Gammaherpesvirus targets peritoneal B-1 B cells for long-term latency.

Abstract:

:Gammaherpesviruses establish life-long infection in most adults and are associated with the development of B cell lymphomas. While the interaction between gammaherpesviruses and splenic B cells has been explored, very little is known about gammaherpesvirus infection of B-1 B cells, innate-like B cells that primarily reside in body cavities. This study demonstrates that B-1 B cells harbor the highest frequency of latently infected cells in the peritoneum throughout chronic infection, highlighting a previously unappreciated feature of gammaherpesvirus biology.

journal_name

Virology

journal_title

Virology

authors

Rekow MM,Darrah EJ,Mboko WP,Lange PT,Tarakanova VL

doi

10.1016/j.virol.2016.02.022

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

140-4

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(16)30017-4

journal_volume

492

pub_type

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