Temperature and density dependent induction of a cytopathic effect following infection with non-cytopathic HAV strains.

abstract：:The dependence of retroviral replication on cell proliferation was described as early as 1958, although different classes of retroviruses are able to infect non-dividing cells with different efficiencies. For example, the human immunodeficiency virus (HIV) and other lentiviruses infect most non-dividing cells nearly a...

journal_title：Virology

authors： Yamashita M,Emerman M

更新日期：2006-01-05 00:00:00

abstract：:Human parainfluenza virus type 1 (hPIV1) and type 3 (hPIV3) initiate infection by sialic acid binding. Here, we investigated sialic acid linkage specificities for binding and infection of hPIV1 and hPIV3 by using sialic acid linkage-modified cells treated with sialidases or sialyltransferases. The hPIV1 is bound to on...

journal_title：Virology

authors： Fukushima K,Takahashi T,Ito S,Takaguchi M,Takano M,Kurebayashi Y,Oishi K,Minami A,Kato T,Park EY,Nishimura H,Takimoto T,Suzuki T

更新日期：2014-09-01 00:00:00

abstract：:V-CATH, a cathepsin L-like cysteine protease encoded by the baculovirus Autographa californica M nucleopolyhedrovirus, has been shown to play an essential role in host liquefaction. Similar to cellular cathepsin L, V-CATH is synthesized as an inactive proenzyme and is activated by cleavage of the propeptide. Previous ...

journal_title：Virology

authors： Hom LG,Ohkawa T,Trudeau D,Volkman LE

更新日期：2002-05-10 00:00:00

abstract：:Previously, VLPs bearing JR-FL strain HIV-1 Envelope trimers elicited potent neutralizing antibodies (nAbs) in 2/8 rabbits (PLoS Pathog 11(5): e1004932) by taking advantage of a naturally absent glycan at position 197 that borders the CD4 binding site (CD4bs). In new immunizations, we attempted to improve nAb response...

journal_title：Virology

authors： Crooks ET,Osawa K,Tong T,Grimley SL,Dai YD,Whalen RG,Kulp DW,Menis S,Schief WR,Binley JM

更新日期：2017-05-01 00:00:00

abstract：:An insertion mutation in the pol gene of Moloney murine leukemia virus (M-MuLV) was found to render the virus temperature-sensitive for replication. A provirus containing a 12-bp insertion at the boundary between the reverse transcriptase (RT) and integrase (IN) domains induced the formation of mutant virions containi...

journal_title：Virology

authors： Tanese N,Roth M,Epstein H,Goff SP

更新日期：1989-06-01 00:00:00

abstract：:An analysis has been made of variants found in preparations of the common (U1) strain of tobacco mosaic virus (TMV) which had been obtained after the inoculum had been passaged through a necrotic local lesion. These lesions were induced with a minimal number of virions (3000 or 30,000) per inoculation point. The relat...

journal_title：Virology

authors： García-Arenal F,Palukaitis P,Zaitlin M

更新日期：1984-01-15 00:00:00

abstract：:Viral infections of the central nervous system and immune responses to these infections cause a variety of neurological diseases. Infection of weanling mice with Sindbis virus causes acute nonfatal encephalomyelitis followed by clearance of infectious virus, but persistence of viral RNA. Infection with a neuroadapted ...

journal_title：Virology

authors： Kimura T,Griffin DE

更新日期：2003-06-20 00:00:00

abstract：:Full-length cDNA clones of both RNAs of pea early browning virus have been constructed. Synthetic transcripts derived in vitro from these clones are infectious when inoculated onto plants. Electron microscopy revealed the presence of virions in transcript-inoculated plants, and both purified RNA and virions isolated f...

journal_title：Virology

authors： MacFarlane SA,Wallis CV,Taylor SC,Goulden MG,Wood KR,Davies JW

更新日期：1991-05-01 00:00:00

abstract：:The nucleotide sequences of the long terminal repeat (LTR) of simian retroviruses (STLV), which are closely related to human T-cell leukemia virus type I (HTLV-I) were found to be of at least two subgroups: an Asian subtype in macaques and an African subtype in African green monkeys and chimpanzee. The nucleotide sequ...

journal_title：Virology

authors： Watanabe T,Seiki M,Hirayama Y,Yoshida M

更新日期：1986-01-30 00:00:00

abstract：:When hemagglutinin (HA) and neuraminidase (NA) are presented together on an intact influenza virus particle, the antigens are competitive, with HA dominant over NA in T- and B-cell priming. Immunization with mixtures of purified HA and NA eliminates antigenic competition between HA and NA, as well as between N1-N2 NA ...

journal_title：Virology

authors： Johansson BE,Kilbourne ED

更新日期：1996-11-01 00:00:00

abstract：:HIV-1 Rev escorts unspliced viral mRNAs out of the nucleus of infected cells, which allows formation of infectious HIV-1 virions. We have identified a putative DEAD box (Asp-Glu-Ala-Asp) RNA helicase, DDX1, as a cellular co-factor of Rev, through yeast and mammalian two-hybrid systems using the N-terminal motif of Rev...

