Antiviral T-cell-independent type 2 antibody responses induced in vivo in the absence of T and NK cells.

abstract：:Open reading frames identified on the four genomic RNAs of beet necrotic yellow vein virus were cloned into bacterial expression vectors and resulting cl-fusion proteins expressed in Escherichia coli were used to raise polyclonal antibodies. This set of antisera was used to show the presence of 7 of 9 predicted viral ...

journal_title：Virology

authors： Niesbach-Klösgen U,Guilley H,Jonard G,Richards K

更新日期：1990-09-01 00:00:00

abstract：:Six mutants of lambda having reduced dependence on the htpR function of Escherichia coli were isolated from lambda cIts857. Burst sizes in htpRts cells at 40.5 degrees were in the range of 10 to 20 particles per cell. Mapping and complementation analysis of one of the mutants suggested that the mutation in this isolat...

journal_title：Virology

authors： Fuerst CR

更新日期：1986-02-01 00:00:00

abstract：:A full-size cloned cDNA copy of the rotavirus gene encoding the structural neutralization glycoprotein (VP7) of Nebraska calf diarrhea virus (NCDV), a strain recently shown to be effective as a vaccine in children, has been sequenced. Comparison of the deduced amino acid sequence of NCDV (serotype 6) VP7 with that of ...

journal_title：Virology

authors： Glass RI,Keith J,Nakagomi O,Nakagomi T,Askaa J,Kapikian AZ,Chanock RM,Flores J

更新日期：1985-03-01 00:00:00

abstract：:Marek' disease virus serotype-1, also know as Gallid herpesvirus 2 (GaHV-2), elicits T-cell lymphomas in chickens. The GaHV-2 genome encodes an oncoprotein, Meq, with similarity to the Jun/Fos family of proteins. We have previously shown that Meq homodimers are not sufficient to induce lymphomas in chickens. In this s...

journal_title：Virology

authors： Suchodolski PF,Izumiya Y,Lupiani B,Ajithdoss DK,Lee LF,Kung HJ,Reddy SM

更新日期：2010-04-10 00:00:00

abstract：:Computational analysis of feline immunodeficiency virus (FIV) RNA sequences indicated that common FIV strains contain a rev response element (RRE) defined by a long unbranched hairpin with 6 stem-loop sub-domains, termed stem-loop A (SLA). To examine the role of the RNA secondary structure of the RRE, mutational analy...

journal_title：Virology

authors： Na H,Huisman W,Ellestad KK,Phillips TR,Power C

更新日期：2010-09-01 00:00:00

abstract：:The amino acid sequence of BMV (brome mosaic virus) coat protein is presented and compared with the sequence derived from RNA structure. Apart from removal of the N-terminal methionine residue and acetylation of the following serine residue, no post-translational modifications occur. ...

journal_title：Virology

authors： Moosic JP,McKean DJ,Shih DS,Kaesberg P

更新日期：1983-09-01 00:00:00

abstract：:Although v-src, the oncogene of Rous sarcoma virus, has been shown to be capable of inducing lethal tumors at visceral sites distal to the primary tumor mass, the mechanisms opposing visceral tumor formation remain to be elucidated. In the present study, we show that visceral tumors, many of which represent a metastas...

journal_title：Virology

authors： Halpern MS,Wisner TW,Brown IP,England JM

更新日期：1993-11-01 00:00:00

abstract：:Adeno-associated virus (AAV) replication proteins Rep78 and Rep68 play major roles in the life cycle of AAV. We have recently provided in vivo evidence for the existence of a covalent association between Rep78 and virion single-stranded (ss) AAV DNA (K. M. R. Prasad and J.P. Trempe(1995) Virology 214, 360-370). In thi...

journal_title：Virology

authors： Prasad KM,Zhou C,Trempe JP

更新日期：1997-03-03 00:00:00

abstract：:For purposes of gene therapy, the tropism of adenovirus (Ad) serotype 5 vectors can be altered with fibers derived from alternative serotypes. However, there is currently limited information available on the cellular receptors used by the approximately 51 known Ad serotypes. Recently, alpha(2-->3)-linked sialic acid (...

journal_title：Virology

authors： Cashman SM,Morris DJ,Kumar-Singh R

更新日期：2004-06-20 00:00:00

abstract：:An Autographa californica nuclear polyhedrosis virus gene encoding an occlusion-derived virus (ODV) envelope protein of 56 kDa was identified and sequenced. Transcription initiates from a conserved baculovirus late motif (ATAAG) with transcripts detected from 16 through 72 hr p.i. The protein is detected in infected c...

