当前位置： SCI文献检索 > VIROLOGY期刊下所有文献 > Disruption of NF-kappa B signaling and chemokine gene activation by retroviral mediated expression of IKK gamma/NEMO mutants.

Disruption of NF-kappa B signaling and chemokine gene activation by retroviral mediated expression of IKK gamma/NEMO mutants.

Abstract：

:Phosphorylation of I kappa Bs--the cytoplasmic inhibitors of the NF-kappa B transcription factors--is the key event which triggers activation of the NF-kappa B cascade. Signal-mediated phosphorylation of I kappa B alpha is mediated by a multiprotein complex, the I kappa B kinase (IKK) complex, which is composed of at least three identified subunits. Two of these polypeptides, IKK alpha and IKK beta, also known as IKK1 and IKK2, are the catalytic subunits of the kinase complex and phosphorylate I kappa B alpha and I kappa B beta. The third component, NEMO/IKK gamma, does not exhibit kinase activity, but rather constitutes a regulatory subunit. In the present study, C-terminal truncated forms of IKK gamma--Delta C-IKK gamma 306 and Delta C-IKK gamma 261--were stably expressed in the myeloid cell line U937 by retroviral-mediated gene transfer. Overexpression of Delta C-IKK gamma resulted in a reduction in IKK kinase activity in vitro, a subsequent decrease in NF-kappa B DNA binding activity, and inhibition of chemokine gene induction in response to TNFalpha stimulation or paramyxovirus infection. This study demonstrates the efficacy of Delta C-IKK gamma as a repressor of IKK signaling and NF-kappa B activation and suggests a potential gene therapy approach to limit chronic inflammation due to chemokine hyperactivation.

journal_name

Virology

journal_title

Virology

authors

Le Page C,Popescu O,Génin P,Lian J,Paquin A,Galipeau J,Hiscott J

doi

10.1006/viro.2001.0999

subject

Has Abstract

pub_date

2001-08-01 00:00:00

pages

422-33

issue

2

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(01)90999-7

journal_volume

286

pub_type

杂志文章

相关文献

VIROLOGY文献大全
  • The insertion domain of the duck hepatitis B virus core protein plays a role in nucleocapsid assembly.

    abstract：:Synthesis of hepadnaviral DNA is dependent upon both the viral DNA polymerase and the viral core protein, the subunit of the nucleocapsids in which viral DNA synthesis takes place. In a study of natural isolates of duck hepatitis B virus (DHBV), we cloned full-length viral genomes from a puna teal. One of the clones f...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2006.06.004

    authors： Guo H,Aldrich CE,Saputelli J,Xu C,Mason WS

    更新日期：2006-09-30 00:00:00

  • Phylogenetic analysis of 49 newly derived HIV-1 group O strains: high viral diversity but no group M-like subtype structure.

    abstract：:We assess the genetic relationships between 49 HIV-1 group O strains from 24 and 25 patients living in Cameroon and France, respectively. Strains were sequenced in four genomic regions: gag (p24) and three env regions (C2-V3, gp41, and for 22 C2-gp41). In each of the genomic regions analyzed, the genetic diversity amo...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2002.1430

    authors： Roques P,Robertson DL,Souquière S,Damond F,Ayouba A,Farfara I,Depienne C,Nerrienet E,Dormont D,Brun-Vézinet F,Simon F,Mauclère P

    更新日期：2002-10-25 00:00:00

  • Efficient inoculation with CaMV 35 S promoter-driven DNA clones of the tobravirus PEBV.

    abstract：:Clones have been constructed containing full-length cDNA copies of PEBV RNA1 and RNA2, flanked by the CaMV 35 S RNA promoter and the nopaline synthase terminator. The clones are infectious when inoculated onto Nicotiana benthamiana plants. Both the viral RNAs and the virus particles were identified in infected plants....

