Abstract:
:The members of the c-myb proto-oncogene family encode sequence-specific transcriptional activators. In T cells, expression of c-myb and the related B-myb gene is induced following mitogenic stimulation. Using a purified recombinant protein, we report here that the human T cell lymphotropic virus type 1 (HTLV-1) LTR contains six specific binding sites for Myb. We also show that HTLV-1 LTR chloramphenicol acetyl transferase reporter plasmids are specifically transactivated by c-Myb. These data suggest a role for members of the Myb family as a link between transcriptional activation of the HTLV-1 LTR and T cell activation events.
journal_name
Virologyjournal_title
Virologyauthors
Bosselut R,Lim F,Romond PC,Frampton J,Brady J,Ghysdael Jdoi
10.1016/0042-6822(92)90044-psubject
Has Abstractpub_date
1992-02-01 00:00:00pages
764-9issue
2eissn
0042-6822issn
1096-0341journal_volume
186pub_type
杂志文章相关文献
VIROLOGY文献大全abstract::Both the brome mosaic virus (BMV) and cowpea chlorotic mottle virus (CCMV) RNA-dependent RNA polymerases (RdRps) were found to recognize the BMV core subgenomic promoter in the same manner, requiring specific functional groups at positions -17, -14, -13, and -11 relative to the subgenomic initiation site (+1). For CCM...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1998.9449
更新日期:1998-12-05 00:00:00
abstract::Lysolecithin permeabilization of vaccinia virus-infected cells was employed to prepare extracts that support faithful transcription initiation in vitro on plasmids possessing early, intermediate, and late viral gene promoters. Conditions which optimize transcription from each promoter were defined. The in vitro system...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1996.0177
更新日期:1996-04-01 00:00:00
abstract::In order to define factors involved in very late Autographa californica nucleopolyhedrovirus (AcMNPV) gene function, random mutagenesis of a baculovirus recombinant (AcUW1.lacZ) by 5'-bromodeoxyuridine treatment was performed. Five viruses were selected with deficiencies in very late gene expression. These were charac...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1996.0121
更新日期:1996-03-01 00:00:00
abstract::The interaction of reovirus with the cytoskeleton was investigated. The soluble components of infected cells were extracted with the nonionic detergent NP-40 in a physiological buffer, and a cytoskeletal extract was prepared from the detergent-insoluble fraction. We observed a selective association of viral-specified ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(87)90464-8
更新日期:1987-08-01 00:00:00
abstract::Many viruses activate the phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway, thereby modulating diverse downstream signaling pathways associated with antiapoptosis, proliferation, cell cycling, protein synthesis and glucose metabolism, in order to augment their replication. To date, the role of the PI3K-Akt p...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2009.06.007
更新日期:2009-08-15 00:00:00
abstract::Therapeutic immunization of HIV-1-infected individuals may induce and/or enhance HIV-1-specific immune responses and decrease the dependency on antiretroviral drug treatment. However, repeated immunizations with live-recombinant vectors may induce vector-specific immune responses that interfere with the elicitation of...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2002.1722
更新日期:2002-12-05 00:00:00
abstract::The envelope protein of yellow fever virus 17D (YFV-17D) contains a solvent-exposed RGD motif, which has led to the suggestion that integrins may function as cellular receptors for YFV-17D. We found that mutating the RGD motif to RGE had no effect on viral titers, whereas changing RGD to TGD, TGE, TAD, TAE, or RGS led...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1999.0026
更新日期:1999-12-05 00:00:00
abstract::Lentiviral vectors have gained much attention in recent years mainly because they integrate into nondividing host-cell genomes. For clinical applications, a safe and efficient lentiviral vector system is required. Previously, we have established a human immunodeficiency virus type 1 (HIV-1)-derived three-plasmid lenti...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1999.9850
更新日期:1999-08-15 00:00:00
abstract::Attenuated mutants of Venezuelan equine encephalitis virus (VEE) were isolated by selection for rapid penetration of cultured cells (R. E. Johnston and J. F. Smith, 1988, Virology 162, 437-443). Sequence analysis of these mutants identified candidate attenuating mutations at four loci in the VEE E2 glycoprotein gene: ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(91)90114-q
更新日期:1991-07-01 00:00:00
