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PrP(Sc) is associated with B cells in the blood of scrapie-infected sheep.

Abstract：

:Recently, we reported that PrP(Sc), a surrogate marker for prion disease, is associated with the cellular fraction of blood from scrapie-infected sheep using a ligand-based immunoassay. In the study reported here, we found that a subset of peripheral blood mononuclear cells is most likely to sequester PrP(Sc) during both the preclinical phase of disease and at clinical end point. These cells had a cell surface phenotype of MHC class II DQ(+), surface immunoglobulin(+), CD11b(+), CD11c(+), CD21(+/)(-), which is consistent with a subpopulation of B cells. What role these cells play in the pathogenesis of scrapie is unclear, but they may contribute to the trafficking of prions to the spleen during early pathogenesis of the disease. Furthermore, tests for preclinical diagnostics could be further improved by targeting these cells.

journal_name

Virology

journal_title

Virology

authors

Edwards JC,Moore SJ,Hawthorn JA,Neale MH,Terry LA

doi

10.1016/j.virol.2010.05.023

subject

Has Abstract

pub_date

2010-09-15 00:00:00

pages

110-9

issue

1

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(10)00354-5

journal_volume

405

pub_type

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