Abstract:
:The superinfection exclusion of VSV has been studied and found to be caused by a combination of three distinct effects on endocytosis by VSV-infected cells: first, a decreased rate of formation of endocytic vesicles as judged by an inhibition of fluid-phase uptake at 2 hr postinfection; second, a decreased rate of internalization of receptor-bound ligands, which was detected at 4 hr postinfection; and third, a competition with newly synthesized virus for occupancy of coated pits, as indicated by electron microscopy of infected cells. At the same time that fluid-phase uptake decreased, numerous uncoated invaginations were observed at the cell surface.
journal_name
Virologyjournal_title
Virologyauthors
Simon KO,Cardamone JJ Jr,Whitaker-Dowling PA,Youngner JS,Widnell CCdoi
10.1016/0042-6822(90)90494-csubject
Has Abstractpub_date
1990-07-01 00:00:00pages
375-9issue
1eissn
0042-6822issn
1096-0341journal_volume
177pub_type
杂志文章相关文献
VIROLOGY文献大全abstract::The phosphorylation and transcriptional competence of the free cytoplasmic form and the virion form of NS protein of vesicular stomatitis virus (VSV-Indiana/Mudd-Summers) were compared. NS protein is known to exist in two distinct phosphorylated states, NS1 and NS2, that are resolvable by gel electrophoresis. In vitro...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(86)90452-6
更新日期:1986-10-30 00:00:00
abstract::The matrix (MA) proteins of human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) are known to be important for the targeting and assembly of lentiviral proteins. The objective of the present study was to determine whether the MA protein of HIV-1 was sufficient for particle assembly and r...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1998.9284
更新日期:1998-08-15 00:00:00
abstract::Feline foamy virus (FeFV) belongs to the group of spumaretroviruses that contain in addition to gag, pol, and env accessory genes collectively called bel genes. Primate FVs have been shown to utilize internal promoters in addition to the 5' LTR promoters. In contrast to other known retroviruses, the FV pol genes are e...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1998.9113
更新日期:1998-05-10 00:00:00
abstract::Genetic variation of the Bovine Leukemia Virus (BLV) appears to be limited in vitro and during the latent phase of the disease. However, cells in tumors often harbor deleted proviruses that are defective for expression. In order to gain insight into the involvement of viral genetic variation during pathogenesis, the B...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/s0042-6822(95)80007-7
更新日期:1995-01-10 00:00:00
abstract::Viral vector particles derived from murine leukemia virus (MLV) mediate highly efficient stable gene transfer used in gene therapeutic approaches and in the generation of transgenic cell lines. However, the establishment of stable viral packaging cells (VPCs) is a time-consuming challenge. To overcome this limitation,...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.02.014
更新日期:2019-05-01 00:00:00
abstract::In an attempt to develop an in vitro human cytomegalovirus (HCMV) latency model system, the growth characteristics of HCMV in a human thyroid papillary carcinoma cell line (TPC-1) were examined. When TPC-1 cultures preheated at 40.5 degrees for 48 hr were infected with HCMV and incubated at a supraoptimal temperature ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(87)90171-1
更新日期:1987-11-01 00:00:00
abstract::Molecular piracy is a biological phenomenon in which one replicon (the pirate) uses the structural proteins encoded by another replicon (the helper) to package its own genome and thus allow its propagation and spread. Such piracy is dependent on a complex web of interactions between the helper and the pirate that occu...
