听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览Journal of Aerosol Medicine and Pulmonary Drug Delivery期刊下所有文献
  • Correcting Photo Reflection Method Output and Its Application in the Dynamic Analysis of Particle Release from Dry Powder Inhalers.

    abstract:: Background: The photo reflection method (PRM) is used to measure light reflected from particles released from dry powder inhalers (DPIs). This simple method depicts time trajectories of released drugs; however, it underestimates the number of particles at high peak inhalat...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2020.1610

    authors: Kondo T,Hibino M,Tanigaki T,Tajiri S,Horiuchi S

    更新日期:2020-11-04 00:00:00

  • Community Masks During the SARS-CoV-2 Pandemic: Filtration Efficacy and Air Resistance.

    abstract:: Background: Many countries have introduced a compulsory use of community masks for certain public areas during the SARS-CoV-2 pandemic. Different manufacturers offer reusable community masks in large quantities. The efficacy of these masks, however, is unknown. ...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2020.1635

    authors: Maurer L,Peris D,Kerl J,Guenther F,Koehler D,Dellweg D

    更新日期:2020-09-23 00:00:00

  • Deposition Mechanisms.

    abstract::The success of inhalation therapy is not only dependent upon the pharmacology of the drugs being inhaled but also upon the site and extent of deposition in the respiratory tract. Similarly, the toxicity of environmental and industrial particulate matter is affected not only by the nature of the dust but also by the am...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2020.29029.cd

    authors: Darquenne C

    更新日期:2020-08-01 00:00:00

  • Adapting the Aerogen Mesh Nebulizer for Dried Aerosol Exposures Using the PreciseInhale Platform.

    abstract:: Background: Many substances used in inhalation research are water soluble and can be administered as nebulized solutions. Typical examples are therapeutic, small-molecular agents, or macromolecules. Another category is a number of water-soluble agents used for airway diagn...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2019.1554

    authors: Gerde P,Nowenwik M,Sjöberg CO,Selg E

    更新日期:2020-04-01 00:00:00

  • Physicochemical and Pharmacokinetic Evaluation of Spray-Dried Coformulation of Salvia miltiorrhiza Polyphenolic Acid and L-Leucine with Improved Bioavailability.

    abstract:: Background: Salvia miltiorrhiza polyphenolic acid (SMPA) is effective in the treatment of cardiovascular diseases and currently it is administered orally or intravenously. However, SMPA is poorly absorbed orally and quickly eliminated in vivo. A long-term frequent intraveno...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2019.1538

    authors: Lu P,Xing Y,Peng H,Liu Z,Zhou QT,Xue Z,Ma Z,Kebebe D,Zhang B,Liu H

    更新日期:2020-04-01 00:00:00

  • Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Accurately Predicts the Better Bronchodilatory Effect of Inhaled Versus Oral Salbutamol Dosage Forms.

    abstract:BACKGROUND:Predicting local lung tissue pharmacodynamic (PD) responses of inhaled drugs is a longstanding challenge related to the lack of experimental techniques to determine local free drug concentrations. This has prompted the use of physiologically based pharmacokinetic (PBPK) modeling to potentially predict local ...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2017.1436

    authors: Boger E,Fridén M

    更新日期:2019-02-01 00:00:00

  • Vitamin A Supplementation by Endotracheal Application of a Nano-encapsulated Preparation Is Feasible in Ventilated Preterm Lambs.

    abstract:BACKGROUND:Vitamin A (VA) is crucial for lung growth and development. In premature infants, inadequate VA levels are associated with an increased risk of bronchopulmonary dysplasia (BPD). Intramuscular VA supplementation has been shown to decrease the incidence of BPD, but is not widely used in the clinical setting due...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2017.1438

    authors: Wahl HB,Hütten MC,Monz D,Tutdibi E,Ophelders D,Nikiforou M,Tschernig T,Gortner L,Nohr D,Biesalski HK,Kramer BW

