Abstract:
:Eight rhesus macaques inoculated with molecularly cloned SIVmac239 developed viremia and virus-binding antibodies, but only one (macaque 2D) developed neutralizing antibodies to the virus. Viremia persisted in macaque 2D even in the presence of neutralizing antibodies. Neutralizing antibodies in the plasma collected from macaque 2D late in infection neutralized virus isolated early in infection. In contrast, these antibodies failed to neutralize the plasma viruses isolated after the appearance of neutralizing antibodies. Only antigenic variants were isolated from blood, spleen, and lymph nodes. Viruses isolated from other macaques that did not develop neutralizing antibodies were neutralized by 2D serum and were of the parental (SIVmac239) phenotype. The variant viruses maintained their strict tropism for lymphocytes, similar to the parental virus.
journal_name
Virologyjournal_title
Virologyauthors
Joag SV,Anderson MG,Clements JE,McEntee MF,Sharma DP,Adams RJ,Narayan Odoi
10.1006/viro.1993.1390subject
Has Abstractpub_date
1993-08-01 00:00:00pages
406-12issue
2eissn
0042-6822issn
1096-0341pii
S0042-6822(83)71390-5journal_volume
195pub_type
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