In vitro characterization of the OptiChamber Diamond valved holding chamber.

abstract：BACKGROUND:Remote inhaler monitoring is an emerging technology that enables the healthcare team to monitor the time and location of a patient's inhaler use. We assessed the feasibility of remote inhaler monitoring for chronic obstructive pulmonary disease (COPD) patients and the pattern of albuterol inhaler use associa...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Sumino K,Locke ER,Magzamen S,Gylys-Colwell I,Humblet O,Nguyen HQ,Thomas RM,Fan VS

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Inhaled alpha1-antitrypsin (AAT) is being developed for treatment of cystic fibrosis to protect the lungs from excessive free elastase. High drug costs mandate a very efficient aerosol system to deliver a high payload to the airways. The I-neb Adaptive Aerosol Delivery (AAD) System is a portable, electronic,...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Geller DE,Kesser KC

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:The objective of this study was to determine optimal aerosol delivery conditions for a full-term (3.6 kg) infant receiving invasive mechanical ventilation by evaluating the effects of aerosol particle size, a new wye connector, and timing of aerosol delivery. METHODS:In vitro experiments used a vibrating mesh ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Longest PW,Azimi M,Hindle M

更新日期：2014-10-01 00:00:00

abstract：:Flexhaler is a multiple-dose, inspiratory flow-driven dry powder inhaler that is a newer version of Turbuhaler, and is identical to the Symbicort Turbuhaler. Sustained performance is of the utmost importance to ensure consistent drug delivery throughout the lifespan of the inhaler. We report functionality testing resu...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Lööf T,Elfman P,Ström P,Törngren A,Borgström L

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Preclinical evaluation of new chemical entities (NCEs) designed to be administered by inhalation route requires lung administration to rodents, especially in the discovery phase. Different administration methods have been used until now, but more efforts are required to obtain controlled and reproducible lun...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Fioni A,Selg E,Cenacchi V,Acevedo F,Brogin G,Gerde P,Puccini P

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:The delivery of antitubercular drugs through direct lung targeting can lead to reduction in the dose as well as side effects of the drug. In the present investigation, carrier (lactose)-based dry-powder inhaler of rifampicin was prepared to achieve direct targeting of the drug into the lungs. METHODS:The dr...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Rawal T,Kremer L,Halloum I,Butani S

更新日期：2017-12-01 00:00:00

abstract：: Background: Many countries have introduced a compulsory use of community masks for certain public areas during the SARS-CoV-2 pandemic. Different manufacturers offer reusable community masks in large quantities. The efficacy of these masks, however, is unknown. ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Maurer L,Peris D,Kerl J,Guenther F,Koehler D,Dellweg D

更新日期：2020-09-23 00:00:00

abstract：: Background: The photo reflection method (PRM) is used to measure light reflected from particles released from dry powder inhalers (DPIs). This simple method depicts time trajectories of released drugs; however, it underestimates the number of particles at high peak inhalat...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Kondo T,Hibino M,Tanigaki T,Tajiri S,Horiuchi S

更新日期：2020-11-04 00:00:00

abstract：BACKGROUND:Computer modeling is used to predict inhaled aerosol deposition in the lung based on definition of the aerosol characteristics and the breathing pattern and airway anatomy of the subject. Validation of the models is limited by the lack of detailed experimental data. Three-dimensional imaging provides an oppo...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Fleming J,Conway J,Majoral C,Katz I,Caillibotte G,Pichelin M,Montesantos S,Bennett M

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:The Abbreviated Impactor Measurement (AIM) concept simplifies determination of aerodynamic size metrics for inhaler quality control testing. A similar approach is needed to compare in vitro particle size distribution metrics with human respiratory tract (HRT) deposition. METHODS:An abbreviated impactor base...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Mitchell J,Copley M,Sizer Y,Russell T,Solomon D

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Model predictions of regional deposition in the respiratory tract are useful in assessing factors that influence the effectiveness of aerosol delivery. Regional deposition models have previously been coupled with models of mucous production and clearance to estimate initial concentrations of drug deposited i...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Martin AR,Finlay WH

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Vitamin A (VA) is crucial for lung growth and development. In premature infants, inadequate VA levels are associated with an increased risk of bronchopulmonary dysplasia (BPD). Intramuscular VA supplementation has been shown to decrease the incidence of BPD, but is not widely used in the clinical setting due...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Wahl HB,Hütten MC,Monz D,Tutdibi E,Ophelders D,Nikiforou M,Tschernig T,Gortner L,Nohr D,Biesalski HK,Kramer BW

更新日期：2018-12-01 00:00:00

abstract：:The success of inhalation therapy is not only dependent upon the pharmacology of the drugs being inhaled but also upon the site and extent of deposition in the respiratory tract. Similarly, the toxicity of environmental and industrial particulate matter is affected not only by the nature of the dust but also by the am...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Darquenne C

更新日期：2020-08-01 00:00:00

abstract：:Antibiotic-resistant bacterial infections have renewed interest in finding substitute methods of treatment. The purpose of the present in vitro study was to investigate the possibility of respiratory delivery of a Burkholderia cepacia complex (BCC) bacteriophage by nebulized aerosol administration. Bacteriophages in i...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Golshahi L,Seed KD,Dennis JJ,Finlay WH

更新日期：2008-12-01 00:00:00

abstract：:The present study aimed at assessing the pharmacokinetics (PK) and safety pharmacodynamics (PD) of 24 microg formoterol delivered via a Novolizer and via an Aerolizer in healthy subjects. This was a randomized, open-label, crossover study. Beside PK, serum potassium, and glucose profiles, vital signs, and ECG were rec...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Petzold U,Kremer HJ,Nguyen DT,Munzel U,Dietrich H,Maus J

