Epidermal growth factor receptor is a co-factor for transmissible gastroenteritis virus entry.

Abstract:

:Transmissible gastroenteritis virus (TGEV) causes severe diarrhea and high mortality in newborn piglets. It is well established that porcine intestinal epithelium is the target of the TGEV infection, however the mechanism that TGEV invades the host epithelium remains largely unknown. Aminopeptidase N (APN) is a known receptor of TGEV. This study discovered that the extracellular receptor binding domain 1 pertaining to epidermal growth receptor (EGFR) interact with TGEV spike protein. APN and EGFR synergistically promote TGEV invasion. TGEV promotes APN and EGFR clustering early in infection. Furthermore APN and EGFR synergistically stimulate PI3K/AKT as well as MEK/ERK1/2 endocytosis signaling pathways. TGEV entry is via clathrin and caveolin mediated endocytosis in IPEC-J2 cells. TGEV binds with EGFR, and subsequently promotes EGFR internalization by a clathrin-mediated endocytosis pathway. These results show that EGFR is a co-factor of TGEV, and that it plays a synergistic role with APN early in TGEV infection.

journal_name

Virology

journal_title

Virology

authors

Hu W,Zhang S,Shen Y,Yang Q

doi

10.1016/j.virol.2018.05.009

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

33-43

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(18)30150-8

journal_volume

521

pub_type

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