Abstract:
:Both the brome mosaic virus (BMV) and cowpea chlorotic mottle virus (CCMV) RNA-dependent RNA polymerases (RdRps) were found to recognize the BMV core subgenomic promoter in the same manner, requiring specific functional groups at positions -17, -14, -13, and -11 relative to the subgenomic initiation site (+1). For CCMV subgenomic RNA synthesis, both RdRps required the same nucleotides and four additional nucleotides at positions -20, -16, -15, and -10. The -20 nucleotide is partially responsible for the differential mode of recognition of the two promoters. These data provide evidence that the RNA can induce RdRps to alter the mode of promoter recognition.
journal_name
Virologyjournal_title
Virologyauthors
Adkins S,Kao CCdoi
10.1006/viro.1998.9449subject
Has Abstractpub_date
1998-12-05 00:00:00pages
1-8issue
1eissn
0042-6822issn
1096-0341pii
S0042-6822(98)99449-1journal_volume
252pub_type
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