当前位置： SCI文献检索 > VIROLOGY期刊下所有文献 > Transforming properties of Felis catus papillomavirus type 2 E6 and E7 putative oncogenes in vitro and their transcriptional activity in feline squamous cell carcinoma in vivo.

Transforming properties of Felis catus papillomavirus type 2 E6 and E7 putative oncogenes in vitro and their transcriptional activity in feline squamous cell carcinoma in vivo.

Abstract：

:Felis catus papillomavirus type 2 (FcaPV2) DNA is found in feline cutaneous squamous cell carcinomas (SCCs); however, its biological properties are still uncharacterized. In this study, we successfully expressed FcaPV2 E6 and E7 putative oncogenes in feline epithelial cells and demonstrated that FcaPV2 E6 binds to p53, impairing its protein level. In addition, E6 and E7 inhibited ultraviolet B (UVB)-triggered accumulation of p53, p21 and pro-apoptotic markers such as Cleaved Caspase3, Bax and Bak, suggesting a synergistic action of the virus with UV exposure in tumour pathogenesis. Furthermore, FcaPV2 E7 bound to feline pRb and impaired pRb levels, resulting in upregulation of the downstream pro-proliferative genes Cyclin A and Cdc2. Importantly, we demonstrated mRNA expression of FcaPV2 E2, E6 and E7 in feline SCC samples, strengthening the hypothesis of a causative role in the development of feline SCC.

journal_name

Virology

journal_title

Virology

authors

Altamura G,Corteggio A,Pacini L,Conte A,Pierantoni GM,Tommasino M,Accardi R,Borzacchiello G

doi

10.1016/j.virol.2016.05.017

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

1-8

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(16)30126-X

journal_volume

496

pub_type

杂志文章

相关文献

VIROLOGY文献大全
  • Temperature-sensitive polioviruses containing mutations in RNA polymerase.

    abstract：:Site-directed mutagenesis was performed to change the wild-type residue (asparagine) to aspartate, histidine, or tyrosine at amino acid 424 of the poliovirus RNA polymerase, 3Dpol. The mutations were introduced into plasmids containing full-length viral cDNA and plasmids which direct the expression of 3Dpol in Escheri...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(92)90580-i

    authors： Burns CC,Richards OC,Ehrenfeld E

    更新日期：1992-08-01 00:00:00

  • Construction, characterization, and utilization of cell lines which inducibly express the adenovirus DNA-binding protein.

    abstract：:To further our understanding of structure-function relationships within the multifunctional adenovirus DNA binding protein (DBP) a more diverse collection of mutants is necessary. DBP-expressing cell lines (gmDBP) were previously constructed that complemented DBP-negative mutants for viral growth. However, they did no...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(92)90900-a

    authors： Brough DE,Cleghon V,Klessig DF

    更新日期：1992-10-01 00:00:00

  • Sequence heterogeneity within three different regions of the hepatitis G virus genome.

    abstract：:Two sets of primers derived from the 5'-terminal region and the NS5 region of the hepatitis G virus (HGV) genome were used to amplify PCR fragments from serum specimens obtained from different parts of the world. All PCR fragments from the 5'-terminal region (5'-PCR, n = 56) and from the NS5 region (NS5-PCR, n = 85) w...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1998.9592

    authors： Cong M,Fried MW,Lambert S,Lopareva EN,Zhan M,Pujol FH,Thyagarajan SP,Byun KS,Fields HA,Khudyakov YE

    更新日期：1999-03-15 00:00:00

  • In vitro synthesis of biologically active beet necrotic yellow vein virus RNA.

    abstract：:Beet necrotic yellow vein virus (BNYVV) has a quadripartite plus-strand RNA genome in which the two smallest genome components, RNA 3 and 4, are not necessary for virus multiplication in leaves. Infectious transcripts of BNYVV RNA 3 and 4 have already been described (V. Ziegler-Graff, S. Bouzoubaa, I. Jupin, H. Guille...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(89)90131-1

    authors： Quillet L,Guilley H,Jonard G,Richards K

    更新日期：1989-09-01 00:00:00

  • Normal replication of vesicular stomatitis virus without C proteins.

