abstract：BACKGROUND:Primary sclerosing cholangitis (PSC) as one of the most common chronic cholestatic liver diseases is a main predisposing factor for the development of cholangiocarcinoma (CCA). Biliary intraepithelial neoplasia (BilIN) is defined as precancerous bile duct epithelial changes, which can be eventually led to ch...

journal_title：Hepatitis monthly

authors： Akbarzadeh L,Geramizadeh B,Kazemi K,Nikeghbalian S,Malekhosseini S

更新日期：2016-12-14 00:00:00

abstract：INTRODUCTION:Since directly acting antivirals (DAAs) for treatment of hepatitis C virus (HCV) were introduced, conflicting data emerged about the risk of hepatocellular carcinoma (HCC) after interferon (IFN)-free treatments. We present a case of recurrent, extra-hepatic HCC in a liver-transplanted patient soon after su...

journal_title：Hepatitis monthly

authors： Strazzulla A,Iemmolo RMR,Carbone E,Postorino MC,Mazzitelli M,De Santis M,Di Benedetto F,Cristiani CM,Costa C,Pisani V,Torti C

更新日期：2016-10-30 00:00:00

abstract：BACKGROUND:Hepatitis B infections, characterized by the presence of a viral genome without detectable hepatitis B surface antigen (HBsAg; Occult hepatitis B infection [OBI]), have been reported recently. OBJECTIVES:We performed serological and molecular characterization of OBI among blood donors at Jiangsu province bl...

journal_title：Hepatitis monthly

authors： Lin H,Zhao H,Tang X,Hu W,Jiang N,Zhu S,Huang C

更新日期：2016-10-02 00:00:00

abstract：CONTEXT:The hepatitis C virus (HCV) is classified into seven genotypes and more than 100 subtypes. The treatment regimen, duration and efficacy of HCV therapy may vary according to the HCV genotype. Therefore, the HCV genotype should be determined prior to antiviral therapy. The objective of the current study was to re...

journal_title：Hepatitis monthly

authors： Ghaderi-Zefrehi H,Gholami-Fesharaki M,Sharafi H,Sadeghi F,Alavian SM

更新日期：2016-08-23 00:00:00

abstract：BACKGROUND:Infection with the hepatitis B virus (HBV) is an important global health problem. Knowledge of the geographic distribution pattern of HBV infection can help to control the spread of the disease. OBJECTIVES:To determine the prevalence of HBV infections and risk factors for the disease for the first time in B...

journal_title：Hepatitis monthly

authors： Ziaee M,Ebrahimzadeh A,Azarkar Z,Namaei MH,Saburi A,Fereidouni M,Bijari B,Karamian M,Sharifzadeh G

更新日期：2016-08-14 00:00:00

abstract：BACKGROUND:The prevalence of newly-diagnosed cases of chronic hepatitis is decisive for the overall incidence rate of hepatitis B observed in Poland. OBJECTIVES:We aimed to determine the chronic hepatitis B incidence trends in Poland, taking into consideration the ages, genders, and environments of the patients. METH...

journal_title：Hepatitis monthly

authors： Stawinska-Witoszynska B,Zysnarska M,Krzywinska-Wiewiorowska M,Wojtyła-Buciorab P,Krzyzaniak A,Wieckowska B

更新日期：2016-07-25 00:00:00

abstract：BACKGROUND:Vaccine-escaped hepatitis B virus (HBV) mutations occur within the "a" determinant area, which is located in the major hydrophilic region (MHR) of the hepatitis B surface antigen (HBsAg) protein. It is now well established that the common G145R mutation is highly capable of escaping from HBsAg immune recogni...

journal_title：Hepatitis monthly

authors： Rezaee R,Poorebrahim M,Najafi S,Sadeghi S,Pourdast A,Alavian SM,Alavian SE,Poortahmasebi V

更新日期：2016-06-28 00:00:00

abstract：BACKGROUND:The entire disease spectrum of chronic HBV infection (CHB) includes asymptomatic carriers (AC), active chronic hepatitis (ACH), cirrhosis (Cir), and hepatocellular carcinoma (HCC). Previous study have demonstrated that the costimulation profiles from the livers of patients influenced immune responses and pla...

