Abstract：
:Wasting is a sign of various underlying disorders and is a common feature of cancer, sepsis, and AIDS. We have developed an in vivo model to study the various stages of wasting following infection of mice with lymphocytic choriomeningitis virus cl-13. Using this model we have identified four distinct stages of wasting and have discovered that all stages occur in the different groups of mice regardless of whether the virus is cleared or persists. However, the degree and extent of wasting vary between groups of mice, depending upon the dose of virus administered. Blocking IFNγ or TNFα, which are believed to take part in the wasting process, did not affect the wasting state. Finally, we found that CD4+ T cells control the maintenance stage of wasting. We believe this model will be useful in studying the regulation of wasting during a persistent viral infection, hopefully leading to improved therapies to ameliorate the disorder.
journal_name
Virologyjournal_title
Virologyauthors
Stamm A,Valentine L,Potts R,Premenko-Lanier Mdoi
10.1016/j.virol.2012.01.005subject
Has Abstractpub_date
2012-04-10 00:00:00pages
122-32issue
2eissn
0042-6822issn
1096-0341pii
S0042-6822(12)00021-9journal_volume
425pub_type
杂志文章相关文献
VIROLOGY文献大全abstract：:Mouse mammary tumour virus (MMTV) encodes a viral superantigen (Sag) and a negative acting factor (Naf) which share parts of their coding sequence. Using 2-dimensional gel electrophoresis (2D-DIGE), we could show that at least 10 different cellular proteins were differentially expressed in Naf positive cells. Also, lu...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2005.10.029
更新日期：2006-03-01 00:00:00
abstract：:Mice inoculated with replication-competent stocks of the murine acquired immunodeficiency syndrome (MAIDS) virus are severely immunocompromised and proned to the development of T- and B-cell lymphomas. We have studied the development of T-cell lymphomas in C57BL/6 and RF/J mice inoculated with helper-free stocks of th...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/s0042-6822(95)80072-7
更新日期：1995-01-10 00:00:00
abstract：:Retrons are unusual, reverse transcriptase-encoding elements found in bacteria. Although there are a number of indications that retrons are mobile elements, their transposition has not been observed. The Escherichia coli retrons Ec67 and Ec86 are different retrons inserted at the same site and we have further characte...
journal_title：Virology
pub_type： 杂志文章
doi：10.1006/viro.1996.0228
更新日期：1996-05-01 00:00:00
abstract：:The main route of small ruminant lentivirus dissemination is the ingestion of infected cells present in colostrum and milk from infected animals. However, whether only macrophages or other cell subtypes are involved in this transmission is unknown. We derived epithelial cell cultures, 100% cytokeratin positive, from m...
journal_title：Virology
pub_type： 杂志文章
doi：10.1006/viro.1999.9752
更新日期：1999-06-20 00:00:00
abstract：:Tomato strain L of tobacco mosaic virus (TMV-L) induces a hypersensitive response (necrotic local lesions) on tobacco plants with the N' gene. A factor responsible for induction of the hypersensitive response has been mapped to the coat protein gene. We have constructed several mutants which have insertions or deletio...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/0042-6822(89)90217-1
更新日期：1989-11-01 00:00:00
abstract：:Polyribosomal RNA from tobacco infected with sonchus yellow net virus (SYNV) contained sequences which hybridized to 125I-labeled SYNV RNA and which were complementary to 80 to 100% of the viral RNA genome. The poly(A)-containing RNA from polyribosomes was complementary to over 90% of the viral genome but the polyribo...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/0042-6822(79)90375-1
更新日期：1979-08-01 00:00:00
abstract：:We have used cells infected with the HIV-1 molecular clone HX10 to study the binding of monoclonal antibodies (mAbs) to different epitopes within the extracellular domain of the HIV-1 transmembrane glycoprotein gp41. Gp41 mAb binding to the infected cells at 4 degrees was variable but weaker than the binding of an ant...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/s0042-6822(95)80094-8
更新日期：1995-01-10 00:00:00
abstract：:Virus genomes are condensed and packaged inside stable proteinaceous capsids that serve to protect them during transit from one cell or host organism, to the next. During virus entry, capsid shells are primed and disassembled in a complex, tightly-regulated, multi-step process termed uncoating. Here we compare the unc...