    abstract：:The expression of two small basic proteins (C and C') encoded by a second open reading frame of the New Jersey serotype of vesicular stomatitis virus (VSV) P gene was reported previously (Spiropoulou and Nichol, J. Virol., 67, 3103-3110, 1993). Here we found that the Indiana serotype virus also expressed C and C' prot...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1996.0066

    authors： Kretzschmar E,Peluso R,Schnell MJ,Whitt MA,Rose JK

    更新日期：1996-02-15 00:00:00

  • Epitopes on foot-and-mouth disease virus particles. I. Topology.

    abstract：:Monoclonal antibodies (MAb) against an O1 Suisse isolate of FMDV were used to identify epitopes on the virus particle and to determine their relative function. Six major antigenic sites containing one or more epitopes were identified using competition ELISA. An epitope relationship is proposed consisting of a trypsin-...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(87)90294-7

    authors： McCullough KC,Crowther JR,Carpenter WC,Brocchi E,Capucci L,De Simone F,Xie Q,McCahon D

    更新日期：1987-04-01 00:00:00

  • Gammaherpesvirus targets peritoneal B-1 B cells for long-term latency.

    abstract：:Gammaherpesviruses establish life-long infection in most adults and are associated with the development of B cell lymphomas. While the interaction between gammaherpesviruses and splenic B cells has been explored, very little is known about gammaherpesvirus infection of B-1 B cells, innate-like B cells that primarily r...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2016.02.022

    authors： Rekow MM,Darrah EJ,Mboko WP,Lange PT,Tarakanova VL

    更新日期：2016-05-01 00:00:00

  • Viral fitness implications of variation within an immunodominant CD8+ T-cell epitope of HIV-1.

    abstract：:Cytotoxic T-lymphocyte (CTL) epitopes within the HIV genome are subject to negative and positive selective pressures, the balance of which influences CTL escape at a given epitope. We investigated whether viral fitness requirements dictate conservation of the HLA-A2 restricted immunodominant epitope SLYNTVATL (SL9). V...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2009.03.003

    authors： Christie NM,Willer DO,Lobritz MA,Chan JK,Arts EJ,Ostrowski MA,Cochrane A,Luscher MA,MacDonald KS

    更新日期：2009-05-25 00:00:00

  • In vitro excision and replication of 5' telomeres of minute virus of mice DNA from cloned palindromic concatemer junctions.

    abstract：:HeLa cell extracts containing wild-type copies of the minute virus of mice NS-1 polypeptide produced from a recombinant vaccinia virus vector could support the excision and replication of viral 5' telomeres from cloned concatemer junction fragments. Resolution did not occur if wild-type NS-1 was omitted from the extra...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(92)91223-h

    authors： Cotmore SF,Nuesch JP,Tattersall P

    更新日期：1992-09-01 00:00:00

  • Deletion and duplication mutations in the C-terminal nonconserved region of Sindbis virus nsP3: effects on phosphorylation and on virus replication in vertebrate and invertebrate cells.

    abstract：:Little is known concerning the function of the C-terminal nonconserved region of Sindbis virus nsP3. In this report, we created a number of in-frame deletions and duplications (from 12 to 159 residues) in this region and examined their effects on Sindbis virus replication. Sindbis RNA transcripts containing these muta...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1994.1338

    authors： Lastarza MW,Grakoui A,Rice CM

    更新日期：1994-07-01 00:00:00

  • Chlorella virus NY-2A encodes at least 12 DNA endonuclease/methyltransferase genes.

