Induction of necrosis via mitochondrial targeting of Melon necrotic spot virus replication protein p29 by its second transmembrane domain.

abstract：:Differing reports exist about the replication of human enteric adenoviruses (EnAds) in various cell lines. There was a suggestion that EnAds are defective, do not grow on primary human diploid cells, and behave like Ad host-range mutants, i.e., they require early gene products from other Ad types for efficient growth....

journal_title：Virology

authors： Pieniazek D,Pieniazek NJ,Macejak D,Coward J,Rayfield M,Luftig RB

更新日期：1990-01-01 00:00:00

abstract：:The location of the RNA start point of in vivo Q-activated late gene RNA of bacteriophage lambda has been determined to be identical to the start point of in vitro 6 S RNA. The 6 S RNA is made early in infection and is efficiently antiterminated by Q. Two RNase III cut sites are located within Q-dependent RNA sequence...

journal_title：Virology

authors： Daniels DL,Subbarao MN,Blattner FR,Lozeron HA

更新日期：1988-12-01 00:00:00

abstract：:Poliovirus type 1 was isolated from an immunodeficient patient 4 days after onset of paresis (IS1) and after 5.5 years of prolonged enteral virus replication (IS2). Antigenic characterization revealed that IS1 was Sabin 1-like, whereas IS2 reacted like poliovirus 1 Mahoney. Complete genomic sequencing demonstrated the...

journal_title：Virology

authors： Bellmunt A,May G,Zell R,Pring-Akerblom P,Verhagen W,Heim A

更新日期：1999-12-20 00:00:00

abstract：:The longest hepatitis B virus transcript is a 3.9-kb mRNA whose function remained unclear. In this study, we wished to identify the translation products and physiological role of this viral transcript. This transcript initiates from the X promoter region ignoring the inefficient and noncanonical viral polyadenylation ...

journal_title：Virology

authors： Doitsh G,Shaul Y

更新日期：2003-05-10 00:00:00

abstract：:The prototypic macrophage-tropic HIV-1 isolate, HIV-1BaL, cannot replicate in the monocytoid cell line THP-1. After induction of differentiation by a phorbol diester, a fraction of THP-1 cells became permissive to HIV-1BaL. In contrast, this treatment decreased permissiveness for the lymphotropic isolate HIV-1LAI. Vir...

journal_title：Virology

authors： Meylan PR,Spina CA,Richman DD,Kornbluth RS

更新日期：1993-03-01 00:00:00

abstract：:The equine herpesvirus 1 (EHV-1) immediate-early (IE) phosphoprotein is essential for the activation of transcription from viral early and late promoters and regulates transcription from its own promoter. The IE protein of 1487 amino acids contains a serine-rich tract (SRT) between residues 181 and 220. Deletion of th...

journal_title：Virology

authors： Kim SK,Buczynski KA,Caughman GB,O'Callaghan DJ

更新日期：2001-01-05 00:00:00

abstract：:The nucleotide sequence of the P gene of human parainfluenza virus type 1 (hPIV1) strain C35 was determined directly from genomic viral RNA and by molecular cloning. The gene contained 1893 nucleotides. Four open reading frames (ORF) capable of encoding a P protein (568 amino acids; M(r) = 64,784), a C' protein (219 a...

journal_title：Virology

authors： Power UF,Ryan KW,Portner A

更新日期：1992-07-01 00:00:00

abstract：:Viruses that establish latent infection must maintain their DNA in the host nucleus through many cellular generations. Here we identify a novel mechanism by which the gammaherpesvirus Kaposi's sarcoma-associated herpesvirus (KSHV) may achieve this persistence in latently infected body cavity-based lymphoma (BCBL) cell...

journal_title：Virology

authors： Cotter MA 2nd,Robertson ES

更新日期：1999-11-25 00:00:00

abstract：:The co-existence of hepatitis B surface antigen (HBsAg) and anti-HBs antibodies (HBsAb) in serum of hepatitis B virus (HBV)-chronic carriers has been previously associated with HBsAg-amino acid (aa) substitutions. However, the aa pattern of HBV-reverse transcriptase (RT) and the clinical settings associated with this ...

journal_title：Virology

authors： Colson P,Borentain P,Motte A,Henry M,Moal V,Botta-Fridlund D,Tamalet C,Gérolami R

更新日期：2007-10-10 00:00:00

abstract：:Murine monoclonal antibodies were developed against the protein products produced by murine C127 cells which had been transfected with a recombinant plasmid clone containing the human T-cell leukemia (lymphotropic) virus type I (HTLV-I) proviral DNA coding regions for part of env, px, and the 3' LTR. Four antibodies w...

