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A chimpanzee adenoviral vector-based rabies vaccine protects beagle dogs from lethal rabies virus challenge.

Abstract：

:Rabies continues to poses serious threats to the public health in many countries. The development of novel inexpensive, safe and effective vaccines has become a high priority for rabies control worldwide. We previously generated a novel recombinant rabies vaccine by cloning rabies virus glycoprotein into a chimpanzee adenoviral vector, termed ChAd68-Gp. The present study evaluated the immune responses and protection afforded by this vaccine in beagle dogs. The results demonstrated that intramuscular immunization with both low-dose and high-dose of ChAd68-Gp induced strong immune responses and provided complete protection in beagles even at low-dose. However, when administered orally, high-dose vaccination was protective while low-dose vaccination was ineffective. Further investigation indicated that the low-pH value of gastric juice in the stomach of beagles might decompose the adenovirus. Therefore, suitable formulation for adenovirus-based oral vaccine should be considered and developed. The chimpanzee adenovirus-vectored rabies vaccine ChAd68-Gp warrants extensive test for clinical application.

journal_name

Virology

journal_title

Virology

authors

Wang X,Fang Z,Xiong J,Yang K,Chi Y,Tang X,Ma L,Zhang R,Deng F,Lan K,Zhou D

doi

10.1016/j.virol.2019.07.022

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

32-38

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(19)30198-9

journal_volume

536

pub_type

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