听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览VIROLOGY期刊下所有文献
  • Gut microbiota is associated with protection against Marek's disease virus infection in chickens.

    abstract::Marek's Disease Virus (MDV) infects chickens via respiratory route and causes lymphomas in internal organs including gastrointestinal tract. MDV infection causes a shift in the gut microbiota composition. However, interactions between the gut microbiota and immune responses against MDV infection are not well understoo...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2020.10.011

    authors: Bavananthasivam J,Astill J,Matsuyama-Kato A,Taha-Abdelaziz K,Shojadoost B,Sharif S

    更新日期:2021-01-15 00:00:00

  • Hsp90 is involved in pseudorabies virus virion assembly via stabilizing major capsid protein VP5.

    abstract::Many viruses utilize molecular chaperone heat shock protein 90 (Hsp90) for protein folding and stabilization, however, the role of Hsp90 in herpesvirus lifecycle is obscure. Here, we provide evidence that Hsp90 participates in pseudorabies virus (PRV) replication. Viral growth kinetics assays show that Hsp90 inhibitor...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2020.10.013

    authors: Zhang WJ,Wang RQ,Li LT,Fu W,Chen HC,Liu ZF

    更新日期:2021-01-15 00:00:00

  • Virome characterization of Cryphonectria parasitica isolates from Azerbaijan unveiled a new mymonavirus and a putative new RNA virus unrelated to described viral sequences.

    abstract::Cryphonectria parasitica, the causal agent of chestnut blight is controlled in Europe through natural spread of Cryphonectria hypovirus 1 (CHV1), a mycovirus able to induce hypovirulence to the host. In recent years C. parasitica was reported infecting Azerbaijani population of chestnut, but the presence of CHV1 still...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2020.10.008

    authors: Forgia M,Isgandarli E,Aghayeva DN,Huseynova I,Turina M

    更新日期:2021-01-15 00:00:00

  • Construction and characterization of an infectious clone generated from Chikungunya virus SL11131 strain.

    abstract::Chikungunya virus (CHIKV) is a mosquito-borne RNA virus that causes Chikungunya fever in humans. In this study, we generated two DNA-based CHIKV infectious clones derived from an Indian Ocean Lineage SL11131 strain and a prototype Ross strain. When the replication capabilities of the infectious CHIKV in various cell l...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2020.09.006

    authors: Suzuki Y,Tanaka A,Maeda Y,Emi A,Fujioka Y,Sakaguchi S,Vasudevan SG,Kobayashi T,Lim CK,Takasaki T,Wu H,Nakano T

    更新日期:2021-01-02 00:00:00

  • Molecular and serological characterization of SARS-CoV-2 infection among COVID-19 patients.

    abstract:BACKGROUND:SARS-CoV-2 is a novel coronavirus and the cause of COVID-19. More than 80% of COVID-19 patients exhibit mild or moderate symptoms. In this study, we investigated the dynamics of viral load and antibodies against SARS-CoV-2 in a longitudinal cohort of COVID-19 patients with severe and mild/moderate diseases. ...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2020.09.008

    authors: Li L,Liang Y,Hu F,Yan H,Li Y,Xie Z,Huang L,Zhao J,Wan Z,Wang H,Shui J,Cai W,Tang S

    更新日期:2020-12-01 00:00:00

  • Influenza C and D viral load in cattle correlates with bovine respiratory disease (BRD): Emerging role of orthomyxoviruses in the pathogenesis of BRD.

    abstract::Bovine respiratory disease (BRD) is the costliest disease affecting the cattle industry globally. Orthomyxoviruses, influenza C virus (ICV) and influenza D virus (IDV) have recently been implicated to play a role in BRD. However, there are contradicting reports about the association of IDV and ICV to BRD. Using the la...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2020.08.014

    authors: Nissly RH,Zaman N,Ibrahim PAS,McDaniel K,Lim L,Kiser JN,Bird I,Chothe SK,Bhushan GL,Vandegrift K,Neibergs HL,Kuchipudi SV

    更新日期:2020-12-01 00:00:00

  • Lassa-VSV chimeric virus targets and destroys human and mouse ovarian cancer by direct oncolytic action and by initiating an anti-tumor response.

