Abstract:
:The genomes of human herpes virus type-1 and type-2 share a high degree of sequence identity; yet, they exhibit important differences in pathology in their natural human host as well as in animal host and cell cultures. Here, we report the comparative analysis of the time and relative abundance profiles of the transcription of each virus type (their transcriptomes) using parallel infections and microarray analysis using HSV-1 probes which hybridize with high efficiency to orthologous HSV-2 transcripts. We have confirmed that orthologous transcripts belong to the same kinetic class; however, the temporal pattern of accumulation of 4 transcripts (U(L)4, U(L)29, U(L)30, and U(L)31) differs in infections between the two virus types. Interestingly, the protein products of these transcripts are all involved in nuclear organization and viral DNA localization. We discuss the relevance of these findings and whether they may have potential roles in the pathological differences of HSV-1 and HSV-2.
journal_name
Virologyjournal_title
Virologyauthors
Aguilar JS,Devi-Rao GV,Rice MK,Sunabe J,Ghazal P,Wagner EKdoi
10.1016/j.virol.2005.12.036subject
Has Abstractpub_date
2006-04-25 00:00:00pages
233-41issue
1eissn
0042-6822issn
1096-0341pii
S0042-6822(05)00847-0journal_volume
348pub_type
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