Herpes simplex virus immediate early gene expression in the absence of transinduction by Vmw65 varies during the cell cycle.

abstract：:The red clover necrotic mosaic dianthovirus (RCNMV) genome is split between two single-stranded RNA species. The polycistronic RNA-1 encodes the viral RNA polymerase and capsid protein (CP) and the monocistronic RNA-2 encodes the 35 kDa cell-to-cell movement protein (MP). Nicotiana benthamiana plants transformed with ...

journal_title：Virology

authors： Vaewhongs AA,Lommel SA

更新日期：1995-10-01 00:00:00

abstract：:Immunodeficiency caused by HIV infection probably results from profound dysregulation of normal T lymphocyte properties by the virus. Despite description of the virus cytopathicity and numerous modifications in T cell functions, such as perturbation of antigen receptor signaling, CD4 downregulation, and induction of a...

journal_title：Virology

authors： Lefebvre JC,Giordanengo V,Doglio A,Cagnon L,Breittmayer JP,Peyron JF,Lesimple J

更新日期：1994-03-01 00:00:00

abstract：:The nucleotide and deduced amino acid sequence of the gene 4 of bovine rotavirus strain B223 is described. The open reading frame is predicted to encode a VP4 of 772 amino acids, shorter than described for any other rotavirus strain sequenced to date. B223 VP4 shows 70 to 73% similarity to other rotavirus VP4 proteins...

journal_title：Virology

authors： Hardy ME,Gorziglia M,Woode GN

更新日期：1992-11-01 00:00:00

abstract：:Nonspecific anti-inflammatory drugs have been purported to reduce the burden of severe influenza disease. We demonstrate that, unlike oseltamivir administration, simvastatin administration did not reduce morbidity, mortality, or viral load of mice infected with H1N1 or H5N1 viruses. No added benefit to the efficacy of...

journal_title：Virology

authors： Belser JA,Szretter KJ,Katz JM,Tumpey TM

更新日期：2013-04-25 00:00:00

abstract：:The simian hemorrhagic fever virus (SHFV) genome differs from those of other members of the family Arterivirus in encoding two adjacent sets of four minor structural protein open reading frames (ORFs). A stable, full-length, infectious SHFV-LVR cDNA clone was constructed. Virus produced from this clone had replication...

journal_title：Virology

authors： Vatter HA,Di H,Donaldson EF,Baric RS,Brinton MA

更新日期：2014-08-01 00:00:00

abstract：:As porcine endogenous retroviruses (PERV) productively infect human cells in vitro, they pose a serious risk in xenotransplantation and xenogeneic cell therapies. We have analyzed the prevalence of six well-characterized full-length PERV, five of them being replication-competent and four of them being chromosomally as...

journal_title：Virology

authors： Niebert M,Tönjes RR

更新日期：2003-09-01 00:00:00

abstract：:We described a simple method to introduce site-specific mutations into region E3 of adenovirus (Ad). Mutations are made in cloned Ad2 EcoRI-D (map position 76-83), then ligated between Ad5 EcoRI-A (map position 0-76) and EcoRI-B (map position 83-100) to complete the viral genome. We have used this method to isolate a ...

journal_title：Virology

authors： Wold WS,Deutscher SL,Takemori N,Bhat BM,Magie SC

更新日期：1986-01-15 00:00:00

abstract：:An immunodominant region of VP3, one of the two structural proteins of infectious bursal disease virus (IBDV strain 002-73), has been mapped by restriction site-specific deletion analysis and subcloning in Escherichia coli, followed by immunoblot analysis of the synthesized products. The epitope located within 58 amin...

journal_title：Virology

authors： Jagadish MN,Azad AA

更新日期：1991-10-01 00:00:00

abstract：:Rotaviruses are the leading cause of severe diarrhea in infants and young children worldwide. Thus, the development of an effective rotavirus vaccine is a major public health goal. This study was performed to identify the gene or genes responsible for rotavirus virulence or host range restriction and attenuation in a ...

journal_title：Virology

authors： Hoshino Y,Saif LJ,Kang SY,Sereno MM,Chen WK,Kapikian AZ

更新日期：1995-05-10 00:00:00

abstract：:Equid herpesvirus-1 (EHV-1) outbreaks continue despite widely used vaccination. We demonstrated previously that an ORF1/ORF71 gene deletion mutant of the EHV-1 strain Ab4 (Ab4ΔORF1/71) is less virulent than its parent Ab4 virus. Here, we describe the Ab4 challenge infection evaluating protection induced by the Ab4ΔORF...

