Abstract:
:We assess the genetic relationships between 49 HIV-1 group O strains from 24 and 25 patients living in Cameroon and France, respectively. Strains were sequenced in four genomic regions: gag (p24) and three env regions (C2-V3, gp41, and for 22 C2-gp41). In each of the genomic regions analyzed, the genetic diversity among the group O strains was higher than that exhibited by group M. We characterize three major group O phylogenetic clusters (O:A, O:B, and O:C) that comprised the same virus strains in each of the genomic regions analyzed. The majority of strains cluster in O:A, a cluster previously identified by analysis of pol and env sequences. Group O recombinants were also identified. Importantly, the distinction between these three major group O clades was weak compared to the strong clustering apparent in the global group M phylogenetic tree that led to the identification of subtypes. Thus, these clusters of group O viruses should not be considered as equivalent to the group M subtypes. This difference between the pattern of group O and the global group M diversity, both taking into account the pandemic status of the group M subtypes and the comparatively small number of group O-infected individuals (the majority being from Cameroon), indicates that the group O phylogeny primarily represents viral divergence in the Cameroon region, analogous to group M viral diversity present in the Democratic Republic of Congo.
journal_name
Virologyjournal_title
Virologyauthors
Roques P,Robertson DL,Souquière S,Damond F,Ayouba A,Farfara I,Depienne C,Nerrienet E,Dormont D,Brun-Vézinet F,Simon F,Mauclère Pdoi
10.1006/viro.2002.1430subject
Has Abstractpub_date
2002-10-25 00:00:00pages
259-73issue
2eissn
0042-6822issn
1096-0341pii
S0042682202914303journal_volume
302pub_type
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