Characterization of a nonhemagglutinating mutant of canine parvovirus.

Abstract:

:A nonhemagglutinating mutant of a 1978 isolate of canine parvovirus (CPV) was derived after repeated passages in the NLFK feline kidney cell line. The mutant CPV was antigenically indistinguishable from wild-type virus when tested with 82 monoclonal antibodies, and it replicated in cat and dog cell lines in culture. Sequences of the VP-1 and VP-2 genes revealed two nucleotide and two predicted amino acid sequence differences at 77 and 88 genome map units in the mutant compared to hemagglutinating viruses. One or both of those two mutations must determine the difference in the ability of the virus to agglutinate erythrocytes.

journal_name

Virology

journal_title

Virology

authors

Parrish CR,Burtonboy G,Carmichael LE

doi

10.1016/0042-6822(88)90255-3

subject

Has Abstract

pub_date

1988-03-01 00:00:00

pages

230-2

issue

1

eissn

0042-6822

issn

1096-0341

journal_volume

163

pub_type

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