journal_title：Virology

authors： Perkins G,Babasyan S,Stout AE,Freer H,Rollins A,Wimer CL,Wagner B

更新日期：2019-05-01 00:00:00

abstract：:The second smallest subgenomic messenger RNA, mRNA5, of the coronavirus infectious bronchitis virus includes in its "5' unique region" two separate open reading frames (5a and 5b), whose coding function has not so far been established, and thus it may represent a dicistronic messenger RNA. We report here that two poly...

journal_title：Virology

authors： Liu DX,Inglis SC

更新日期：1992-01-01 00:00:00

abstract：:The nucleocapsids of many plant viruses are significantly more robust and protective of their RNA contents than those of enveloped animal viruses. In particular, the capsid protein (CP) of the plant virus Cowpea Chlorotic Mottle Virus (CCMV) is of special interest because it has been shown to spontaneously package, wi...

journal_title：Virology

authors： Azizgolshani O,Garmann RF,Cadena-Nava R,Knobler CM,Gelbart WM

更新日期：2013-06-20 00:00:00

abstract：:To better understand the origin of human T-cell leukemia virus type l (HTLV-l) in South America, we conducted a phylogenetic study on 27 new HTLV-ls in Brazil. These were obtained from Brazilians of various ethnic origins, such as Japanese immigrants, whites, blacks and mulattos. We amplified and sequenced proviral DN...

journal_title：Virology

authors： Yamashita M,Veronesi R,Menna-Barreto M,Harrington WJ Jr,Sampio C,Brites C,Badaro R,Andrade-Filho AS,Okhura S,Igarashi T,Takehisa J,Miura T,Chamone D,Bianchini O,Jardim C,Sonoda S,Hayami M

更新日期：1999-08-15 00:00:00

abstract：:To identify ranavirus virulence genes, we engineered Frog Virus 3 (FV3) knockout (KO) mutants defective for a putative viral caspase activation and recruitment domain-containing (CARD) protein (Δ64R-FV3) and a β-hydroxysteroid dehydrogenase homolog (Δ52L-FV3). Compared to wild type (WT) FV3, infection of Xenopus tadpo...

journal_title：Virology

authors： Andino Fde J,Grayfer L,Chen G,Chinchar VG,Edholm ES,Robert J

更新日期：2015-11-01 00:00:00

abstract：:Mixed infections of tobacco protoplasts with Cowpea chlorotic mottle virus (CCMV) and brome mosaic virus (BMV) have been studied. Fluorescent antibody staining showed that capsids of both viruses were made in doubly infected protoplasts but only infectious BMV could be recovered, i.e., BMV dominated in mixed infection...

journal_title：Virology

authors： Watts JW,Dawson JR

更新日期：1980-09-01 00:00:00

abstract：:The immediate-early transcripts of pseudorabies virus have been located in a region of the genome situated internally within the inverted repeat between map positions 0.99 and 0.95. A single immediate-early transcript (approximately 6 kb) can be detected both in the cytoplasmic and nuclear fractions of infected, cyclo...

journal_title：Virology

authors： Ihara S,Feldman L,Watanabe S,Ben-Porat T

更新日期：1983-12-01 00:00:00

abstract：:Hantaan virus, the prototype virus of hemorrhagic fever with renal syndrome, was examined for nucleic acid characteristics which would support its previously proposed inclusion in the virus family Bunyaviridae. Nucleocapsid RNA from Hantaan virions and a control bunyavirus were examined for ribonuclease A (RNase A) se...

journal_title：Virology

authors： Schmaljohn CS,Dalrymple JM

更新日期：1983-12-01 00:00:00

abstract：:The porcine lymphotropic herpesvirus 1 (PLHV-1), the first gammaherpesvirus of pigs, has been detected at a high prevalence in healthy pig populations. A porcine gammaherpesvirus has also been detected at high copy numbers in animals suffering from posttransplant lymphoproliferative disease (PTLD). While human PTLD is...

journal_title：Virology

authors： Goltz M,Ericsson T,Patience C,Huang CA,Noack S,Sachs DH,Ehlers B

更新日期：2002-03-15 00:00:00

abstract：:Bluetongue virus (BTV) VP1 protein, a component of the viral RNA-directed RNA polymerase, but not the VP4 or VP6 proteins, was specifically incorporated into baculovirus expressed BTV core-like particles (composed of VP3 and VP7) and BTV virus-like particles (composed of VP2, VP3, VP5, and VP7). The VP1 protein has be...

journal_title：Virology

authors： Loudon PT,Roy P

更新日期：1991-02-01 00:00:00

abstract：:The interaction between the viral envelope protein gp120 and the cellular surface antigen CD4 is a key event in HIV-1 infection. Reciprocal high affinity binding sites have been located in the first domain of CD4 and in the carboxy-terminal region of gp120, respectively. Upon infection, the membranes of the target cel...

