Specific interference among strains of Newcastle disease virus. I. Demonstration and measurement of the interference.

abstract：:The 5' untranslated region (5'UTR) of coxsackievirus B3 (CVB3) RNA forms a highly ordered secondary structure that has been implicated in controlling initiation of viral translation by internal ribosomal entry. To test this hypothesis, synthetic bicistronic RNAs, with all or part of the 5'UTR in the intercistronic spa...

journal_title：Virology

authors： Yang D,Wilson JE,Anderson DR,Bohunek L,Cordeiro C,Kandolf R,McManus BM

更新日期：1997-02-03 00:00:00

abstract：:Genetically engineered mice with targeted mutations in genes encoding immunologically relevant molecules were used to elucidate the role of different immune effector mechanisms in protection against a rabies virus (RV) infection. In vaccinated animals challenged with a highly virulent strain of RV, antibodies were cru...

journal_title：Virology

authors： Xiang ZQ,Knowles BB,McCarrick JW,Ertl HC

更新日期：1995-12-20 00:00:00

abstract：:Expression of foreign peptides on the surface of cowpea mosaic virus particles leads to the creation of chimaeras with a variety of phenotypes and yields. Two factors were shown to be particularly significant in determining the properties of a given chimaera: the length of the inserted sequence and its isoelectric poi...

journal_title：Virology

authors： Porta C,Spall VE,Findlay KC,Gergerich RC,Farrance CE,Lomonossoff GP

更新日期：2003-05-25 00:00:00

abstract：:Replication and transmission of avian influenza virus in humans poses a pandemic threat. The molecular determinants that facilitate this process are not well understood. We used DBA/2 mice to identify viral factors that mediate the difference in pathogenesis between a virulent (H7N3) and a non-virulent (H7N9) avian in...

journal_title：Virology

authors： DesRochers BL,Chen RE,Gounder AP,Pinto AK,Bricker T,Linton CN,Rogers CD,Williams GD,Webby RJ,Boon AC

更新日期：2016-07-01 00:00:00

abstract：:In HSV types 1 and 2, gH forms a noncovalent heterodimer with gL. Previous studies demonstrated that the first 323 amino acids of gH1 and the first 161 amino acids of gL1 are sufficient for gH/gL binding. For gL1, substitution of any of its four cysteine (C) residues (all located within the gH/gL binding region) destr...

journal_title：Virology

authors： Cairns TM,Landsburg DJ,Whitbeck JC,Eisenberg RJ,Cohen GH

更新日期：2005-02-20 00:00:00

abstract：:Vaccinia virus gene D12L, which lies between nucleotides 14,350 and 13,487 in the HindIII D fragment, is transcribed at early times in infection and is capable of encoding a protein 287 amino acids in length with a predicted molecular mass of 33,331. A polyclonal antiserum was raised in rabbits to a fusion protein con...

journal_title：Virology

authors： Niles EG,Lee-Chen GJ,Shuman S,Moss B,Broyles SS

更新日期：1989-10-01 00:00:00

abstract：:Recent interest focused on the dynamics of HIV-1 replication in primary monocytes/macrophages and T-lymphocytes of the immune system, as well as the standardization of virological and immunological in vitro assays with primary isolates, provided the impetus for these studies. These types of studies have never been per...

journal_title：Virology

authors： Tsai WP,Conley SR,Kung HF,Garrity RR,Nara PL

更新日期：1996-12-15 00:00:00

abstract：:The adenovirus (Ad) single-stranded DNA binding protein (DBP) is a multifunctional protein. It is thought to consist of two domains, the amino-terminal domain involved in host-range determination and the carboxyl-terminal domain functioning in DNA replication and DNA binding. We have determined the nucleotide sequence...

journal_title：Virology

authors： Vos HL,van der Lee FM,Reemst AM,van Loon AE,Sussenbach JS

更新日期：1988-03-01 00:00:00

abstract：:Functions of the coat protein of white clover mosaic potexvirus (WCIMV) were investigated using C-terminal deletion mutants. Whereas plants inoculated with RNA transcripts of a full-length wild-type clone of WCIMV produced typical infections, plants inoculated with transcripts of each mutant did not produce symptoms, ...

journal_title：Virology

authors： Forster RL,Beck DL,Guilford PJ,Voot DM,Van Dolleweerd CJ,Andersen MT

更新日期：1992-11-01 00:00:00

abstract：:The host-virus interaction during the cellular entry of Japanese encephalitis virus (JEV) is poorly characterized. The ubiquitin-proteasome system (UPS), the major intracellular proteolytic pathway, mediates diverse cellular processes, including endocytosis and signal transduction, which may be involved in the entry o...

