Abstract:
:Retroperitoneal fibromatosis herpesvirus (RFHV), the macaque homolog of the human rhadinovirus, Kaposi's sarcoma-associated herpesvirus (KSHV), was first identified in retroperitoneal fibromatosis (RF) tumor lesions of macaques with simian AIDS. We cloned and sequenced the ORF73 latency-associated nuclear antigen (LANA) of RFHVMn from the pig-tailed macaque. RFHVMn LANA is structurally analogous to KSHV ORF73 LANA and contains an N-terminal serine-proline-rich region, a large internal glutamic acidic-rich repeat region and a conserved C-terminal domain. RFHVMn LANA reacts with monoclonal antibodies specific for a glutamic acid-proline dipeptide motif and a glutamic acid-glutamine-rich motif in the KSHV LANA repeat region. Immunohistochemical and immunofluorescence analysis revealed that RFHVMn LANA is a nuclear antigen which is highly expressed in RF spindloid tumor cells. These data suggest that RFHV LANA is an ortholog of KSHV LANA and will function similarly to maintain viral latency and play a role in tumorigenicity in macaques.
journal_name
Virologyjournal_title
Virologyauthors
Burnside KL,Ryan JT,Bielefeldt-Ohmann H,Gregory Bruce A,Thouless ME,Tsai CC,Rose TMdoi
10.1016/j.virol.2006.06.022subject
Has Abstractpub_date
2006-10-10 00:00:00pages
103-15issue
1eissn
0042-6822issn
1096-0341pii
S0042-6822(06)00404-1journal_volume
354pub_type
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