journal_title：Hepatitis monthly

authors： Yin JW,Ping Huang M,Zhong B

更新日期：2016-05-23 00:00:00

abstract：BACKGROUND:Hemophilic patients require long-life intravenous infusion of factor concentrates to treat bleedings. This could increase the risk of transmission of blood-borne infections like hepatitis C. OBJECTIVES:The current study was aimed at investigating the immunity status against hepatitis A in hemophilic patient...

journal_title：Hepatitis monthly

authors： Mirzaei J,Ziaee M,Farsad SA,Fereydooni M,Anani Sarab G,Rezvani Khorashad MR

更新日期：2016-04-05 00:00:00

abstract：BACKGROUND:Cytokines are proteins that mediate innate and adaptive immunity responses. It is hypothesized that interferon lambda 3 (IFNL3) levels can influence the outcome of chronic hepatitis B virus (HBV) infection. Polymorphisms in IFN genes have been associated with response to infection. OBJECTIVES:This study was...

journal_title：Hepatitis monthly

authors： Heidari Z,Moudi B,Mahmoudzadeh-Sagheb H,Hashemi M

更新日期：2016-03-05 00:00:00

abstract：BACKGROUND:A functional cure of chronic hepatitis B (CHB) is feasible, but a clear view of the intrahepatic viral dynamics in each patient is needed. Intrahepatic covalently closed circular DNA (cccDNA) is the stable form of the viral genome in infected cells, and represents the ideal marker of parenchymal colonization...

journal_title：Hepatitis monthly

authors： Minosse C,Coen S,Visco Comandini U,Lionetti R,Montalbano M,Cerilli S,Vincenti D,Baiocchini A,Capobianchi MR,Menzo S

更新日期：2016-02-29 00:00:00

abstract：BACKGROUND:Hepatitis B virus (HBV), hepatitis D virus (HDV), and human immunodeficiency virus (HIV) are transmitted by blood transfusion. Thus, hemodialysis (HD) patients are more prone to become the carriers of these infections due to their treatment demands. OBJECTIVES:The aim of this study was to assess the prevale...

journal_title：Hepatitis monthly

authors： Bahri F,Kargar Kheirabad A,Ghasemzadeh I,Shoja S,Gouklani H

更新日期：2016-01-23 00:00:00

abstract：BACKGROUND:There have been very few studies evaluating the close association between excess iron and cirrhosis; however, cirrhosis could be regarded as an iron-loading disorder. OBJECTIVES:In this study, the goal was to show the levels of the iron content in the liver tissue in certain types of cirrhosis. PATIENTS AN...

journal_title：Hepatitis monthly

authors： Geramizadeh B,Ghazanfari Y,Nikeghbalian S,Malekhosseini SA

更新日期：2015-12-28 00:00:00

abstract：BACKGROUND:Viral hepatitis is a major health problem in Brazil and worldwide. The state of Santa Catarina has high endemic areas, and the disease burden is unknown. OBJECTIVES:To estimate and analyze the burden of hepatitis B in the state of Santa Catarina, in 2005 - 2010. MATERIALS AND METHODS:A time-series analysis...

journal_title：Hepatitis monthly

authors： Marcon CE,Schneider IJ,Schuelter-Trevisol F,Traebert J

更新日期：2015-11-28 00:00:00

abstract：BACKGROUND:Precore stop codon (G1896A) mutation is one of the commonest mutations found in patients with chronic hepatitis B. However, over the years, this mutation was not reported much in Malaysia. OBJECTIVES:We therefore investigated the presence of G1896A mutation in Malaysian population and its association with H...

journal_title：Hepatitis monthly

authors： Suppiah J,Mohd Zain R,Bahari N,Haji Nawi S,Saat Z

更新日期：2015-10-28 00:00:00

abstract：BACKGROUND:Nearly 0.5% of Iranians are infected with HCV. Peginterferon-alpha-2a and Peginterferon-alpha-2b are the two available types of interferon for the treatment of hepatitis C. Comparing the results of these two treatments is still a challenge. OBJECTIVES:The aim of this study was to compare the results of Pegi...