    abstract::Ovarian cancer is the third most common female cancer, with poor survival in later stages of metastatic spread. We test a chimeric virus consisting of genes from Lassa and vesicular stomatitis viruses, LASV-VSV; the native VSV glycoprotein is replaced by the Lassa glycoprotein, greatly reducing neurotropism. Human ova...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2020.10.009

    authors: van den Pol AN,Zhang X,Lima E,Pitruzzello M,Albayrak N,Alvero A,Davis JN,Mor G

    更新日期:2020-11-12 00:00:00

  • Host cell p53 associates with the feline calicivirus major viral capsid protein VP1, the protease-polymerase NS6/7, and the double-stranded RNA playing a role in virus replication.

    abstract::p53 is implicated in several cellular pathways such as induction of cell-cycle arrest, differentiation, senescence, and apoptosis. p53 is activated by a broad range of stress signals, including viral infections. While some viruses activate p53, others induce its inactivation, and occasionally p53 is differentially mod...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2020.08.008

    authors: Trujillo-Uscanga A,Gutiérrez-Escolano AL

    更新日期:2020-11-01 00:00:00

  • Experimental validation of influenza A virus matrix protein (M1) interaction with host cellular alpha enolase and pyruvate kinase.

    abstract::Influenza A virus, a respiratory pathogen manipulates various host cellular processes to establish a successful infection in a host. We had reported earlier the interaction of influenza A virus nucleoprotein with host glycolytic enzymes; alpha enolase and pyruvate kinase in A549 cells. Matrix protein (M1), another mul...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2020.07.019

    authors: Mishra S,Goyal P,Kumar D,Chaudhari R,Rajala MS

    更新日期:2020-10-01 00:00:00

  • β-HPV 8E6 combined with TERT expression promotes long-term proliferation and genome instability after cytokinesis failure.

    abstract::Human papillomavirus (HPV) is a family of viruses divided into five genera: alpha, beta, gamma, mu, and nu. There is an ongoing discussion about whether beta genus HPVs (β-HPVs) contribute to cutaneous squamous cell carcinoma (cSCC). The data presented here add to this conversation by determining how a β-HPV E6 protei...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2020.07.016

    authors: Dacus D,Riforgiate E,Wallace NA

    更新日期:2020-10-01 00:00:00

  • Cytomegalovirus infection elicits a conserved chemokine response from human and guinea pig amnion cells.

    abstract::Human cytomegalovirus (HCMV) infects the chorioamnion, but whether these infections cause fetal membrane dysfunction remains poorly understood. We sought to assess whether guinea pig cytomegalovirus (GPCMV) infects amnion-derived cells in vitro, compare the inflammatory response of amnion cells to GPCMV and HCMV, and ...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2020.06.005

    authors: Putri DS,Berkebile ZW,Mustafa HJ,Fernández-Alarcón C,Abrahante JE,Schleiss MR,Bierle CJ

    更新日期:2020-09-01 00:00:00

  • DNA repair gene expression is increased in HPV positive head and neck squamous cell carcinomas.

    abstract::The incidence of head and neck squamous cell carcinomas (HNSCCs) is rising in developed countries. This is driven by an increase in HNSCCs caused by high-risk human papillomavirus (HPV) infections or HPV + HNSCCs. Compared to HNSCCs not caused by HPV (HPV- HNSCCs), HPV + HNSCCs are more responsive to therapy and assoc...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2020.07.004

    authors: Holcomb AJ,Brown L,Tawfik O,Madan R,Shnayder Y,Thomas SM,Wallace NA

    更新日期:2020-09-01 00:00:00

  • Viral metagenomics in Brazilian Pekin ducks identifies two gyrovirus, including a new species, and the potentially pathogenic duck circovirus.

    abstract::Viral metagenomics coupled to high-throughput sequencing has provided a powerful tool for large-scale detection of known and unknown viruses associated to distinct hosts and environments. Using this approach, known and novel viruses have been characterized from sylvatic and commercial avian hosts, increasing our under...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2020.05.013

    authors: Cibulski S,Weber MN,de Sales Lima FE,Lima DA,Fernandes Dos Santos H,Teixeira TF,Varela APM,Tochetto C,Mayer FQ,Roehe PM