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(92)90488-b

    authors： MacFarlane SA,Gilmer D,Davies JW

    更新日期：1992-04-01 00:00:00

  • A highly pathogenic porcine reproductive and respiratory syndrome virus generated from an infectious cDNA clone retains the in vivo virulence and transmissibility properties of the parental virus.

    abstract：:The nucleotide sequence of a highly pathogenic porcine reproductive and respiratory syndrome virus (PRRSV) was determined. Transfection of MARC-145 cells with capped in vitro transcripts derived from a full-length cDNA clone of the viral genome resulted in infectious PRRSV with growth characteristics similar to that o...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2004.04.046

    authors： Truong HM,Lu Z,Kutish GF,Galeota J,Osorio FA,Pattnaik AK

    更新日期：2004-08-01 00:00:00

  • Two N-terminal regions of the Sendai virus L RNA polymerase protein participate in oligomerization.

    abstract：:The RNA dependent RNA polymerase of Sendai virus consists of a complex of the large (L) and phosphoprotein (P) subunits where L is thought to be responsible for all the catalytic activities necessary for viral RNA synthesis. We previously showed that the L protein forms an oligomer [Smallwood, S., Cevik, B., Moyer, S....

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2007.01.032

    authors： Cevik B,Smallwood S,Moyer SA

    更新日期：2007-06-20 00:00:00

  • Equivalent immunogenicity of the highly attenuated poxvirus-based ALVAC-SIV and NYVAC-SIV vaccine candidates in SIVmac251-infected macaques.

    abstract：:Therapeutic immunization of HIV-1-infected individuals may induce and/or enhance HIV-1-specific immune responses and decrease the dependency on antiretroviral drug treatment. However, repeated immunizations with live-recombinant vectors may induce vector-specific immune responses that interfere with the elicitation of...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2002.1722

    authors： Hel Z,Nacsa J,Tsai WP,Thornton A,Giuliani L,Tartaglia J,Franchini G

    更新日期：2002-12-05 00:00:00

  • Epidermal growth factor receptor is a co-factor for transmissible gastroenteritis virus entry.

    abstract：:Transmissible gastroenteritis virus (TGEV) causes severe diarrhea and high mortality in newborn piglets. It is well established that porcine intestinal epithelium is the target of the TGEV infection, however the mechanism that TGEV invades the host epithelium remains largely unknown. Aminopeptidase N (APN) is a known ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2018.05.009

    authors： Hu W,Zhang S,Shen Y,Yang Q

    更新日期：2018-08-01 00:00:00

  • Different evolution of simian immunodeficiency virus in a natural host and a new host.

    abstract：:To address the mechanisms of host-virus adaptation and pathogenesis of lentiviral infections, we compared the evolution of the same isolate of simian immunodeficiency virus (SIVsmm9) in two different situations: nonpathogenic infection of its natural host, the sooty mangabey, and AIDS-inducing infection of a new host,...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1998.9217

    authors： Courgnaud V,Saurin W,Villinger F,Sonigo P

    更新日期：1998-07-20 00:00:00

  • Immunolocalization of the dengue virus nonstructural glycoprotein NS1 suggests a role in viral RNA replication.

    abstract：:Although many workers have investigated the maturation and processing of the flavivirus nonstructural glycoprotein NS1 in infected cells, these studies have provided little insight into a possible function for NS1. In this study we investigated the subcellular localization of NS1 both by immunofluorescence and cryo-im...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1996.0307

    authors： Mackenzie JM,Jones MK,Young PR

    更新日期：1996-06-01 00:00:00

  • Bovine herpesvirus 1 U(S) ORF8 protein induces apoptosis in infected cells and facilitates virus egress.

    abstract：:The bovine herpesvirus 1 (BHV-1) U(S) ORF8 protein with homology to the Us9 protein of other alphaherpesviruses induces apoptosis in rabbit kidney (RK13) cells without the presence of other BHV-1-encoded proteins. In this article, we have characterized the cytotoxicity and growth behavior of a BHV-1 recombinant, BHV-1...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2002.1656

    authors： Nakamichi K,Matsumoto Y,Otsuka H

    更新日期：2002-12-05 00:00:00

  • Transcription mapping and characterization of 284R and 121R proteins produced from early region 3 of bovine adenovirus type 3.