journal_title:Virology
pub_type: 杂志文章,评审
doi:10.1016/j.virol.2012.10.028
更新日期:2012-12-20 00:00:00
abstract::The utilization of transgenic plants expressing recombinant antigens to be used in the formulation of experimental immunogens has been recently communicated. We report here the development of transgenic plants of alfalfa expressing the structural protein VP1 of foot and mouth disease virus (FMDV). The presence of the ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1998.9590
更新日期:1999-03-15 00:00:00
abstract::Foot-and-mouth disease virus (FMDV) VP1 G-H loop contains the major antigenic site. By replacing the sequence upstream of the RGD motif with a FLAG epitope, a marker virus for pathogenesis studies was generated. In cell culture, the recombinant virus containing FLAG (A24-FLAG) exhibited similar plaque phenotypes and g...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2012.11.001
更新日期:2013-02-05 00:00:00
abstract::In this study, we show how the red spotted grouper nervous necrosis virus (RGNNV) causes loss of mitochondrial membrane potential and promotes host secondary apoptotic necrosis. RGNNV viral proteins such as protein alpha (42 kDa) and protein A (110 kDa) were quickly expressed between 12 h and 24 h postinfection (p.i.)...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2005.11.052
更新日期:2006-04-10 00:00:00
abstract::A stem-loop structure, formed by a pair of inverted repeats during DNA replication, is a conserved feature at the origin of DNA replication among plant and animal viruses, bacteriophages and plasmids that replicate their genomes via the rolling-circle replication (RCR) mechanism. In this work, a head-to-tail tandem co...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2007.01.017
更新日期:2007-06-20 00:00:00
abstract::The Pr76Gag and Pr180Gag-Pol polyprotein precursors of Rous sarcoma virus contain a 22-amino-acid spacer peptide, called p2, located between the amino acid sequences of the mature Gag proteins MA and p10. This spacer peptide is present in stoichiometric amounts in the virion, albeit cleaved into two parts, but its fun...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1994.1450
更新日期:1994-08-15 00:00:00
abstract::A pseudorabies virus (PrV) mutant, deficient in the nonessential glycoprotein E (gE) and expressing the LacZ gene (gE- beta gal+ PrV), and its rescued virus were inoculated intranasally in mice. The median lethal dose of gE- beta gal+ PrV was similar to that of the parental Kaplan strain, but mice survived longer and ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1996.0247
更新日期:1996-05-01 00:00:00
abstract::Infectious bronchitis virus (IBV) infection and associated illness may be dramatically modified by passive transfer of immune T lymphocytes. Lymphocytes collected 10 days postinfection were transferred to naive chicks before challenge with virus. As determined by respiratory illness and viral load, transfer of syngene...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2000.0211
更新日期:2000-03-30 00:00:00
abstract::Human cytomegalovirus (HCMV) was recently shown to encode a large number of spliced mRNAs. While the nuclear export of unspliced viral transcripts has been extensively studied, the role of host mRNA export factors in HCMV mRNA trafficking remains poorly defined. We found that the eIF4AIII RNA helicase, a component of ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.12.009
更新日期:2016-02-01 00:00:00
abstract::Coronavirus E protein is a small viral envelope protein that plays an essential role in coronavirus assembly; coexpression of coronavirus M and E proteins results in the production of virus-like particles. The present study demonstrated that mouse hepatitis virus (MHV) E protein was released as an integral membrane pr...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1999.9955
更新日期:1999-10-25 00:00:00
abstract::Female BALB/c mice were infected with coxsackievirus B3 in the diestrus, proestrus, estrus, or metestrus phases of the ovarian cycle. Cycle stage was determined by vaginal smear. All mice were killed 7 days after infection. Females infected in the diestrus and especially the proestrus phases developed myocarditis. CD4...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2004.06.051
更新日期:2004-12-05 00:00:00
abstract::In this study we have used an expression system based on Semliki Forest virus (SFV) to study assembly and intracellular localization of certain capsid proteins of rotavirus in neurons and mammalian epithelial cells. The complete genes of vp2 (vp2A) and vp6 (vp6A) of group A rotavirus (SA-11) and gene 5 encoding vp6 (v...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1997.8987
更新日期:1998-03-15 00:00:00
