Characterization of the Rep78/adeno-associated virus complex.

abstract：:VP5, a 5'-terminal, small open reading frame in segment A of the aquatic birnavirus (infectious pancreatic necrosis virus, IPNV) genome, encodes a 17-kDa nonstructural protein. We previously reported apoptosis induced by IPNV in a fish cell line. In the present study, we cloned and identified VP5 and tested its functi...

journal_title：Virology

authors： Hong JR,Gong HY,Wu JL

更新日期：2002-04-10 00:00:00

abstract：:Ovine pulmonary carcinoma is a contagious neoplastic disease of sheep which can be transmitted experimentally with cell-free filtrate. Products homologous to structural proteins of type D and type B retroviruses are expressed in the tumors, but an infectious retrovirus has yet to be isolated. Retroviral RNA was isolat...

journal_title：Virology

authors： Hecht SJ,Carlson JO,DeMartin JC

更新日期：1994-07-01 00:00:00

abstract：:All lepidopteran baculovirus genomes sequenced to date encode a viral fibroblast growth factor homolog (vfgf), suggesting that vfgf may play an important role in the infection cycle of lepidopteran baculoviruses. Here, we describe the characterization of a Bombyx mori nucleopolyhedrovirus (BmNPV) mutant lacking functi...

journal_title：Virology

authors： Katsuma S,Horie S,Daimon T,Iwanaga M,Shimada T

更新日期：2006-11-10 00:00:00

abstract：:Interferon gamma (IFNγ) has complex immunomodulatory and antiviral properties. While IFNγ is detected in the airways in response to infection with the pneumovirus pathogen, pneumonia virus of mice (PVM; Family Paramyxoviridae), its role in promoting disease has not been fully explored. Here, we evaluate PVM infection ...

journal_title：Virology

authors： Glineur SF,Bowen AB,Percopo CM,Garcia-Crespo KE,Dyer KD,Ochkur SI,Lee NA,Lee JJ,Domachowske JB,Rosenberg HF

更新日期：2014-11-01 00:00:00

abstract：:The requirement for the herpes simplex virus type 1 (HSV-1) protein Vmw65 (VP16) for activation of immediate early (IE) gene expression was examined in synchronized HeLa cells. Analyses of IE RNA levels were conducted during infection with a viral Vmw65 mutant, in1814. The results revealed an increased requirement for...

journal_title：Virology

authors： Daksis JI,Preston CM

更新日期：1992-07-01 00:00:00

abstract：:A combinatorial, phage-display library of human Fab antibody fragments was generated from IgG heavy chain (HC) and light chain (LC) genes cloned from the lymphocytes of a vaccinia virus (VACV)-immune donor. To ascertain the complexity of the library, nucleotide sequences of the variable regions of the HC and LC genes ...

journal_title：Virology

authors： Schmaljohn C,Cui Y,Kerby S,Pennock D,Spik K

更新日期：1999-05-25 00:00:00

abstract：:It is unresolved whether recently transmitted human immunodeficiency viruses (HIV) have genetic features that specifically favour their transmissibility. To identify potential "transmission signatures", we compared 20 full-length HIV-1 subtype C genomes from primary infections, with 66 sampled from ethnically and geog...

journal_title：Virology

authors： Treurnicht FK,Seoighe C,Martin DP,Wood N,Abrahams MR,Rosa Dde A,Bredell H,Woodman Z,Hide W,Mlisana K,Karim SA,Gray CM,Williamson C

更新日期：2010-01-20 00:00:00

abstract：:From previously constructed genomic libraries of a Taiwan WSSV isolate, a putative WSSV tk-tmk gene was identified. Uniquely, the open reading frame (ORF) of this gene was predicted to encode a novel chimeric protein of 388 amino acids with significant homology to two proteins: thymidine kinase (TK) and thymidylate ki...

journal_title：Virology

authors： Tsai MF,Yu HT,Tzeng HF,Leu JH,Chou CM,Huang CJ,Wang CH,Lin JY,Kou GH,Lo CF

更新日期：2000-11-10 00:00:00

abstract：:A pseudorabies virus (PrV) mutant, deficient in the nonessential glycoprotein E (gE) and expressing the LacZ gene (gE- beta gal+ PrV), and its rescued virus were inoculated intranasally in mice. The median lethal dose of gE- beta gal+ PrV was similar to that of the parental Kaplan strain, but mice survived longer and ...

journal_title：Virology

authors： Babic N,Klupp B,Brack A,Mettenleiter TC,Ugolini G,Flamand A

更新日期：1996-05-01 00:00:00

abstract：:We compared the outcome of different cellular and viral factors on the regulation of the HPV-16 early viral gene expression in trophoblastic and cervical cancer cells. A high variability of the long control (LCR) activity was observed, prompting us to evaluate the role of secreted factors in the control of the early g...

