Abstract:
:A nonhemagglutinating mutant of a 1978 isolate of canine parvovirus (CPV) was derived after repeated passages in the NLFK feline kidney cell line. The mutant CPV was antigenically indistinguishable from wild-type virus when tested with 82 monoclonal antibodies, and it replicated in cat and dog cell lines in culture. Sequences of the VP-1 and VP-2 genes revealed two nucleotide and two predicted amino acid sequence differences at 77 and 88 genome map units in the mutant compared to hemagglutinating viruses. One or both of those two mutations must determine the difference in the ability of the virus to agglutinate erythrocytes.
journal_name
Virologyjournal_title
Virologyauthors
Parrish CR,Burtonboy G,Carmichael LEdoi
10.1016/0042-6822(88)90255-3subject
Has Abstractpub_date
1988-03-01 00:00:00pages
230-2issue
1eissn
0042-6822issn
1096-0341journal_volume
163pub_type
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