    更新日期:2020-09-01 00:00:00

  • Effects of tumor necrosis factor on viral replication and pulmonary inflammation during acute mouse adenovirus type 1 respiratory infection.

    abstract::CD8 T cells contribute to effective clearance of mouse adenovirus type 1 (MAV-1) and to virus-induced pulmonary inflammation. We characterized effects of a CD8 T cell effector, TNF, on MAV-1 pathogenesis. TNF inhibited MAV-1 replication in vitro. TNF deficiency or immunoneutralization had no effect on lung viral loads...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2020.05.004

    authors: Pant K,Chandrasekaran A,Chang CJ,Vageesh A,Popkov AJ,Weinberg JB

    更新日期:2020-08-01 00:00:00

  • Antiviral activity of lycorine against Zika virus in vivo and in vitro.

    abstract::The emergence and re-emergence of Zika virus (ZIKV), is a cause for international concern. These highly pathogenic arboviruses represent a serious health burden in tropical and subtropical areas worldwide. Despite these burdens, antiviral therapies do not exist, and inhibitors of ZIKV are therefore urgently needed. To...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2020.04.009

    authors: Chen H,Lao Z,Xu J,Li Z,Long H,Li D,Lin L,Liu X,Yu L,Liu W,Li G,Wu J

    更新日期:2020-07-01 00:00:00

  • Association of viral load with serum biomakers among COVID-19 cases.

    abstract::Since SARS-CoV-2 spreads rapidly around the world, data have been needed on the natural fluctuation of viral load and clinical indicators associated with it. We measured and compared viral loads of SARS-CoV-2 from pharyngeal swab, IgM anti-SARS-CoV-2, CRP and SAA from serum of 114 COVID-19 patients on admission. Posit...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2020.04.011

    authors: Shi F,Wu T,Zhu X,Ge Y,Zeng X,Chi Y,Du X,Zhu L,Zhu F,Zhu B,Cui L,Wu B

    更新日期:2020-07-01 00:00:00

  • Comparison of the antiviral activity of the microbicide candidate griffithsin and its tandemers derivatives against different modes of HIV-1 transmission.

    abstract::Tandemers 2MG, 2MG3, 3MG and 4MG are derivatives of the potent anti-HIV-1 microbicide candidate griffithsin (GRFT). We compared these compounds anti-HIV-1 activity to GRFT using the viruses CAP206.08 and CAAN5342.A2 that have decreased sensitivity to this lectin. The 2MG and 2MG3 tandemers had similar activity to GRFT...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2020.01.017

    authors: Alexandre K,Malatji K,Mulaudzi T

    更新日期:2020-05-01 00:00:00

  • Hyper-phosphorylation of nsp2-related proteins of porcine reproductive and respiratory syndrome virus.

    abstract::Viruses exploit phosphorylation of both viral and host proteins to support viral replication. In this study, we demonstrate that porcine reproductive and respiratory syndrome virus replicase nsp2, and two nsp2-related -2/-1 frameshifting products, nsp2TF and nsp2N, are hyper-phosphorylated. By mapping phosphorylation ...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2020.01.018

    authors: Shang P,Yuan F,Misra S,Li Y,Fang Y

    更新日期:2020-04-01 00:00:00

  • Zika virus NS5 nuclear accumulation is protective of protein degradation and is required for viral RNA replication.

    abstract::Zika virus (ZIKV) nonstructural protein 5 (NS5) is a multifunctional protein possessing methyltransferase and RNA-dependent RNA polymerase activities. In the present study, we have carried out an extensive mutagenesis analysis to determine the importance of nuclear localization sequences (NLS) of NS5 in its nuclear ac...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2019.10.010

    authors: Ji W,Luo G

    更新日期:2020-02-01 00:00:00

  • Cloning and characterization of antiviral cytotoxic T lymphocytes in channel catfish, Ictalurus punctatus.