abstract::Although lentiviruses like HIV-1 are able to infect non-dividing cells, particular resting cells such as non-stimulated primary peripheral blood mononuclear cells (PBMC) are resistant to infection. In contrast to other lentiviruses, SIVsmmPBj can replicate in non-stimulated PBMC. Moreover, SIVsmmPBj-derived, but not H...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2007.03.008
更新日期:2007-08-01 00:00:00
abstract::Previous reports from our lab had shown that sera obtained from SIV(mac)-infected animals neutralized SIV(mac) infectivity in CD4(+) T cells but failed to protect monkey primary macrophages from infection with the virus. However, the antibodies could inhibit completion of the viral life cycle in the macrophages at the...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2001.1053
更新日期:2001-09-01 00:00:00
abstract::Currently, little is known about the ankyrin/F-box protein B4. Here, we report that B4R-null viruses exhibited reduced plaque size in tissue culture, and decreased ability to spread, as assessed by multiple-step growth analysis. Electron microscopy indicated that B4R-null viruses still formed mature and extracellular ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.03.019
更新日期:2014-05-01 00:00:00
abstract::The expression of type I murine interferon (MuIFN) genes and several other cellular genes was examined in poly rI.rC induced and Newcastle disease virus (NDV) infected mouse cells. Northern analysis of RNA from induced L cells revealed that the MuIFN-alpha s are expressed efficiently in NDV infected cells but only at ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(85)90140-0
更新日期:1985-12-01 00:00:00
abstract::Lloviu virus (LLOV), a phylogenetically divergent filovirus, is the proposed etiologic agent of die-offs of Schreibers's long-fingered bats (Miniopterus schreibersii) in western Europe. Studies of LLOV remain limited because the infectious agent has not yet been isolated. Here, we generated a recombinant vesicular sto...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.08.019
更新日期:2014-11-01 00:00:00
abstract::Equid herpesvirus-1 (EHV-1) outbreaks continue despite widely used vaccination. We demonstrated previously that an ORF1/ORF71 gene deletion mutant of the EHV-1 strain Ab4 (Ab4ΔORF1/71) is less virulent than its parent Ab4 virus. Here, we describe the Ab4 challenge infection evaluating protection induced by the Ab4ΔORF...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2019.03.014
更新日期:2019-05-01 00:00:00
abstract::HPV16 is the most carcinogenic HPV type, but only a minority of HPV16 infections progress to cancer. Intratype genetic variants of HPV16 have been suggested to confer differential carcinogenicity. To investigate risk implications of HPV16 variants among Chinese women, a case-control study was conducted with 298 cervic...
journal_title:Virology
pub_type: 杂志文章,meta分析
doi:10.1016/j.virol.2015.11.016
更新日期:2016-01-15 00:00:00
abstract::The repetitive DNA sequences of the genome of Molluscum contagiosum virus type 1 (MCV-1) have been localized within the terminal regions of the viral genome corresponding to the BamHI MCV-1 DNA fragments B (18 kbp; 0 to 0.095 map units (m.u.)) and E (10.5 kbp; 0.944 to 1 m.u.). The fine mapping of these particular reg...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1993.1050
更新日期:1993-01-01 00:00:00
abstract::The complete nucleotide sequence of cloned cDNAs corresponding to the full length of the mRNA encoding the measles virus hemagglutinin (H) protein has been determined. the mRNA contains a single large open reading frame which is capable of encoding a protein of 617 amino acids with a molecular mass of 69,250 Da. The d...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(86)90312-0
更新日期:1986-04-30 00:00:00
abstract::Naturally occurring mutations in Human T-cell Leukemia Virus Type 1 (HTLV-1) Tax protein lead to loss of recognition by cytotoxic T-lymphocytes. Most of these mutations also abolish or severely impair the transactivation function of Tax. Ninety percent of the rex gene, which encodes the viral regulator of mRNA splicin...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1997.8789
更新日期:1997-10-27 00:00:00
abstract::The Epstein-Barr virus (EBV) nuclear antigen EBNA-1 is essential for viral genome maintenance in vitro and may be the only EBV protein expressed by the majority of latently infected cells in vivo. EBNA-1 may therefore be critical to the evasion of host immunity which allows persistent infection. EBNA-1 includes a poly...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1995.1183
更新日期:1995-04-20 00:00:00
abstract::Differing reports exist about the replication of human enteric adenoviruses (EnAds) in various cell lines. There was a suggestion that EnAds are defective, do not grow on primary human diploid cells, and behave like Ad host-range mutants, i.e., they require early gene products from other Ad types for efficient growth....