更新日期：2008-09-01 00:00:00

abstract：:This article provides a concise review of the use of magnetic resonance imaging (MRI) for measurement of regional aerosol deposition in the lungs. Basic aspects of MRI and its use in lung imaging and measurement of regional ventilation are introduced. Imaging of hydrogen protons (water) and inhaled hyperpolarized gase...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Thompson RB,Finlay WH

更新日期：2012-04-01 00:00:00

abstract：:Since the early 1960s, there has been a continuous evolution in scientific understanding regarding bioequivalence (BE) of oral dosage forms, intermittently punctuated by some breakthrough research findings and conceptual advances. The accumulated knowledge from this body of research has been translated into a sophisti...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Horhota ST

更新日期：2014-12-01 00:00:00

abstract：:Significant advances have been made in the last 50 years in developing safe and efficacious aerosol formulations for pulmonary delivery. The key to future innovation may lie at the interface between biology and particle engineering. Improved understanding of biological processes including particle clearance, cellular ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Weers JG,Bell J,Chan HK,Cipolla D,Dunbar C,Hickey AJ,Smith IJ

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Secondary lung infections are the primary cause of morbidity associated with cystic fibrosis lung disease. Aerosolized antibiotic inhalation is potentially advantageous but has limited effectiveness due to altered airway aerodynamics and deposition patterns that limit drug access to infected regions. One pot...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Iasella SV,Stetten AZ,Corcoran TE,Garoff S,Przybycien TM,Tilton RD

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:The site of deposition in the respiratory tract for aerosolized, inhaled therapeutic drugs depends on both the particles' aerodynamic size and the patient's breathing pattern. METHODS:In 21 healthy subjects with normal lung function, we evaluated an extremely slow inhalation of a large 9.5-μm MMAD particle ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Zeman KL,Wu J,Bennett WD

更新日期：2010-12-01 00:00:00

abstract：:Inhalation is a potentially viable route of administration for numerous agents. In diabetes mellitus, the need for frequent injections to achieve ideal glycemic control remains a significant limitation for initiating and complying with insulin therapy in a large number of patients. To overcome this barrier, inhaled in...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Zarogoulidis P,Papanas N,Kouliatsis G,Spyratos D,Zarogoulidis K,Maltezos E

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVES:This experimental study was conducted to determine the effects of training on inhaler technique and quality of life in patients with chronic obstructive pulmonary disease (COPD). METHODS:Among the patients who applied at the outpatient clinic of chest diseases between March 2009 and May 2010, a total of 69 ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Göriş S,Taşci S,Elmali F

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Understanding the regional partition of deposition of inhaled particles within the lung is important for improving targeted delivery of inhaled aerosolized drugs. One factor affecting regional deposition is gravity. As the lung deforms under its own weight, changes in lung volume, in airway geometries, and i...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Sá RC,Zeman KL,Bennett WD,Prisk GK,Darquenne C

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Researchers, using checklists, have identified that 30%-90% of patients make errors in inhaler use. It is not certain whether these errors affect the delivery of medication. We have developed an electronic monitor (INCA™) that records audio each time an inhaler is used, providing objective information on inh...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Sulaiman I,Seheult J,Sadasivuni N,MacHale E,Killane I,Giannoutsos S,Cushen B,Mokoka MC,Bhreathnach AS,Boland F,Reilly RB,Costello RW

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:The unit dose dry powder inhaler (UD-DPI) is being considered as an alternative inhaler platform that, if developed, has the potential to improve access to inhaled respiratory medicines in developing countries. AIM:This study compared the systemic exposure of fluticasone furoate after delivery from the UD-D...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Mehta R,Moore A,Riddell K,Joshi S,Chan R

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Inhaled atropine is being developed as a systemic and pulmonary treatment for the extended recovery period after chemical weapons exposure. We performed a pharmacokinetics study comparing inhaled atropine delivery using the MicroDose Therapeutx Dry Powder Inhaler (DPIA) with intramuscular (IM) atropine deliv...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Corcoran TE,Venkataramanan R,Hoffman RM,George MP,Petrov A,Richards T,Zhang S,Choi J,Gao YY,Oakum CD,Cook RO,Donahoe M

更新日期：2013-02-01 00:00:00

abstract：:Exhaled breath condensate (EBC) consists mainly of water, but also contains semivolatile and nonvolatile compounds. The aim of this study was to develop a system in which two condensers are simultaneously used in series to clarify the mechanisms of EBC condensation. Two aliquots of EBC (EBC1 and EBC2) were collected f...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Corradi M,Goldoni M,Caglieri A,Folesani G,Poli D,Corti M,Mutti A

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:The Respimat Soft Mist Inhaler is reported to generate an aerosol with low spray momentum and a small droplet size. However, the transport characteristics of the Respimat aerosol are not well understood. The objective of this study was to characterize the transport and deposition of an aerosol emitted from t...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Worth Longest P,Hindle M

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:High flow nasal cannula oxygen therapy (HFT) is increasingly used in intensive and emergency care departments. Patients suffering from respiratory failure, who are likely to benefit from HFT, may require aerosolized bronchodilators; therefore, combining nebulization with HFT may be relevant. This study aimed...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Réminiac F,Vecellio L,Heuzé-Vourc'h N,Petitcollin A,Respaud R,Cabrera M,Pennec DL,Diot P,Ehrmann S

更新日期：2016-04-01 00:00:00

abstract：: Background: Many substances used in inhalation research are water soluble and can be administered as nebulized solutions. Typical examples are therapeutic, small-molecular agents, or macromolecules. Another category is a number of water-soluble agents used for airway diagn...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Gerde P,Nowenwik M,Sjöberg CO,Selg E

更新日期：2020-04-01 00:00:00