Conserved aromatic residues of the hepatitis B virus Precore propeptide are involved in a switch between distinct dimeric conformations and essential in the formation of heterocapsids.

abstract：:Human embryo lung cells pretreated with a combination of human leukocyte interferon and acyclovir were infected with human cytomegalovirus (HCMV) and treated daily for 14 days with the same inhibitor combination. After removal of the inhibitors, the incubation temperature was maintained at either 37 or 40.5 degrees. I...

journal_title：Virology

authors： Bucher LJ,Wigdahl B,Rapp F

更新日期：1983-10-15 00:00:00

abstract：:The influenza RNA polymerase is known to be important in pathogenicity and adaptation of avian influenza viruses to mammalian hosts. However, the molecular mechanisms responsible are only partly understood. Here we investigated the role of the polymerase in two different, closely related, H5N1 influenza viruses - a hi...

journal_title：Virology

authors： Leung BW,Chen H,Brownlee GG

更新日期：2010-05-25 00:00:00

abstract：:Human adenovirus (HAdV) is a cause of significant morbidity and mortality in immunocompromised patients, especially after stem cell transplantation (SCT). Viral clearance has been attributed to CD4(+) T-cell responses against the Hexon-protein, but the frequency of specific T(HELPER) cells is extremely low or not dete...

journal_title：Virology

authors： Serangeli C,Bicanic O,Scheible MH,Wernet D,Lang P,Rammensee HG,Stevanovic S,Handgretinger R,Feuchtinger T

更新日期：2010-02-20 00:00:00

abstract：:Transient expression studies using a Nicotiana benthamiana suspension cell-derived protoplast system have identified a minimal sequence that is necessary and sufficient for activation of the tomato golden mosaic virus coat protein (CP) promoter by the viral TrAP protein (also called AL2). The sequence has a bipartite ...

journal_title：Virology

authors： Sunter G,Bisaro DM

更新日期：2003-01-20 00:00:00

abstract：:Soluble RNA-dependent RNA polymerases from healthy and alfalfa mosaic virus (AMV)-infected leaves were purified more than 400-fold from the 100,000g supernatant of leaf homogenates, using ammonium sulfate precipitation, Sephadex G-100 filtration, and chromatography on DEAE Sephadex A25 and P11-phosphocellulose. The DE...

journal_title：Virology

authors： Chifflot S,Sommer P,Hartmann D,Stussi-Garaud C,Hirth L

更新日期：1980-01-15 00:00:00

abstract：:The Tat regulatory protein encoded by human immunodeficiency virus type 1 (HIV-1) induces high levels of transcription from the viral long terminal repeat (LTR) promoter element after interacting with a promoter proximal RNA target sequence. In the wild-type HIV-1 LTR, this activation is facilitated by the synergistic...

journal_title：Virology

authors： Madore SJ,Cullen BR

更新日期：1995-02-01 00:00:00

abstract：:The repetitive DNA sequences of the genome of Molluscum contagiosum virus type 1 (MCV-1) have been localized within the terminal regions of the viral genome corresponding to the BamHI MCV-1 DNA fragments B (18 kbp; 0 to 0.095 map units (m.u.)) and E (10.5 kbp; 0.944 to 1 m.u.). The fine mapping of these particular reg...

journal_title：Virology

authors： Bugert JJ,Raab K,Rösen-Wolff A,Janssen W,Darai G

更新日期：1993-01-01 00:00:00

abstract：:The immortalizing function of the human adenovirus 5 E1A oncoprotein requires efficient localization to the nucleus. In 1987, a consensus monopartite nuclear localization sequence (NLS) was identified at the C-terminus of E1A. Since that time, various experiments have suggested that other regions of E1A influence nucl...

journal_title：Virology

authors： Cohen MJ,King CR,Dikeakos JD,Mymryk JS

更新日期：2014-11-01 00:00:00

abstract：:Powassan virus (POWV, Flaviviridae: Flavivirus) is the sole North American member of the tick-borne encephalitis complex and consists of two distinct lineages that are maintained in ecologically discrete enzootic transmission cycles. The underlying genetic mechanisms that lead to niche partitioning in arboviruses are ...

journal_title：Virology

authors： Brackney DE,Brown IK,Nofchissey RA,Fitzpatrick KA,Ebel GD

更新日期：2010-07-05 00:00:00

abstract：:The V3 region of the HIV-1 envelope (Env) glycoprotein gp120 is a key functional domain yet it exhibits distinct mutational patterns across subtypes. Here an invariant residue (Ile 309) was replaced with Leu in 7 subtype C patient-derived Envs from recent infection and 4 related neutralizing antibody escape variants t...

