Transcriptional activation from the long-terminal repeat of human immunodeficiency virus in vitro.

abstract：:The preS(21-47) sequence of the hepatitis B virus (HBV) envelope protein is involved in binding of the virus to cell receptors. A protein similarity search revealed a partial homology between this sequence and a segment of the human immunoglobulin A (IgA) heavy chain constant region, suggesting that the cell attachmen...

journal_title：Virology

authors： Neurath AR,Strick N

更新日期：1990-10-01 00:00:00

abstract：:Although lentiviruses like HIV-1 are able to infect non-dividing cells, particular resting cells such as non-stimulated primary peripheral blood mononuclear cells (PBMC) are resistant to infection. In contrast to other lentiviruses, SIVsmmPBj can replicate in non-stimulated PBMC. Moreover, SIVsmmPBj-derived, but not H...

journal_title：Virology

authors： Wolfrum N,Mühlebach MD,Schüle S,Kaiser JK,Kloke BP,Cichutek K,Schweizer M

更新日期：2007-08-01 00:00:00

abstract：:To investigate the role of Tobacco vein banding mosaic virus (TVBMV) 3'-UTR in virus systemic infection, three types of deletions were introduced into TVBMV infectious clone pCaTVBMV-GFP. Mutants with deletions at the nucleotide position 8-42, 43-141, or 163-174 in the 3'-UTR failed to cause systemic infection in N. b...

journal_title：Virology

authors： Wang Y,Yang ZY,Tian YP,Geng C,Yuan XF,Li XD

更新日期：2019-01-15 00:00:00

abstract：:In order to gain a better perspective on the true variability of varicella-zoster virus (VZV) and to catalogue the location and number of differences, 11 new complete genome sequences were compared with those previously in the public domain (18 complete genomes in total). Three of the newly sequenced genomes were deri...

journal_title：Virology

authors： Tyler SD,Peters GA,Grose C,Severini A,Gray MJ,Upton C,Tipples GA

更新日期：2007-03-15 00:00:00

abstract：:There is no effective vaccine for Marburg virus (MBGV) or any other filovirus, nor enough pertinent information to expedite rational vaccine development. To ascertain some of the minimal requirements for a MBGV vaccine, we determined whether whole inactivated MBGV, or a baculovirus-expressed virion subunit, could be u...

journal_title：Virology

authors： Hevey M,Negley D,Geisbert J,Jahrling P,Schmaljohn A

更新日期：1997-12-08 00:00:00

abstract：:Retroperitoneal fibromatosis herpesvirus (RFHV), the macaque homolog of the human rhadinovirus, Kaposi's sarcoma-associated herpesvirus (KSHV), was first identified in retroperitoneal fibromatosis (RF) tumor lesions of macaques with simian AIDS. We cloned and sequenced the ORF73 latency-associated nuclear antigen (LAN...

journal_title：Virology

authors： Burnside KL,Ryan JT,Bielefeldt-Ohmann H,Gregory Bruce A,Thouless ME,Tsai CC,Rose TM

更新日期：2006-10-10 00:00:00

abstract：:The presence of anti-Tax antibody responses in human T cell leukemia virus type I (HTLV-I)-infected individuals has been correlated with increased proviral load, increased risk of transmitting infection, and increased risk of developing tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM). In this study...

journal_title：Virology

authors： Lydy SL,Conner ME,Marriott SJ

更新日期：1998-10-10 00:00:00

abstract：:Mouse hepatitis virus (MHV) JHMV and its soluble receptor-resistant (srr) mutants, srr7, srr11, and srr18, grew and induced syncytia equally well in BHK-R1 cells expressing the MHVR1 receptor derived from MHV-susceptible BALB/c mice. In contrast, srr growth and syncytia formations were drastically reduced relative to ...

journal_title：Virology

authors： Matsuyama S,Taguchi F

更新日期：2000-07-20 00:00:00

abstract：:The effect of adenovirus infection or transformation on the DNA replication of Minute Virus of Mice (MVM) was studied in human fibroblast cell lines. In WI38, HeLa, and 293 cells MVM infection allowed production of viral NS-1 and capsid proteins with or without adenovirus 2 (Ad2) co-infection. However, MVM DNA replica...

journal_title：Virology

authors： Fox E,Moen PT Jr,Bodnar JW

更新日期：1990-06-01 00:00:00

abstract：:In genetically susceptible C57BL/6 mice the LP-BM5 isolate of murine retroviruses causes profound splenomegaly, lymphadenopathy, hypergammaglobulinemia, and an immunodeficiency syndrome bearing many similarities to the pathologies seen in AIDS. Because of these similarities, which also include terminal B cell lymphoma...

