当前位置： SCI文献检索 > VIROLOGY期刊下所有文献 > Pathogenesis of the slow disease of the central nervous system associated with wild mouse virus. III. Role of input virus and MCF recombinants in disease.

Pathogenesis of the slow disease of the central nervous system associated with wild mouse virus. III. Role of input virus and MCF recombinants in disease.

Abstract：

:Inbred mice bearing the FV-1n marker when inoculated at birth with an ecotropic murine leukemia virus (WM 1504-E) obtained from wild mice develop a progressive central nervous system (CNS) disease manifested by hindlimb paralysis and incoordination that begins by 6 to 7 weeks of age. Studies of infected SWR/J mice at 3 days to 4 months of age indicated the following: (1) Expression of MuLV gp69/70 and p30 antigens in CNS rises beginning as early as 3 days after inoculation and increases with time. (2) Neuronal damage is evident by Day 7, and neuronal lesions develop in all mice by Day 14. (3) WM 1504-E virus can be isolated from CNS tissue by 48 hr after initiating infection. (4) Upon passage into susceptible newborn mice, the WM 1504-E isolates cause neuronal disease. (5) "Dual-tropic" mink cell focus forming (MCF) -like virus is found in splenic but not CNS tissues by 8 weeks after initiating infection. (6) MCF viruses that arise by env gene recombination between WM 1504-E and endogenous xenotropic viruses do not cause CNS disease upon inoculation into susceptible newborn mice. Similarly inoculated WM 1504-amphotropic virus (WM 1504-A) does not cause CNS disease (7). Results in SWR/J mice can be duplicated in C3H/St and C57Br/cdj mice. These observations define the wild mouse ecotropic virus as the sole infectious agent responsible and sufficient for the development of this neurologic disease. Evidently, the disease from this "slow virus infection" begins early in life shortly after introduction of the infectious agent, but becomes clinically apparent only as neuronal destruction accumulates over the lifetime of the host.

journal_name

Virology

journal_title

Virology

authors

Oldstone MB,Jensen F,Elder J,Dixon FJ,Lampert PW

doi

10.1016/0042-6822(83)90326-4

subject

Has Abstract

pub_date

1983-07-15 00:00:00

pages

154-65

issue

1

eissn

0042-6822

issn

1096-0341

journal_volume

128

pub_type

杂志文章

相关文献

VIROLOGY文献大全
  • Cellular mechanisms in the superinfection exclusion of vesicular stomatitis virus.

    abstract：:The superinfection exclusion of VSV has been studied and found to be caused by a combination of three distinct effects on endocytosis by VSV-infected cells: first, a decreased rate of formation of endocytic vesicles as judged by an inhibition of fluid-phase uptake at 2 hr postinfection; second, a decreased rate of int...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(90)90494-c

    authors： Simon KO,Cardamone JJ Jr,Whitaker-Dowling PA,Youngner JS,Widnell CC

    更新日期：1990-07-01 00:00:00

  • Molecular cloning and characterization of MSRV-related sequences associated with retrovirus-like particles.

    abstract：:New sequences have been obtained by successive overlapping RT-PCR extensions from the pol region of a retroviral RNA (multiple sclerosis-associated retroviral element, MSRV) amplified in retrovirus-like particles from patients with multiple sclerosis. gag and pol sequences are related to type C oncoviruses, whereas th...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1999.9792

    authors： Komurian-Pradel F,Paranhos-Baccala G,Bedin F,Ounanian-Paraz A,Sodoyer M,Ott C,Rajoharison A,Garcia E,Mallet F,Mandrand B,Perron H

    更新日期：1999-07-20 00:00:00

  • Mutations of amino acids in the DNA-recognition domain of Epstein-Barr virus ZEBRA protein alter its sub-nuclear localization and affect formation of replication compartments.