journal_title：Virology

authors： Lynch RM,Rong R,Li B,Shen T,Honnen W,Mulenga J,Allen S,Pinter A,Gnanakaran S,Derdeyn CA

更新日期：2010-08-15 00:00:00

abstract：:We have quantitated replication of the RNA genomes of vesicular stomatitis virus (VSV) and its defective interfering (DI) particles in a BHK21 cell-free system into which nucleocapsids were introduced in varying amounts and ratios, with or without addition of purified virus polymerase components. The quantitative tran...

journal_title：Virology

authors： Giachetti C,Holland JJ

更新日期：1989-05-01 00:00:00

abstract：:The genetic diversity of group M HIV-1 is highest in west central Africa. Blood samples from four locations in Cameroon were collected to determine the molecular epidemiology of HIV-1. The C2-V5 region of envelope was sequenced from 39 of the 40 samples collected, and 7 samples were sequenced across the genome. All st...

journal_title：Virology

authors： Carr JK,Torimiro JN,Wolfe ND,Eitel MN,Kim B,Sanders-Buell E,Jagodzinski LL,Gotte D,Burke DS,Birx DL,McCutchan FE

更新日期：2001-07-20 00:00:00

abstract：:Rotaviruses are the leading cause of severe diarrhea in infants and young children worldwide. Thus, the development of an effective rotavirus vaccine is a major public health goal. This study was performed to identify the gene or genes responsible for rotavirus virulence or host range restriction and attenuation in a ...

journal_title：Virology

authors： Hoshino Y,Saif LJ,Kang SY,Sereno MM,Chen WK,Kapikian AZ

更新日期：1995-05-10 00:00:00

abstract：:The porcine lymphotropic herpesvirus 1 (PLHV-1), the first gammaherpesvirus of pigs, has been detected at a high prevalence in healthy pig populations. A porcine gammaherpesvirus has also been detected at high copy numbers in animals suffering from posttransplant lymphoproliferative disease (PTLD). While human PTLD is...

journal_title：Virology

authors： Goltz M,Ericsson T,Patience C,Huang CA,Noack S,Sachs DH,Ehlers B

更新日期：2002-03-15 00:00:00

abstract：:The 94-kDa virion-associated RNA-dependent RNA polymerase (RdRp) is present in infectious pancreatic necrosis virus in two forms: (i) as a free polypeptide (VP1) and (ii) as a genome linked protein (VPg) (J. G. Calvert et al., 1991, J. Gen. Virol. 72, 2563-2567). VP1 was guanylylated in vitro by incubating purified vi...

journal_title：Virology

authors： Dobos P

更新日期：1995-04-01 00:00:00

abstract：:B-HIV1, an oligoclone of immortalized cells derived from human peripheral B lymphocytes infected in vitro with the TIIIB isolate of HIV-1, produces low levels of replication-competent HIV when propagated in 1% serum, but increases production > or = 5-fold after phorbol myristate acetate (PMA) exposure. Electron micros...

journal_title：Virology

authors： Laurence J,Grimison B,Rodriguez-Alfageme C,Astrin SM

更新日期：1993-10-01 00:00:00

abstract：:The tail sheath protein of giant bacteriophage phiKZ Pseudomonas aeruginosa encoded by gene 29 was identified and its expression system was developed. Localization of the protein on the virion was confirmed by immunoelectron microscopy. Properties of gene product (gp) 29 were studied by electron microscopy, immunoblot...

journal_title：Virology

authors： Kurochkina LP,Aksyuk AA,Sachkova MY,Sykilinda NN,Mesyanzhinov VV

更新日期：2009-12-20 00:00:00

abstract：:It has been widely demonstrated that the human immunodeficiency virus type 1 (HIV-1) envelope, specifically the V3 loop of the gp120 spike, evolves to facilitate adaptation to different cellular populations within an infected host. Less energy has been directed at determining whether the viral promoter, designated the...

journal_title：Virology

authors： McAllister JJ,Phillips D,Millhouse S,Conner J,Hogan T,Ross HL,Wigdahl B

更新日期：2000-09-01 00:00:00

abstract：:Information about the basic biological properties of human rhinovirus-C (HRV-C) viruses is lacking due to difficulties with culturing these viruses. Our objective was to develop a cell culture system to grow HRV-C. Epithelial cells from human sinuses (HSEC) were differentiated at air-liquid interface (ALI). Differenti...

journal_title：Virology

authors： Ashraf S,Brockman-Schneider R,Bochkov YA,Pasic TR,Gern JE

更新日期：2013-02-05 00:00:00

abstract：:Broad bean mottle bromovirus (BBMV) was shown to accumulate RNA2-derived defective interfering (DI) RNAs [Romero et al., Virology 194, 576-584 (1993); Pogany et al., Virology 212, 574-586 (1995)]. In this work, we utilize three sets of BBMV RNA2-derived artificial DI RNA constructs to determine factors that affect the...