journal_title：Virology

authors： Wang S,Liu H,Zu X,Liu Y,Chen L,Zhu X,Zhang L,Zhou Z,Xiao G,Wang W

更新日期：2016-11-01 00:00:00

abstract：:Bovine immunodeficiency-like virus (BIV) is a recently identified lentivirus that infects cattle. The virus has structural and genetic similarities to human HIV. The present study demonstrates that BIV can be activated by bovine herpesvirus type 1 (BHV-1), a pathogen frequently associated with cattle diseases. Activat...

journal_title：Virology

authors： Geng Y,Kashanchi F,Wood C

更新日期：1992-04-01 00:00:00

abstract：:The allele Pp of gene ref(2)P of Drosophila melanogaster is known to inhibit the multiplication of certain strains of Sigma virus. From a viral strain for which the allele PP of ref(2)P is nonpermissive, host adapted (haP) mutants were selected after mutagenesis in vivo. Mutagenized virus was extracted from infected f...

journal_title：Virology

authors： Contamine D

更新日期：1981-10-31 00:00:00

abstract：:This report presents a procedure for evaluating the relative affinities of simple sialoside receptor determinants for their interaction with the receptor binding pocket of the influenza virus hemagglutinin. The virus examined was A/Memphis/102/72, previously shown to exhibit preferential binding specificity for enzyma...

journal_title：Virology

authors： Pritchett TJ,Brossmer R,Rose U,Paulson JC

更新日期：1987-10-01 00:00:00

abstract：:The sequence of gene VI from figwort mosaic virus (FMV) clone x4 was determined and compared with that previously published for FMV clone DxS. Both clones originated from the same virus isolation, but the virus used to clone DxS was propagated extensively in a host of a different family prior to cloning whereas that u...

journal_title：Virology

authors： Sanger M,Daubert S,Goodman RM

更新日期：1991-06-01 00:00:00

abstract：:During abortive infection of Go/G1-arrested primary baby mouse kidney (BMK) cell cultures with simian virus 40 (SV40), expression of the viral large T antigen is followed by a mitotic host response including the stimulation of host macromolecular synthesis and induction into the cell cycle of Go/G1-arrested cells. We ...

journal_title：Virology

authors： Duthu A,Ehrhart JC,Benchimol S,Chandrasekaran K,May P

更新日期：1985-12-01 00:00:00

abstract：:The open reading frame of the large subunit (R1) of herpes simplex virus type 1 (HSV-1) ribonucleotide reductase has been positioned downstream of the phage T7 gene 10 promoter in the expression vector, pET. Transformation of this recombinant plasmid into Escherichia coli BL21 DE3 cells containing the T7 RNA polymeras...

journal_title：Virology

authors： Furlong J,Conner J,McLauchlan J,Lankinen H,Galt C,Marsden HS,Clements JB

更新日期：1991-06-01 00:00:00

abstract：:Zika virus (ZIKV) nonstructural protein 5 (NS5) is a multifunctional protein possessing methyltransferase and RNA-dependent RNA polymerase activities. In the present study, we have carried out an extensive mutagenesis analysis to determine the importance of nuclear localization sequences (NLS) of NS5 in its nuclear ac...

journal_title：Virology

authors： Ji W,Luo G

更新日期：2020-02-01 00:00:00

abstract：:Bacteriophage T4 tails contain a set of extended protein molecules in the central channel of the tail tube through which the DNA must exit during infection. Treatment of tails with guanidine hydrochloride separates the baseplates, leaving the tail tube and several specific tube-associated proteins. Methods were develo...

journal_title：Virology

authors： Duda RL,Gingery M,Eiserling FA

更新日期：1986-06-01 00:00:00

abstract：:The simian virus 40 (SV40) large T antigen was used as an immunogenic vector to express a herpes simplex virus type 1 (HSV-1) glycoprotein B (gB), H-2Kb-restricted cytotoxic T lymphocyte (CTL) recognition epitope corresponding to amino acid residues 498-505. Immunization of naive, C57BL/6 mice with a cell line, B6/350...

journal_title：Virology

authors： Bonneau RH,Fu TM,Tevethia SS

更新日期：1993-12-01 00:00:00

abstract：:Spontaneous proteolysis of influenza virus M1 protein during crystallisation has defined an N-terminal domain of amino acids 1--164. Full-length M1, the N-terminal domain, and the C-terminal part of M1 (residues 165--252) were produced in Escherichia coli. In vitro tests showed that only full-length M1 and its N-termi...

