AFV1, a novel virus infecting hyperthermophilic archaea of the genus acidianus.

abstract：:Selective inactivation of critical cysteine residues in human immunodeficiency virus type one (HIV-1) was observed after treatment with 4-vinylpyridine (4-VP), with and without the membrane-permeable metal chelator N,N,N',N'-tetrakis(2-pyridylmethyl)-ethylenediamine (TPEN). Chromatographic analysis showed that cystein...

journal_title：Virology

authors： Morcock DR,Thomas JA,Sowder RC 2nd,Henderson LE,Crise BJ,Gorelick RJ

更新日期：2008-05-25 00:00:00

abstract：:The mitotic spindle assembly checkpoint (SAC) ensures faithful chromosome segregation during mitosis by censoring kinetochore-microtubule interactions. It is frequently rendered dysfunctional during carcinogenesis causing chromosome missegregation and genomic instability. There are conflicting reports whether the HPV1...

journal_title：Virology

authors： Yu Y,Munger K

更新日期：2012-10-10 00:00:00

abstract：:KSHV establishes characteristic latent infections in vitro, while RRV, a related macaque rhadinovirus, establishes characteristic permissive infections with virus replication. We identified cells that are not permissive for RRV replication and recapitulate the latent KSHV infection and reactivation processes. The RRV ...

journal_title：Virology

authors： DeMaster LK,Rose TM

更新日期：2014-01-05 00:00:00

abstract：:Our previous studies have demonstrated that virus-specific cell-mediated cytotoxicity of sensitized leukocytes can be induced using clonal ginbuna crucian carp and their syngeneic cell lines. In the present study, we attempt to determine if virus-specific cytotoxic cell populations of fish express CD8alpha and TCRbeta...

journal_title：Virology

authors： Somamoto T,Yoshiura Y,Sato A,Nakao M,Nakanishi T,Okamoto N,Ototake M

更新日期：2006-05-10 00:00:00

abstract：:Entry determinants in the XPR1 receptor for the xenotropic/polytropic mouse leukemia viruses (XP-MLVs) lie in its third and fourth putative extracellular loops (ECLs). The critical ECL3 receptor determinant overlies a splice donor and is evolutionarily conserved in vertebrate XPR1 genes; 2 of the 3 rare replacement mu...

journal_title：Virology

authors： Lu X,Martin C,Bouchard C,Kozak CA

更新日期：2014-11-01 00:00:00

abstract：:The SARS-coronavirus (SARS-CoV) is the etiological agent of severe acute respiratory syndrome (SARS). The SARS-CoV spike (S) glycoprotein mediates membrane fusion events during virus entry and virus-induced cell-to-cell fusion. To delineate functional domains of the SARS-CoV S glycoprotein, single point mutations, clu...

journal_title：Virology

authors： Petit CM,Melancon JM,Chouljenko VN,Colgrove R,Farzan M,Knipe DM,Kousoulas KG

更新日期：2005-10-25 00:00:00

abstract：:When DNase-digested calf thymus DNA is used as primer, the RNA-directed DNA polymerase of avian myeloblastosis virus will accept potato spindle tuber viroid (PSTV) as a template for DNA synthesis. The DNA obtained hybridizes specifically to PSTV and low molecular weight RNA isolated from PSTV-infected plants; no hybri...

journal_title：Virology

authors： Owens RA

更新日期：1978-09-01 00:00:00

abstract：:Six deletion mutations and an insertion were generated in the env gene of cloned copies of Moloney murine leukemia virus DNA. All seven mutants were replication-defective as tested by transformation of NIH/3T3 cells. The mutant DNAs were introduced into NIH/3T3 cells to generate stable producer lines; all released vir...

journal_title：Virology

authors： Granowitz C,Colicelli J,Goff SP

更新日期：1991-08-01 00:00:00

abstract：:Human adenovirus type 5 (Ad5) has been the most popular platform for the development of oncolytic Ads. Alternative Ad serotypes with low seroprevalence might allow for improved anticancer efficacy in Ad5-immune patients. We studied the safety and efficacy of rare serotypes Ad6, Ad11 and Ad35. In vitro cytotoxicity of ...

journal_title：Virology

authors： Shashkova EV,May SM,Barry MA

更新日期：2009-11-25 00:00:00

abstract：:Human adenovirus (HAdV) is a cause of significant morbidity and mortality in immunocompromised patients, especially after stem cell transplantation (SCT). Viral clearance has been attributed to CD4(+) T-cell responses against the Hexon-protein, but the frequency of specific T(HELPER) cells is extremely low or not dete...

journal_title：Virology

authors： Serangeli C,Bicanic O,Scheible MH,Wernet D,Lang P,Rammensee HG,Stevanovic S,Handgretinger R,Feuchtinger T