journal_title：Virology

authors： Weyn C,Vanderwinden JM,Rasschaert J,Englert Y,Fontaine V

更新日期：2011-03-30 00:00:00

abstract：:Various lectins were tested for blocking rotavirus infection of MA104 cells and it was observed that galactose-specific lectins were the most inhibitory. Of these Ricinus agglutinin was able to inhibit infection (by human and animal strains) at concentrations as low as 10(-9) M. In addition, in a virus overlay protein...

journal_title：Virology

authors： Jolly CL,Beisner BM,Holmes IH

更新日期：2000-09-15 00:00:00

abstract：:Nucleos(t)ide analogues that inhibit hepatitis B virus (HBV) DNA replication are typically used as monotherapy for chronically infected patients. Treatment with a nucleos(t)ide analogue eliminates most HBV DNA replication intermediates and produces a gradual decline in levels of covalently closed circular DNA (cccDNA)...

journal_title：Virology

authors： Reaiche-Miller GY,Thorpe M,Low HC,Qiao Q,Scougall CA,Mason WS,Litwin S,Jilbert AR

更新日期：2013-11-01 00:00:00

abstract：:LMP2A deletion and point mutants, with mutations in phosphotyrosine-containing protein-protein interaction motifs, were transiently expressed in 293 cells and their phosphorylation was examined in immune complex kinase assays as well as in vivo. In vitro LMP2A phosphorylation depended on tyrosine 112. In vivo, mutatio...

journal_title：Virology

authors： Scholle F,Longnecker R,Raab-Traub N

更新日期：2001-12-20 00:00:00

abstract：:Rotaviral RNA was detected in the stool sample of an asymptomatic fattening pig at a Slovenian pig farm. To characterize the rotavirus, RT-PCR was used, employing primers specific for the VP7, VP4 and NSP4 genes. Specific products were purified and the sequencing reaction was performed for the molecular analysis of am...

journal_title：Virology

authors： Steyer A,Poljsak-Prijatelj M,Barlic-Maganja D,Jamnikar U,Mijovski JZ,Marin J

更新日期：2007-03-15 00:00:00

abstract：:Mutations disrupting helicase domain motifs of the Tobacco mosaic virus 126/183-kDa proteins were investigated for their effect on replicase function and assembly. These mutations inhibited virus replication but did not affect 126-kDa induced N gene resistance or RNAi suppression. However, in vivo expressed 126-kDa mo...

journal_title：Virology

authors： Wang X,Kelman Z,Culver JN

更新日期：2010-07-05 00:00:00

abstract：:Five monoclonal antibodies (MAbs) to porcine group (gp) C rotaviruses (Cowden and Ah strains) reactive with both gp A and C rotaviruses in cell culture immunofluorescence (CCIF) tests were produced and characterized. These MAbs reacted with three strains of gp A and two strains of gp C rotaviruses in a CCIF test and w...

journal_title：Virology

authors： Tsunemitsu H,Ojeh CK,Jiang B,Simkins RA,Weilnau PA,Saif LJ

更新日期：1992-11-01 00:00:00

abstract：:We present a case of sexual transmission of HIV-1 predicted to have CXCR4-tropism during male-to-male sexual exposure. Phylogenetic analyses exclude cell-free virus in the seminal plasma of the source partner and possibly point to the seminal cells as the origin of the transmission event. ...

journal_title：Virology

authors： Gianella S,Mehta SR,Young JA,Vargas MV,Little SJ,Richman DD,Kosakovsky Pond SL,Smith DM

更新日期：2012-12-05 00:00:00

abstract：:Several sulfated polysaccharides (dextran sulfate, pentosan polysulfate, heparin) and copolymers of acrylic acid with vinylalcohol sulfate have proved to be potent inhibitors of human cytomegalovirus (CMV) infectivity in vitro. Sulfated alpha-cyclodextrins are only weak inhibitors of CMV. A close correlation was found...

journal_title：Virology

authors： Neyts J,Snoeck R,Schols D,Balzarini J,Esko JD,Van Schepdael A,De Clercq E

更新日期：1992-07-01 00:00:00

abstract：:We determined the effect of the overproduction of viral nonstructural proteins on alphavirus plus-strand and minus-strand RNA synthesis. Because alphavirus minus-strand synthesis ceases normally at 3 to 4 hr postinfection and requires continuous protein synthesis [D. L. Sawicki and S. G. Sawicki, J. Virol. 34, 108-118...

journal_title：Virology

authors： Sawicki SG,Sawicki DL

更新日期：1986-07-30 00:00:00

abstract：:The alphaherpesviruses establish latent infections in sensory neuronal cells, during which a number of latency-associated RNA transcripts (LATs) are produced. The reasons for the production of the LATs, however, and the mechanism by which the LAT region of the genome remains active during latency are unknown. Here we ...