journal_title：Virology
pub_type： 杂志文章,评审
doi：10.1016/j.virol.2015.01.024
更新日期：2015-05-01 00:00:00
abstract：:The HPV16 E7 oncoprotein and 17β-estradiol are important factors for the induction of premalignant lesions and cervical cancer. The study of these factors is crucial for a better understanding of cervical tumorigenesis. Here, we assessed the global gene expression profiles induced by the HPV16 E7 oncoprotein and/or 17...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2013.08.036
更新日期：2013-12-01 00:00:00
abstract：:The nucleotide sequence of the P gene of human parainfluenza virus type 1 (hPIV1) strain C35 was determined directly from genomic viral RNA and by molecular cloning. The gene contained 1893 nucleotides. Four open reading frames (ORF) capable of encoding a P protein (568 amino acids; M(r) = 64,784), a C' protein (219 a...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/0042-6822(92)90712-x
更新日期：1992-07-01 00:00:00
abstract：:The majority of HIV-1 infections occur via sexual intercourse. Women are the most affected by the epidemic, particularly in developing countries, due to their socio-economic dependence on men and the fact that they are often victims of gender based sexual violence. Despite significant efforts that resulted in the redu...
journal_title：Virology
pub_type： 杂志文章,评审
doi：10.1016/j.virol.2016.07.004
更新日期：2016-10-01 00:00:00
abstract：:Animal viruses profoundly modify the metabolism of lipids, the synthesis of new membranes, and membrane traffic. These alterations are related to the replication of viral genomes. Addition of oleic acid from the beginning of poliovirus infection inhibits the appearance of virus polypeptides at concentrations that do n...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/0042-6822(91)90802-i
更新日期：1991-11-01 00:00:00
abstract：:Recently, the product of equine herpesvirus type 1 (EHV-1) ORF1, a homolog to HSV-1 pUL56, was shown to modulate MHC-I expression and innate immunity. Here, we investigated modulation of respiratory epithelial immunity by EHV-1 pUL56 and compared responses to those of PBMCs, which are important target cells that allow...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2014.05.023
更新日期：2014-09-01 00:00:00
abstract：:Naturally occurring mutations in Human T-cell Leukemia Virus Type 1 (HTLV-1) Tax protein lead to loss of recognition by cytotoxic T-lymphocytes. Most of these mutations also abolish or severely impair the transactivation function of Tax. Ninety percent of the rex gene, which encodes the viral regulator of mRNA splicin...
journal_title：Virology
pub_type： 杂志文章
doi：10.1006/viro.1997.8789
更新日期：1997-10-27 00:00:00
abstract：:The Hepatitis B virus Precore protein, present in the secretory pathway as the HBeAg precursor, can associate in the cytoplasm with the Core protein to form heterocapsids, likely to favor viral persistence. Core and Precore proteins share their primary sequence except for ten additional aminoacids at the N-terminus of...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2014.06.013
更新日期：2014-08-01 00:00:00
abstract：:We have investigated the effect of a monoclonal antibody on influenza virus release and the cell surface expression of M2, comparing virus strains which were observed previously to be sensitive (A/Udorn) or resistant (A/WSN and A/Udorn variants) to growth inhibition by M2 antibody 14C2. Incubation of A/Udorn virus-inf...
journal_title：Virology
pub_type： 杂志文章
doi：10.1006/viro.1995.1498
更新日期：1995-10-01 00:00:00
abstract：:The most recent introduction of an avian influenza A virus without reassortment into mammals occurred in 1979 when H1N1 strains could be isolated from diseased pigs in northern Europe. This newly introduced avian virus formed a stable lineage in pigs and, in the meantime, spread all over Europe. In 1991 highly pathoge...