    abstract：:The 380-kb chlorella virus NY-2A genome is highly methylated; 45% of the cytosines are 5-methylcytosine (5mC) and 37% of the adenines are N6-methyladenine (6mA). Based on the sensitivity/resistance of NY-2A DNA to 80 methylation-sensitive DNA restriction endonucleases, the virus is predicted to encode at least 10 DNA ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1997.8936

    authors： Zhang Y,Nelson M,Nietfeldt J,Xia Y,Burbank D,Ropp S,Van Etten JL

    更新日期：1998-01-20 00:00:00

  • Characterization of a viroid associated with avocado sunblotch disease.

    abstract：:A viroid has been purified from avocado leaves infected by sunblotch disease and designated the avocado sunblotch viroid. It is a covalently closed circular RNA molecule with a molecular weight lower than that of chrysanthemum stunt viroid and citrus exocortis viroid while hybridization analysis with 32P-labeled compl...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(79)90045-x

    authors： Palukaitis P,Hatta T,Alexander DM,Symons RH

    更新日期：1979-11-01 00:00:00

  • Editing the human cytomegalovirus genome with the CRISPR/Cas9 system.

    abstract：:Human Cytomegalovirus (HCMV) is an opportunistic pathogen that causes substantial disease in neonates and immunocompromised individuals. Reverse genetic analysis of the HCMV genome is a powerful tool to dissect the roles that various viral genes play during infection. However, genetic engineering of HCMV is hampered b...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2019.01.021

    authors： King MW,Munger J

    更新日期：2019-03-01 00:00:00

  • The genome of the archaeal virus SIRV1 has features in common with genomes of eukaryal viruses.

    abstract：:The virus SIRV1 of the extremely thermophilic archaeon Sulfolobus has a double-stranded DNA genome similar in architecture to the genomes of eukaryal viruses of the families Poxviridae, Pycodnaviridae, and Asfarviridae: the two strands of the 32,301 bp long linear genome are covalently connected forming a continuous p...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2000.0776

    authors： Blum H,Zillig W,Mallok S,Domdey H,Prangishvili D

    更新日期：2001-03-01 00:00:00

  • Cucumber mosaic virus-induced RNA replicase: solubilization and partial purification of the particulate enzyme.

    abstract：:Cucumber seedlings infected with cucumber mosaic virus (CMV) contain a virus-induced RNA-dependent RNA polymerase (RNA replicase) in both soluble and particulate fractions of plant extracts; no such activity is found in uninfected plants. The extensive purification and characterization of the soluble RNA replicase has...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(81)90131-8

    authors： Gill DS,Kumarasamy R,Symons RH

    更新日期：1981-08-01 00:00:00

  • Mutations of amino acids in the DNA-recognition domain of Epstein-Barr virus ZEBRA protein alter its sub-nuclear localization and affect formation of replication compartments.

    abstract：:ZEBRA, a transcription factor and DNA replication protein encoded by the Epstein-Barr virus (EBV) BZLF1 gene, plays indispensable roles in the EBV lytic cycle. We recently described the phenotypes of 46 single amino acid substitutions introduced into the DNA-recognition region of ZEBRA [Heston, L., El-Guindy, A., Coun...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2008.09.009

    authors： Park R,Heston L,Shedd D,Delecluse HJ,Miller G

    更新日期：2008-12-20 00:00:00

  • Neutralizing monoclonal antibodies to human immunodeficiency virus type 1 do not inhibit viral transcytosis through mucosal epithelial cells.

    abstract：:HIV-1 transcytosis has been proposed as a potential mechanism allowing the virus to cross the epithelium during mucosal transmission. Epitopes of the HIV-1 envelope involved in this process have not been identified yet. Here, we assessed a large panel of HIV neutralizing antibodies recognizing well-characterized epito...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2007.09.006

    authors： Chomont N,Hocini H,Gody JC,Bouhlal H,Becquart P,Krief-Bouillet C,Kazatchkine M,Bélec L

    更新日期：2008-01-20 00:00:00

  • Characterization of a nonhemagglutinating mutant of canine parvovirus.

