Histamine enhances HIV-1-induced modulation of dendritic cells to skew naïve T cell differentiation toward regulatory T cells.

Abstract:

:Altered cytokine profiles and imbalanced frequencies of CD4(+) T helper cell subsets are thought to be linked with HIV-1/AIDS pathogenesis, but the causes need to be further clarified. Histamine, a biogenic amine with many functions, shows enhancement in HIV-1 infected individuals, which are considered to link with disease progression, but is poorly understood. This study investigated histamine-assisted HIV-1 modulation of dendritic cell (DC) functions. Histamine and HIV-1 showed a synergistic role in induction of interleukin-10; histamine inhibited HIV-1-induced IL-12 production from MDDCs (monocyte-derived DCs); notably, histamine augmented HIV-1-induced MDDC functional polarization and skewed naïve T cell differentiation toward regulatory T cells (Tregs). The results indicate the novel role of histamine in HIV-1-induced DC functional regulation, which promoted Treg cell differentiation and up-regulated immunosuppressive factors. These findings help to bridge the correlation between elevated histamine and increased Treg cell frequency in HIV-1 infected individuals, and add to our understanding of HIV-1-induced immunosuppression.

journal_name

Virology

journal_title

Virology

authors

Zhai RR,Jiang AP,Wang HB,Ma L,Ren XX,Jiang JF,Wu L,Wei JF,Wang JH

doi

10.1016/j.virol.2013.04.009

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

163-72

issue

2

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(13)00203-1

journal_volume

442

pub_type

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