    abstract：:ZEBRA, a transcription factor and DNA replication protein encoded by the Epstein-Barr virus (EBV) BZLF1 gene, plays indispensable roles in the EBV lytic cycle. We recently described the phenotypes of 46 single amino acid substitutions introduced into the DNA-recognition region of ZEBRA [Heston, L., El-Guindy, A., Coun...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2008.09.009

    authors： Park R,Heston L,Shedd D,Delecluse HJ,Miller G

    更新日期：2008-12-20 00:00:00

  • Molecular pathways executing the "trophic sentinel" response in HPV-16 E7-expressing normal human diploid fibroblasts upon growth factor deprivation.

    abstract：:In response to oncogenic insults, normal human cells execute a defense response that culminates in cellular suicide, apoptosis. Normal human diploid fibroblasts expressing the human papillomavirus type 16 (HPV-16) E7 oncoprotein are predisposed to apoptosis when they are deprived of growth factors. Even though a domin...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2003.11.008

    authors： Eichten A,Rud DS,Grace M,Piboonniyom SO,Zacny V,Münger K

    更新日期：2004-02-05 00:00:00

  • Phosphoprotein NS of vesicular stomatitis virus: phosphorylated states and transcriptional activities of intracellular and virion forms.

    abstract：:The phosphorylation and transcriptional competence of the free cytoplasmic form and the virion form of NS protein of vesicular stomatitis virus (VSV-Indiana/Mudd-Summers) were compared. NS protein is known to exist in two distinct phosphorylated states, NS1 and NS2, that are resolvable by gel electrophoresis. In vitro...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(86)90452-6

    authors： Masters PS,Banerjee AK

    更新日期：1986-10-30 00:00:00

  • Latent infection can be established with drastically restricted transcription and replication of the HSV-1 genome.

    abstract：:Viral functions essential for the establishment of latent infection in murine sensory neurons in vivo were investigated by employing a herpes simplex virus type 1 (HSV-1) variant (KD6/B11) deleted for expression of the ICP4 gene and therefore unable to replicate. Since the viral DNA persisted in these cells, the laten...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1993.1089

    authors： Sedarati F,Margolis TP,Stevens JG

    更新日期：1993-02-01 00:00:00

  • Receptor determinants of human and animal influenza virus isolates: differences in receptor specificity of the H3 hemagglutinin based on species of origin.

    abstract：:The binding of influenza virus to erythrocytes and host cells is mediated by the interaction of the viral hemagglutinin (H) with cell surface receptors containing sialic acid (SA). The specificity of this interaction for 19 human and animal influenza isolates was examined using human erythrocytes enzymatically modifie...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(83)90150-2

    authors： Rogers GN,Paulson JC

    更新日期：1983-06-01 00:00:00

  • Vaccinia virus exhibits cell-type-dependent entry characteristics.

    abstract：:Differing and sometimes conflicting data have been reported regarding several aspects of vaccinia virus (VV) entry. To address this, we used a beta-galactosidase reporter virus to monitor virus entry into multiple cell types under varying conditions. Entry into HeLa, B78H1 and L cells was strongly inhibited by heparin...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2008.12.029

    authors： Whitbeck JC,Foo CH,Ponce de Leon M,Eisenberg RJ,Cohen GH

    更新日期：2009-03-15 00:00:00

  • Early activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, and c-Jun N-terminal kinase in response to binding of simian immunodeficiency virus to Jurkat T cells expressing CCR5

    abstract：:We have shown that the binding of simian immunodeficiency virus (SIV) to Jurkat T cells expressing CD4 receptor strongly induces mitogen-activated protein (MAP) kinase kinase (MEK) and extracellular signal-regulated kinases 1 and 2 (ERK1/2) and only weakly induces p38 MAP kinase and c-Jun N-terminal kinase (JNK). Simi...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1998.9466

    authors： Popik W,Pitha PM

    更新日期：1998-12-05 00:00:00

  • Bipartite geminivirus host adaptation determined cooperatively by coding and noncoding sequences of the genome.