journal_title：Hepatitis monthly

authors： Pouresmaeeli M,Alavian SM,Keshvari M,Salimi S,Mehrnoush L

更新日期：2015-09-29 00:00:00

abstract：BACKGROUNDS:Serum hepatitis B surface antigen (HBsAg) levels are associated with fibrosis in patients with chronic hepatitis B (CHB) infection. OBJECTIVES:The aim of our study was to evaluate serum HBsAg level as a biomarker for compensated cirrhosis in hepatitis B e antigen (HBeAg) positive CHB patients. PATIENTS AN...

journal_title：Hepatitis monthly

authors： Jia W,Qi X,Ji YY,Xun YH,Wang H,Zhang WH,Yang JH,Wang JY,Zhu HX,Mao RC,Zhang JM

更新日期：2015-08-30 00:00:00

abstract：BACKGROUND:Interleukin-10 (IL-10) is an important anti-inflammatory cytokine. The polymorphisms of its promoter gene have been considered to be related with the chronicity of hepatitis B infection. OBJECTIVES:The aim of this study was to evaluate the polymorphisms at different positions in the IL-10 promoter gene in p...

journal_title：Hepatitis monthly

authors： Ghaleh Baghi S,Alavian SM,Mehrnoush L,Salimi S

更新日期：2015-07-22 00:00:00

abstract：BACKGROUND:Hepatitis C virus infection is one of the leading causes of end stage liver diseases. The innate immune response slows down viral replication by activating cytokines such as type I interferon (IFN-α/β), which trigger the synthesis of antiviral proteins and modulate the adaptive immune system. Recently, leuci...

journal_title：Hepatitis monthly

authors： Liu Y,Zou Z,Zhu B,Hu Z,Zeng P,Wu L

更新日期：2015-05-23 00:00:00

abstract：BACKGROUND:While Roux-en-Y hepaticojejunostomy (RYH) is the common anastomotic technique for liver transplantation (LT) in patients with primary sclerosing cholangitis (PSC), duct-to-duct (DD) reconstruction may be used if the recipient common bile duct is normal. There are conflicting observational data on the rate of...

journal_title：Hepatitis monthly

authors： Al-Judaibi B,Hernandez Alejandro R,Uhanova J,Marotta P,Mosli M,Chandok N

更新日期：2015-05-23 00:00:00

abstract：BACKGROUND:Hepatitis A, a fecal-oral transmitted disease, which has been considered endemic in developing countries, seems to change its pattern in developing countries because of their improved socioeconomic status. OBJECTIVES:In the present study, we aimed to determine the need of vaccination in 270 students at AJA ...

journal_title：Hepatitis monthly

authors： Hosseini Shokouh SJ,Dadashi A,Abiri M,Zohrevand I,Eshraghian A,Khoshdel A,Heidari B,Khoshkish S

更新日期：2015-03-31 00:00:00

abstract：BACKGROUND:Hepatitis viruses are one of the most important concerns in the patients on hemodialysis who are at high risk for blood-borne infections. GB virus C (GBV-C)/hepatitis G virus (HGV) is positive-stranded RNA virus with global distribution, which codes structural and nonstructural proteins (such as NS3). OBJEC...

journal_title：Hepatitis monthly

authors： Dadmanesh M,Ranjbar MM,Alavian SM,Ghorban K

更新日期：2015-03-05 00:00:00

abstract：BACKGROUND:GB virus C (GBV-C) or hepatitis G virus (HGV) is a newly discovered and enveloped RNA positive-stranded flavivirus-like particle, which has not yet been proven to have major negative effects on liver. OBJECTIVES:Increasing the risk of blood-borne infections in hemodialysis patients is a main health care con...

journal_title：Hepatitis monthly

authors： Dadmanesh M,Hosseinzadeh M,Keyvani H,Ghorban K,Rahimi M,Hosseinzadeh M,Ranjbar MM

