Vitamin A Supplementation by Endotracheal Application of a Nano-encapsulated Preparation Is Feasible in Ventilated Preterm Lambs.

abstract：BACKGROUND:Mechanically ventilated patients commonly suffer from ventilator-associated pneumonia, hypoxemia, and other lower respiratory tract infection as a result of pathogen colonization and poor sputum clearance. Consequently, there is a high rate of morbidity and mortality in these patients. Dry powder mannitol in...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Feng B,Tang P,Leung SS,Dhanani J,Chan HK

更新日期：2017-04-01 00:00:00

abstract：: Background: The photo reflection method (PRM) is used to measure light reflected from particles released from dry powder inhalers (DPIs). This simple method depicts time trajectories of released drugs; however, it underestimates the number of particles at high peak inhalat...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Kondo T,Hibino M,Tanigaki T,Tajiri S,Horiuchi S

更新日期：2020-11-04 00:00:00

abstract：BACKGROUND:Understanding the regional partition of deposition of inhaled particles within the lung is important for improving targeted delivery of inhaled aerosolized drugs. One factor affecting regional deposition is gravity. As the lung deforms under its own weight, changes in lung volume, in airway geometries, and i...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Sá RC,Zeman KL,Bennett WD,Prisk GK,Darquenne C

更新日期：2015-12-01 00:00:00

abstract：:Flexhaler is a multiple-dose, inspiratory flow-driven dry powder inhaler that is a newer version of Turbuhaler, and is identical to the Symbicort Turbuhaler. Sustained performance is of the utmost importance to ensure consistent drug delivery throughout the lifespan of the inhaler. We report functionality testing resu...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Lööf T,Elfman P,Ström P,Törngren A,Borgström L

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:The site of deposition in the respiratory tract for aerosolized, inhaled therapeutic drugs depends on both the particles' aerodynamic size and the patient's breathing pattern. METHODS:In 21 healthy subjects with normal lung function, we evaluated an extremely slow inhalation of a large 9.5-μm MMAD particle ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Zeman KL,Wu J,Bennett WD

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Particle size and velocity are two of the most significant factors that impact the deposition of pressurized metered-dose inhaler (pMDI) sprays in the mouth cavity. pMDIs are prominently used around the world in the treatment of patients suffering from a variety of lung diseases such as asthma and chronic ob...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Alatrash A,Matida E

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Predicting local lung tissue pharmacodynamic (PD) responses of inhaled drugs is a longstanding challenge related to the lack of experimental techniques to determine local free drug concentrations. This has prompted the use of physiologically based pharmacokinetic (PBPK) modeling to potentially predict local ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Boger E,Fridén M

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Preclinical evaluation of new chemical entities (NCEs) designed to be administered by inhalation route requires lung administration to rodents, especially in the discovery phase. Different administration methods have been used until now, but more efforts are required to obtain controlled and reproducible lun...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Fioni A,Selg E,Cenacchi V,Acevedo F,Brogin G,Gerde P,Puccini P

更新日期：2018-02-01 00:00:00

abstract：: Background: Many countries have introduced a compulsory use of community masks for certain public areas during the SARS-CoV-2 pandemic. Different manufacturers offer reusable community masks in large quantities. The efficacy of these masks, however, is unknown. ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Maurer L,Peris D,Kerl J,Guenther F,Koehler D,Dellweg D

更新日期：2020-09-23 00:00:00

abstract：BACKGROUND:Model predictions of regional deposition in the respiratory tract are useful in assessing factors that influence the effectiveness of aerosol delivery. Regional deposition models have previously been coupled with models of mucous production and clearance to estimate initial concentrations of drug deposited i...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Martin AR,Finlay WH

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:The delivery of antitubercular drugs through direct lung targeting can lead to reduction in the dose as well as side effects of the drug. In the present investigation, carrier (lactose)-based dry-powder inhaler of rifampicin was prepared to achieve direct targeting of the drug into the lungs. METHODS:The dr...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Rawal T,Kremer L,Halloum I,Butani S

更新日期：2017-12-01 00:00:00

abstract：: Background: Inhalation of medications is the cornerstone in the treatment of patients with lung diseases. A variety of inhalation devices exists and each device has specific requirements to achieve optimum inhalation of the drug. The goal of this study was to establish a c...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Pohlmann G,Hohlfeld JM,Haidl P,Pankalla J,Cloes RM

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Use of a valved holding chamber (VHC) in conjunction with a pressurized metered dose inhaler (pMDI) can reduce issues relating to poor actuation-inhalation coordination and potentially improve the lung deposition of aerosol, compared with use of a pMDI alone. However, the performance of a VHC is influenced b...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Hatley RH,von Hollen D,Sandell D,Slator L

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:The effectiveness of metered-dose inhalers (MDIs) in delivering medication to the lungs highly depends on its correct usage technique. Current guidelines state optimal technique for high lung deposition should include a slow inhalation (>5 seconds) at an inspiratory flow rate of 30 L/min and inhaler actuatio...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Biswas R,Hanania NA,Sabharwal A

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:Many methods have been developed to evaluate dry powder inhalation techniques and their efficiency for disease control in asthma patients. However, it is difficult to apply these methods to clinical practice and research. In this study, we introduce a simple new method that can be applied to dry powder inhalati...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Liang Y,Hu H,Tian C,Lei Y,Liu C,Luo F

更新日期：2016-10-01 00:00:00

abstract：:This article provides a concise review of the use of magnetic resonance imaging (MRI) for measurement of regional aerosol deposition in the lungs. Basic aspects of MRI and its use in lung imaging and measurement of regional ventilation are introduced. Imaging of hydrogen protons (water) and inhaled hyperpolarized gase...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Thompson RB,Finlay WH