    abstract：:Bipartite geminiviruses are small, plant-infecting viruses with genomes composed of circular, single-stranded DNA molecules, designated A and B. Although they are closely related genetically, individual bipartite geminiviruses frequently exhibit host-specific adaptation. Two such viruses are bean golden mosaic virus (...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2000.0620

    authors： Petty IT,Carter SC,Morra MR,Jeffrey JL,Olivey HE

    更新日期：2000-11-25 00:00:00

  • Reduction of soluble dipeptidyl peptidase 4 levels in plasma of patients infected with Middle East respiratory syndrome coronavirus.

    abstract：:Dipeptidyl peptidase 4 (DPP4) is a receptor for MERS-CoV. The soluble form of DPP4 (sDPP4) circulates systematically and can competitively inhibit MERS-CoV entry into host cells. Here, we measured the concentration of sDPP4 in the plasma and sputa of 14 MERS-CoV-infected patients of various degrees of disease severity...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2018.03.015

    authors： Inn KS,Kim Y,Aigerim A,Park U,Hwang ES,Choi MS,Kim YS,Cho NH

    更新日期：2018-05-01 00:00:00

  • Viral fitness implications of variation within an immunodominant CD8+ T-cell epitope of HIV-1.

    abstract：:Cytotoxic T-lymphocyte (CTL) epitopes within the HIV genome are subject to negative and positive selective pressures, the balance of which influences CTL escape at a given epitope. We investigated whether viral fitness requirements dictate conservation of the HLA-A2 restricted immunodominant epitope SLYNTVATL (SL9). V...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2009.03.003

    authors： Christie NM,Willer DO,Lobritz MA,Chan JK,Arts EJ,Ostrowski MA,Cochrane A,Luscher MA,MacDonald KS

    更新日期：2009-05-25 00:00:00

  • The conserved process of TCR/CD3 complex down-modulation by SIV Nef is mediated by the central core, not endocytic motifs.

    abstract：:The Nef protein of Simian immunodeficiency virus (SIV) associates with multiple T lymphocyte signaling proteins, including the T cell receptor (TCR) zeta chain. We demonstrate here that these interactions are conserved and highly specific. Nefs derived from genetically diverse strains of SIV (SIV(mac)239, SIV(smm)PBj,...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2002.1628

    authors： Schaefer TM,Bell I,Pfeifer ME,Ghosh M,Trible RP,Fuller CL,Ashman C,Reinhart TA

    更新日期：2002-10-10 00:00:00

  • Replication of alfalfa mosaic virus RNA: evidence for a soluble replicase in healthy and infected tobacco leaves.

    abstract：:Soluble RNA-dependent RNA polymerases from healthy and alfalfa mosaic virus (AMV)-infected leaves were purified more than 400-fold from the 100,000g supernatant of leaf homogenates, using ammonium sulfate precipitation, Sephadex G-100 filtration, and chromatography on DEAE Sephadex A25 and P11-phosphocellulose. The DE...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(80)90554-1

    authors： Chifflot S,Sommer P,Hartmann D,Stussi-Garaud C,Hirth L

    更新日期：1980-01-15 00:00:00

  • Friend murine leukemia virus A8 regulates Env protein expression through an intron sequence.

    abstract：:Friend murine leukemia virus (Fr-MLV) produces unspliced mRNAs, as well as singly-spliced mRNAs by which the Env protein is generated. We investigated the role of the intron within the Fr-MLV gene in Env expression using vectors with serially truncated introns. The up-regulatory regions, the 361-878 and the 5135-5399 ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2008.11.040

    authors： Yamamoto N,Takase-Yoden S

    更新日期：2009-03-01 00:00:00

  • Variable infectivity and conserved engagement in cell-to-cell viral transfer by HIV-1 Env from Clade B transmitted founder clones.

    abstract：:HIV-1 transmission is usually initiated by a single viral strain called transmitted/ founder (T/F) virus. In in vitro models, HIV-1 can efficiently spread via cell-free and virological synapse (VS)-mediated cell-to-cell infection. Both modes of infection require the viral glycoprotein Envelope (Env). The efficiency wi...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2018.10.016

    authors： Li H,Chen BK

    更新日期：2019-01-02 00:00:00

  • A chimpanzee adenoviral vector-based rabies vaccine protects beagle dogs from lethal rabies virus challenge.