    abstract::To determine the role of piscine anti-viral cytotoxic cells, we analyzed the response of channel catfish to Ictalurid herpesvirus 1, commonly designated channel catfish virus (CCV). Peripheral blood leukocytes (PBL) from catfish immunized with MHC-matched, CCV-infected G14D cells (G14D-CCV) showed marked lysis of G14D...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2019.11.014

    authors: Taylor EB,Chinchar VG,Quiniou SMA,Wilson M,Bengtén E

    更新日期:2020-01-15 00:00:00

  • A comprehensive proteomics analysis of JC virus Agnoprotein-interacting proteins: Agnoprotein primarily targets the host proteins with coiled-coil motifs.

    abstract::JC virus (JCV) Agnoprotein (Agno) plays critical roles in successful completion of the viral replication cycle. Understanding its regulatory roles requires a complete map of JCV-host protein interactions. Here, we report the first Agno interactome with host cellular targets utilizing "Two-Strep-Tag" affinity purificat...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2019.10.005

    authors: Saribas AS,Datta PK,Safak M

    更新日期:2020-01-15 00:00:00

  • Early antibody responses map to non-protective, PCV2 capsid protein epitopes.

    abstract::Porcine circovirus type 2 (PCV2) is an economically important cause of post-weaning multisystemic wasting syndrome (PMWS) in weanling piglets. Current commercial vaccines against PCV2 are highly effective. Yet, a recurring emergence of new genotypes in vaccinated herds necessitates a better understanding of protective...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2019.11.008

    authors: Ilha M,Nara P,Ramamoorthy S

    更新日期:2020-01-15 00:00:00

  • Molecular characterisation of a novel pathogenic avipoxvirus from the Australian magpie (Gymnorhina tibicen).

    abstract::Avipoxviruses are significant pathogens infecting a wide range of wild and domestic bird species globally. Here, we describe a novel genome sequence of magpiepox virus (MPPV) isolated from an Australian magpie. In the present study, histopathologically confirmed cutaneous pox lesions were used for transmission electro...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2019.11.005

    authors: Sarker S,Batinovic S,Talukder S,Das S,Park F,Petrovski S,Forwood JK,Helbig KJ,Raidal SR

    更新日期:2020-01-15 00:00:00

  • A convenient in vivo cap donor delivery system to investigate the cap snatching of plant bunyaviruses.

    abstract::Like their animal-infecting counterparts, plant bunyaviruses use capped RNA leaders cleaved from host cellular mRNAs to prime viral genome transcription in a process called cap-snatching, but in vivo systems to investigate the details of this process are lacking for them. Here, we report that Rice stripe tenuivirus (R...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2019.10.017

    authors: Lin W,Wu R,Qiu P,Jing Jin,Yang Y,Wang J,Lin Z,Zhang J,Wu Z,Du Z

    更新日期:2020-01-02 00:00:00

  • Generating and evaluating type I interferon receptor-deficient and feline TMPRSS2-expressing cells for propagating serotype I feline infectious peritonitis virus.

    abstract::Feline coronavirus infection can progress to a fatal infectious peritonitis, which is a widespread feline disease without an effective vaccine. Generating feline cells with reduced ability to respond to interferon (IFN) is an essential step facilitating isolation of new candidate vaccine strains. Here, we describe the...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2019.08.030

    authors: Mettelman RC,O'Brien A,Whittaker GR,Baker SC

    更新日期:2019-11-01 00:00:00

  • Structural characterization of the PCV2d virus-like particle at 3.3 Å resolution reveals differences to PCV2a and PCV2b capsids, a tetranucleotide, and an N-terminus near the icosahedral 3-fold axes.

    abstract::Porcine circovirus 2 (PCV2) has a major impact on the swine industry. Eight PCV2 genotypes (a-h) have been identified using capsid sequence analysis. PCV2d has been designated as the emerging genotype. The cryo-electron microscopy molecular envelope of PCV2d virus-like particles identifies differences between PCV2a, b...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2019.09.001

    authors: Khayat R,Wen K,Alimova A,Gavrilov B,Katz A,Galarza JM,Gottlieb P

    更新日期:2019-11-01 00:00:00

  • Molecular characterization of Equine Infectious Anemia Viruses using targeted sequence enrichment and next generation sequencing.