更新日期：2010-02-20 00:00:00

abstract：:The biological phenotype of HIV-1 isolates from 21 subjects with primary HIV-1 infection was determined in primary lymphocytes and monocyte-derived macrophages as well as in three T-cell lines (MT-2, HUT78, and C8166). Seven isolates (33%) replicated on at least one cell line and were classified as rapid/high (n = 6) ...

journal_title：Virology

authors： Fiore JR,Björndal A,Peipke KA,Di Stefano M,Angarano G,Pastore G,Gaines H,Fenyö EM,Albert J

更新日期：1994-10-01 00:00:00

abstract：:We have investigated the effect of a monoclonal antibody on influenza virus release and the cell surface expression of M2, comparing virus strains which were observed previously to be sensitive (A/Udorn) or resistant (A/WSN and A/Udorn variants) to growth inhibition by M2 antibody 14C2. Incubation of A/Udorn virus-inf...

journal_title：Virology

authors： Hughey PG,Roberts PC,Holsinger LJ,Zebedee SL,Lamb RA,Compans RW

更新日期：1995-10-01 00:00:00

abstract：:A method was devised which allows the easy detection of mutations within the ner gene of Mu DNA. This method is based upon the observation that a transcriptional gene A-galK fusion containing the complete ner gene and the cts62 allele does not express the galK gene in an Escherichia coli strain lacking functional inte...

journal_title：Virology

authors： König U,Kirschner P,Schumann W

更新日期：1988-05-01 00:00:00

abstract：:Most adenovirus-specific mRNAs expressed late after infection originate from a single transcription unit, the so-called major late transcription unit. All mRNAs expressed from this unit have in common a 201 nucleotide-long spliced tripartite leader segment attached to their 5' ends. Human adenovirus mutants that carry...

journal_title：Virology

authors： Ohman K,Nordqvist K,Akusjärvi G

更新日期：1993-05-01 00:00:00

abstract：:Ribavirin is the first synthetic, broad-spectrum antiviral nucleoside. Despite its more than 30 year history, the mechanism of action of this compound remains unclear and somewhat controversial. Recent data suggest the possibility that the activity of ribavirin against RNA viruses is a reflection of incorporation of r...

journal_title：Virology

authors： Graci JD,Cameron CE

更新日期：2002-07-05 00:00:00

abstract：:Piglets infected in utero with porcine reproductive and respiratory syndrome virus (PRRSV) are born severely immunocompromised. In this article we more closely examine the effects of in utero PRRSV infection on circulating and thymic T cell populations. Numbers of CD4+, CD8+, and dual-positive lymphocytes were quantit...

journal_title：Virology

authors： Feng WH,Tompkins MB,Xu JS,Brown TT,Laster SM,Zhang HX,McCaw MB

更新日期：2002-10-25 00:00:00

abstract：:Persistent infection with the Edmonston strain of measles virus (MV) has been established in IC-21 cells, an immortalized murine macrophage cell line. Persistence was established immediately without syncytia formation or cytopathic effects. MV was expressed in the majority of the cells as evidenced by immunofluorescen...

journal_title：Virology

authors： Goldman MB,Buckthal DJ,Picciotto S,O'Bryan TA,Goldman JN

更新日期：1995-02-20 00:00:00

abstract：:Small non-coding microRNAs (miRNAs) can modulate the outcome of virus infection. Here we explore the role of miRNAs in insect-virus interactions, in vivo, using the natural Drosophila melanogaster-Drosophila C virus (DCV) model system. Comparison of the miRNA expression profiles in DCV-infected and uninfected flies sh...

journal_title：Virology

authors： Monsanto-Hearne V,Tham ALY,Wong ZS,Asgari S,Johnson KN

更新日期：2017-02-01 00:00:00

abstract：:Primary strains of human immunodeficiency virus type 1 (HIV-1) are known to adapt to replication in cell lines in vitro by becoming sensitive to soluble CD4 (sCD4) and neutralizing antibodies (NAb). T-cell lines favor isolation of variants that use CXCR4 as a co-receptor, while primary isolates predominantly use CCR5....

journal_title：Virology

authors： Pugach P,Kuhmann SE,Taylor J,Marozsan AJ,Snyder A,Ketas T,Wolinsky SM,Korber BT,Moore JP

更新日期：2004-03-30 00:00:00

abstract：:Circomics was coined to describe the combination of rolling circle amplification (RCA), restriction fragment length polymorphism (RFLP) and pyro-sequencing to investigate the genome structures of small circular DNAs. A batch procedure is described using 61 plant samples from Asia, South America and Central America whi...