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Genetic polymorphisms may play role in the pathophysiology of nonalcoholic steatohepatitis (NASH). OBJECTIVES:We purposed to assess the role of interleukin 6 (IL 6) and interleukin 8 (IL 8) gene polymorphisms in the pathogenesis of NASH. PATIENTS AND METHODS:Consecutive patients with biopsy proven NASH and...

journal_title：Hepatitis monthly

authors： Cengiz M,Yasar DG,Ergun MA,Akyol G,Ozenirler S

更新日期：2014-12-24 00:00:00

abstract：BACKGROUND:There are limited data on the prevalence of the hepatitis B virus (HBV) infection in the agricultural population worldwide. OBJECTIVES:This study aimed to determine the prevalence of HBV infection and associated risk factors in the reproductive-age female farmworker. MATERIALS AND METHODS:This cross-sectio...

journal_title：Hepatitis monthly

authors： Yentur Doni N,Simsek Z,Keklik Z,Gurses G,Zeyrek FY

更新日期：2014-11-23 00:00:00

abstract：BACKGROUND:About 30% of individuals with hepatitis C virus (HCV) infection are able to clear HCV spontaneously. Differences in host genetics affect the outcome of HCV infection. Single nucleotide polymorphisms (SNPs) of the Interferon lambda (IFNL) genes were associated with spontaneous and treatment-induced clearance ...

journal_title：Hepatitis monthly

authors： Sharafi H,Alavian SM,Behnava B,Pouryasin A,Keshvari M

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Hepatitis B is a common infectious disease in China. Many studies have shown that the genotype of hepatitis B virus (HBV) is probably associated with the efficacy of some antiviral drugs such as interferon α (IFN-α) and Lamivudine (LAM). However, the association between HBV genotype and adefovir dipivoxil (A...

journal_title：Hepatitis monthly

authors： Wen Z,Zhang H,Zhang M,Tan D,Li Q,Zhang H,Wu P,Deng L

更新日期：2014-08-17 00:00:00

abstract：BACKGROUND:Due to the high efficacy of combination antiretroviral therapy (cART), the number of patients living with HIV is increasing. Chronic HCV infection has become a leading cause of non-AIDS related morbidity and mortality in patients with HIV infection. OBJECTIVES:The aim of this cross-sectional study was to id...

journal_title：Hepatitis monthly

authors： Brescini L,Orsetti E,Gesuita R,Piraccini F,Marchionni E,Staffolani S,Castelli P,Drenaggi D,Barchiesi F

更新日期：2014-08-05 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) is able to down-regulate innate immune response. It is important to know the immune pathways that this virus interacts with. HCV non-structural protein 3 (NS3) plays an important role in this viral feature. HCV NS3 protein could affect the expression of antiviral protein such as viper...

journal_title：Hepatitis monthly

authors： Khanlari Z,Sabahi F,Hosseini SY,Ghaderi M

更新日期：2014-06-08 00:00:00

abstract：BACKGROUND:Current guidelines introduce periodic monitoring of serum alanine transaminase (ALT) as the first-line modality in follow-up patients, with a hepatitis B virus (HBV) inactive carrier state. OBJECTIVES:This study aimed to determine the incidence rate and patterns of ALT fluctuations and prognostic values for...

journal_title：Hepatitis monthly

authors： Farzi H,Ebrahimi Daryani N,Mehrnoush L,Salimi S,Alavian SM

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Approximately 5% of hepatitis B virus (HBV) carriers are coinfected with hepatitis D virus (HDV). HBV/HDV coinfection is a major cause of cirrhosis and end stage liver disease in chronic HBsAg carriers. The only approved therapy for chronic hepatitis delta is interferon alpha (IFN α) in either pegylated or c...

journal_title：Hepatitis monthly

authors： Keshvari M,Alavian SM,Sharafi H,Karimi G,Gholami Fesharaki M

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:The hepatitis B virus (HBV) antigen-induced cellular immune response plays an important role in HBV clearance. Changes in the diversity of complementarity determining region 3 (CDR3) and T-cell receptor (TCR) sequences are used to monitor the response of T cells to antigens. OBJECTIVES:The aim of the presen...

