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Antibody neutralization of retargeted measles viruses.

Abstract：

:The measles virus (MV) vaccine lineage is a promising oncolytic but prior exposure to the measles vaccine or wild-type MV strains limits treatment utility due to the presence of anti-measles antibodies. MV entry can be redirected by displaying a polypeptide ligand on the Hemagglutinin (H) C-terminus. We hypothesized that retargeted MV would escape neutralization by monoclonal antibodies (mAbs) recognizing the H receptor-binding surface and be less susceptible to neutralization by human antisera. Using chimeric H proteins, with and without mutations that ablate MV receptor binding, we show that retargeted MVs escape mAbs that target the H receptor-binding surface by virtue of mutations that ablate infection via SLAM and CD46. However, C-terminally displayed domains do not mediate virus entry in the presence of human antibodies that bind to the underlying H domain. In conclusion, utility of retargeted oncolytic measles viruses does not extend to evasion of human serum neutralization.

journal_name

Virology

journal_title

Virology

authors

Lech PJ,Pappoe R,Nakamura T,Tobin GJ,Nara PL,Russell SJ

doi

10.1016/j.virol.2014.01.027

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

237-46

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(14)00040-3

journal_volume

454-455

pub_type

杂志文章

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