Abstract：
BACKGROUND:Remote inhaler monitoring is an emerging technology that enables the healthcare team to monitor the time and location of a patient's inhaler use. We assessed the feasibility of remote inhaler monitoring for chronic obstructive pulmonary disease (COPD) patients and the pattern of albuterol inhaler use associated with COPD exacerbations. METHODS:Thirty-five participants with COPD used an electronic inhaler sensor for 12 weeks which recorded the date and time of each albuterol actuation. Self-reported COPD exacerbations and healthcare utilization were assessed monthly. We used generalized estimating equations with a logit link to compare the odds of an exacerbation day to a nonexacerbation day by the frequency of daily albuterol use. RESULTS:Average daily albuterol use on nonexacerbation days varied greatly between patients, ranging from 1.5 to 17.5 puffs. There were 48 exacerbation events observed in 29 participants during the study period, of which 16 were moderate-to-severe exacerbations. During the moderate-to-severe exacerbation days, the median value in average daily albuterol use increased by 14.1% (interquartile range: 2.7%-56.9%) compared to average nonexacerbation days. A 100% increase in inhaler use was associated with increased odds of a moderate-to severe exacerbation (odds ratio 1.54; 95% CI: 1.21-1.97). Approximately 74% of participants reported satisfaction with the sensor. CONCLUSIONS:The electronic inhaler sensor was well received in older patients with COPD over a 12-week period. Increased albuterol use captured by the device was associated with self-reported episodes of moderate-to-severe exacerbations.
journal_name
J Aerosol Med Pulm Drug Delivjournal_title
Journal of aerosol medicine and pulmonary drug deliveryauthors
Sumino K,Locke ER,Magzamen S,Gylys-Colwell I,Humblet O,Nguyen HQ,Thomas RM,Fan VSdoi
10.1089/jamp.2017.1383subject
Has Abstractpub_date
2018-06-01 00:00:00pages
191-198issue
3eissn
1941-2711issn
1941-2703journal_volume
31pub_type
杂志文章abstract：BACKGROUND:Researchers, using checklists, have identified that 30%-90% of patients make errors in inhaler use. It is not certain whether these errors affect the delivery of medication. We have developed an electronic monitor (INCA™) that records audio each time an inhaler is used, providing objective information on inh...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
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doi：10.1089/jamp.2016.1334
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2007.0644
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
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doi：10.1089/jamp.2020.29029.cd
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
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doi：10.1089/jamp.2015.1278
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2011.0925
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章,评审
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2017.1436
更新日期：2019-02-01 00:00:00
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章,评审
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章,评审
doi：10.1089/jamp.2016.1300
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2017.1438
更新日期：2018-12-01 00:00:00
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2013.1067
更新日期：2014-08-01 00:00:00
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2017.1369
更新日期：2018-02-01 00:00:00
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2009.0778
更新日期：2010-10-01 00:00:00
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2008.0708
更新日期：2009-06-01 00:00:00
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2019.1554
更新日期：2020-04-01 00:00:00
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2008.0700
更新日期：2008-12-01 00:00:00
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2020.1635
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
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doi：10.1089/jamp.2017.1412
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
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doi：10.1089/jamp.2017.1377
更新日期：2018-02-01 00:00:00
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章,多中心研究
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更新日期：2016-04-01 00:00:00
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2009.0793
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:Currently bronchial provocation testing (BPT) using mannitol powder cannot be performed in children under 6 years. A primary reason is it is challenging for children at this age to generate a consistent inspiratory effort to inhale mannitol efficiently from a dry powder inhaler. A prototype system, which doe...
journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2015.1208
更新日期：2015-12-01 00:00:00
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2014.1205
更新日期：2016-04-01 00:00:00
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
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doi：10.1089/jamp.2019.1538
更新日期：2020-04-01 00:00:00
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章,评审
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更新日期：2014-12-01 00:00:00
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
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更新日期：2015-12-01 00:00:00
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章,评审
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更新日期：2013-06-01 00:00:00
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journal_title：Journal of aerosol medicine and pulmonary drug delivery
pub_type： 杂志文章
doi：10.1089/jamp.2020.1610
更新日期：2020-11-04 00:00:00