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(90)90072-y
更新日期:1990-01-01 00:00:00
abstract::Feline panleukopenia virus (FPV) is a pathogen whose canine-adapted form (canine parvovirus (CPV)) emerged in 1978. These viruses infect by binding host transferrin receptor type-1 (TfR), but also hemagglutinate erythrocytes. We show that hemagglutination involves selective recognition of the non-human sialic acid N-g...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.02.009
更新日期:2013-05-25 00:00:00
abstract::A collection of randomly generated temperature-sensitive (ts) vaccinia virus (strain IHD-W) mutants were reported by S. Dales et al., (1978, Virology, 84, 403-428) in 1978 and characterized by electron microscopy. We have performed further genetic analysis on the Dales collection of mutants to make the mutants more us...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2002.1745
更新日期:2003-01-20 00:00:00
abstract::The function of rice dwarf virus segment 11 and the corresponding segments of other phytoreoviruses is not yet determined. The amino acid sequence of Pns11, encoded by segment 11, contains a putative zinc finger and five flanking basic regions at the C-terminus. The full-length Pns11 protein and three truncated deriva...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1997.8945
更新日期:1998-01-20 00:00:00
abstract::Frog virus 3 (FV3) is the type species member of the genus Ranavirus (family Iridoviridae). To better understand the molecular mechanisms involved in the replication of FV3, including transcription of its highly methylated DNA genome, we have determined the complete nucleotide sequence of the FV3 genome. The FV3 genom...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2004.02.019
更新日期:2004-05-20 00:00:00
abstract::Friend murine leukemia virus (Fr-MLV) produces unspliced mRNAs, as well as singly-spliced mRNAs by which the Env protein is generated. We investigated the role of the intron within the Fr-MLV gene in Env expression using vectors with serially truncated introns. The up-regulatory regions, the 361-878 and the 5135-5399 ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2008.11.040
更新日期:2009-03-01 00:00:00
abstract::RNA silencing is a fundamental antiviral response in eukaryotic organisms. We investigated the counterdefense strategy of a fungal virus (mycovirus) against RNA silencing in the white root rot fungus, Rosellinia necatrix. We generated an R. necatrix strain that constitutively induced RNA silencing of the exogenous gre...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2013.07.010
更新日期:2013-09-01 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1) Tat transcriptionally activates expression from a number of viral and cellular promoters. Recent studies demonstrate the ability of Tat to differentially modulate cellular responses to apoptotic signaling. The antiapoptotic effects of Tat appear to correlate with increased e...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1999.9688
更新日期:1999-05-10 00:00:00
abstract::A method was devised which allows the easy detection of mutations within the ner gene of Mu DNA. This method is based upon the observation that a transcriptional gene A-galK fusion containing the complete ner gene and the cts62 allele does not express the galK gene in an Escherichia coli strain lacking functional inte...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(88)90621-6
更新日期:1988-05-01 00:00:00
abstract::We have previously shown that peroxisome proliferator-activated receptor-gamma (PPARgamma) agonists inhibited the inflammatory response of RSV-infected human lung epithelial cells. In this study, we supply evidence that specific PPARgamma agonists (15d-PGJ2, ciglitazone, troglitazone, Fmoc-Leu) efficiently blocked the...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2006.03.008
更新日期:2006-07-05 00:00:00