journal_title：Virology

authors： Newman MJ,Baker IT,Reitz MS,Eiden M,Blattner WA,Gallo RC,Mann DL

更新日期：1986-04-15 00:00:00

abstract：:We examined the kinetics of membrane fusion of wild type (wt) and Delta6K mutant Semliki Forest virus in a liposomal model system. The final extent of membrane fusion of the mutant (at pH 5.5) was approximately one third that of the wt virus, although the level of E1 (fusion protein) trimerization was, in fact, greate...

journal_title：Virology

authors： McInerney GM,Smit JM,Liljeström P,Wilschut J

更新日期：2004-08-01 00:00:00

abstract：:In the present study, 10 clinical isolates of dengue virus were selected according to their susceptibility to the inhibitory effect of nitric oxide radical, NO. Five of them are nitric oxide-susceptible viruses while the other five are nitric oxide-resistant viruses. These isolates were investigated to identify geneti...

journal_title：Virology

authors： Ubol S,Chareonsirisuthigul T,Kasisith J,Klungthong C

更新日期：2008-07-05 00:00:00

abstract：:The influenza RNA polymerase is known to be important in pathogenicity and adaptation of avian influenza viruses to mammalian hosts. However, the molecular mechanisms responsible are only partly understood. Here we investigated the role of the polymerase in two different, closely related, H5N1 influenza viruses - a hi...

journal_title：Virology

authors： Leung BW,Chen H,Brownlee GG

更新日期：2010-05-25 00:00:00

abstract：:Tissues from Australian brushtail possums (Trichosurus vulpecula) that had been experimentally infected with wobbly possum disease (WPD) virus (WPDV) were examined to elucidate pathogenesis of WPDV infection. Mononuclear inflammatory cell infiltrates were present in livers, kidneys, salivary glands and brains of WPD-a...

journal_title：Virology

authors： Giles J,Perrott M,Roe W,Shrestha K,Aberdein D,Morel P,Dunowska M

更新日期：2018-09-01 00:00:00

abstract：:A non-plaque-forming vaccine strain of NDV (NDV-B1) interferes with the infection of cultured chick embryo cells by the virulent plaque-forming NDV-L strain. The level of interference increases when the concentration of interfering virus is increased or when the time between infection and superinfection is increased. ...

journal_title：Virology

authors： Bratt MA,Rubin H

更新日期：1967-12-01 00:00:00

abstract：:Re-emergence of ZIKV has caused infections in more than 1.5 million people. The molecular mechanism and pathogenesis of ZIKV is not well explored due to unavailability of adequate model and lack of publically accessible resources to provide information of ZIKV-Human protein interactome map till today. This study made ...

journal_title：Virology

authors： Gurumayum S,Brahma R,Naorem LD,Muthaiyan M,Gopal J,Venkatesan A

更新日期：2018-01-15 00:00:00

abstract：:When effector CD4+ T cells carrying integrated HIV-1 proviruses revert back to a resting memory state, the virus can remain silent in those cells for years. Following re-exposure to the nominal antigen or in response to other stimuli (e.g. pro-inflammatory cytokines), these cells can begin to produce virus. Here we de...

journal_title：Virology

authors： Thibault S,Imbeault M,Tardif MR,Tremblay MJ

更新日期：2009-06-20 00:00:00

abstract：:We have used a yeast two-hybrid system to identify a baculoviral gene encoding a protein kinase-interacting protein (PKIP). The pkip gene is located at 15.8-16.2 m.u (map units) and represents ORF 24 in the sequence of Ayres et al. (1994) of the Autographa californica nuclear polyhedrosis virus. PKIP is a 19.2-kDa pro...

journal_title：Virology

authors： Fan X,McLachlin JR,Weaver RF

更新日期：1998-01-20 00:00:00

abstract：:Human herpesvirus 6 (HHV-6) glycoprotein B (gB) is an abundantly expressed viral glycoprotein required for viral entry and cell fusion, and is highly conserved among herpesviruses. The present study examined the function of HHV-6 gB cytoplasmic tail domain (CTD). A gB CTD deletion mutant was constructed which, in cont...

journal_title：Virology

authors： Mahmoud NF,Jasirwan C,Kanemoto S,Wakata A,Wang B,Hata Y,Nagamata S,Kawabata A,Tang H,Mori Y

更新日期：2016-03-01 00:00:00

abstract：:DNA obtained from New Zealand white rabbit oral papillomas was analyzed for the presence of papillomavirus DNA. The viral genome was cloned as three separate subclones, which were each mapped and oriented with respect to one another. Comparisons with other papillomavirus DNAs by Southern blot hybridization under vario...

journal_title：Virology

authors： O'Banion MK,Cialkowski ME,Reichmann ME,Sundberg JP

更新日期：1988-01-01 00:00:00

abstract：:The replicative form (RF) of spiroplasma virus 4 (SpV4) has been purified from infected cells of Spiroplasma melliferum strain G1 by alkaline lysis followed by low melting point agarose gel electrophoresis. A partial restriction map has been established. The circular RF was linearized by cutting at the unique ClaI res...

