rosazza C,Sciarrabba CS,Principi N

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Particle size and velocity are two of the most significant factors that impact the deposition of pressurized metered-dose inhaler (pMDI) sprays in the mouth cavity. pMDIs are prominently used around the world in the treatment of patients suffering from a variety of lung diseases such as asthma and chronic ob...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Alatrash A,Matida E

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:Many methods have been developed to evaluate dry powder inhalation techniques and their efficiency for disease control in asthma patients. However, it is difficult to apply these methods to clinical practice and research. In this study, we introduce a simple new method that can be applied to dry powder inhalati...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Liang Y,Hu H,Tian C,Lei Y,Liu C,Luo F

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Very little is known about the role of nasal morphology due to ethnic variation on particle deposition pattern in the sinonasal cavity. This preliminary study utilizes computational fluid dynamics (CFD) modeling to investigate sinonasal airway morphology and deposition patterns of intranasal sprayed particle...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Keeler JA,Patki A,Woodard CR,Frank-Ito DO

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:To validate the 'Test of Adherence to Inhalers' (TAI), a 12-item questionnaire designed to assess the adherence to inhalers in patients with COPD or asthma. METHODS:A total of 1009 patients with asthma or COPD participated in a cross-sectional multicenter study. Patients with electronic adherence ≥80% were ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Plaza V,Fernández-Rodríguez C,Melero C,Cosío BG,Entrenas LM,de Llano LP,Gutiérrez-Pereyra F,Tarragona E,Palomino R,López-Viña A,TAI Study Group.

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:High flow nasal cannula oxygen therapy (HFT) is increasingly used in intensive and emergency care departments. Patients suffering from respiratory failure, who are likely to benefit from HFT, may require aerosolized bronchodilators; therefore, combining nebulization with HFT may be relevant. This study aimed...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Réminiac F,Vecellio L,Heuzé-Vourc'h N,Petitcollin A,Respaud R,Cabrera M,Pennec DL,Diot P,Ehrmann S

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Computer modeling is used to predict inhaled aerosol deposition in the lung based on definition of the aerosol characteristics and the breathing pattern and airway anatomy of the subject. Validation of the models is limited by the lack of detailed experimental data. Three-dimensional imaging provides an oppo...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Fleming J,Conway J,Majoral C,Katz I,Caillibotte G,Pichelin M,Montesantos S,Bennett M

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Currently bronchial provocation testing (BPT) using mannitol powder cannot be performed in children under 6 years. A primary reason is it is challenging for children at this age to generate a consistent inspiratory effort to inhale mannitol efficiently from a dry powder inhaler. A prototype system, which doe...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Tang P,Leung SS,Hor E,Ruzycki CA,Carrigy NB,Finlay WH,Brannan JD,Devadason S,Anderson SD,Sly PD,Samnick K,Chan HK

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Understanding the regional partition of deposition of inhaled particles within the lung is important for improving targeted delivery of inhaled aerosolized drugs. One factor affecting regional deposition is gravity. As the lung deforms under its own weight, changes in lung volume, in airway geometries, and i...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Sá RC,Zeman KL,Bennett WD,Prisk GK,Darquenne C

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Spiromax(®) is a novel dry powder inhaler for patients with asthma or chronic obstructive pulmonary disease (COPD). The studies presented here provide further data on attributes (in vitro dosing consistency with budesonide-formoterol (DuoResp) Spiromax; flow rates through empty versions of the Spiromax and T...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Canonica GW,Arp J,Keegstra JR,Chrystyn H

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:To our knowledge, quantification of intranasal deposition of aerosol generated by Accuspray(™) (AS) in children has never been published. We hypothesized that deposition would vary significantly with age and with placement of the device within, or outside, of the nostril. METHODS:We tested these hypotheses ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Laube BL,Sharpless G,Vikani AR,Harrand V,Zinreich SJ,Sedberry K,Knaus D,Barry J,Papania M