    更新日期:2018-12-01 00:00:00

  • Assessment of the Power Required for Optimal Use of Current Inhalation Devices.

    abstract:: Background: Inhalation of medications is the cornerstone in the treatment of patients with lung diseases. A variety of inhalation devices exists and each device has specific requirements to achieve optimum inhalation of the drug. The goal of this study was to establish a c...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2017.1376

    authors: Pohlmann G,Hohlfeld JM,Haidl P,Pankalla J,Cloes RM

    更新日期:2018-12-01 00:00:00

  • Aerosolizing Lipid Dispersions Enables Antibiotic Transport Across Mimics of the Lung Airway Surface Even in the Presence of Pre-existing Lipid Monolayers.

    abstract:BACKGROUND:Secondary lung infections are the primary cause of morbidity associated with cystic fibrosis lung disease. Aerosolized antibiotic inhalation is potentially advantageous but has limited effectiveness due to altered airway aerodynamics and deposition patterns that limit drug access to infected regions. One pot...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2017.1412

    authors: Iasella SV,Stetten AZ,Corcoran TE,Garoff S,Przybycien TM,Tilton RD

    更新日期:2018-08-01 00:00:00

  • Use of a Remote Inhaler Monitoring Device to Measure Change in Inhaler Use with Chronic Obstructive Pulmonary Disease Exacerbations.

    abstract:BACKGROUND:Remote inhaler monitoring is an emerging technology that enables the healthcare team to monitor the time and location of a patient's inhaler use. We assessed the feasibility of remote inhaler monitoring for chronic obstructive pulmonary disease (COPD) patients and the pattern of albuterol inhaler use associa...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2017.1383

    authors: Sumino K,Locke ER,Magzamen S,Gylys-Colwell I,Humblet O,Nguyen HQ,Thomas RM,Fan VS

    更新日期:2018-06-01 00:00:00

  • Model Calculations of Regional Deposition and Disposition for Single Doses of Inhaled Liposomal and Dry Powder Ciprofloxacin.

    abstract:BACKGROUND:Model predictions of regional deposition in the respiratory tract are useful in assessing factors that influence the effectiveness of aerosol delivery. Regional deposition models have previously been coupled with models of mucous production and clearance to estimate initial concentrations of drug deposited i...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2017.1377

    authors: Martin AR,Finlay WH

    更新日期:2018-02-01 00:00:00

  • Investigation of Lung Pharmacokinetic of the Novel PDE4 Inhibitor CHF6001 in Preclinical Models: Evaluation of the PreciseInhale Technology.

    abstract:BACKGROUND:Preclinical evaluation of new chemical entities (NCEs) designed to be administered by inhalation route requires lung administration to rodents, especially in the discovery phase. Different administration methods have been used until now, but more efforts are required to obtain controlled and reproducible lun...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2017.1369

    authors: Fioni A,Selg E,Cenacchi V,Acevedo F,Brogin G,Gerde P,Puccini P

    更新日期:2018-02-01 00:00:00

  • Pulmonary Toxicity of Benzalkonium Chloride.

    abstract::The available toxicity data of benzalkonium chloride (BKC) clearly shows that it is toxic; however, the weight of evidence favors the view that at doses encountered in nasally and orally inhaled pharmaceutical preparations it is well tolerated. The adverse toxicological data predominantly come from in vitro and animal...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章,评审

    doi:10.1089/jamp.2017.1390

    authors: Johnson NF

    更新日期:2018-02-01 00:00:00

  • Dry-Powder Inhaler Formulation of Rifampicin: An Improved Targeted Delivery System for Alveolar Tuberculosis.

    abstract:BACKGROUND:The delivery of antitubercular drugs through direct lung targeting can lead to reduction in the dose as well as side effects of the drug. In the present investigation, carrier (lactose)-based dry-powder inhaler of rifampicin was prepared to achieve direct targeting of the drug into the lungs. METHODS:The dr...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2017.1379

    authors: Rawal T,Kremer L,Halloum I,Butani S

    更新日期:2017-12-01 00:00:00

  • Pharmacokinetic Comparison of a Unit Dose Dry Powder Inhaler with a Multidose Dry Powder Inhaler for Delivery of Fluticasone Furoate.

