Correlation between polymerase activity and pathogenicity in two duck H5N1 influenza viruses suggests that the polymerase contributes to pathogenicity.

abstract：:The OC43 strain of human coronavirus (HCoV-OC43) is an ubiquitous respiratory tract pathogen possessing neurotropic capacities. Coronavirus structural envelope (E) protein possesses specific motifs involved in protein-protein interaction or in homo-oligomeric ion channel formation, which are known to play various role...

journal_title：Virology

authors： Stodola JK,Dubois G,Le Coupanec A,Desforges M,Talbot PJ

更新日期：2018-02-01 00:00:00

abstract：:Measles virus (MV) causes various responses including the induction of immune responses, transient immunosuppression and establishment of long-lasting immunity. To obtain a comprehensive view of the effects of MV infection on target cells, DNA microarray analyses of two different cell-types were performed. An epitheli...

journal_title：Virology

authors： Sato H,Honma R,Yoneda M,Miura R,Tsukiyama-Kohara K,Ikeda F,Seki T,Watanabe S,Kai C

更新日期：2008-06-05 00:00:00

abstract：:The role of the nucleocapsid protein of HIV-1 Gag in virus assembly was investigated using Gag truncation mutants, a nucleocapsid deletion mutant, and point mutations in the nucleocapsid region of Gag, in transfected COS cells, and in stable T-cell lines. Consistent with previous investigations, a truncation containin...

journal_title：Virology

authors： Dawson L,Yu XF

更新日期：1998-11-10 00:00:00

abstract：:Resistance to lethal encephalitis in mice infected with HSV-1 via the oral mucosa is mouse strain dependent. In susceptible BALB/c, HSV-1 spreads throughout the CNS but in resistant BL/6 mice, virus is restricted to the brainstem. To examine the contribution of cellular immunity in restricting viral spread, we used a ...

journal_title：Virology

authors： Kastrukoff LF,Lau AS,Takei F,Smyth MJ,Jones CM,Clarke SR,Carbone FR

更新日期：2010-05-10 00:00:00

abstract：:Hantaan virus, the prototype virus of hemorrhagic fever with renal syndrome, was examined for nucleic acid characteristics which would support its previously proposed inclusion in the virus family Bunyaviridae. Nucleocapsid RNA from Hantaan virions and a control bunyavirus were examined for ribonuclease A (RNase A) se...

journal_title：Virology

authors： Schmaljohn CS,Dalrymple JM

更新日期：1983-12-01 00:00:00

abstract：:Mapping of the 5' ends of virion-derived hepatitis B virus DNA molecules was carried out after cloning and sequencing linearized genomes made fully double stranded. Of five clones obtained, three of four minus strand termini mapped to the G in position 1826 and one to the T in position 1827. Plus strand 5' ends were m...

journal_title：Virology

authors： Saldanha JA,Qiu H,Thomas HC,Monjardino J

更新日期：1992-05-01 00:00:00

abstract：:A procedure was developed for the purification of the pea enation mosaic virus (PEMV) using differential and rate zonal centrifugation in sucrose density gradients. Infectivity and serological data indicated that the highest virus concentration occurs in infected peas (Pisum sativum) 10-12 days after mechanical inocul...

journal_title：Virology

authors： Izadpanah K,Shepherd RJ

更新日期：1966-03-01 00:00:00

abstract：:In this study, we present enzymatic differences found between recombinant RTs derived from feline leukemia virus and feline immunodeficiency virus. Firstly, FIV RT showed low steady state K(m) values for dNTPs compared to FeLV RT. Consistent with this, FIV RT synthesized DNA more efficiently than FeLV RT at low dNTP c...

journal_title：Virology

authors： Operario DJ,Reynolds HM,Kim B

更新日期：2005-04-25 00:00:00

abstract：:Turnip crinkle virus (TCV) is associated with many subviral RNAs including satellite (sat-) RNAs which require a helper virus for infectivity. When plants were inoculated with TCV and transcripts of TCV sat-RNA C containing deletions of 3 to 8 nucleotides beginning at position 100 and extending toward the 5' end, some...

journal_title：Virology

authors： Carpenter CD,Cascone PJ,Simon AE

更新日期：1991-08-01 00:00:00

abstract：:West Nile virus (WNV) genome cyclization is mediated by two pairs of long-distance RNA/RNA interactions: the 5'CS/3'CSI (conserved sequence) and the 5'UAR/3'UAR (upstream AUG region) base pairings. Antisense peptide-conjugated phosphorodiamidate morpholino oligomers (PPMOs), designed to interfere with the 5'CS/3'CSI o...