journal_title：Virology

authors： Braunagel SC,Elton DM,Ma H,Summers MD

更新日期：1996-03-01 00:00:00

abstract：:Pre-exposure prophylaxis (PrEP) strategies utilizing anti-retroviral drugs show considerable promise for HIV prevention. However there is insufficient pharmacokinetic (PK) data on drug concentrations required for protection at the relevant mucosal tissues where the infection is initiated. Here we evaluated the utility...

journal_title：Virology

authors： Veselinovic M,Yang KH,LeCureux J,Sykes C,Remling-Mulder L,Kashuba ADM,Akkina R

更新日期：2014-09-01 00:00:00

abstract：:The molecular mechanism(s) by which human immunodeficiency virus (HIV-1) injures a T-cell line was studied. A pathological role for viral env proteins, which are inserted into the plasma membrane, has been previously demonstrated for HIV as well as other retroviruses which are cytopathic. We therefore initiated studie...

journal_title：Virology

authors： Lynn WS,Tweedale A,Cloyd MW

更新日期：1988-03-01 00:00:00

abstract：:Both the brome mosaic virus (BMV) and cowpea chlorotic mottle virus (CCMV) RNA-dependent RNA polymerases (RdRps) were found to recognize the BMV core subgenomic promoter in the same manner, requiring specific functional groups at positions -17, -14, -13, and -11 relative to the subgenomic initiation site (+1). For CCM...

journal_title：Virology

authors： Adkins S,Kao CC

更新日期：1998-12-05 00:00:00

abstract：:In human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) the gag gene encodes the precursor polyprotein Pr55Gag, which is cleaved by the viral protease to produce the major structural proteins. Recently, it has been shown that HIV and SIV gag RNAs contain internal ribosome entry sites (IR...

journal_title：Virology

authors： Nicholson MG,Barber SA,Clements JE

更新日期：2007-03-30 00:00:00

abstract：:Synthesis of unintegrated retroviral DNA via reverse transcription is thought to involve two separate template switches. Minus-strand strong-stop DNA, a major product of in vitro reactions using detergent-treated virions, is synthesized prior to the first template switch. Plus-strand strong-stop DNA, which is found ba...

journal_title：Virology

authors： Li P,Stephenson AJ,Kuiper LJ,Burrell CJ

更新日期：1993-05-01 00:00:00

abstract：:The display of foreign proteins on the surface of baculovirus virions has provided a tool for the analysis of protein-protein interactions and for cell-specific targeting in gene transfer applications. To evaluate the baculovirus display system as a vaccine vehicle, we have generated a recombinant baculovirus (AcNPV-C...

journal_title：Virology

authors： Yoshida S,Kondoh D,Arai E,Matsuoka H,Seki C,Tanaka T,Okada M,Ishii A

更新日期：2003-11-10 00:00:00

abstract：:To study the process of membrane fusion in Morbilliviruses, the fusion (F) glycoproteins of Peste des petits ruminants virus (PPRV) and Rinderpest virus (RPV) were expressed transiently in mammalian cells. The recombinant F proteins were found to be localized at the surface of transfected cells. The fusion activity, a...

journal_title：Virology

authors： Seth S,Shaila MS

更新日期：2001-10-10 00:00:00

abstract：:Re-emergence of ZIKV has caused infections in more than 1.5 million people. The molecular mechanism and pathogenesis of ZIKV is not well explored due to unavailability of adequate model and lack of publically accessible resources to provide information of ZIKV-Human protein interactome map till today. This study made ...

journal_title：Virology

authors： Gurumayum S,Brahma R,Naorem LD,Muthaiyan M,Gopal J,Venkatesan A

更新日期：2018-01-15 00:00:00

abstract：:It was recently proposed that HIV RT mutations that decrease RNase H activity increase zidovudine (AZT) resistance by delaying the degradation of the RNA template, allowing more time for AZTMP excision from the 3' end of the viral DNA. This predicts that suboptimal concentrations of an RNase H Inhibitor (RNHI), which ...

journal_title：Virology

authors： Davis CA,Parniak MA,Hughes SH

更新日期：2011-10-25 00:00:00

abstract：:The satellite RNA of Bamboo mosaic virus (satBaMV) contains on open reading frame for a 20-kDa protein that is flanked by a 5'-untranslated region (UTR) of 159 nucleotides (nt) and a 3'-UTR of 129 nt. A secondary structure was predicted for the 5'-UTR of satBaMV RNA, which folds into a large stem-loop (LSL) and a smal...