    abstract:BACKGROUND:The unit dose dry powder inhaler (UD-DPI) is being considered as an alternative inhaler platform that, if developed, has the potential to improve access to inhaled respiratory medicines in developing countries. AIM:This study compared the systemic exposure of fluticasone furoate after delivery from the UD-D...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/jamp.2016.1322

    authors: Mehta R,Moore A,Riddell K,Joshi S,Chan R

    更新日期:2017-10-01 00:00:00

  • Factors Determining In Vitro Lung Deposition of Albuterol Aerosol Delivered by Ventolin Metered-Dose Inhaler.

    abstract:BACKGROUND:The effectiveness of metered-dose inhalers (MDIs) in delivering medication to the lungs highly depends on its correct usage technique. Current guidelines state optimal technique for high lung deposition should include a slow inhalation (>5 seconds) at an inspiratory flow rate of 30 L/min and inhaler actuatio...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2015.1278

    authors: Biswas R,Hanania NA,Sabharwal A

    更新日期:2017-08-01 00:00:00

  • The Impact of Common Inhaler Errors on Drug Delivery: Investigating Critical Errors with a Dry Powder Inhaler.

    abstract:BACKGROUND:Researchers, using checklists, have identified that 30%-90% of patients make errors in inhaler use. It is not certain whether these errors affect the delivery of medication. We have developed an electronic monitor (INCA™) that records audio each time an inhaler is used, providing objective information on inh...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2016.1334

    authors: Sulaiman I,Seheult J,Sadasivuni N,MacHale E,Killane I,Giannoutsos S,Cushen B,Mokoka MC,Bhreathnach AS,Boland F,Reilly RB,Costello RW

    更新日期:2017-08-01 00:00:00

  • A Novel In-Line Delivery System to Administer Dry Powder Mannitol to Mechanically Ventilated Patients.

    abstract:BACKGROUND:Mechanically ventilated patients commonly suffer from ventilator-associated pneumonia, hypoxemia, and other lower respiratory tract infection as a result of pathogen colonization and poor sputum clearance. Consequently, there is a high rate of morbidity and mortality in these patients. Dry powder mannitol in...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2016.1320

    authors: Feng B,Tang P,Leung SS,Dhanani J,Chan HK

    更新日期:2017-04-01 00:00:00

  • Inhaled Antibiotic Therapy for the Treatment of Upper Respiratory Tract Infections.

    abstract::Upper respiratory tract infections (URTIs), primarily acute rhinopharyngitis, tonsillitis, adenoiditis, and rhinosinusitis (RS), are major causes of morbidity in both children and adults of any age. In addition to the frequent occurrence of related medical problems and the associated socioeconomic costs, URTIs have a ...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章,评审

    doi:10.1089/jamp.2016.1300

    authors: Esposito S,Rosazza C,Sciarrabba CS,Principi N

    更新日期:2017-02-01 00:00:00

  • Characterization of Medication Velocity and Size Distribution from Pressurized Metered-Dose Inhalers by Phase Doppler Anemometry.

    abstract:BACKGROUND:Particle size and velocity are two of the most significant factors that impact the deposition of pressurized metered-dose inhaler (pMDI) sprays in the mouth cavity. pMDIs are prominently used around the world in the treatment of patients suffering from a variety of lung diseases such as asthma and chronic ob...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2015.1264

    authors: Alatrash A,Matida E

    更新日期:2016-12-01 00:00:00

  • A New Quantitative Method for Evaluating Dry Powder Inhalation Efficiency in Asthma Patients.

