The outer capsid protein VP4 of murine rotavirus strain Eb represents a tentative new P type.

Abstract:

:The nucleotide and deduced amino acid sequence of the gene 4 of murine rotavirus strain Eb were determined. The gene is 2359 nucleotides in length and encodes for a protein of 775 amino acids. Comparison of the VP4 amino acid sequence of the Eb strain with several human and animal rotavirus strains which represent all of the currently recognized distinct VP4 genotypes revealed amino acid identities of from 55.7-75.1% for VP4, 37.1-63.3% for VP8, and 23.9-52.1% for the B region (amino acids 84-180). In addition, antisera to recombinant VP4s of five distinct rotavirus serotypes and two subtypes failed to react significantly by neutralization assay with the Eb strain. Thus, it appears that the Eb strain should be considered a new VP4 genotype and/or serotype.

journal_name

Virology

journal_title

Virology

authors

Sereno MM,Gorziglia MI

doi

10.1006/viro.1994.1153

subject

Has Abstract

pub_date

1994-03-01 00:00:00

pages

500-4

issue

2

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(84)71153-6

journal_volume

199

pub_type

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