journal_title：Virology

authors： Green KA,Noelle RJ,Green WR

更新日期：1998-02-15 00:00:00

abstract：:Previously, an epitope recognized by a set of neutralizing monoclonal antibodies directed against the S protein of transmissible gastroenteritis has been identified. This neutralization epitope can be simulated by a single peptide combining residues 380 to 387 and 1176 to 1184 of the S protein; this combination peptid...

journal_title：Virology

authors： Posthumus WP,Lenstra JA,van Nieuwstadt AP,Schaaper WM,van der Zeijst BA,Meloen RH

更新日期：1991-05-01 00:00:00

abstract：:A distinct host cellular protein binding element was mapped within a 38-nucleotide (nt) sequence 166-129 nucleotides upstream of the 3' end of the MHV-JHM genome using a RNase T1 protection/gel mobility shift electrophoresis assay. The resultant RNA-protein complex contains six host cellular proteins, one protein of 1...

journal_title：Virology

authors： Liu Q,Yu W,Leibowitz JL

更新日期：1997-05-26 00:00:00

abstract：:Cytoplasmic tails of envelope (Env) glycoproteins of many retroviruses inhibit their membrane fusion activity. The cytoplasmic 16-amino acid peptide of ecotropic murine leukemia virus (E-MLV) Env protein, called the R-peptide, also inhibits the membrane fusion activity of the Env protein. However, the molecular mechan...

journal_title：Virology

authors： Kubo Y,Izumida M,Togawa K,Zhang F,Hayashi H

更新日期：2019-06-01 00:00:00

abstract：:Recently, we reported that in vitro and in vivo persistent infection of neurons by lymphocytic choriomeningitis virus (LCMV) downregulated GAP43 expression, a protein involved in neuronal plasticity associated with learning and memory. Here, we investigated the transcriptional and posttranscriptional events involved. ...

journal_title：Virology

authors： Cao W,Oldstone MB,De La Torre JC

更新日期：1997-04-14 00:00:00

abstract：:Geminiviruses constitute one of the largest groups of plant viruses, having characteristic twinned geminate particles encapsidating small circular single-stranded DNA molecules. Geminiviral promoters are generally located within the intergenic region, although promoters have also been detected within the genes. Simila...

journal_title：Virology

authors： Borah BK,Zarreen F,Baruah G,Dasgupta I

更新日期：2016-08-01 00:00:00

abstract：:We mutagenized and characterized a 41-kilobase-pair subgenomic cloned fragment from the unique long (UL) region of pseudorabies virus (PRV). Forty mutant clones, each carrying a single inserted oligonucleotide, were used for cotransfection with overlapping cloned viral DNA fragments. More than half of these transfecti...

journal_title：Virology

authors： De Wind N,Peeters BP,Zuderveld A,Gielkens AL,Berns AJ,Kimman TG

更新日期：1994-05-01 00:00:00

abstract：:The primary objective of characterizing bovine adenovirus type 3 (BAV3) in greater detail is to develop it as a vector for gene therapy and vaccination of humans and animals. A series of BAV3 early region 4 (E4) deletion-mutant viruses, containing deletions in individual E4 open reading frames (Orf) or combinations of...

journal_title：Virology

authors： Baxi MK,Robertson J,Babiuk LA,Tikoo SK

更新日期：2001-11-10 00:00:00

abstract：:The DNA extracted from bacteriophage 643, which infects group N strains of Streptococci, could be separated into four components by electrophoresis on agarose gels. Electron microscopy established the predominant form of the DNA to be a relaxed, circular molecule of molecular weight 14.9 X 10(6). The four species obse...

journal_title：Virology

authors： Lyttle DJ,Petersen GB

更新日期：1984-03-01 00:00:00

abstract：:Cellular organelles of cauliflower mosaic virus-infected turnip plants were isolated, incubated with 32P-labeled deoxyribonucleoside triphosphates and assayed for their ability to synthesize virus-specific DNA. Only nuclei were found to synthesize a labeled DNA product. This DNA migrated during agarose gel electrophor...

journal_title：Virology

authors： Ansa OA,Bowyer JW,Shepherd RJ

更新日期：1982-08-01 00:00:00

abstract：:Hepatitis B virus transcripts and DNA from paired samples of neoplastic and nonneoplastic liver tissue of HBsAg seropositive patients were analyzed. The data obtained support the view that transcription of integrated DNA is frequent, both in neoplastic as well as in nonneoplastic liver tissue. In the case of one patie...

journal_title：Virology

authors： Loncarević IF,Schranz P,Zentgraf H,Liang XH,Herrmann G,Tang ZY,Schröder CH