    abstract::Equine infectious anemia virus (EIAV) is responsible of acute disease episodes characterized by fever, anemia, thrombocytopenia and anorexia in equids. The high mutation rate in EIAV genome limited the number of full genome sequences availability. In the present study, we used the SureSelect target enrichment system w...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2019.08.016

    authors: Deshiere A,Berthet N,Lecouturier F,Gaudaire D,Hans A

    更新日期:2019-11-01 00:00:00

  • Single-cell RNA sequencing reveals cell type-specific HPV expression in hyperplastic skin lesions.

    abstract::Human Papillomavirus infection is highly prevalent worldwide. While most types of HPV cause benign warts, some high-risk types are known to cause cervical cancer, as well as cancer of the oral cavity and head and neck. Persistent cutaneous HPV infection can be particularly problematic in patients with chronic immunosu...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2019.08.007

    authors: Devitt K,Hanson SJ,Tuong ZK,McMeniman E,Soyer HP,Frazer IH,Lukowski SW

    更新日期:2019-11-01 00:00:00

  • The evolution and characterization of influenza A(H7N9) virus under the selective pressure of peramivir.

    abstract::Human infection with H7N9 virus has provoked global public health concern due to the substantial morbidity and mortality. Neuraminidase inhibitors (NAIs) are used as first-line drugs to treat the infection. However, virus quasispecies can evolve rapidly under drug pressure, which may alter various biological character...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2019.08.004

    authors: Ge Y,Chi Y,Min X,Zhao K,Wu B,Wu T,Zhu X,Shi Z,Zhu F,Cui L

    更新日期:2019-10-01 00:00:00

  • A chimpanzee adenoviral vector-based rabies vaccine protects beagle dogs from lethal rabies virus challenge.

    abstract::Rabies continues to poses serious threats to the public health in many countries. The development of novel inexpensive, safe and effective vaccines has become a high priority for rabies control worldwide. We previously generated a novel recombinant rabies vaccine by cloning rabies virus glycoprotein into a chimpanzee ...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2019.07.022

    authors: Wang X,Fang Z,Xiong J,Yang K,Chi Y,Tang X,Ma L,Zhang R,Deng F,Lan K,Zhou D

    更新日期:2019-10-01 00:00:00

  • Association of polymorphisms in NFκB1 promoter and NFκBIA gene with the development of antibodies against HHV-8 in HIV-infected individuals.

    abstract::Human gammaherpesvirus 8 (HHV-8) is the etiologic agent of Kaposi's sarcoma, multicentric Castleman's disease and primary effusion lymphoma. Like other herpesviruses, the HHV-8 may exhibit latent or lytic cycle, both regulated by viral and host factors. Regarding host factors, we analysed the association of polymorphi...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2019.07.011

    authors: Gonçales JP,Silva Júnior JVJ,Lopes TRR,Tozetto-Mendoza TR,de Farias Guimarães D,de Morais VMS,Coêlho MRCD

    更新日期:2019-09-01 00:00:00

  • HPV8 activates cellular gene expression mainly through Sp1/3 binding sites.

    abstract::The human papillomavirus type 8 (HPV8) is associated with skin cancer development. The goal of this study was to investigate the effects of HPV8 oncoproteins on cellular gene expression and the identification of key regulators. We performed affymetrix microarray analyses to identify differentially expressed genes and ...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2019.06.019

    authors: Kirschberg M,Heuser S,Syed AS,Steger G,Majewski S,Hufbauer M,Akgül B

    更新日期:2019-09-01 00:00:00

  • Genetics and pathogenicity of H5N6 highly pathogenic avian influenza viruses isolated from wild birds and a chicken in Japan during winter 2017-2018.

    abstract::An H5N6 highly pathogenic avian influenza virus (HPAIV) outbreak occurred in poultry in Japan during January 2018, and H5N6 HPAIVs killed several wild birds in 3 prefectures during Winter 2017-2018. Time-measured phylogenetic analyses demonstrated that the Hemagglutinin (HA) and internal genes of these isolates were g...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2019.04.011

    authors: Mine J,Uchida Y,Nakayama M,Tanikawa T,Tsunekuni R,Sharshov K,Takemae N,Sobolev I,Shestpalov A,Saito T

    更新日期:2019-07-01 00:00:00

  • Cytoplasmic R-peptide of murine leukemia virus envelope protein negatively regulates its interaction with the cell surface receptor.