    abstract:PURPOSE:Many methods have been developed to evaluate dry powder inhalation techniques and their efficiency for disease control in asthma patients. However, it is difficult to apply these methods to clinical practice and research. In this study, we introduce a simple new method that can be applied to dry powder inhalati...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2014.1193

    authors: Liang Y,Hu H,Tian C,Lei Y,Liu C,Luo F

    更新日期:2016-10-01 00:00:00

  • A Computational Study of Nasal Spray Deposition Pattern in Four Ethnic Groups.

    abstract:BACKGROUND:Very little is known about the role of nasal morphology due to ethnic variation on particle deposition pattern in the sinonasal cavity. This preliminary study utilizes computational fluid dynamics (CFD) modeling to investigate sinonasal airway morphology and deposition patterns of intranasal sprayed particle...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2014.1205

    authors: Keeler JA,Patki A,Woodard CR,Frank-Ito DO

    更新日期:2016-04-01 00:00:00

  • Aerosol Therapy in Adults Receiving High Flow Nasal Cannula Oxygen Therapy.

    abstract:BACKGROUND:High flow nasal cannula oxygen therapy (HFT) is increasingly used in intensive and emergency care departments. Patients suffering from respiratory failure, who are likely to benefit from HFT, may require aerosolized bronchodilators; therefore, combining nebulization with HFT may be relevant. This study aimed...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2015.1219

    authors: Réminiac F,Vecellio L,Heuzé-Vourc'h N,Petitcollin A,Respaud R,Cabrera M,Pennec DL,Diot P,Ehrmann S

    更新日期:2016-04-01 00:00:00

  • Validation of the 'Test of the Adherence to Inhalers' (TAI) for Asthma and COPD Patients.

    abstract:BACKGROUND:To validate the 'Test of Adherence to Inhalers' (TAI), a 12-item questionnaire designed to assess the adherence to inhalers in patients with COPD or asthma. METHODS:A total of 1009 patients with asthma or COPD participated in a cross-sectional multicenter study. Patients with electronic adherence ≥80% were ...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章,多中心研究

    doi:10.1089/jamp.2015.1212

    authors: Plaza V,Fernández-Rodríguez C,Melero C,Cosío BG,Entrenas LM,de Llano LP,Gutiérrez-Pereyra F,Tarragona E,Palomino R,López-Viña A,TAI Study Group.

    更新日期:2016-04-01 00:00:00

  • Effect of Posture on Regional Deposition of Coarse Particles in the Healthy Human Lung.

    abstract:BACKGROUND:Understanding the regional partition of deposition of inhaled particles within the lung is important for improving targeted delivery of inhaled aerosolized drugs. One factor affecting regional deposition is gravity. As the lung deforms under its own weight, changes in lung volume, in airway geometries, and i...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2014.1189

    authors: Sá RC,Zeman KL,Bennett WD,Prisk GK,Darquenne C

    更新日期:2015-12-01 00:00:00

  • An Apparatus to Deliver Mannitol Powder for Bronchial Provocation in Children Under Six Years Old.

    abstract:BACKGROUND:Currently bronchial provocation testing (BPT) using mannitol powder cannot be performed in children under 6 years. A primary reason is it is challenging for children at this age to generate a consistent inspiratory effort to inhale mannitol efficiently from a dry powder inhaler. A prototype system, which doe...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2015.1208

    authors: Tang P,Leung SS,Hor E,Ruzycki CA,Carrigy NB,Finlay WH,Brannan JD,Devadason S,Anderson SD,Sly PD,Samnick K,Chan HK

    更新日期:2015-12-01 00:00:00

  • Controlled, Parametric, Individualized, 2-D and 3-D Imaging Measurements of Aerosol Deposition in the Respiratory Tract of Asthmatic Human Subjects for Model Validation.

    abstract:BACKGROUND:Computer modeling is used to predict inhaled aerosol deposition in the lung based on definition of the aerosol characteristics and the breathing pattern and airway anatomy of the subject. Validation of the models is limited by the lack of detailed experimental data. Three-dimensional imaging provides an oppo...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2014.1191

    authors: Fleming J,Conway J,Majoral C,Katz I,Caillibotte G,Pichelin M,Montesantos S,Bennett M