journal_title：Virology

authors： Pogany J,Romero J,Bujarski JJ

更新日期：1997-02-17 00:00:00

abstract：:Recombinant RNAs generated in plants 3 weeks postinoculation with turnip crinkle virus (TCV) genomic RNA and an associated satellite RNA, sat-RNA D, have a majority of TCV crossover sites in a 24-nucleotide repeat (motif IIIA/IIIB) that forms part of a stable hairpin (Carpenter et al., 1995, J. Mol.Biol. 245, 608-622)...

journal_title：Virology

authors： Carpenter CD,Simon AE

更新日期：1996-09-01 00:00:00

abstract：:The Autographa californica nuclear polyhedrosis virus da26 gene codes for an envelope protein of both budded virus (BV) and occlusion derived virus (ODV). Western blot and temporal analysis of infected cell extracts detected a protein of 26 kDa by 4 h postinfection (p.i.). The amount of protein increased by 16 h p.i. ...

journal_title：Virology

authors： Beniya H,Braunagel SC,Summers MD

更新日期：1998-01-05 00:00:00

abstract：:Coxsackievirus B4 (CBV4), a member of the Picornavirus genus, has long been implicated in the development of insulin-dependent diabetes mellitus (IDDM), by viral-induced pancreatic cell damage. Although the pancreotropic nature of this virus is well documented, the early stages of CBV4 viral infection that involve the...

journal_title：Virology

authors： Triantafilou K,Triantafilou M

更新日期：2004-08-15 00:00:00

abstract：:Porcine circovirus type 2 (PCV2) is the causative agent of an emerging swine disease, postweaning multisystemic wasting syndrome. In this work, the RNAs of PCV2 synthesized during productive infection in porcine kidney cells were characterized. A total of nine RNAs were detected. They include the viral capsid protein ...

journal_title：Virology

authors： Cheung AK

更新日期：2003-01-05 00:00:00

abstract：:HIV infects macrophages and microglia in the central nervous system (CNS). Mechanisms that enhance HIV macrophage/microglial tropism are not well understood. Here, we identify an HIV Env variant in the V4 region of gp120, Asp 386 (D386), that eliminates an N-linked glycosylation site at position 386, enhances viral re...

journal_title：Virology

authors： Dunfee RL,Thomas ER,Wang J,Kunstman K,Wolinsky SM,Gabuzda D

更新日期：2007-10-10 00:00:00

abstract：:The effects of inhibitors, which interfere with oligosaccharide trimming by blocking mannosidases, on the processing and export of the viral glycoproteins of Rous sarcoma virus (RSV), have been studied. 1-Deoxymannojirimycin (DIM) prevents removal of mannose residues from the Man9 (GlcNAc)2 oligosaccharide whereas swa...

journal_title：Virology

authors： Bosch JV,Tlusty A,McDowell W,Legler G,Schwarz RT

更新日期：1985-05-01 00:00:00

abstract：:Re-emergence of ZIKV has caused infections in more than 1.5 million people. The molecular mechanism and pathogenesis of ZIKV is not well explored due to unavailability of adequate model and lack of publically accessible resources to provide information of ZIKV-Human protein interactome map till today. This study made ...

journal_title：Virology

authors： Gurumayum S,Brahma R,Naorem LD,Muthaiyan M,Gopal J,Venkatesan A

更新日期：2018-01-15 00:00:00

abstract：:The 85-kDa polypeptide previously shown to be associated with the restricted (R) component of the EBV-induced early antigen (EA) complex was subjected to amino acid sequencing analysis. This was accomplished by cyanogen bromide cleavage and by separation of individual peptides by high-pressure liquid chromatography em...

journal_title：Virology

authors： Goldschmidts W,Luka J,Pearson GR

更新日期：1987-03-01 00:00:00

abstract：:Autographa californica multiple nucleopolyhedrovirus (AcMNPV) ac92 is a core gene encoding a protein associated with occlusion derived virus (ODV), binds human P53 and also has flavin adenine dinucleotide linked sulfhydryl oxidase activity but its role in the virus life cycle is not known. To determine ac92 function a...

journal_title：Virology

authors： Nie Y,Fang M,Theilmann DA

更新日期：2011-01-05 00:00:00

abstract：:Twelve lytic viruses (PgV) infecting the marine unicellular eukaryotic harmful algal bloom species Phaeocystis globosa were isolated from the southern North Sea in 2000-2001 and partially characterized. All PgV isolates shared common phenotypic features with other algal viruses belonging to the family Phycodnaviridae ...

journal_title：Virology

authors： Baudoux AC,Brussaard CP

更新日期：2005-10-10 00:00:00