    abstract：:We established the transcription map of early region (E) 3 of bovine adenovirus 3 (BAV-3) by Northern blot, S1 nuclease protection assays, cDNA sequencing, and RT-PCR analysis. Five major classes of mRNAs were identified, which shared the 3' ends. Four classes of mRNAs transcribed from the E3 promoter also shared the ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1999.9626

    authors： Idamakanti N,Reddy PS,Babiuk LA,Tikoo SK

    更新日期：1999-04-10 00:00:00

  • Induction of the SOS response by bacteriophage lytic development in Salmonella enterica.

    abstract：:Infection of Salmonella enterica with lytic mutants of either P22 or SE1 bacteriophages triggers the expression of its DNA damage-inducible SOS response through a lexA-dependent pathway. This induction of the SOS system strictly requires the presence of the bacteriophage kil gene. Accordingly, plasmid overexpression o...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2006.04.001

    authors： Campoy S,Hervàs A,Busquets N,Erill I,Teixidó L,Barbé J

    更新日期：2006-08-01 00:00:00

  • Conserved aromatic residues of the hepatitis B virus Precore propeptide are involved in a switch between distinct dimeric conformations and essential in the formation of heterocapsids.

    abstract：:The Hepatitis B virus Precore protein, present in the secretory pathway as the HBeAg precursor, can associate in the cytoplasm with the Core protein to form heterocapsids, likely to favor viral persistence. Core and Precore proteins share their primary sequence except for ten additional aminoacids at the N-terminus of...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2014.06.013

    authors： Duriez M,Thouard A,Bressanelli S,Rossignol JM,Sitterlin D

    更新日期：2014-08-01 00:00:00

  • An improved reverse genetics system for mammalian orthoreoviruses.

    abstract：:Mammalian orthoreoviruses (reoviruses) are highly useful models for studies of double-stranded RNA virus replication and pathogenesis. We previously developed a strategy to recover prototype reovirus strain T3D from cloned cDNAs transfected into murine L929 fibroblast cells. Here, we report the development of a second...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2009.11.037

    authors： Kobayashi T,Ooms LS,Ikizler M,Chappell JD,Dermody TS

    更新日期：2010-03-15 00:00:00

  • Begomovirus genetic diversity in the native plant reservoir Solanum nigrum: Evidence for the presence of a new virus species of recombinant nature.

    abstract：:We examined the native plant host Solanum nigrum as reservoir of genetic diversity of begomoviruses that cause the tomato yellow leaf curl disease (TYLCD) emerging in southern Spain. Presence of isolates of all the species and strains found associated with TYLCD in this area was demonstrated. Mixed infections were com...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2006.02.028

    authors： García-Andrés S,Monci F,Navas-Castillo J,Moriones E

    更新日期：2006-07-05 00:00:00

  • The coat protein of turnip crinkle virus is involved in subviral RNA-mediated symptom modulation and accumulation.

    abstract：:Some satellite (sat-) and defective interfering (DI) RNAs associated with plant viruses intensify or ameliorate the symptoms of the virus. We recently demonstrated that the TCV coat protein (CP) is involved in symptom modulation by sat-RNA C. Two additional subviral RNAs have now been tested for effect of the CP on sy...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1997.8853

    authors： Kong Q,Oh JW,Carpenter CD,Simon AE

    更新日期：1997-11-24 00:00:00

  • Experimental confirmation of a hepatitis B virus (HBV) epsilon-like bulge-and-loop structure in avian HBV RNA encapsidation signals.

