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The ubiquitin-proteasome system is essential for the productive entry of Japanese encephalitis virus.

Abstract：

:The host-virus interaction during the cellular entry of Japanese encephalitis virus (JEV) is poorly characterized. The ubiquitin-proteasome system (UPS), the major intracellular proteolytic pathway, mediates diverse cellular processes, including endocytosis and signal transduction, which may be involved in the entry of virus. Here, we showed that the proteasome inhibitors, MG132 and lactacystin, impaired the productive entry of JEV by effectively interfering with viral intracellular trafficking at the stage between crossing cell membrane and the initial translation of the viral genome after uncoating. Using confocal microscopy, it was demonstrated that a proportion of the internalized virions were misdirected to lysosomes following treatment with MG132, resulting in non-productive entry. In addition, using specific siRNAs targeting ubiquitin, we verified that protein ubiquitination was involved in the entry of JEV. Overall, our study demonstrated the UPS is essential for the productive entry of JEV and might represent a potential antiviral target for JEV infection.

journal_name

Virology

journal_title

Virology

authors

Wang S,Liu H,Zu X,Liu Y,Chen L,Zhu X,Zhang L,Zhou Z,Xiao G,Wang W

doi

10.1016/j.virol.2016.08.013

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

116-127

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(16)30220-3

journal_volume

498

pub_type

杂志文章

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