journal_title：Virology

authors： Zhang B,Dong H,Stein DA,Shi PY

更新日期：2008-12-05 00:00:00

abstract：:Vaccinia topoisomerase provides a model system for structure-function analysis of the type IB topoisomerase family. Here we performed an alanine scan of eight positions in the beta4 and beta5 strands of the N-terminal domain (Leu57, Ile58, Phe59, Val60, Gly61, Ser62, Gln69 and Gly73) and eight positions in the alpha8-...

journal_title：Virology

authors： Tian L,Shuman S

更新日期：2007-03-15 00:00:00

abstract：:Mouse mammary tumour virus (MMTV) encodes a viral superantigen (Sag) and a negative acting factor (Naf) which share parts of their coding sequence. Using 2-dimensional gel electrophoresis (2D-DIGE), we could show that at least 10 different cellular proteins were differentially expressed in Naf positive cells. Also, lu...

journal_title：Virology

authors： Metzner C,Salmons B,Gunzburg WH,Gemeiner M,Miller I,Gesslbauer B,Kungl A,Dangerfield JA

更新日期：2006-03-01 00:00:00

abstract：:We cloned and sequenced the cDNAs against genomic RNAs and mRNAs for phosphoproteins (Ps) of human parainfluenza virus types 4A (PIV-4A) and 4B (PIV-4B). The PIV-4A and -4B P genes were 1535 nucleotides including poly(A) tract and were found to have two small open reading frames, neither of which was apparently large ...

journal_title：Virology

authors： Kondo K,Bando H,Tsurudome M,Kawano M,Nishio M,Ito Y

更新日期：1990-09-01 00:00:00

abstract：:The location of the cistron encoding the genome-linked protein (VPg) in the potyvirus tobacco vein mottling virus (TVMV) was investigated. Precipitation of 125I-labeled VPg with anti-tobacco etch virus 49K nuclear inclusion protein antiserum (which reacts with the NIa nuclear inclusion protein of TVMV) indicated that ...

journal_title：Virology

authors： Shahabuddin M,Shaw JG,Rhoads RE

更新日期：1988-04-01 00:00:00

abstract：:Crosslinking reagents were used to interrupt the process of filamentous phage morphogenesis and investigate the orientation in which nascent virions are extruded through the host cell membrane. Infected bacteria with emerging phage particles were crosslinked with glutaraldehyde. Immunoferritin-labeling studies on thes...

journal_title：Virology

authors： Lopez J,Webster RE

更新日期：1983-05-01 00:00:00

abstract：:Most adenovirus transducing vectors have the cytomegalovirus major immediate-early (CMV) or the Rous sarcoma virus long terminal repeat (RSV) promoter driving expression of the transgene. Both of these promoters are highly active in transfection and transduction assays in 293 cells, in which transducing vectors are co...

journal_title：Virology

authors： Schaack J,Allen B,Orlicky DJ,Bennett ML,Maxwell IH,Smith RL

更新日期：2001-12-05 00:00:00

abstract：:Chlorella virus PBCV-1 encodes two putative chitinase genes, a181/182r and a260r, and one chitosanase gene, a292l. The three genes were cloned and expressed in Escherichia coli. The recombinant A181/182R protein has endochitinase activity, recombinant A260R has both endochitinase and exochitinase activities, and recom...

journal_title：Virology

authors： Sun L,Adams B,Gurnon JR,Ye Y,Van Etten JL

更新日期：1999-10-25 00:00:00

abstract：:Many antiviral drugs must be metabolized to their active form by cellular enzymes. Their antiviral activity may therefore be limited by an inefficient metabolism, leading to low intracellular concentration of the active form or to the accumulation of toxic intermediate metabolites. Gene transfer might be used to overc...

journal_title：Virology

authors： Guettari N,Loubière L,Brisson E,Klatzmann D

更新日期：1997-09-01 00:00:00

abstract：:We describe the in vitro selection and characterisation of virus derived from B/Beijing/1/87 passaged in the presence of zanamivir. During zanamivir passage, the phenotype of virus isolates was either drug dependent or drug resistant in plaque reduction assays. The susceptibility of the neuraminidase of the drug-depen...

journal_title：Virology

authors： Barnett JM,Cadman A,Burrell FM,Madar SH,Lewis AP,Tisdale M,Bethell R

更新日期：1999-12-20 00:00:00

abstract：:Infection of Salmonella enterica with lytic mutants of either P22 or SE1 bacteriophages triggers the expression of its DNA damage-inducible SOS response through a lexA-dependent pathway. This induction of the SOS system strictly requires the presence of the bacteriophage kil gene. Accordingly, plasmid overexpression o...

journal_title：Virology

authors： Campoy S,Hervàs A,Busquets N,Erill I,Teixidó L,Barbé J

更新日期：2006-08-01 00:00:00

abstract：:We previously demonstrated in trials of a variety of experimental vaccines to equine infectious anemia virus (EIAV) a remarkable spectrum of efficacy ranging from sterilizing protection to severe enhancement of virus replication and disease, depending on the immunization strategy used. This range of vaccine efficacy o...

