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The equine arteritis virus induces apoptosis via caspase-8 and mitochondria-dependent caspase-9 activation.

Abstract：

:We have previously showed that equine arteritis virus (EAV), an arterivirus, induces apoptosis in vitro. To determine the caspase activation pathways involved in EAV-induced apoptosis, target cells were treated with peptide inhibitors of apoptosis Z-VAD-FMK (pan-caspase inhibitor), Z-IETD-FMK (caspase-8-specific inhibitor) or Z-LEHD-FMK (caspase-9-specific inhibitor) 4 h prior to infection with the EAV T1329 Canadian isolate. Significant inhibition of apoptosis was obtained with all peptide inhibitors used. Furthermore, apoptosis was inhibited in cells expressing the R1 subunit of herpes simplex virus type 2 ribonucleotide reductase (HSV2-R1) or hsp70, two proteins which are known to inhibit apoptosis associated with caspase-8 activation and cytochrome c release-dependent caspase-9 activation, respectively. Given the activation of Bid and the translocation of cytochrome c within the cytoplasm, the overall results indicate that EAV induces apoptosis initiated by caspase-8 activation and subsequent mitochondria-dependent caspase-9 activation.

journal_name

Virology

journal_title

Virology

authors

St-Louis MC,Archambault D

doi

10.1016/j.virol.2007.05.023

subject

Has Abstract

pub_date

2007-10-10 00:00:00

pages

147-55

issue

1

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(07)00377-7

journal_volume

367

pub_type

杂志文章

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