journal_title：Virology
pub_type： 杂志文章
doi：10.1006/viro.1994.1344
更新日期：1994-07-01 00:00:00
abstract：:HIV-1 transmission is usually initiated by a single viral strain called transmitted/ founder (T/F) virus. In in vitro models, HIV-1 can efficiently spread via cell-free and virological synapse (VS)-mediated cell-to-cell infection. Both modes of infection require the viral glycoprotein Envelope (Env). The efficiency wi...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2018.10.016
更新日期：2019-01-02 00:00:00
abstract：:The influenza RNA polymerase is known to be important in pathogenicity and adaptation of avian influenza viruses to mammalian hosts. However, the molecular mechanisms responsible are only partly understood. Here we investigated the role of the polymerase in two different, closely related, H5N1 influenza viruses - a hi...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2010.01.036
更新日期：2010-05-25 00:00:00
abstract：:Exosomes are membranous extracellular nanovesicles secreted by diverse cell types. Exosomes from healthy human semen have been shown to inhibit HIV-1 replication and to impair progeny virus infectivity. In this study, we examined the ability of healthy human semen exosomes to restrict HIV-1 and LP-BM5 murine AIDS viru...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2015.03.040
更新日期：2015-08-01 00:00:00
abstract：:The 3' ends of three genomic RNAs (gRNAs) of cowpea chlorotic mottle virus (CCMV) terminate in a highly conserved tRNA-like structure (3'TLS). To examine the intrinsic role played the 3'TLS in packaging, the competence of each gRNA lacking the 3' TLS (DeltaTLS-gRNA) to interact with dissociated coat protein (CP) subun...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2004.12.009
更新日期：2005-02-20 00:00:00
abstract：:It is now widely recognized that BPV-1 and less commonly BPV-2 are the causative agents of equine sarcoids. Here we present the generation of equine cell lines harboring BPV-1 genomes and expressing viral genes. These lines have been either explanted from sarcoid biopsies or generated in vitro by transfection of prima...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2007.11.037
更新日期：2008-04-10 00:00:00
abstract：:Outbreaks of avian influenza virus H5N8 first occurred in 2014, and spread to poultry farms in Korea. Although there was no report of human infection by this subtype, it has the potential to threaten human public health. Therefore, we evaluated the pathogenesis of H5N8 viruses in ferrets. Two representative Korean H5N...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2015.02.042
更新日期：2015-07-01 00:00:00
abstract：:The open reading frame EP153R, located within the EcoRI E' fragment of the African swine fever (ASF) virus genome, is predicted to encode a membrane protein of 153 amino acids that presents significant homology to the N-terminal region of several CD44 molecules. EP153R contains multiple putative sites for N-glycosylat...
journal_title：Virology
pub_type： 杂志文章
doi：10.1006/viro.1999.0080
更新日期：2000-01-20 00:00:00
abstract：:Using high resolution electron microscopic autoradiography and immunocytochemistry with monoclonal antibodies against poliovirus proteins of the P2 genomic region, the location of these proteins in respect to the virus-induced vesicle formation and the viral RNA synthesis was followed during the viral replication cycl...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/0042-6822(87)90063-8
更新日期：1987-09-01 00:00:00
abstract：:Hepatitis A virus infection and growth in cultured cells is protracted, cell-type restricted, and generally not accompanied by the appearance of a cytopathic effect, with the exception of some culture-adapted strains. We demonstrate that the non-cytopathic HAV strain HM175/clone 1 can be induced to exhibit a cytopathi...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2012.04.010
更新日期：2012-08-15 00:00:00
abstract：:We investigated the origin and the effect of insertion D67D-THGERDLGPA within HIV-1 RT from a patient failing antiviral therapy. The insertion developed within the context of pre-existing NRTI and NNRTI mutations (M41L, L210W, T215Y and N348I). Concurrently, the NRTI mutations T69I and V118I and the NNRTI mutations K1...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2014.03.023
更新日期：2014-05-01 00:00:00
abstract：:Flock house virus (FHV) encodes a suppressor protein B2 to overcome antiviral RNA silencing during infection. Biochemical analyses have shown that a homodimer of B2 binds to double-stranded RNA to inhibit dicer-mediated cleavage of dsRNA and incorporation of small interfering RNAs into the RNA-induced silencing comple...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2012.05.023
更新日期：2012-10-25 00:00:00
abstract：:A non-plaque-forming vaccine strain of NDV (NDV-B1) interferes with the infection of cultured chick embryo cells by the virulent plaque-forming NDV-L strain. The level of interference increases when the concentration of interfering virus is increased or when the time between infection and superinfection is increased. ...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/0042-6822(67)90059-1
更新日期：1967-12-01 00:00:00
abstract：:CD8 T cells are necessary for controlling tumors induced by mouse polyoma virus (PyV), but the effector mechanism(s) responsible have not been determined. We examined the PyV tumorigenicity in C57BL/6 mice mutated in Fas or carrying targeted disruptions in the perforin gene or in both TNF receptor type I and type II g...
journal_title：Virology
pub_type： 杂志文章
doi：10.1016/j.virol.2006.08.044
更新日期：2007-02-20 00:00:00