journal_title：Virology

authors： Hammond SA,Raabe ML,Issel CJ,Montelaro RC

更新日期：1999-09-30 00:00:00

abstract：:The failure of HIV-1 to escape at some cytotoxic T-lymphocyte (CTL) epitopes has generally been explained in terms of viral fitness costs or ineffective or attenuated CTL responses. Relatively little attention has been paid to the evolutionary time required for escape mutants to be detected. This time is significantly...

journal_title：Virology

authors： Liu Y,Mullins JI,Mittler JE

更新日期：2006-03-30 00:00:00

abstract：:The recently described taxon Negevirus is comprised of a diverse group of insect-specific viruses isolated from mosquitoes and phlebotomine sandflies. In this study, a comprehensive genetic characterization, molecular, epidemiological and evolutionary analyses were conducted on nearly full-length sequences of 91 new n...

journal_title：Virology

authors： Nunes MRT,Contreras-Gutierrez MA,Guzman H,Martins LC,Barbirato MF,Savit C,Balta V,Uribe S,Vivero R,Suaza JD,Oliveira H,Nunes Neto JP,Carvalho VL,da Silva SP,Cardoso JF,de Oliveira RS,da Silva Lemos P,Wood TG,Widen SG

更新日期：2017-04-01 00:00:00

abstract：:Re-emergence of ZIKV has caused infections in more than 1.5 million people. The molecular mechanism and pathogenesis of ZIKV is not well explored due to unavailability of adequate model and lack of publically accessible resources to provide information of ZIKV-Human protein interactome map till today. This study made ...

journal_title：Virology

authors： Gurumayum S,Brahma R,Naorem LD,Muthaiyan M,Gopal J,Venkatesan A

更新日期：2018-01-15 00:00:00

abstract：:An infectious raccoon poxvirus (RCNV) was used to express the feline panleukopenia virus (FPV) open reading frame VP2. The recombinant, RCNV/FPV, was constructed by homologous recombination with a chimeric plasmid for inserting the expression cassette into the thymidine kinase (TK) locus of RCNV. Expression of the VP2...

journal_title：Virology

authors： Hu L,Esposito JJ,Scott FW

更新日期：1996-04-01 00:00:00

abstract：:Assembly of icosahedral capsids of proper size and symmetry is not understood. Residue F170 in bacteriophage P22 coat protein is critical for conformational switching during assembly. Substitutions at this site cause assembly of tubes of hexamerically arranged coat protein. Intragenic suppressors of the ts phenotype o...

journal_title：Virology

authors： Suhanovsky MM,Teschke CM

更新日期：2011-09-01 00:00:00

abstract：:Genomic and messenger RNAs of a Zaire strain of Ebola virus were cloned, and inserts specific for the nucleoprotein gene were isolated and sequenced. The nucleoprotein gene is located proximal to the 3' end of the genome and is preceeded by a putative leader sequence. The gene begins with the transcriptional start sit...

journal_title：Virology

authors： Sanchez A,Kiley MP,Holloway BP,McCormick JB,Auperin DD

更新日期：1989-05-01 00:00:00

abstract：:The VP6 gene of human group C rotavirus was cloned and sequenced. Hybridization to the human group C and the porcine group C/Cowden dsRNA genomes assigned this coding sequence to segment 5. The complete human VP6 sequence contained an open reading frame of 1185 nucleotides (395 amino acids; deduced Mr 44,669 Da). The ...

journal_title：Virology

authors： Cooke SJ,Lambden PR,Caul EO,Clarke IN

更新日期：1991-10-01 00:00:00

abstract：:Hepatitis C virus (HCV) encodes a polyprotein that is processed to produce the structural and nonstructural proteins of the virus. Nonstructural protein 3 (NS3) is a serine proteinase that cleaves the polyprotein to release the NS4A, NS4B, NS5A, and NS5B proteins. To characterize the substrate specificity of NS3, we s...

journal_title：Virology

authors： Leinbach SS,Bhat RA,Xia SM,Hum WT,Stauffer B,Davis AR,Hung PP,Mizutani S

更新日期：1994-10-01 00:00:00

abstract：:HAV particles isolated from infected cells banded at buoyant densities of 1.42, 1.32, and 1.20 g/ml, and distinctive protein patterns were established by gel electrophoresis and reverse phase high performance liquid chromatography. The relatively higher amounts of p30 in particles with lower buoyant densities suggest ...

journal_title：Virology

authors： Gauss-Müller V,Lottspeich F,Deinhardt F

更新日期：1986-12-01 00:00:00