    abstract::Cytoplasmic tails of envelope (Env) glycoproteins of many retroviruses inhibit their membrane fusion activity. The cytoplasmic 16-amino acid peptide of ecotropic murine leukemia virus (E-MLV) Env protein, called the R-peptide, also inhibits the membrane fusion activity of the Env protein. However, the molecular mechan...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2019.04.005

    authors: Kubo Y,Izumida M,Togawa K,Zhang F,Hayashi H

    更新日期:2019-06-01 00:00:00

  • Calu-3 cells are largely resistant to entry driven by filovirus glycoproteins and the entry defect can be rescued by directed expression of DC-SIGN or cathepsin L.

    abstract::Priming of the viral glycoprotein (GP) by the cellular proteases cathepsin B and L (CatB, CatL) is believed to be essential for cell entry of filoviruses. However, pseudotyping systems that predominantly produce non-filamentous particles have frequently been used to prove this concept. Here, we report that GP-mediated...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2019.03.020

    authors: González-Hernández M,Müller A,Hoenen T,Hoffmann M,Pöhlmann S

    更新日期:2019-06-01 00:00:00

  • Intranasal IgG4/7 antibody responses protect horses against equid herpesvirus-1 (EHV-1) infection including nasal virus shedding and cell-associated viremia.

    abstract::Equid herpesvirus-1 (EHV-1) outbreaks continue despite widely used vaccination. We demonstrated previously that an ORF1/ORF71 gene deletion mutant of the EHV-1 strain Ab4 (Ab4ΔORF1/71) is less virulent than its parent Ab4 virus. Here, we describe the Ab4 challenge infection evaluating protection induced by the Ab4ΔORF...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2019.03.014

    authors: Perkins G,Babasyan S,Stout AE,Freer H,Rollins A,Wimer CL,Wagner B

    更新日期:2019-05-01 00:00:00

  • Rapid establishment of stable retroviral packaging cells and recombinant susceptible target cell lines employing novel transposon vectors derived from Sleeping Beauty.

    abstract::Viral vector particles derived from murine leukemia virus (MLV) mediate highly efficient stable gene transfer used in gene therapeutic approaches and in the generation of transgenic cell lines. However, the establishment of stable viral packaging cells (VPCs) is a time-consuming challenge. To overcome this limitation,...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2019.02.014

    authors: Berg K,Schäfer VN,Bartnicki N,Eggenschwiler R,Cantz T,Stitz J

    更新日期:2019-05-01 00:00:00

  • Discovery of endogenous retroviruses with mammalian envelopes in avian genomes uncovers long-term bird-mammal interaction.

    abstract::Endogenous retroviruses (ERVs) arise from the infection and integration of past retroviruses into animal hosts. We performed large-scale genomic mining of 101 avian genomes for discovery of ERVs having none-avian origin and investigated the cross-species transmission events. Phylogenetic analysis of the reverse transc...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2019.02.005

    authors: Chen M,Cui J

    更新日期:2019-04-01 00:00:00

  • Activation of protein kinase R by hepatitis C virus RNA-dependent RNA polymerase.

    abstract::Hepatitis C virus (HCV) was shown to activate protein kinase R (PKR), which inhibits expression of interferon (IFN) and IFN-stimulated genes by controlling the translation of newly transcribed mRNAs. However, it is unknown exactly how HCV activates PKR. To address the molecular mechanism(s) of PKR activation mediated ...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2019.01.024

    authors: Suzuki R,Matsuda M,Shimoike T,Watashi K,Aizaki H,Kato T,Suzuki T,Muramatsu M,Wakita T

    更新日期:2019-03-01 00:00:00

  • Editing the human cytomegalovirus genome with the CRISPR/Cas9 system.

    abstract::Human Cytomegalovirus (HCMV) is an opportunistic pathogen that causes substantial disease in neonates and immunocompromised individuals. Reverse genetic analysis of the HCMV genome is a powerful tool to dissect the roles that various viral genes play during infection. However, genetic engineering of HCMV is hampered b...

    journal_title:Virology

    pub_type: 杂志文章

    doi:10.1016/j.virol.2019.01.021

    authors: King MW,Munger J

    更新日期:2019-03-01 00:00:00

1835 条记录 1/46 页 « 12345678...4546 »