    abstract：:Hepatitis B viruses replicate via reverse transcription of an RNA intermediate. This RNA pregenome serves as mRNA and is packaged into capsids and reverse transcribed. Both processes require the interaction of the viral reverse transcriptase, P protein, with the 5'-proximal epsilon-signals on the pregenome. For epsilo...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1996.8329

    authors： Beck J,Bartos H,Nassal M

    更新日期：1997-01-20 00:00:00

  • Nucleotide sequence of the structural glycoprotein VP7 gene of Nebraska calf diarrhea virus rotavirus: comparison with homologous genes from four strains of human and animal rotaviruses.

    abstract：:A full-size cloned cDNA copy of the rotavirus gene encoding the structural neutralization glycoprotein (VP7) of Nebraska calf diarrhea virus (NCDV), a strain recently shown to be effective as a vaccine in children, has been sequenced. Comparison of the deduced amino acid sequence of NCDV (serotype 6) VP7 with that of ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(85)90260-0

    authors： Glass RI,Keith J,Nakagomi O,Nakagomi T,Askaa J,Kapikian AZ,Chanock RM,Flores J

    更新日期：1985-03-01 00:00:00

  • A novel type D simian retrovirus naturally infecting the Indian Hanuman langur (Semnopithecus entellus).

    abstract：:As a simian species, the langurs are not known to harbor simian retroviruses, except for one report on a simian Type D endogenous retrovirus from the spectacled langur (Trachypithecus obscurus) from Malaysia. The present report describes for the first time natural infection of the common Hanuman langur (Semnopithecus ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2000.0567

    authors： Nandi JS,Bhavalkar-Potdar V,Tikute S,Raut CG

    更新日期：2000-11-10 00:00:00

  • Envelope and nucleoid ultrastructure of Molluscum contagiosum virus.

    abstract：:The ultrastructure of the mature and immature poxvirus Molluscum contagiosum has been examined by electron microscopy. With freeze-fracturing one fracture plane was observed in the viral envelope. During the conversion of immature into mature virus, particles inside the envelope become partly rearranged into parallel ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(77)90215-x

    authors： Vreeswijk J,Kalsbeek GL,Nanninga N

    更新日期：1977-11-01 00:00:00

  • Injection of the sciatic nerve with TMEV: a new model for peripheral nerve demyelination.

    abstract：:Demyelination of the human peripheral nervous system (PNS) can be caused by diverse mechanisms including viral infection. Despite association of several viruses with the development of peripheral demyelination, animal models of the condition have been limited to disease that is either autoimmune or genetic in origin. ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2006.09.009

    authors： Drescher KM,Tracy SM

    更新日期：2007-03-01 00:00:00

  • Domain- and nucleotide-specific Rev response element regulation of feline immunodeficiency virus production.

    abstract：:Computational analysis of feline immunodeficiency virus (FIV) RNA sequences indicated that common FIV strains contain a rev response element (RRE) defined by a long unbranched hairpin with 6 stem-loop sub-domains, termed stem-loop A (SLA). To examine the role of the RNA secondary structure of the RRE, mutational analy...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2010.04.009

    authors： Na H,Huisman W,Ellestad KK,Phillips TR,Power C

    更新日期：2010-09-01 00:00:00

  • Oxygen tension level and human viral infections.

    abstract：:The role of oxygen tension level is a well-known phenomenon that has been studied in oncology and radiotherapy since about 60 years. Oxygen tension may inhibit or stimulate propagation of viruses in vitro as well as in vivo. In turn modulating oxygen metabolism may constitute a novel approach to treat viral infections...

    journal_title：Virology

    pub_type： 杂志文章,评审

    doi：10.1016/j.virol.2013.06.018

    authors： Morinet F,Casetti L,François JH,Capron C,Pillet S

    更新日期：2013-09-01 00:00:00

  • Temperature-sensitive mutants in the vaccinia virus 4b virion structural protein assemble malformed, transcriptionally inactive intracellular mature virions.