journal_title：Virology

authors： Coffin RS,Howard MK,Latchman DS

更新日期：1995-06-01 00:00:00

abstract：:Cells transformed with specific regions of the foot-and-mouth disease virus (FMDV) genome have been constructed and analyzed with respect to viability and susceptibility to FMDV infection. Constitutive expression of an active protease 3C under the control of the tk promoter has been documented by the ability of transf...

journal_title：Virology

authors： Martínez-Salas E,Domingo E

更新日期：1995-09-10 00:00:00

abstract：:The promotion of membrane fusion by the paramyxovirus hemagglutinin-neuraminidase (HN) and fusion (F) proteins requires that they be derived from homologous viruses, suggesting the possibility that the promotion of fusion requires a virus-specific communication between the two glycoprotein spikes. We have evaluated th...

journal_title：Virology

authors： Deng R,Wang Z,Mirza AM,Iorio RM

更新日期：1995-06-01 00:00:00

abstract：:Rotavirus infection was studied in adult nude mice (BALB/c background), alpha beta or gamma delta and alpha beta/gamma delta T cell receptor (TCR) knockout (-/-) mice (C57BL/6 and C57BL/6 x 129 backgrounds), and SCID mice (C57BL/6 background). The gamma delta TCR -/- mice cleared infection just like control mice. All ...

journal_title：Virology

authors： Franco MA,Greenberg HB

更新日期：1997-11-24 00:00:00

abstract：:An immunological relationship was detected between the coat protein of the common (U1) strain of tobacco mosaic virus (TMV) and the large subunit of the ubiquitous CO2-fixing host enzyme, ribulose-1,5-biphosphate carboxylase (RuBisCo). When assayed by Western immunoblotting or indirect ELISA, polyclonal antisera to TM...

journal_title：Virology

authors： Dietzgen RG,Zaitlin M

更新日期：1986-11-01 00:00:00

abstract：:Feline morbillivirus (FmoPV) has recently been identified in Hong Kong and Japan. FmoPV is considered to belong to the genus Morbillivirus, in the family Paramyxoviridae. In this study, the complete nucleotide sequences of three strains of FmoPV detected in cats in Japan were determined. Among the six genes in FmoPV; ...

journal_title：Virology

authors： Park ES,Suzuki M,Kimura M,Maruyama K,Mizutani H,Saito R,Kubota N,Furuya T,Mizutani T,Imaoka K,Morikawa S

更新日期：2014-11-01 00:00:00

abstract：:IFN responses control acute HSV infection, but their role in regulating HSV latency is poorly understood. To address this we used mice lacking IFN signaling specifically in neural tissues. These mice supported a higher acute viral load in nervous tissue and delayed establishment of latency. While latent HSV-1 genome c...

journal_title：Virology

authors： Rosato PC,Katzenell S,Pesola JM,North B,Coen DM,Leib DA

更新日期：2016-10-01 00:00:00

abstract：:A human cytomegalovirus (HCMV)-induced polypeptide of 68,000 Da (p68) with protein kinase activity was identified using a monoclonal antibody (F6b) produced against HCMV-infected cell proteins. p68 was detected by immunoprecipitation from 3 to 120 hr after infection and was induced by several strains of human and not ...

journal_title：Virology

authors： Michelson S,Tardy-Panit M,Bârzu O

更新日期：1984-04-30 00:00:00

abstract：:Studies using transformed human cell lines suggest that most SIV strains use CCR5 as co-receptor. Our analysis of primary rhesus macaque CD4(+) T-cell clones revealed marked differences in susceptibility to SIV(mac)239 infection. We investigated whether different levels of CCR5 expression account for clonal difference...

journal_title：Virology

authors： Minang JT,Trivett MT,Barsov EV,Del Prete GQ,Trubey CM,Thomas JA,Gorelick RJ,Piatak M Jr,Ott DE,Ohlen C

更新日期：2011-01-05 00:00:00

abstract：:West Nile virus is a mosquito-borne, neurotropic flavivirus that causes encephalitis in humans and animals. Since being introduced into the Western hemisphere in 1999, WNV has spread rapidly across North America, identifying this virus as an important emerging pathogen. In this study, we developed a DNA-launched infec...

journal_title：Virology

authors： Pierson TC,Diamond MS,Ahmed AA,Valentine LE,Davis CW,Samuel MA,Hanna SL,Puffer BA,Doms RW

更新日期：2005-03-30 00:00:00

abstract：:The RNA genomes of cytopathogenic bovine viral diarrhea virus (BVDV) isolates contain insertions highly homologous to cellular sequences. For two of them the insert was identified as ubiquitin coding sequence. The genome of BVDV Osloss contains exactly one ubiquitin gene monomer. In the case of BVDV CP1 the cellular i...

journal_title：Virology

authors： Meyers G,Tautz N,Dubovi EJ,Thiel HJ

更新日期：1991-02-01 00:00:00