解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Marek's Disease Virus (MDV) infects chickens via respiratory route and causes lymphomas in internal organs including gastrointestinal tract. MDV infection causes a shift in the gut microbiota composition. However, interactions between the gut microbiota and immune responses against MDV infection are not well understoo...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2020.10.011
更新日期:2021-01-15 00:00:00
abstract::Many viruses utilize molecular chaperone heat shock protein 90 (Hsp90) for protein folding and stabilization, however, the role of Hsp90 in herpesvirus lifecycle is obscure. Here, we provide evidence that Hsp90 participates in pseudorabies virus (PRV) replication. Viral growth kinetics assays show that Hsp90 inhibitor...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2020.10.013
更新日期:2021-01-15 00:00:00
abstract::Cryphonectria parasitica, the causal agent of chestnut blight is controlled in Europe through natural spread of Cryphonectria hypovirus 1 (CHV1), a mycovirus able to induce hypovirulence to the host. In recent years C. parasitica was reported infecting Azerbaijani population of chestnut, but the presence of CHV1 still...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2020.10.008
更新日期:2021-01-15 00:00:00
abstract::Chikungunya virus (CHIKV) is a mosquito-borne RNA virus that causes Chikungunya fever in humans. In this study, we generated two DNA-based CHIKV infectious clones derived from an Indian Ocean Lineage SL11131 strain and a prototype Ross strain. When the replication capabilities of the infectious CHIKV in various cell l...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2020.09.006
更新日期:2021-01-02 00:00:00
abstract:BACKGROUND:SARS-CoV-2 is a novel coronavirus and the cause of COVID-19. More than 80% of COVID-19 patients exhibit mild or moderate symptoms. In this study, we investigated the dynamics of viral load and antibodies against SARS-CoV-2 in a longitudinal cohort of COVID-19 patients with severe and mild/moderate diseases. ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2020.09.008
更新日期:2020-12-01 00:00:00
abstract::Bovine respiratory disease (BRD) is the costliest disease affecting the cattle industry globally. Orthomyxoviruses, influenza C virus (ICV) and influenza D virus (IDV) have recently been implicated to play a role in BRD. However, there are contradicting reports about the association of IDV and ICV to BRD. Using the la...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2020.08.014
更新日期:2020-12-01 00:00:00
abstract::Ovarian cancer is the third most common female cancer, with poor survival in later stages of metastatic spread. We test a chimeric virus consisting of genes from Lassa and vesicular stomatitis viruses, LASV-VSV; the native VSV glycoprotein is replaced by the Lassa glycoprotein, greatly reducing neurotropism. Human ova...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2020.10.009
更新日期:2020-11-12 00:00:00
abstract::p53 is implicated in several cellular pathways such as induction of cell-cycle arrest, differentiation, senescence, and apoptosis. p53 is activated by a broad range of stress signals, including viral infections. While some viruses activate p53, others induce its inactivation, and occasionally p53 is differentially mod...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2020.08.008
更新日期:2020-11-01 00:00:00
abstract::Influenza A virus, a respiratory pathogen manipulates various host cellular processes to establish a successful infection in a host. We had reported earlier the interaction of influenza A virus nucleoprotein with host glycolytic enzymes; alpha enolase and pyruvate kinase in A549 cells. Matrix protein (M1), another mul...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2020.07.019
更新日期:2020-10-01 00:00:00
abstract::Human papillomavirus (HPV) is a family of viruses divided into five genera: alpha, beta, gamma, mu, and nu. There is an ongoing discussion about whether beta genus HPVs (β-HPVs) contribute to cutaneous squamous cell carcinoma (cSCC). The data presented here add to this conversation by determining how a β-HPV E6 protei...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2020.07.016
更新日期:2020-10-01 00:00:00
abstract::Human cytomegalovirus (HCMV) infects the chorioamnion, but whether these infections cause fetal membrane dysfunction remains poorly understood. We sought to assess whether guinea pig cytomegalovirus (GPCMV) infects amnion-derived cells in vitro, compare the inflammatory response of amnion cells to GPCMV and HCMV, and ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2020.06.005
更新日期:2020-09-01 00:00:00
abstract::The incidence of head and neck squamous cell carcinomas (HNSCCs) is rising in developed countries. This is driven by an increase in HNSCCs caused by high-risk human papillomavirus (HPV) infections or HPV + HNSCCs. Compared to HNSCCs not caused by HPV (HPV- HNSCCs), HPV + HNSCCs are more responsive to therapy and assoc...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2020.07.004
更新日期:2020-09-01 00:00:00
abstract::Viral metagenomics coupled to high-throughput sequencing has provided a powerful tool for large-scale detection of known and unknown viruses associated to distinct hosts and environments. Using this approach, known and novel viruses have been characterized from sylvatic and commercial avian hosts, increasing our under...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2020.05.013
更新日期:2020-09-01 00:00:00