journal_title：Virology

authors： Pascarel-Devilder MC,Renaudin J,Bove JM

更新日期：1986-06-01 00:00:00

abstract：:Naturally occurring mutations in Human T-cell Leukemia Virus Type 1 (HTLV-1) Tax protein lead to loss of recognition by cytotoxic T-lymphocytes. Most of these mutations also abolish or severely impair the transactivation function of Tax. Ninety percent of the rex gene, which encodes the viral regulator of mRNA splicin...

journal_title：Virology

authors： Smith RE,Niewiesk S,Booth S,Bangham CR,Daenke S

更新日期：1997-10-27 00:00:00

abstract：:We have used a yeast two-hybrid system to show that human papillomavirus E7 proteins can form oligomeric complexes in vivo. The carboxyl-terminal cysteine-rich metal-binding domain is critical for this activity although amino-terminal sequences also contribute to oligomerization. Our experiments also reveal that E7 po...

journal_title：Virology

authors： Clemens KE,Brent R,Gyuris J,Münger K

更新日期：1995-12-01 00:00:00

abstract：:Marek's disease virus (MDV) is a representative alpha herpes virus able to induce rapid-onset T-cell lymphoma in its natural host and regarded as an ideal model for the study of virus-induced tumorigenesis. Recent studies have shown that the mdv1-miR-M4-5p, a viral analog of cellular miR-155, is critical for MDV׳s onc...

journal_title：Virology

authors： Chi JQ,Teng M,Yu ZH,Xu H,Su JW,Zhao P,Xing GX,Liang HD,Deng RG,Qu LH,Zhang GP,Luo J

更新日期：2015-02-01 00:00:00

abstract：:HCV culture in vitro results in massive cell death, which suggests the presence of HCV-induced cytopathic effects. Therefore, we investigated its mechanisms and viral nucleotide sequences involved in this effect using HCV-JFH1 cell culture and a newly developed HCV plaque assay technique. The plaque assay developed cy...

journal_title：Virology

authors： Sekine-Osajima Y,Sakamoto N,Mishima K,Nakagawa M,Itsui Y,Tasaka M,Nishimura-Sakurai Y,Chen CH,Kanai T,Tsuchiya K,Wakita T,Enomoto N,Watanabe M

更新日期：2008-02-05 00:00:00

abstract：:A recombinant vaccinia virus that expresses the nucleoprotein gene of Lassa virus (Josiah strain) under the control of the P7.5 promoter was constructed using the lacZ coexpression transfer vector pSC11. Southern blot analysis demonstrated that recombination of the sequences inserted within the thymidine kinase gene o...

journal_title：Virology

authors： Morrison HG,Bauer SP,Lange JV,Esposito JJ,McCormick JB,Auperin DD

更新日期：1989-07-01 00:00:00

abstract：:The tail sheath protein of giant bacteriophage phiKZ Pseudomonas aeruginosa encoded by gene 29 was identified and its expression system was developed. Localization of the protein on the virion was confirmed by immunoelectron microscopy. Properties of gene product (gp) 29 were studied by electron microscopy, immunoblot...

journal_title：Virology

authors： Kurochkina LP,Aksyuk AA,Sachkova MY,Sykilinda NN,Mesyanzhinov VV

更新日期：2009-12-20 00:00:00

abstract：:Successful HIV-1 infection requires a number of specific stages leading to integration of the provirus. We previously suggested that members of the VPAC neuroendocrine receptor family may play a role in HIV-1 infection. We now show that stimulation of the VPAC2 receptor with specific agonists provides strong resistanc...

journal_title：Virology

authors： Bokaei PB,Ma XZ,Sakac D,Branch DR

更新日期：2007-05-25 00:00:00

abstract：:It has been widely demonstrated that the human immunodeficiency virus type 1 (HIV-1) envelope, specifically the V3 loop of the gp120 spike, evolves to facilitate adaptation to different cellular populations within an infected host. Less energy has been directed at determining whether the viral promoter, designated the...

journal_title：Virology

authors： McAllister JJ,Phillips D,Millhouse S,Conner J,Hogan T,Ross HL,Wigdahl B

更新日期：2000-09-01 00:00:00

abstract：:Using reverse genetics methods, we constructed three different transfectant influenza A viruses encoding an Ld-restricted, nine amino-acid-long fragment, corresponding to amino-acid residues 876-884, of beta-galactosidase (beta-gal). Sequences encoding this epitope were nested within the hemagglutinin (HA) or neuramin...

journal_title：Virology

authors： Restifo NP,Surman DR,Zheng H,Palese P,Rosenberg SA,García-Sastre A

更新日期：1998-09-15 00:00:00