    更新日期:2015-12-01 00:00:00

  • Spiromax, a New Dry Powder Inhaler: Dose Consistency under Simulated Real-World Conditions.

    abstract:BACKGROUND:Spiromax(®) is a novel dry powder inhaler for patients with asthma or chronic obstructive pulmonary disease (COPD). The studies presented here provide further data on attributes (in vitro dosing consistency with budesonide-formoterol (DuoResp) Spiromax; flow rates through empty versions of the Spiromax and T...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2015.1216

    authors: Canonica GW,Arp J,Keegstra JR,Chrystyn H

    更新日期:2015-10-01 00:00:00

  • Intranasal Deposition of Accuspray™ Aerosol in Anatomically Correct Models of 2-, 5-, and 12-Year-Old Children.

    abstract:BACKGROUND:To our knowledge, quantification of intranasal deposition of aerosol generated by Accuspray(™) (AS) in children has never been published. We hypothesized that deposition would vary significantly with age and with placement of the device within, or outside, of the nostril. METHODS:We tested these hypotheses ...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2014.1174

    authors: Laube BL,Sharpless G,Vikani AR,Harrand V,Zinreich SJ,Sedberry K,Knaus D,Barry J,Papania M

    更新日期:2015-10-01 00:00:00

  • Nebulized medications for the treatment of dyspnea: a literature review.

    abstract:BACKGROUND:Dyspnea significantly impacts quality of life and is one of the most common symptoms in advanced illness. Systemically-administered opioids and benzodiazepines have been the most studied and utilized pharmacologic treatments for refractory dyspnea. Less attention has been given to the use of these medication...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章,评审

    doi:10.1089/jamp.2014.1136

    authors: Boyden JY,Connor SR,Otolorin L,Nathan SD,Fine PG,Davis MS,Muir JC

    更新日期:2015-02-01 00:00:00

  • Evaluation of comparative performance of orally inhaled drug products in view of the classical bioequivalence paradigms: an analysis of the current scientific and regulatory dilemmas of inhaler evaluation.

    abstract::Since the early 1960s, there has been a continuous evolution in scientific understanding regarding bioequivalence (BE) of oral dosage forms, intermittently punctuated by some breakthrough research findings and conceptual advances. The accumulated knowledge from this body of research has been translated into a sophisti...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章,评审

    doi:10.1089/jamp.2014.1144

    authors: Horhota ST

    更新日期:2014-12-01 00:00:00

  • Optimal delivery of aerosols to infants during mechanical ventilation.

    abstract:PURPOSE:The objective of this study was to determine optimal aerosol delivery conditions for a full-term (3.6 kg) infant receiving invasive mechanical ventilation by evaluating the effects of aerosol particle size, a new wye connector, and timing of aerosol delivery. METHODS:In vitro experiments used a vibrating mesh ...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2013.1077

    authors: Longest PW,Azimi M,Hindle M

    更新日期:2014-10-01 00:00:00

  • In vitro characterization of the OptiChamber Diamond valved holding chamber.

    abstract:BACKGROUND:Use of a valved holding chamber (VHC) in conjunction with a pressurized metered dose inhaler (pMDI) can reduce issues relating to poor actuation-inhalation coordination and potentially improve the lung deposition of aerosol, compared with use of a pMDI alone. However, the performance of a VHC is influenced b...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2013.1067

    authors: Hatley RH,von Hollen D,Sandell D,Slator L

    更新日期:2014-08-01 00:00:00

  • The effects of training on inhaler technique and quality of life in patients with COPD.

    abstract:OBJECTIVES:This experimental study was conducted to determine the effects of training on inhaler technique and quality of life in patients with chronic obstructive pulmonary disease (COPD). METHODS:Among the patients who applied at the outpatient clinic of chest diseases between March 2009 and May 2010, a total of 69 ...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/jamp.2012.1017

    authors: Göriş S,Taşci S,Elmali F

    更新日期:2013-12-01 00:00:00

  • The co-imaging of gamma camera measurements of aerosol deposition and respiratory anatomy.