更新日期：1990-01-01 00:00:00

abstract：:We have studied the population dynamics in response to selective drug pressure of mixtures of wild-type and mutant HIV viruses exposed to either an inhibitor of the viral protease or a nonnucleoside allosteric inhibitor of the viral reverse transcriptase. In order to quantitate mutant virus present in a mixed populati...

journal_title：Virology

authors： Rayner MM,Cordova B,Jackson DA

更新日期：1997-09-15 00:00:00

abstract：:During replication, the lengthy genome of dsDNA viruses is translocated with remarkable velocity into the limited space within the preformed procapsid. We previously found that a viral-encoded RNA (pRNA) played a key role in bacterial virus phi29 DNA translocation. Design of mutant pRNA sets containing two and three i...

journal_title：Virology

authors： Zhang C,Trottier M,Chen C,Guo P

更新日期：2001-03-15 00:00:00

abstract：:A mutant (dp 201) of human adenovirus type 2 has been isolated that has the left 3% (1110 bp) of the genome duplicated at the right terminus. The structure of the mutant genome was studied by restriction endonuclease analysis and by direct DNA sequence analysis. The duplication has resulted in a deletion of 10 bp of t...

journal_title：Virology

authors： Brusca JS,Chinnadurai G

更新日期：1983-09-01 00:00:00

abstract：:Vaccinia virus DNA ligase has been expressed in Escherichia coli, purified, and biochemically characterized. The enzyme ligates double-stranded (ds) DNA substrates with either cohesive or blunt-end termini and the latter reaction is stimulated by PEG. Vaccinia virus DNA ligase can also ligate oligo(dT) when annealed t...

journal_title：Virology

authors： Odell M,Kerr SM,Smith GL

更新日期：1996-07-01 00:00:00

abstract：:The reticuloendotheliosis virus (REV) group of retroviruses and type D simian retroviruses (SRV) belong to the same receptor interference group. The cellular receptor for these viruses has not yet been identified. In order to study the distribution of the receptor and to identify a receptor negative cell line, vector ...

journal_title：Virology

authors： Koo HM,Parthasarathi S,Ron Y,Dougherty JP

更新日期：1994-11-15 00:00:00

abstract：:Few human endogenous retroviruses (HERVs) have been extensively studied in non-human primates. Such investigations have demonstrated that several element classes are primate unique, contain members with important biological function, are conserved in specific primate lineages, and have in some cases expanded in copy n...

journal_title：Virology

authors： Greenwood AD,Stengel A,Erfle V,Seifarth W,Leib-Mösch C

更新日期：2005-04-10 00:00:00

abstract：:Lloviu virus (LLOV), a phylogenetically divergent filovirus, is the proposed etiologic agent of die-offs of Schreibers's long-fingered bats (Miniopterus schreibersii) in western Europe. Studies of LLOV remain limited because the infectious agent has not yet been isolated. Here, we generated a recombinant vesicular sto...

journal_title：Virology

authors： Ng M,Ndungo E,Jangra RK,Cai Y,Postnikova E,Radoshitzky SR,Dye JM,Ramírez de Arellano E,Negredo A,Palacios G,Kuhn JH,Chandran K

更新日期：2014-11-01 00:00:00

abstract：:Measles virus infection causes a profound immunosuppression. The basis for this immunosuppression is not known. This immunosuppression could be due to virus acting directly on lymphoid cells, the production of an immunosuppressive viral product, or a lymphoid product. We have developed an antigen-specific T cell syste...

journal_title：Virology

authors： Sun X,Burns JB,Howell JM,Fujinami RS

更新日期：1998-06-20 00:00:00

abstract：:Although rodents are important reservoirs for RNA viruses, to date only one species of rodent coronavirus (CoV) has been identified. Herein, we describe a new CoV, denoted Lucheng Rn rat coronavirus (LRNV), and novel variants of two Betacoronavirus species termed Longquan Aa mouse coronavirus (LAMV) and Longquan Rl ra...

journal_title：Virology

authors： Wang W,Lin XD,Guo WP,Zhou RH,Wang MR,Wang CQ,Ge S,Mei SH,Li MH,Shi M,Holmes EC,Zhang YZ

更新日期：2015-01-01 00:00:00

abstract：:The spike glycoprotein (G protein) of rabies virus (CVS strain) expressed in HeLa cells from cloned cDNA mediated membrane fusion after exposure to pHs of 6.1 or below. Chemical crosslinking showed that the rabies G protein, like the vesicular stomatitis virus (VSV) G protein, could be crosslinked to dimers and trimer...

journal_title：Virology

authors： Whitt MA,Buonocore L,Prehaud C,Rose JK

更新日期：1991-12-01 00:00:00