    abstract：:Rabies continues to poses serious threats to the public health in many countries. The development of novel inexpensive, safe and effective vaccines has become a high priority for rabies control worldwide. We previously generated a novel recombinant rabies vaccine by cloning rabies virus glycoprotein into a chimpanzee ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2019.07.022

    authors： Wang X,Fang Z,Xiong J,Yang K,Chi Y,Tang X,Ma L,Zhang R,Deng F,Lan K,Zhou D

    更新日期：2019-10-01 00:00:00

  • Subviral agents associated with plant single-stranded DNA viruses.

    abstract：:Begomoviruses (family Geminiviridae) are responsible for many economically important crop diseases worldwide. The majority of these diseases are caused by bipartite begomovirus infections, although a rapidly growing number of diseases of the Old World are associated with monopartite begomoviruses. With the exception o...

    journal_title：Virology

    pub_type： 杂志文章,随机对照试验,评审

    doi：10.1016/j.virol.2005.09.042

    authors： Briddon RW,Stanley J

    更新日期：2006-01-05 00:00:00

  • Transcriptional block of HTLV-I LTR by sequence-specific methylation.

    abstract：:HTLV-I infection is characterized by low viremia and restricted viral expression. While the mechanisms regulating viral latency are poorly understood, it is believed that interactions between viral and host cellular factor(s) are involved. Several lines of evidence indicate that HTLV-I provirus may be methylated in pr...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(91)90649-v

    authors： Saggioro D,Forino M,Chieco-Bianchi L

    更新日期：1991-05-01 00:00:00

  • The X protein of hepatitis B virus has a ribo/deoxy ATPase activity.

    abstract：:The X protein (pX) of hepatitis B virus (HBV) is a general transcription regulator and directly associated with the transcription machinery. pX cannot bind DNA directly but interacts with cellular factors that bind the regulatory elements. There is an accumulation of evidence concerning different activities exerted by...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1994.1356

    authors： de-Medina T,Haviv I,Noiman S,Shaul Y

    更新日期：1994-07-01 00:00:00

  • Are the acid-labile interferon alpha and interferon omega-1 identical?

    abstract：:The interferon (IFN) activity found in human leukocyte IFN alpha preparations, autoimmune and AIDS sera, and others was reported to have distinct antigenic and deviating biological properties. This led to its vague designation as acid-labile and thermolabile IFN alpha. However, using specific monoclonal antibodies, th...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(91)90517-f

    authors： Kontsek P,Borecký L,Novák M

    更新日期：1991-03-01 00:00:00

  • N-linked glycosylation of Gn (but not Gc) is important for Crimean Congo hemorrhagic fever virus glycoprotein localization and transport.

    abstract：:The mature Gn glycoprotein of Crimean Congo hemorrhagic fever (CCHF) virus contains two predicted glycosylation sites (557N and 755N). Of these, N-glycans are added only at 557N, as evidenced by abrogation of Gn-glycosylation by mutation of 557N but not 755N site. Mutational block of Gn-glycosylation at 557N did not s...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2006.11.023

    authors： Erickson BR,Deyde V,Sanchez AJ,Vincent MJ,Nichol ST

    更新日期：2007-05-10 00:00:00

  • A new DNA binding protein highly conserved in diverse crenarchaeal viruses.

    abstract：:Sulfolobus turreted icosahedral virus (STIV) infects Sulfolobus species found in the hot springs of Yellowstone National Park. Its 37 open reading frames (ORFs) generally lack sequence similarity to other genes. One exception, however, is ORF B116. While its function is unknown, orthologs are found in three additional...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2007.01.027

    authors： Larson ET,Eilers BJ,Reiter D,Ortmann AC,Young MJ,Lawrence CM

    更新日期：2007-07-05 00:00:00

  • Neutralizing antibodies decrease the envelope fluidity of HIV-1.