    abstract：:A nonhemagglutinating mutant of a 1978 isolate of canine parvovirus (CPV) was derived after repeated passages in the NLFK feline kidney cell line. The mutant CPV was antigenically indistinguishable from wild-type virus when tested with 82 monoclonal antibodies, and it replicated in cat and dog cell lines in culture. S...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(88)90255-3

    authors： Parrish CR,Burtonboy G,Carmichael LE

    更新日期：1988-03-01 00:00:00

  • Production of cucumber mosaic virus RNA5 and its role in recombination.

    abstract：:Cucumber Mosaic Virus (CMV) is a plant infecting tripartite positive-strand RNA virus. In addition to three genomic and two known subgenomic RNAs, CMV strains of subgroup II (e.g. Q-CMV), but not subgroup I (e.g. Fny-CMV), produce and package a redundant RNA5 encompassing the 3' 304-307 nucleotides of RNAs 2 and 3. Th...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2008.10.023

    authors： de Wispelaere M,Rao AL

    更新日期：2009-02-05 00:00:00

  • Cross-reactive monoclonal antibodies to multiple HIV-1 subtype and SIVcpz envelope glycoproteins.

    abstract：:The extraordinarily high level of genetic variation of HIV-1 env genes poses a challenge to obtain antibodies that cross-react with multiple subtype Env glycoproteins. To determine if cross-reactive monoclonal antibodies (mAbs) to highly conserved epitopes in HIV-1 envelope glycoproteins can be induced, we immunized m...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2009.07.041

    authors： Gao F,Scearce RM,Alam SM,Hora B,Xia S,Hohm JE,Parks RJ,Ogburn DF,Tomaras GD,Park E,Lomas WE,Maino VC,Fiscus SA,Cohen MS,Moody MA,Hahn BH,Korber BT,Liao HX,Haynes BF

    更新日期：2009-11-10 00:00:00

  • Systematic search fails to detect immunogenic MHC class-I-restricted determinants encoded by influenza A virus noncoding sequences.

    abstract：:It has been demonstrated in a number of systems that CD8+ T cells (T CD8+) can be induced by peptides encoded in alternative reading frames (ARFs) that do not appear to code for bona fide proteins. The biological relevance of ARF peptides remains to be firmly established, however. With this as a goal, we systematicall...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2002.1744

    authors： Chen W,Bennink JR,Yewdell JW

    更新日期：2003-01-05 00:00:00

  • The latency-associated nuclear antigen tethers the Kaposi's sarcoma-associated herpesvirus genome to host chromosomes in body cavity-based lymphoma cells.

    abstract：:Viruses that establish latent infection must maintain their DNA in the host nucleus through many cellular generations. Here we identify a novel mechanism by which the gammaherpesvirus Kaposi's sarcoma-associated herpesvirus (KSHV) may achieve this persistence in latently infected body cavity-based lymphoma (BCBL) cell...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1999.9999

    authors： Cotter MA 2nd,Robertson ES

    更新日期：1999-11-25 00:00:00

  • Adenovirus transformation revertant resistant to retransformation by E1 but not by SV40-T and HPV16-E7 oncogenes.

    abstract：:We have previously described a revertant cell line which expresses a dominant tumor suppressor phenotype to E1 but not to heterologous oncogenes such as c-myc, N-ras, or polyoma middle t (Sircar et al. (1988) Oncogene 3, 725-728). DNA tumor virus oncogenes have been suggested to transform cells via the common mechanis...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(92)90180-w

    authors： Sircar S,Horvath J,Roberge D,Diouri M,Weber JM

    更新日期：1992-11-01 00:00:00

  • Structural and mutational analyses of cis-acting sequences in the 5'-untranslated region of satellite RNA of bamboo mosaic potexvirus.