更新日期：2012-04-01 00:00:00

abstract：: Background: Many substances used in inhalation research are water soluble and can be administered as nebulized solutions. Typical examples are therapeutic, small-molecular agents, or macromolecules. Another category is a number of water-soluble agents used for airway diagn...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Gerde P,Nowenwik M,Sjöberg CO,Selg E

更新日期：2020-04-01 00:00:00

abstract：:Exhaled breath condensate (EBC) consists mainly of water, but also contains semivolatile and nonvolatile compounds. The aim of this study was to develop a system in which two condensers are simultaneously used in series to clarify the mechanisms of EBC condensation. Two aliquots of EBC (EBC1 and EBC2) were collected f...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Corradi M,Goldoni M,Caglieri A,Folesani G,Poli D,Corti M,Mutti A

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:The unit dose dry powder inhaler (UD-DPI) is being considered as an alternative inhaler platform that, if developed, has the potential to improve access to inhaled respiratory medicines in developing countries. AIM:This study compared the systemic exposure of fluticasone furoate after delivery from the UD-D...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Mehta R,Moore A,Riddell K,Joshi S,Chan R

更新日期：2017-10-01 00:00:00

abstract：:The use of gamma camera imaging following the inhalation of a radiolabel has been widely used by researchers to investigate the fate of inhaled aerosols. The application of two-dimensional (2D) planar gamma scintigraphy and single-photon emission computed tomography (SPECT) to the study of inhaled aerosols is discusse...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Conway J,Fleming J,Bennett M,Havelock T

更新日期：2013-06-01 00:00:00

abstract：:The success of inhalation therapy is not only dependent upon the pharmacology of the drugs being inhaled but also upon the site and extent of deposition in the respiratory tract. Similarly, the toxicity of environmental and industrial particulate matter is affected not only by the nature of the dust but also by the am...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Darquenne C

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Researchers, using checklists, have identified that 30%-90% of patients make errors in inhaler use. It is not certain whether these errors affect the delivery of medication. We have developed an electronic monitor (INCA™) that records audio each time an inhaler is used, providing objective information on inh...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Sulaiman I,Seheult J,Sadasivuni N,MacHale E,Killane I,Giannoutsos S,Cushen B,Mokoka MC,Bhreathnach AS,Boland F,Reilly RB,Costello RW

更新日期：2017-08-01 00:00:00

abstract：:The available toxicity data of benzalkonium chloride (BKC) clearly shows that it is toxic; however, the weight of evidence favors the view that at doses encountered in nasally and orally inhaled pharmaceutical preparations it is well tolerated. The adverse toxicological data predominantly come from in vitro and animal...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Johnson NF

更新日期：2018-02-01 00:00:00

abstract：:Significant advances have been made in the last 50 years in developing safe and efficacious aerosol formulations for pulmonary delivery. The key to future innovation may lie at the interface between biology and particle engineering. Improved understanding of biological processes including particle clearance, cellular ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Weers JG,Bell J,Chan HK,Cipolla D,Dunbar C,Hickey AJ,Smith IJ

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:High flow nasal cannula oxygen therapy (HFT) is increasingly used in intensive and emergency care departments. Patients suffering from respiratory failure, who are likely to benefit from HFT, may require aerosolized bronchodilators; therefore, combining nebulization with HFT may be relevant. This study aimed...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Réminiac F,Vecellio L,Heuzé-Vourc'h N,Petitcollin A,Respaud R,Cabrera M,Pennec DL,Diot P,Ehrmann S

更新日期：2016-04-01 00:00:00

abstract：:Inhalation is a potentially viable route of administration for numerous agents. In diabetes mellitus, the need for frequent injections to achieve ideal glycemic control remains a significant limitation for initiating and complying with insulin therapy in a large number of patients. To overcome this barrier, inhaled in...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Zarogoulidis P,Papanas N,Kouliatsis G,Spyratos D,Zarogoulidis K,Maltezos E

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVES:This experimental study was conducted to determine the effects of training on inhaler technique and quality of life in patients with chronic obstructive pulmonary disease (COPD). METHODS:Among the patients who applied at the outpatient clinic of chest diseases between March 2009 and May 2010, a total of 69 ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Göriş S,Taşci S,Elmali F

更新日期：2013-12-01 00:00:00

abstract：:Upper respiratory tract infections (URTIs), primarily acute rhinopharyngitis, tonsillitis, adenoiditis, and rhinosinusitis (RS), are major causes of morbidity in both children and adults of any age. In addition to the frequent occurrence of related medical problems and the associated socioeconomic costs, URTIs have a ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Esposito S,Rosazza C,Sciarrabba CS,Principi N

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Programmed cell death 4 (PDCD4), a protein that binds to eukaryotic initiation factor 4A (eIF4A), inhibits the initiation of translation. Although a number of tumor suppressors target transcription, Pdcd4 is the first suppressor targeting protein translation, and has also been suggested to function as a tumo...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Hwang SK,Minai-Tehrani A,Lim HT,Shin JY,An GH,Lee KH,Park KR,Kim YS,Beck GR Jr,Yang HS,Cho MH

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:To validate the 'Test of Adherence to Inhalers' (TAI), a 12-item questionnaire designed to assess the adherence to inhalers in patients with COPD or asthma. METHODS:A total of 1009 patients with asthma or COPD participated in a cross-sectional multicenter study. Patients with electronic adherence ≥80% were ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Plaza V,Fernández-Rodríguez C,Melero C,Cosío BG,Entrenas LM,de Llano LP,Gutiérrez-Pereyra F,Tarragona E,Palomino R,López-Viña A,TAI Study Group.

更新日期：2016-04-01 00:00:00