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ZikaBase: An integrated ZIKV- Human Interactome Map database.

Abstract：

:Re-emergence of ZIKV has caused infections in more than 1.5 million people. The molecular mechanism and pathogenesis of ZIKV is not well explored due to unavailability of adequate model and lack of publically accessible resources to provide information of ZIKV-Human protein interactome map till today. This study made an attempt to curate the ZIKV-Human interaction proteins from published literatures and RNA-Seq data. 11 direct interaction, 12 associated genes are retrieved from literatures and 3742 Differentially Expressed Genes (DEGs) are obtained from RNA-Seq analysis. The genes have been analyzed to construct the ZIKV-Human Interactome Map. The importance of the study has been illustrated by the enrichment analysis and observed that direct interaction and associated genes are enriched in viral entry into host cell. Also, ZIKV infection modulates 32% signal and 27% immune system pathways. The integrated database, ZikaBase has been developed to help the virology research community and accessible at https://test5.bicpu.edu.in.

journal_name

Virology

journal_title

Virology

authors

Gurumayum S,Brahma R,Naorem LD,Muthaiyan M,Gopal J,Venkatesan A

doi

10.1016/j.virol.2017.11.007

subject

Has Abstract

pub_date

2018-01-15 00:00:00

pages

203-210

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(17)30380-X

journal_volume

514

pub_type

杂志文章

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