Abstract:
:The VP6 gene of human group C rotavirus was cloned and sequenced. Hybridization to the human group C and the porcine group C/Cowden dsRNA genomes assigned this coding sequence to segment 5. The complete human VP6 sequence contained an open reading frame of 1185 nucleotides (395 amino acids; deduced Mr 44,669 Da). The protein sequence demonstrated low homology with the group A VP6 sequences (41.7 to 42.7%) and high homology (88.9%) with the porcine group C VP6 sequence. However, the protein sequence alignments revealed a region of 10 amino acids that were significantly different between the human and the porcine group C viruses.
journal_name
Virologyjournal_title
Virologyauthors
Cooke SJ,Lambden PR,Caul EO,Clarke INdoi
10.1016/0042-6822(91)90452-hsubject
Has Abstractpub_date
1991-10-01 00:00:00pages
781-5issue
2eissn
0042-6822issn
1096-0341journal_volume
184pub_type
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