    abstract：:The satellite RNA of Bamboo mosaic virus (satBaMV) contains on open reading frame for a 20-kDa protein that is flanked by a 5'-untranslated region (UTR) of 159 nucleotides (nt) and a 3'-UTR of 129 nt. A secondary structure was predicted for the 5'-UTR of satBaMV RNA, which folds into a large stem-loop (LSL) and a smal...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/s0042-6822(03)00178-8

    authors： Annamalai P,Hsu YH,Liu YP,Tsai CH,Lin NS

    更新日期：2003-06-20 00:00:00

  • Differential dependence of the infectivity of HIV-1 group O isolates on the cellular protein cyclophilin A.

    abstract：:The cellular protein Cyclophilin A (Cyp A) is packaged into human immunodeficiency virus type 1 (HIV-1) particles through a specific interaction with the capsid domain of the Gag polyprotein. Inhibition of Cyp A incorporation by mutagenesis or cyclosporin treatment severely affects infectivity of all HIV-1 M subtypes ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2001.1347

    authors： Wiegers K,Kräusslich HG

    更新日期：2002-03-15 00:00:00

  • Analysis of the roles of bluetongue virus outer capsid proteins VP2 and VP5 in determination of virus serotype.

    abstract：:Analyses of reassortant and parental strains of BTV serotypes 3 and 10, in serum neutralization tests, confirmed the major role of outer capsid protein VP2 in determination of virus serotype and its involvement in serum neutralization. However, a reassortant BTV strain (R70), containing protein VP5 derived from BTV 3 ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(89)90447-9

    authors： Mertens PP,Pedley S,Cowley J,Burroughs JN,Corteyn AH,Jeggo MH,Jennings DM,Gorman BM

    更新日期：1989-06-01 00:00:00

  • Polymorphisms of the cytidine deaminase APOBEC3F have different HIV-1 restriction efficiencies.

    abstract：:The APOBEC3 enzyme family are host restriction factors that induce mutagenesis of HIV-1 proviral genomes through the deamination of cytosine to form uracil in nascent single-stranded (-)DNA. HIV-1 suppresses APOBEC3 activity through the HIV-1 protein Vif that induces APOBEC3 degradation. Here we compared two common po...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2018.11.004

    authors： Mohammadzadeh N,Follack TB,Love RP,Stewart K,Sanche S,Chelico L

    更新日期：2019-01-15 00:00:00

  • Cloning and molecular characterization of an oral papillomavirus of domestic rabbits.

    abstract：:DNA obtained from New Zealand white rabbit oral papillomas was analyzed for the presence of papillomavirus DNA. The viral genome was cloned as three separate subclones, which were each mapped and oriented with respect to one another. Comparisons with other papillomavirus DNAs by Southern blot hybridization under vario...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(88)90411-4

    authors： O'Banion MK,Cialkowski ME,Reichmann ME,Sundberg JP

    更新日期：1988-01-01 00:00:00

  • A reassortant between influenza A viruses (H7N2) synthesizing an enzymatically inactive neuraminidase at 40 degrees which is not incorporated into infectious particles.

    abstract：:Cells infected with a reassortant (113/Ho, H7N2) between A/fowl plague/Rostock/34 (FPV, H7N1) and A/Hong Kong/1/68 (H3N2) carrying RNA segments 1 and 6 of the Hong Kong virus and the residual genes of FPV, synthesized at 40 degrees a neuraminidase (NA) which is enzymatically not active and which is not incorporated in...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(86)90266-7

    authors： Breuning A,Scholtissek C

    更新日期：1986-04-15 00:00:00

  • Activities and substrate specificity of the evolutionarily conserved central domain of retroviral integrase.

    abstract：:The retroviral integrase (IN) is a virus-encoded enzyme that is essential for insertion of viral DNA into the host chromosome. In order to map and define the properties of a minimal functional domain for this unique viral enzyme, a series of N- and C-terminal deletions of both Rous sarcoma virus (RSV) and human immuno...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/s0042-6822(95)80060-3

    authors： Kulkosky J,Katz RA,Merkel G,Skalka AM

    更新日期：1995-01-10 00:00:00