    abstract::The use of gamma camera imaging following the inhalation of a radiolabel has been widely used by researchers to investigate the fate of inhaled aerosols. The application of two-dimensional (2D) planar gamma scintigraphy and single-photon emission computed tomography (SPECT) to the study of inhaled aerosols is discusse...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章,评审

    doi:10.1089/jamp.2011.0960

    authors: Conway J,Fleming J,Bennett M,Havelock T

    更新日期:2013-06-01 00:00:00

  • Systemic delivery of atropine sulfate by the MicroDose Dry-Powder Inhaler.

    abstract:BACKGROUND:Inhaled atropine is being developed as a systemic and pulmonary treatment for the extended recovery period after chemical weapons exposure. We performed a pharmacokinetics study comparing inhaled atropine delivery using the MicroDose Therapeutx Dry Powder Inhaler (DPIA) with intramuscular (IM) atropine deliv...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/jamp.2011.0948

    authors: Corcoran TE,Venkataramanan R,Hoffman RM,George MP,Petrov A,Richards T,Zhang S,Choi J,Gao YY,Oakum CD,Cook RO,Donahoe M

    更新日期:2013-02-01 00:00:00

  • Adapting the Abbreviated Impactor Measurement (AIM) concept to make appropriate inhaler aerosol measurements to compare with clinical data: a scoping study with the "Alberta" idealized throat (AIT) inlet.

    abstract:BACKGROUND:The Abbreviated Impactor Measurement (AIM) concept simplifies determination of aerodynamic size metrics for inhaler quality control testing. A similar approach is needed to compare in vitro particle size distribution metrics with human respiratory tract (HRT) deposition. METHODS:An abbreviated impactor base...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2011.0925

    authors: Mitchell J,Copley M,Sizer Y,Russell T,Solomon D

    更新日期:2012-08-01 00:00:00

  • Development of an in vitro model to assess deposition of aerosol particles in a representative replica of the rat's respiratory tract.

    abstract:BACKGROUND:Small rodents continue to be the mainstay for the assessment of pharmacological and toxicological data of inhaled therapeutics. For meaningful interpretation of the results information about deposition of aerosol particles in the respiratory tract is warranted, but not trivial to obtain for animals with nose...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2011.0902

    authors: Ahmed A,Prime D,Burnell PK,Högger P

    更新日期:2012-06-01 00:00:00

  • Using MRI to measure aerosol deposition.

    abstract::This article provides a concise review of the use of magnetic resonance imaging (MRI) for measurement of regional aerosol deposition in the lungs. Basic aspects of MRI and its use in lung imaging and measurement of regional ventilation are introduced. Imaging of hydrogen protons (water) and inhaled hyperpolarized gase...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章,评审

    doi:10.1089/jamp.2011.0897

    authors: Thompson RB,Finlay WH

    更新日期:2012-04-01 00:00:00

  • Age-dependent deterioration of peak inspiratory flow with two kinds of dry powder corticosteroid inhalers (Diskus and Turbuhaler) and relationships with asthma control.

    abstract:BACKGROUND:Inhaled corticosteroid (ICS) therapy has improved the quality of life (QOL) for many asthmatics and reduced mortality rates associated with asthma. However, some patients do not obtain therapeutic benefit despite satisfactory adherence. OBJECTIVES:To determine whether asthmatic patients were using ICS devic...

    journal_title:Journal of aerosol medicine and pulmonary drug delivery

    pub_type: 杂志文章

    doi:10.1089/jamp.2010.0868

    authors: Baba K,Tanaka H,Nishimura M,Yokoe N,Takahashi D,Yagi T,Yamaguchi E,Maeda Y,Muto T,Hasegawa T

    更新日期:2011-12-01 00:00:00

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