abstract::CD8 T cells contribute to effective clearance of mouse adenovirus type 1 (MAV-1) and to virus-induced pulmonary inflammation. We characterized effects of a CD8 T cell effector, TNF, on MAV-1 pathogenesis. TNF inhibited MAV-1 replication in vitro. TNF deficiency or immunoneutralization had no effect on lung viral loads...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2020.05.004
更新日期:2020-08-01 00:00:00
abstract::The emergence and re-emergence of Zika virus (ZIKV), is a cause for international concern. These highly pathogenic arboviruses represent a serious health burden in tropical and subtropical areas worldwide. Despite these burdens, antiviral therapies do not exist, and inhibitors of ZIKV are therefore urgently needed. To...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2020.04.009
更新日期:2020-07-01 00:00:00
abstract::Since SARS-CoV-2 spreads rapidly around the world, data have been needed on the natural fluctuation of viral load and clinical indicators associated with it. We measured and compared viral loads of SARS-CoV-2 from pharyngeal swab, IgM anti-SARS-CoV-2, CRP and SAA from serum of 114 COVID-19 patients on admission. Posit...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2020.04.011
更新日期:2020-07-01 00:00:00
abstract::Tandemers 2MG, 2MG3, 3MG and 4MG are derivatives of the potent anti-HIV-1 microbicide candidate griffithsin (GRFT). We compared these compounds anti-HIV-1 activity to GRFT using the viruses CAP206.08 and CAAN5342.A2 that have decreased sensitivity to this lectin. The 2MG and 2MG3 tandemers had similar activity to GRFT...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2020.01.017
更新日期:2020-05-01 00:00:00
abstract::Viruses exploit phosphorylation of both viral and host proteins to support viral replication. In this study, we demonstrate that porcine reproductive and respiratory syndrome virus replicase nsp2, and two nsp2-related -2/-1 frameshifting products, nsp2TF and nsp2N, are hyper-phosphorylated. By mapping phosphorylation ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2020.01.018
更新日期:2020-04-01 00:00:00
abstract::Zika virus (ZIKV) nonstructural protein 5 (NS5) is a multifunctional protein possessing methyltransferase and RNA-dependent RNA polymerase activities. In the present study, we have carried out an extensive mutagenesis analysis to determine the importance of nuclear localization sequences (NLS) of NS5 in its nuclear ac...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.10.010
更新日期:2020-02-01 00:00:00
abstract::Avipoxviruses are significant pathogens infecting a wide range of wild and domestic bird species globally. Here, we describe a novel genome sequence of magpiepox virus (MPPV) isolated from an Australian magpie. In the present study, histopathologically confirmed cutaneous pox lesions were used for transmission electro...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.11.005
更新日期:2020-01-15 00:00:00
abstract::To determine the role of piscine anti-viral cytotoxic cells, we analyzed the response of channel catfish to Ictalurid herpesvirus 1, commonly designated channel catfish virus (CCV). Peripheral blood leukocytes (PBL) from catfish immunized with MHC-matched, CCV-infected G14D cells (G14D-CCV) showed marked lysis of G14D...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.11.014
更新日期:2020-01-15 00:00:00
abstract::Porcine circovirus type 2 (PCV2) is an economically important cause of post-weaning multisystemic wasting syndrome (PMWS) in weanling piglets. Current commercial vaccines against PCV2 are highly effective. Yet, a recurring emergence of new genotypes in vaccinated herds necessitates a better understanding of protective...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.11.008
更新日期:2020-01-15 00:00:00
abstract::JC virus (JCV) Agnoprotein (Agno) plays critical roles in successful completion of the viral replication cycle. Understanding its regulatory roles requires a complete map of JCV-host protein interactions. Here, we report the first Agno interactome with host cellular targets utilizing "Two-Strep-Tag" affinity purificat...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.10.005
更新日期:2020-01-15 00:00:00
abstract::Like their animal-infecting counterparts, plant bunyaviruses use capped RNA leaders cleaved from host cellular mRNAs to prime viral genome transcription in a process called cap-snatching, but in vivo systems to investigate the details of this process are lacking for them. Here, we report that Rice stripe tenuivirus (R...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.10.017
更新日期:2020-01-02 00:00:00
abstract::Porcine circovirus 2 (PCV2) has a major impact on the swine industry. Eight PCV2 genotypes (a-h) have been identified using capsid sequence analysis. PCV2d has been designated as the emerging genotype. The cryo-electron microscopy molecular envelope of PCV2d virus-like particles identifies differences between PCV2a, b...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.09.001
更新日期:2019-11-01 00:00:00
abstract::Feline coronavirus infection can progress to a fatal infectious peritonitis, which is a widespread feline disease without an effective vaccine. Generating feline cells with reduced ability to respond to interferon (IFN) is an essential step facilitating isolation of new candidate vaccine strains. Here, we describe the...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.08.030
更新日期:2019-11-01 00:00:00
abstract::Equine infectious anemia virus (EIAV) is responsible of acute disease episodes characterized by fever, anemia, thrombocytopenia and anorexia in equids. The high mutation rate in EIAV genome limited the number of full genome sequences availability. In the present study, we used the SureSelect target enrichment system w...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.08.016
