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β-HPV 8E6 combined with TERT expression promotes long-term proliferation and genome instability after cytokinesis failure.

Abstract：

:Human papillomavirus (HPV) is a family of viruses divided into five genera: alpha, beta, gamma, mu, and nu. There is an ongoing discussion about whether beta genus HPVs (β-HPVs) contribute to cutaneous squamous cell carcinoma (cSCC). The data presented here add to this conversation by determining how a β-HPV E6 protein (β-HPV 8E6) alters the cellular response to cytokinesis failure. Specifically, cells were observed after cytokinesis failure was induced by dihydrocytochalasin B (H2CB). β-HPV 8E6 attenuated the immediate toxicity associated with H2CB but did not promote long-term proliferation after H2CB. Immortalization by telomerase reverse transcriptase (TERT) activation also rarely allowed cells to sustain proliferation after H2CB exposure. In contrast, TERT expression combined with β-HPV 8E6 expression allowed cells to proliferate for months following cytokinesis failure. However, this continued proliferation comes with genome destabilizing consequences. Cells that survived H2CB-induced cytokinesis failure suffered from changes in ploidy.

journal_name

Virology

journal_title

Virology

authors

Dacus D,Riforgiate E,Wallace NA

doi

10.1016/j.virol.2020.07.016

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

32-38

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(20)30143-4

journal_volume

549

pub_type

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