journal_title：Virology

authors： Autiero M,Abrescia P,Dettin M,Di Bello C,Guardiola J

更新日期：1991-12-01 00:00:00

abstract：:Successful HIV-1 infection requires a number of specific stages leading to integration of the provirus. We previously suggested that members of the VPAC neuroendocrine receptor family may play a role in HIV-1 infection. We now show that stimulation of the VPAC2 receptor with specific agonists provides strong resistanc...

journal_title：Virology

authors： Bokaei PB,Ma XZ,Sakac D,Branch DR

更新日期：2007-05-25 00:00:00

abstract：:The promotion of membrane fusion by the paramyxovirus hemagglutinin-neuraminidase (HN) and fusion (F) proteins requires that they be derived from homologous viruses, suggesting the possibility that the promotion of fusion requires a virus-specific communication between the two glycoprotein spikes. We have evaluated th...

journal_title：Virology

authors： Deng R,Wang Z,Mirza AM,Iorio RM

更新日期：1995-06-01 00:00:00

abstract：:We constructed a sensitive and quantitative assay system to examine human T-cell leukemia virus type I (HTLV-I) envelope (env) glycoprotein-mediated cell fusion in which T7 RNA polymerase in donor cells coexpressing env glycoproteins activates a reporter gene in recipient cells upon cell fusion. An efficient expressio...

journal_title：Virology

authors： Okuma K,Nakamura M,Nakano S,Niho Y,Matsuura Y

更新日期：1999-02-15 00:00:00

abstract：:The phosphatidylinositol-3-kinase (PI3K)-Akt signaling pathway regulates several key cellular functions including protein synthesis, cell growth, glucose metabolism, and inflammation. Many viruses have evolved mechanisms to manipulate this signaling pathway to ensure successful virus replication. The human herpesvirus...

journal_title：Virology

authors： Liu X,Cohen JI

更新日期：2015-05-01 00:00:00

abstract：:We have studied somatically murine leukemia proviral integrations in primary N-methyl-N-nitrosourea (MNU)-induced thymic lymphomas of AKR/J mice. The majority of MNU-induced lymphomas contain newly acquired murine leukemia proviral sequences. In contrast to spontaneous AKR/J lymphomas which contain multiple integratio...

journal_title：Virology

authors： Richie ER,Angel JM,McEntire B

更新日期：1988-05-01 00:00:00

abstract：:Binding of a specific peptide(s) from a viral protein to major histocompatibility complex (MHC) class I molecules is a critical step in the activation of CD8(+) cytotoxic T lymphocytes (CTLs). Once activated, CTLs can cause lethal disease in an infected host, for example, by killing virus-containing ependymal and vent...

journal_title：Virology

authors： Oldstone MB,von Herrath M,Lewicki H,Hudrisier D,Whitton JL,Gairin JE

更新日期：1999-04-10 00:00:00

abstract：:Growth of clinical specimens of influenza viruses in eggs can result in the selection of antigenic variants distinct from corresponding viruses grown in mammalian tissue culture. To evaluate the contribution of host cell selection on the antigenic diversity of human influenza isolates, as seen in annual surveillance s...

journal_title：Virology

authors： Meyer WJ,Wood JM,Major D,Robertson JS,Webster RG,Katz JM

更新日期：1993-09-01 00:00:00

abstract：:Nucleotide sequence analysis has shown previously that the genomic-length mRNA (mRNA1) of the coronavirus infectious bronchitis virus (IBV) contains two large open reading frames (ORFs), 1a and 1b, with the potential to encode polyproteins of approximately 441 and 300 kDa, respectively. We have characterized the speci...

journal_title：Virology

authors： Liu DX,Tibbles KW,Cavanagh D,Brown TD,Brierley I

更新日期：1995-04-01 00:00:00

abstract：:Binding of interferons (IFNs) to their cell surface receptors stimulates rapid translocation of cytoplasmic proteins to the nucleus and the expression of a variety of cellular genes within minutes. Translocated proteins subsequently bind to the interferon-stimulated response element (ISRE) located in the promoters of ...

journal_title：Virology

authors： Nakagawa Y,Petricoin EF 3rd,Akai H,Grimley PM,Rupp B,Larner AC

更新日期：1992-09-01 00:00:00

abstract：:By employing two different buffer solutions for polyacrylamide gel electrophoresis, all genome segments of Fiji disease and maize rough dwarf virus were separated. Fiji disease virus contains ten genome segments with approximate genome molecular weights of 19.26 x 10(6) and 19.85 x 10(6), depending on the buffer emplo...

journal_title：Virology

authors： Reddy DV,Boccardo G,Outridge R,Teakle DS,Black LM

更新日期：1975-01-01 00:00:00