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Dyspnea significantly impacts quality of life and is one of the most common symptoms in advanced illness. Systemically-administered opioids and benzodiazepines have been the most studied and utilized pharmacologic treatments for refractory dyspnea. Less attention has been given to the use of these medication...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Boyden JY,Connor SR,Otolorin L,Nathan SD,Fine PG,Davis MS,Muir JC

更新日期：2015-02-01 00:00:00

abstract：:Since the early 1960s, there has been a continuous evolution in scientific understanding regarding bioequivalence (BE) of oral dosage forms, intermittently punctuated by some breakthrough research findings and conceptual advances. The accumulated knowledge from this body of research has been translated into a sophisti...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Horhota ST

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:The objective of this study was to determine optimal aerosol delivery conditions for a full-term (3.6 kg) infant receiving invasive mechanical ventilation by evaluating the effects of aerosol particle size, a new wye connector, and timing of aerosol delivery. METHODS:In vitro experiments used a vibrating mesh ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Longest PW,Azimi M,Hindle M

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Use of a valved holding chamber (VHC) in conjunction with a pressurized metered dose inhaler (pMDI) can reduce issues relating to poor actuation-inhalation coordination and potentially improve the lung deposition of aerosol, compared with use of a pMDI alone. However, the performance of a VHC is influenced b...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Hatley RH,von Hollen D,Sandell D,Slator L

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVES:This experimental study was conducted to determine the effects of training on inhaler technique and quality of life in patients with chronic obstructive pulmonary disease (COPD). METHODS:Among the patients who applied at the outpatient clinic of chest diseases between March 2009 and May 2010, a total of 69 ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Göriş S,Taşci S,Elmali F

更新日期：2013-12-01 00:00:00

abstract：:The use of gamma camera imaging following the inhalation of a radiolabel has been widely used by researchers to investigate the fate of inhaled aerosols. The application of two-dimensional (2D) planar gamma scintigraphy and single-photon emission computed tomography (SPECT) to the study of inhaled aerosols is discusse...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Conway J,Fleming J,Bennett M,Havelock T

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Inhaled atropine is being developed as a systemic and pulmonary treatment for the extended recovery period after chemical weapons exposure. We performed a pharmacokinetics study comparing inhaled atropine delivery using the MicroDose Therapeutx Dry Powder Inhaler (DPIA) with intramuscular (IM) atropine deliv...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Corcoran TE,Venkataramanan R,Hoffman RM,George MP,Petrov A,Richards T,Zhang S,Choi J,Gao YY,Oakum CD,Cook RO,Donahoe M

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:The Abbreviated Impactor Measurement (AIM) concept simplifies determination of aerodynamic size metrics for inhaler quality control testing. A similar approach is needed to compare in vitro particle size distribution metrics with human respiratory tract (HRT) deposition. METHODS:An abbreviated impactor base...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Mitchell J,Copley M,Sizer Y,Russell T,Solomon D

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Small rodents continue to be the mainstay for the assessment of pharmacological and toxicological data of inhaled therapeutics. For meaningful interpretation of the results information about deposition of aerosol particles in the respiratory tract is warranted, but not trivial to obtain for animals with nose...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Ahmed A,Prime D,Burnell PK,Högger P

更新日期：2012-06-01 00:00:00

abstract：:This article provides a concise review of the use of magnetic resonance imaging (MRI) for measurement of regional aerosol deposition in the lungs. Basic aspects of MRI and its use in lung imaging and measurement of regional ventilation are introduced. Imaging of hydrogen protons (water) and inhaled hyperpolarized gase...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Thompson RB,Finlay WH

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Inhaled corticosteroid (ICS) therapy has improved the quality of life (QOL) for many asthmatics and reduced mortality rates associated with asthma. However, some patients do not obtain therapeutic benefit despite satisfactory adherence. OBJECTIVES:To determine whether asthmatic patients were using ICS devic...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Baba K,Tanaka H,Nishimura M,Yokoe N,Takahashi D,Yagi T,Yamaguchi E,Maeda Y,Muto T,Hasegawa T

更新日期：2011-12-01 00:00:00