journal_title：Virology

authors： Wyant PS,Strohmeier S,Schäfer B,Krenz B,Assunção IP,Lima GS,Jeske H

更新日期：2012-06-05 00:00:00

abstract：:Arabis mosaic virus is a subgroup A nepovirus. The RNA1-encoded polyprotein (P1) contains the domains for the NTP-binding protein (NTB), VPg, proteinase (Pro) and polymerase at its C-terminus. Putative cleavage sites delineating these domains have been proposed. However, the number and location of cleavage sites upstr...

journal_title：Virology

authors： Wetzel T,Chisholm J,Bassler A,Sanfaçon H

更新日期：2008-05-25 00:00:00

abstract：:The lentivirus caprine arthritis-encephalitis virus (CAEV) is closely related by nucleotide sequence homology to visna virus and other sheep lentiviruses and shows less similarity to the other animal and human lentiviruses. The genomic organization of CAEV is very similar to that of visna virus and the South African o...

journal_title：Virology

authors： Saltarelli M,Querat G,Konings DA,Vigne R,Clements JE

更新日期：1990-11-01 00:00:00

abstract：:Flock house virus (FHV) is the best studied member of the Nodaviridae, a family of small, nonenveloped, isometric RNA viruses of insects and fish. Nodavirus genomes comprise two single-stranded positive-sense RNA segments (RNAs 1 and 2) that encode the viral RNA-dependent RNA polymerase (RdRp) and capsid protein precu...

journal_title：Virology

authors： Albariño CG,Price BD,Eckerle LD,Ball LA

更新日期：2001-10-25 00:00:00

abstract：:A series of nucleotide substitutions (G46----C; C47----A; C315----U; U317----C) were introduced into the virulence modulating region of the intermediate strain of potato spindle tuber viroid (PSTVd) in order to examine their effect upon viroid infectivity and pathogenicity with the presence of all four mutations resul...

journal_title：Virology

authors： Hammond RW

更新日期：1992-04-01 00:00:00

abstract：:The nucleic acid of carnation cryptic virus has been identified as double-stranded RNA on the basis of (i) susceptibility to RNase in 0.1 x SSC (SSC = 0.15 M NaCl-0.015 M sodium citrate buffer, pH 7.0) and resistance to RNase in 2 x SSC and to DNase, (ii) reaction with an antiserum containing antibodies to dsRNA, and ...

journal_title：Virology

authors： Lisa V,Boccardo G,Milne RG

更新日期：1981-12-01 00:00:00

abstract：:The nucleotide sequence of the genome of the nucleopolyhedrovirus (NPV) from Mamestra configurata (MacoNPV, isolate 90/2), a group II NPV, was determined and analyzed. The MacoNPV DNA genome consists of 155,060 bp and has an overall G+C content of 41.7%. Computer-assisted analysis predicted 169 open reading frames (OR...

journal_title：Virology

authors： Li Q,Donly C,Li L,Willis LG,Theilmann DA,Erlandson M

更新日期：2002-03-01 00:00:00

abstract：:A new strain of wound tumor virus (WTV) has been isolated from a periwinkle plant (Catharanthus roseus) that was among several used as bait plants in a blueberry field. The 12 segments of double-stranded RNA of the viral genome were isolated directly from infected tissue and found to have mobilities through agarose ge...

journal_title：Virology

authors： Hillman BI,Anzola JV,Halpern BT,Cavileer TD,Nuss DL

更新日期：1991-12-01 00:00:00

abstract：:Maturation of T4 can proceed in the presence of 5-methyltryptophan or puromycin. Puromycin inhibits phage protein synthesis within a few seconds, thus limiting the amount of phage precursor material available for maturation. After the arrest of protein synthesis, maturation continues unabated until the limiting protei...

journal_title：Virology

authors： Piechowski MM,Susman M

更新日期：1966-03-01 00:00:00

abstract：:Magnetic birefringence measurements are reported on solutions of two double-stranded DNA containing viruses: icosahedral cauliflower mosaic virus (CaMV) and SD, an isometric bacteriophage with a short tail. Assuming the signal comes predominantly from the DNA, constraints can be put on its packing geometry. The anisot...

journal_title：Virology

authors： Torbet J,Timmins PA,Lvov Y

更新日期：1986-12-01 00:00:00

abstract：:A dodecapeptide containing the sequence of the C terminus of the nonstructural polyprotein of Sindbis virus has been synthesized and used to immunize rabbits. The antisera obtained precipitated polypeptides from cells infected with the HR strains of Sindbis or with temperature-sensitive mutants ts11 or ts18. Four diff...

journal_title：Virology

authors： Lopez S,Bell JR,Strauss EG,Strauss JH

更新日期：1985-03-01 00:00:00