journal_title：Virology

authors： Annamalai P,Hsu YH,Liu YP,Tsai CH,Lin NS

更新日期：2003-06-20 00:00:00

abstract：:The bipartite genomic RNAs of red clover necrotic mosaic virus (RCNMV) lack a 5' cap and a 3' poly(A) tail. RNA1 encodes viral replication proteins, and RNA2 encodes a movement protein (MP). These proteins are translated in a cap-independent manner. We previously identified two cis-acting RNA elements that cooperative...

journal_title：Virology

authors： Tajima Y,Iwakawa HO,Hyodo K,Kaido M,Mise K,Okuno T

更新日期：2017-09-01 00:00:00

abstract：:Activation of the minute virus of mice (MVM) P4 promoter is a key step in the life cycle of the virus and is completely dependent on host transcription factors. Since transcription-factor composition varies widely in different cell types, there is the possibility that only some cell types in the host organism have the...

journal_title：Virology

authors： Davis C,Segev-Amzaleg N,Rotem I,Mincberg M,Amir N,Sivan S,Gitelman I,Tal J

更新日期：2003-02-15 00:00:00

abstract：:The human hepatitis B Virus genome (HBV) contains a liver-specific enhancer upstream of the X ORF which has been studied in detail by several investigators. A second liver-specific enhancer element, designated here as enhancer II, has been relatively recently described in the HBV genome, which is located within the co...

journal_title：Virology

authors： López-Cabrera M,Letovsky J,Hu KQ,Siddiqui A

更新日期：1991-08-01 00:00:00

abstract：:Cardioviruses cause diseases in many animals including, in rare cases, humans. Although they share common features with all picornaviruses, cardioviruses have unique properties that distinguish them from other family members, including enteroviruses. One feature shared by all picornaviruses is the covalent attachment ...

journal_title：Virology

authors： Maciejewski S,Ullmer W,Semler BL

更新日期：2018-03-01 00:00:00

abstract：:Sulfolobus turreted icosahedral virus (STIV) infects Sulfolobus species found in the hot springs of Yellowstone National Park. Its 37 open reading frames (ORFs) generally lack sequence similarity to other genes. One exception, however, is ORF B116. While its function is unknown, orthologs are found in three additional...

journal_title：Virology

authors： Larson ET,Eilers BJ,Reiter D,Ortmann AC,Young MJ,Lawrence CM

更新日期：2007-07-05 00:00:00

abstract：:Avian infectious laryngotracheitis virus (ILTV), a herpesvirus, is a highly contagious pathogen that causes an upper respiratory tract infection in chickens. It is one of the major problems in the poultry industry worldwide. Current vaccines are not satisfactory due to the induction of latent infection. Here we descri...

journal_title：Virology

authors： Guo P,Scholz E,Maloney B,Welniak E

更新日期：1994-08-01 00:00:00

abstract：:Infection with the Tucson strain of coxsackievirus B1 (CVB1T) causes the development of chronic inflammatory myopathy (CIM) and hind limb weakness in susceptible strains of mice. In this study, a panel of six plaque-purified viruses exhibiting either small or large plaque phenotypes was derived from parental CVB1T and...

journal_title：Virology

authors： Tam PE,Messner RP

更新日期：1997-06-23 00:00:00

abstract：:A short upstream open reading frame (uORF2) in the human cytomegalovirus (CMV) gpUL4 (gp48) transcript leader is conserved among CMV strains and inhibits translation of a downstream cistron. Remarkably, this inhibitory effect depends on the amino acid coding information of uORF2, at least in transient transfection ass...

journal_title：Virology

authors： Cao J,Geballe AP

更新日期：1994-11-15 00:00:00

abstract：:The 85-kDa polypeptide previously shown to be associated with the restricted (R) component of the EBV-induced early antigen (EA) complex was subjected to amino acid sequencing analysis. This was accomplished by cyanogen bromide cleavage and by separation of individual peptides by high-pressure liquid chromatography em...

journal_title：Virology

authors： Goldschmidts W,Luka J,Pearson GR

更新日期：1987-03-01 00:00:00

abstract：:The X protein (pX) of hepatitis B virus (HBV) is a general transcription regulator and directly associated with the transcription machinery. pX cannot bind DNA directly but interacts with cellular factors that bind the regulatory elements. There is an accumulation of evidence concerning different activities exerted by...

journal_title：Virology

authors： de-Medina T,Haviv I,Noiman S,Shaul Y

更新日期：1994-07-01 00:00:00