abstract::Segmented genomes of RNA viruses are thought to evolve and be maintained in analogy to sexual recombination and reassortment in eukaryotic systems. If reassortment among genomes is an important event in cucumoviral evolution, then such events should be detectable among extant viruses. In this study, phylogenetic analy...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1995.1088
更新日期:1995-02-20 00:00:00
abstract::The HIV-1 accessory gene product Vpr can inhibit cell proliferation via cell cycle arrest at the G(2) phase, and it can induce apoptosis after G(2) arrest. We found recently that C81, a carboxy-terminally truncated form of Vpr, induced apoptosis via G(1) arrest but did not induce G(2) arrest of the cell cycle. Thus, i...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2000.0534
更新日期:2000-10-10 00:00:00
abstract::Rift Valley fever virus-induced protein synthesis was examined by polyacrylamide gel electrophoresis and fluorography. Five virus-induced polypeptides were detected, the nucleocapsid protein N, the nucleus-associated nonstructural protein NS1, the glycoproteins G1 and G2, and a protein of molecular weight 80K. The N, ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(84)90277-0
更新日期:1984-04-15 00:00:00
abstract::Analogous to transmission of human T-cell leukemia virus type 1 (HTLV-1) in vivo, an in vitro cell-to-cell infection model was established by coculturing MT-2 cells as virus donors and HUT78 cells as recipients. At a donor:recipient ratio of 1:2, cell fusion occurred and a new round of HTLV-1 genome replication was in...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1998.9111
更新日期:1998-05-10 00:00:00
abstract::The cowpea strain of Southern bean mosaic virus (SBMV-C), a T = 3 icosahedral RNA virus, was dissociated to yield a ribonucleoprotein complex (RNPC) composed of the viral RNA and coat protein subunits. To determine if the coat protein subunits were bound to a specific site on the viral RNA, the RNPC was treated with r...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1995.1117
更新日期:1995-03-10 00:00:00
abstract::The protruding (P) domain of norovirus VP1 is responsible for immune recognition and host receptor interaction. Our previous studies have demonstrated that a modification of the ends of the P domain affects the conformation and/or function of the P protein. An expression of the P domain with or without the hinge, or w...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2010.11.017
更新日期:2011-02-20 00:00:00
abstract::We have investigated a novel strategy for coexpressing two genes from a retroviral vector. The 5' nontranslated leader region of at least some picornavirus RNAs contains a sequence that can act as an internal ribosome entry site allowing initiation of translation at a downstream AUG codon in a 5' cap-independent manne...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(92)90033-l
更新日期:1992-02-01 00:00:00
abstract::Ribavirin is the first synthetic, broad-spectrum antiviral nucleoside. Despite its more than 30 year history, the mechanism of action of this compound remains unclear and somewhat controversial. Recent data suggest the possibility that the activity of ribavirin against RNA viruses is a reflection of incorporation of r...
journal_title:Virology
pub_type: 杂志文章,评审
doi:10.1006/viro.2002.1487
更新日期:2002-07-05 00:00:00
abstract::To study the possible role of immune selection in the in vivo generation of pathogenic recombinant murine leukemia viruses (MuLV), we have constructed recombinant vaccinia viruses (rVV) expressing the envelope genes of three MuLV: AKR623, MCF247, and MCF13. rVV expressing either AKR623 or MCF247 env could prime H-2b m...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1994.1370
更新日期:1994-07-01 00:00:00
abstract::The influenza A virus nucleoprotein previously expressed in Escherichia coli after fusion to 32 heterologous amino acids has now been purified and tested for its ability to form complexes with RNA in vitro. By using a simple filter binding assay, we show that ribonucleoprotein (RNP) complexes form readily with single-...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(87)90419-3
更新日期:1987-02-01 00:00:00
abstract::Two tick-borne encephalitis (TBE) virus variants were studied: mouse brain-adapted strain EK-328 and its derivate adapted to Hyalomma marginatum ticks. The tick-adapted virus exhibited small-plaque phenotype and slower replication in PEK cells, higher yield in ticks, decreased neuroinvasiveness in mice, increased bind...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2006.12.013
更新日期:2007-05-25 00:00:00
abstract::The human hepatitis B Virus genome (HBV) contains a liver-specific enhancer upstream of the X ORF which has been studied in detail by several investigators. A second liver-specific enhancer element, designated here as enhancer II, has been relatively recently described in the HBV genome, which is located within the co...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(91)91019-d
更新日期:1991-08-01 00:00:00