    abstract：:Two noncomplementing vaccinia virus temperature-sensitive mutants, Cts8 and Cts26, were mapped to the A3L gene, which encodes the major virion structural protein, 4b. The two ts mutants display normal patterns of gene expression, DNA replication, telomere resolution, and protein processing during infection. Morphogene...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2004.08.038

    authors： Kato SE,Strahl AL,Moussatche N,Condit RC

    更新日期：2004-12-05 00:00:00

  • Experimental validation of influenza A virus matrix protein (M1) interaction with host cellular alpha enolase and pyruvate kinase.

    abstract：:Influenza A virus, a respiratory pathogen manipulates various host cellular processes to establish a successful infection in a host. We had reported earlier the interaction of influenza A virus nucleoprotein with host glycolytic enzymes; alpha enolase and pyruvate kinase in A549 cells. Matrix protein (M1), another mul...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2020.07.019

    authors： Mishra S,Goyal P,Kumar D,Chaudhari R,Rajala MS

    更新日期：2020-10-01 00:00:00

  • Structural and mutational analyses of cis-acting sequences in the 5'-untranslated region of satellite RNA of bamboo mosaic potexvirus.

    abstract：:The satellite RNA of Bamboo mosaic virus (satBaMV) contains on open reading frame for a 20-kDa protein that is flanked by a 5'-untranslated region (UTR) of 159 nucleotides (nt) and a 3'-UTR of 129 nt. A secondary structure was predicted for the 5'-UTR of satBaMV RNA, which folds into a large stem-loop (LSL) and a smal...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/s0042-6822(03)00178-8

    authors： Annamalai P,Hsu YH,Liu YP,Tsai CH,Lin NS

    更新日期：2003-06-20 00:00:00

  • Noninfectious L-particles supply functions which can facilitate infection by HSV-1.

    abstract：:The tegument of herpes simplex virus contains proteins important for the efficient initiation of infection. L-particles are noninfectious virion-related particles that lack the nucleocapsid but do contain tegument and envelope. Their ability to deliver functional proteins into cells was compared to that of virions by ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(92)90906-6

    authors： McLauchlan J,Addison C,Craigie MC,Rixon FJ

    更新日期：1992-10-01 00:00:00

  • A new retrovirus produced by tissue culture cell line from mammary tumor of a house musk shrew, Suncus murinus.

    abstract：:A new type of retrovirus (Sm-MTV) released by cultured cells of a spontaneous mammary tumor from a house musk shrew, Suncus murinus, is described. The Sm-MTV is distinct morphologically from type C particles. In spite of certain morphological similarities to type B and type D retroviruses, the Sm-MTV is readily distin...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(85)90324-1

    authors： Tsutsui Y,Nagayoshi S,Saga S,Takahashi M,Aoyama A,Malavasi JY,Hayakawa S,Yokoi T,Oda S,Hoshino M

    更新日期：1985-07-15 00:00:00

  • Effects of host-dependent glycosylation of hemagglutinin on receptor-binding properties on H1N1 human influenza A virus grown in MDCK cells and in embryonated eggs.

    abstract：:There is growing evidence that the receptor-binding characteristics of influenza viruses are affected by the host-dependent glycosylation of viral hemagglutinin (HA). To better understand these effects, we propagated two variants of the human influenza virus USSR/90/77 (which differed by the mutation Asn131 reversible...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1998.9224

    authors： Gambaryan AS,Marinina VP,Tuzikov AB,Bovin NV,Rudneva IA,Sinitsyn BV,Shilov AA,Matrosovich MN

    更新日期：1998-08-01 00:00:00

  • cDNA cloning of each genomic segment of the group B rotavirus ADRV: molecular characterization of the 11th RNA segment.

    abstract：:The group B noncultivatable rotavirus, ADRV, was purified from infected stool specimens. Double-stranded RNA was extracted, polyadenylated, reverse transcribed into cDNA, and cloned into plasmid vector pAT153. Each cDNA clone hybridized to a single ADRV RNA segment and cDNA clones of each genomic RNA segment were iden...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(90)90450-6

    authors： Chen GM,Hung T,Mackow ER

    更新日期：1990-04-01 00:00:00