    abstract：:For successful penetration of HIV-1, the formation of a fusion pore may be required in order to accumulate critical numbers of fusion-activated gp41 with the help of fluidization of the plasma membrane and viral envelope. An increase in temperature to 40 degrees C after viral adsorption at 25 degrees C enhanced the in...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2007.08.021

    authors： Harada S,Monde K,Tanaka Y,Kimura T,Maeda Y,Yusa K

    更新日期：2008-01-05 00:00:00

  • Variability and genetic structure of the population of watermelon mosaic virus infecting melon in Spain.

    abstract：:The genetic structure of the population of Watermelon mosaic virus (WMV) in Spain was analysed by the biological and molecular characterisation of isolates sampled from its main host plant, melon. The population was a highly homogeneous one, built of a single pathotype, and comprising isolates closely related genetica...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2003.10.002

    authors： Moreno IM,Malpica JM,Díaz-Pendón JA,Moriones E,Fraile A,García-Arenal F

    更新日期：2004-01-05 00:00:00

  • Identification and characterization of a protein kinase-interacting protein encoded by the Autographa californica nuclear polyhedrosis virus.

    abstract：:We have used a yeast two-hybrid system to identify a baculoviral gene encoding a protein kinase-interacting protein (PKIP). The pkip gene is located at 15.8-16.2 m.u (map units) and represents ORF 24 in the sequence of Ayres et al. (1994) of the Autographa californica nuclear polyhedrosis virus. PKIP is a 19.2-kDa pro...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1997.8944

    authors： Fan X,McLachlin JR,Weaver RF

    更新日期：1998-01-20 00:00:00

  • Enhancement of dengue virus translation: role of the 3' untranslated region and the terminal 3' stem-loop domain.

    abstract：:An essential step for a productive infection by the dengue flavivirus (DEN) is translation of the m(7)G-capped, nonpolyadenylated positive-sense RNA genome. We have recently identified sequences within the DEN 3' untranslated region (UTR) that modulate viral translation. Here, we show that the DEN type 2 (DEN2) 3'UTR ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2004.08.004

    authors： Holden KL,Harris E

    更新日期：2004-11-10 00:00:00

  • Quantitative comparison of the HSV-1 and HSV-2 transcriptomes using DNA microarray analysis.

    abstract：:The genomes of human herpes virus type-1 and type-2 share a high degree of sequence identity; yet, they exhibit important differences in pathology in their natural human host as well as in animal host and cell cultures. Here, we report the comparative analysis of the time and relative abundance profiles of the transcr...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2005.12.036

    authors： Aguilar JS,Devi-Rao GV,Rice MK,Sunabe J,Ghazal P,Wagner EK

    更新日期：2006-04-25 00:00:00

  • Expression of the large 5'-proximal cistron of tobacco mosaic virus by 70 S ribosomes during cotranslational disassembly in a prokaryotic cell-free system.

    abstract：:In vitro translation of pH 8-washed particles of tobacco mosaic virus (TMV; vulgare, common, or U1 strain) in a cell-free system derived from Escherichia coli (MRE 600) results in a broad size range of TMV RNA-encoded products, including significant amounts of the distinctive 126-kDa polypeptide which is encoded by th...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(86)90394-6

    authors： Wilson TM

    更新日期：1986-07-15 00:00:00

  • Isolation and molecular characterization of a novel cytopathogenic paramyxovirus from tree shrews.

    abstract：:A cytopathic infectious agent was isolated from the kidneys of an apparently healthy tree shrew (Tupaia belangeri) that had been captured in the area around Bangkok. The infectivity was propagated in Tupaia fibroblast and kidney cell cultures. Paramyxovirus-like pleomorphic enveloped particles and helical nucleocapsid...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1999.9693

    authors： Tidona CA,Kurz HW,Gelderblom HR,Darai G

    更新日期：1999-06-05 00:00:00