journal_title：Virology

authors： Baudin F,Petit I,Weissenhorn W,Ruigrok RW

更新日期：2001-03-01 00:00:00

abstract：:Among 489 bats of 11 species in China, three novel paramyxoviruses [Tuhokovirus 1, 2 and 3 (ThkPV-1, ThkPV-2 and ThkPV-3)] were discovered in 15 Leschenault's rousettes. Phylogenetically, the three viruses are most closely related to Menangle and Tioman virus. Genome analysis showed that their 3'-leader sequences are ...

journal_title：Virology

authors： Lau SK,Woo PC,Wong BH,Wong AY,Tsoi HW,Wang M,Lee P,Xu H,Poon RW,Guo R,Li KS,Chan KH,Zheng BJ,Yuen KY

更新日期：2010-08-15 00:00:00

abstract：:Hepatitis A virus infection and growth in cultured cells is protracted, cell-type restricted, and generally not accompanied by the appearance of a cytopathic effect, with the exception of some culture-adapted strains. We demonstrate that the non-cytopathic HAV strain HM175/clone 1 can be induced to exhibit a cytopathi...

journal_title：Virology

authors： Wales SQ,Ngo D,Hida K,Kulka M

更新日期：2012-08-15 00:00:00

abstract：:Human cytomegalovirus (HCMV) was recently shown to encode a large number of spliced mRNAs. While the nuclear export of unspliced viral transcripts has been extensively studied, the role of host mRNA export factors in HCMV mRNA trafficking remains poorly defined. We found that the eIF4AIII RNA helicase, a component of ...

journal_title：Virology

authors： Ziehr B,Lenarcic E,Cecil C,Moorman NJ

更新日期：2016-02-01 00:00:00

abstract：:Rice dwarf virus (RDV) spreads, along actin-based filopodia, as one of the ways of its transport, from infected to non-infected cells of its vector insect via tubules that are composed of the viral nonstructural protein Pns10 and contain viral particles. An inhibitor that perturbs the endomembrane system, namely, bref...

journal_title：Virology

authors： Wei T,Shimizu T,Omura T

更新日期：2008-03-15 00:00:00

abstract：:High-risk human papillomaviruses (HPVs) are etiologically implicated in human cervical cancer. Two viral genes, E6 and E7, are commonly found expressed in these cancer cells. We have previously shown that mice transgenic for the HPV-16 E6 gene or E7 gene, in which the E6 or E7 was expressed in the basal layer of epith...

journal_title：Virology

authors： Song S,Liem A,Miller JA,Lambert PF

更新日期：2000-02-15 00:00:00

abstract：:Flavivirus infection as dengue and yellow fever persists as a terrible menace to pandemics, due to Aedes prevalence in the Americas. Yellow fever is characterized by hepatocyte damage, with steatosis, apoptosis and necrosis, mainly in the midzonal region of the liver, but the injury mechanism has not been studied at t...

journal_title：Virology

authors： Quaresma JA,Barros VL,Pagliari C,Fernandes ER,Guedes F,Takakura CF,Andrade HF Jr,Vasconcelos PF,Duarte MI

更新日期：2006-02-05 00:00:00

abstract：:Intact clones containing partial repeats of the genomic components of African cassava mosaic (ACMV DNAs A and B) are infectious when mechanically coinoculated onto Nicotiana benthamiana. Monomeric genomic components may be generated either by homologous recombination or, when two copies of the origin of replication (o...

journal_title：Virology

authors： Stanley J

更新日期：1995-01-10 00:00:00

abstract：:To investigate the mode of gene expression of red clover mottle virus (RCMV) middle component (M) RNA, we have synthesized an oligopeptide corresponding to the predicted carboxy-terminus of the RCMV counterparts of the cowpea mosaic virus (CPMV) 48K and 58K proteins. Using an antiserum raised against this synthetic ol...

journal_title：Virology

authors： Shanks M,Tomenius K,Clapham D,Huskisson NS,Barker PJ,Wilson IG,Maule AJ,Lomonossoff GP

更新日期：1989-12-01 00:00:00

abstract：:Mutations disrupting helicase domain motifs of the Tobacco mosaic virus 126/183-kDa proteins were investigated for their effect on replicase function and assembly. These mutations inhibited virus replication but did not affect 126-kDa induced N gene resistance or RNAi suppression. However, in vivo expressed 126-kDa mo...

journal_title：Virology

authors： Wang X,Kelman Z,Culver JN

更新日期：2010-07-05 00:00:00

abstract：:Recently, we reported that PrP(Sc), a surrogate marker for prion disease, is associated with the cellular fraction of blood from scrapie-infected sheep using a ligand-based immunoassay. In the study reported here, we found that a subset of peripheral blood mononuclear cells is most likely to sequester PrP(Sc) during b...

journal_title：Virology

authors： Edwards JC,Moore SJ,Hawthorn JA,Neale MH,Terry LA

更新日期：2010-09-15 00:00:00