Abstract:
:The nucleotide and deduced amino acid sequence of the gene 4 of murine rotavirus strain Eb were determined. The gene is 2359 nucleotides in length and encodes for a protein of 775 amino acids. Comparison of the VP4 amino acid sequence of the Eb strain with several human and animal rotavirus strains which represent all of the currently recognized distinct VP4 genotypes revealed amino acid identities of from 55.7-75.1% for VP4, 37.1-63.3% for VP8, and 23.9-52.1% for the B region (amino acids 84-180). In addition, antisera to recombinant VP4s of five distinct rotavirus serotypes and two subtypes failed to react significantly by neutralization assay with the Eb strain. Thus, it appears that the Eb strain should be considered a new VP4 genotype and/or serotype.
journal_name
Virologyjournal_title
Virologyauthors
Sereno MM,Gorziglia MIdoi
10.1006/viro.1994.1153subject
Has Abstractpub_date
1994-03-01 00:00:00pages
500-4issue
2eissn
0042-6822issn
1096-0341pii
S0042-6822(84)71153-6journal_volume
199pub_type
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