journal_title：Hepatitis monthly

authors： Xiong Y,Tan Y,Song YG

更新日期：2014-02-25 00:00:00

abstract：BACKGROUND:During antiviral therapy for chronic hepatitis B, renal function impairment could be a critical concern when oral nucleot(s)ide analogues were used. Paradoxically, long-term telbivudine treatment was associated with an increase of estimated glomerular filtration rate (eGFR) through unknown mechanisms. OBJEC...

journal_title：Hepatitis monthly

authors： Liang KH,Chen YC,Hsu CW,Chang ML,Yeh CT

更新日期：2014-01-31 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) infection as a worldwide health problem is associated with cirrhosis and hepatocellular carcinoma. With current treatment regimen, pegylated interferon (PEG-IFN) plus ribavirin, sustain virological response (SVR) is achieved in only 50% of infected individuals. In HCV infection, an in...

journal_title：Hepatitis monthly

authors： Sarvari J,Norozian H,Fattahi MR,Pirbonyeh N,Moattari A

更新日期：2014-01-23 00:00:00

abstract：BACKGROUND:Human leukocyte antigen (HLA) typing in autoimmune hepatitis (AIH) has been investigated in different populations and ethnic groups, but no such data is available from Pakistan. OBJECTIVES:The aim of this study was to evaluate the clinical profile of autoimmune hepatitis (AIH), and determine the associated ...

journal_title：Hepatitis monthly

authors： Hassan N,Siddiqui AR,Abbas Z,Hassan SM,Soomro GB,Mubarak M,Anis S,Muzaffar R,Zafar MN

更新日期：2013-12-16 00:00:00

abstract：BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in western world. However, NAFLD shows an increasing trend in China every year, which has attracted the attention of national health authorities. The previous studies have shown that NAFLD caused severe gastrointestina...

journal_title：Hepatitis monthly

authors： Lu ML,Huang H,Liu LM,Chang J

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:The prevalence of hepatitis C in Iran is 1% and 18% in general population and thalassemia patients respectively. The cost effectiveness analysis of adding Ribavirin to Peginterferon alfa-2a (PEG IFN alfa-2a) as a combination treatment strategy of chronic hepatitis C in thalassemia patients in comparison with...

journal_title：Hepatitis monthly

authors： Mehrazmay A,Alavian SM,Moradi-Lakeh M,Mokhtari Payam M,Hashemi-Meshkini A,Behnava B,Miri SM,Karimi Elizee P,Tabatabaee SV,Keshvari M,Bagheri Lankarani K

更新日期：2013-09-01 00:00:00

abstract：CONTEXT:The modern practice of anesthesia is highly dependent ona group of anesthetic drugs which many of them are metabolized in the liver. EVIDENCE ACQUISITION:The liver, of course, usually tolerates this burden. However, this is not always an unbroken rule. Anesthetic induced apoptosis has gained great concern duri...

journal_title：Hepatitis monthly

authors： Dabbagh A,Rajaei S

更新日期：2013-08-25 00:00:00

abstract：CONTEXT:Cystic fibrosis (CF) is the most widespread autosomal recessive genetic disorder that limits life expectation amongst the Caucasian population. As the median survival has increased related to early multidisciplinary intervention, other manifestations of CF have emerged especially for the broad spectrum of hepat...

journal_title：Hepatitis monthly

authors： Parisi GF,Di Dio G,Franzonello C,Gennaro A,Rotolo N,Lionetti E,Leonardi S

更新日期：2013-08-14 00:00:00

abstract：BACKGROUND:Cyclosporine A (CsA)-induced hepatotoxicity could be due to a reduction in α2β1 integrin expression that may either be from the direct effect of CsA itself or from reactive oxygen species (ROS) overproduction. OBJECTIVES:In this study we aimed to identify the cellular mechanisms underlying CsA-induced hepat...

journal_title：Hepatitis monthly

authors： Mostafavi-Pour Z,Khademi F,Zal F,Sardarian AR,Amini F

更新日期：2013-08-13 00:00:00