更新日期:2019-11-01 00:00:00
abstract::Human Papillomavirus infection is highly prevalent worldwide. While most types of HPV cause benign warts, some high-risk types are known to cause cervical cancer, as well as cancer of the oral cavity and head and neck. Persistent cutaneous HPV infection can be particularly problematic in patients with chronic immunosu...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.08.007
更新日期:2019-11-01 00:00:00
abstract::Human infection with H7N9 virus has provoked global public health concern due to the substantial morbidity and mortality. Neuraminidase inhibitors (NAIs) are used as first-line drugs to treat the infection. However, virus quasispecies can evolve rapidly under drug pressure, which may alter various biological character...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.08.004
更新日期:2019-10-01 00:00:00
abstract::Rabies continues to poses serious threats to the public health in many countries. The development of novel inexpensive, safe and effective vaccines has become a high priority for rabies control worldwide. We previously generated a novel recombinant rabies vaccine by cloning rabies virus glycoprotein into a chimpanzee ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.07.022
更新日期:2019-10-01 00:00:00
abstract::Human gammaherpesvirus 8 (HHV-8) is the etiologic agent of Kaposi's sarcoma, multicentric Castleman's disease and primary effusion lymphoma. Like other herpesviruses, the HHV-8 may exhibit latent or lytic cycle, both regulated by viral and host factors. Regarding host factors, we analysed the association of polymorphi...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.07.011
更新日期:2019-09-01 00:00:00
abstract::The human papillomavirus type 8 (HPV8) is associated with skin cancer development. The goal of this study was to investigate the effects of HPV8 oncoproteins on cellular gene expression and the identification of key regulators. We performed affymetrix microarray analyses to identify differentially expressed genes and ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.06.019
更新日期:2019-09-01 00:00:00
abstract::An H5N6 highly pathogenic avian influenza virus (HPAIV) outbreak occurred in poultry in Japan during January 2018, and H5N6 HPAIVs killed several wild birds in 3 prefectures during Winter 2017-2018. Time-measured phylogenetic analyses demonstrated that the Hemagglutinin (HA) and internal genes of these isolates were g...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.04.011
更新日期:2019-07-01 00:00:00
abstract::Cytoplasmic tails of envelope (Env) glycoproteins of many retroviruses inhibit their membrane fusion activity. The cytoplasmic 16-amino acid peptide of ecotropic murine leukemia virus (E-MLV) Env protein, called the R-peptide, also inhibits the membrane fusion activity of the Env protein. However, the molecular mechan...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.04.005
更新日期:2019-06-01 00:00:00
abstract::Priming of the viral glycoprotein (GP) by the cellular proteases cathepsin B and L (CatB, CatL) is believed to be essential for cell entry of filoviruses. However, pseudotyping systems that predominantly produce non-filamentous particles have frequently been used to prove this concept. Here, we report that GP-mediated...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.03.020
更新日期:2019-06-01 00:00:00
abstract::Viral vector particles derived from murine leukemia virus (MLV) mediate highly efficient stable gene transfer used in gene therapeutic approaches and in the generation of transgenic cell lines. However, the establishment of stable viral packaging cells (VPCs) is a time-consuming challenge. To overcome this limitation,...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.02.014
更新日期:2019-05-01 00:00:00
abstract::Equid herpesvirus-1 (EHV-1) outbreaks continue despite widely used vaccination. We demonstrated previously that an ORF1/ORF71 gene deletion mutant of the EHV-1 strain Ab4 (Ab4ΔORF1/71) is less virulent than its parent Ab4 virus. Here, we describe the Ab4 challenge infection evaluating protection induced by the Ab4ΔORF...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.03.014
更新日期:2019-05-01 00:00:00
abstract::Endogenous retroviruses (ERVs) arise from the infection and integration of past retroviruses into animal hosts. We performed large-scale genomic mining of 101 avian genomes for discovery of ERVs having none-avian origin and investigated the cross-species transmission events. Phylogenetic analysis of the reverse transc...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.02.005
更新日期:2019-04-01 00:00:00
abstract::Human Cytomegalovirus (HCMV) is an opportunistic pathogen that causes substantial disease in neonates and immunocompromised individuals. Reverse genetic analysis of the HCMV genome is a powerful tool to dissect the roles that various viral genes play during infection. However, genetic engineering of HCMV is hampered b...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.01.021
更新日期:2019-03-01 00:00:00
abstract::To comprehensively understand the endocytosis of Sapelovirus A (PSV) entry into PK-15 cells, we studied PSV infection in the context of cell perturbations through drug inhibition, siRNA silencing and overexpression of dominant negative (DN) mutants. We showed here that PSV infection of PK-15 cells was unaffected by pr...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.01.009
更新日期:2019-03-01 00:00:00