journal_title：Virology

authors： Fang J,Kubota S,Yang B,Zhou N,Zhang H,Godbout R,Pomerantz RJ

更新日期：2004-12-20 00:00:00

abstract：:Differing reports exist about the replication of human enteric adenoviruses (EnAds) in various cell lines. There was a suggestion that EnAds are defective, do not grow on primary human diploid cells, and behave like Ad host-range mutants, i.e., they require early gene products from other Ad types for efficient growth....

journal_title：Virology

authors： Pieniazek D,Pieniazek NJ,Macejak D,Coward J,Rayfield M,Luftig RB

更新日期：1990-01-01 00:00:00

abstract：:Loading of most endogenous peptides on major histocompatibility complex class I molecules is conditional on their transport into the endoplasmic reticulum (ER) by the peptide transporter TAP. We describe an HSV-2/1 cross-reactive cytotoxic T-cell (CTL) epitope that is processed in a TAP1-independent manner in vivo fol...

journal_title：Virology

authors： Paliard X,Doe B,Selby MJ,Hartog K,Lee AY,Burke RL,Walker CM

更新日期：2001-03-30 00:00:00

abstract：:Hepatitis C virus (HCV) was shown to activate protein kinase R (PKR), which inhibits expression of interferon (IFN) and IFN-stimulated genes by controlling the translation of newly transcribed mRNAs. However, it is unknown exactly how HCV activates PKR. To address the molecular mechanism(s) of PKR activation mediated ...

journal_title：Virology

authors： Suzuki R,Matsuda M,Shimoike T,Watashi K,Aizaki H,Kato T,Suzuki T,Muramatsu M,Wakita T

更新日期：2019-03-01 00:00:00

abstract：:In structural studies, the retrovirus capsid interdomain linker region has been shown as a flexible connector between the CA N-terminal domain and its C-terminal domain. To analyze the function of the linker region, we have examined the effects of three Moloney murine leukemia virus (M-MuLV) capsid linker mutations/va...

journal_title：Virology

authors： Arvidson B,Seeds J,Webb M,Finlay L,Barklis E

更新日期：2003-03-30 00:00:00

abstract：:Guinea-Bissau in West Africa has the highest prevalence of human immunodeficiency virus (HIV)-2 infection in the world, but recently the HIV-1 prevalence increased rapidly with the subsequent appearance of HIV-1 and HIV-2 dual infections. Information about the genetic subtypes of HIV in the region is limited. Therefor...

journal_title：Virology

authors： Andersson S,Norrgren H,Dias F,Biberfeld G,Albert J

更新日期：1999-09-30 00:00:00

abstract：:Vaccinia virus gene D12L, which lies between nucleotides 14,350 and 13,487 in the HindIII D fragment, is transcribed at early times in infection and is capable of encoding a protein 287 amino acids in length with a predicted molecular mass of 33,331. A polyclonal antiserum was raised in rabbits to a fusion protein con...

journal_title：Virology

authors： Niles EG,Lee-Chen GJ,Shuman S,Moss B,Broyles SS

更新日期：1989-10-01 00:00:00

abstract：:We investigated the origin and the effect of insertion D67D-THGERDLGPA within HIV-1 RT from a patient failing antiviral therapy. The insertion developed within the context of pre-existing NRTI and NNRTI mutations (M41L, L210W, T215Y and N348I). Concurrently, the NRTI mutations T69I and V118I and the NNRTI mutations K1...

journal_title：Virology

authors： Megens S,Vaira D,De Baets G,Dekeersmaeker N,Schrooten Y,Li G,Schymkowitz J,Rousseau F,Vandamme AM,Moutschen M,Van Laethem K

更新日期：2014-05-01 00:00:00

abstract：:We used serial protein misfolding cyclic amplification (sPMCA) to amplify the D10 strain of CWD prions in a linear relationship over two logs of D10 dilutions. The resultant PMCA-amplified D10 induced terminal TSE disease in CWD-susceptible Tg(cerPrP)1536 mice with a survival time approximately 80 days shorter than th...

journal_title：Virology

authors： Meyerett C,Michel B,Pulford B,Spraker TR,Nichols TA,Johnson T,Kurt T,Hoover EA,Telling GC,Zabel MD

更新日期：2008-12-20 00:00:00

abstract：:We investigated the localization of host mRNA during Rift Valley fever virus (RVFV) infection. Fluorescence in situ hybridization revealed that infection with RVFV altered the localization of host mRNA. mRNA accumulated in the nuclei of RVFV-infected but not mock-infected cells. Further, overexpression of the NSS gene...

journal_title：Virology

authors： Copeland AM,Van Deusen NM,Schmaljohn CS

更新日期：2015-12-01 00:00:00

abstract：:The Hepatitis B virus precore protein is processed in the endoplasmic reticulum (ER) into secreted hepatitis B e antigen (HBeAg), which acts as an immune tolerogen to establish chronic infection. Downregulation of secreted HBeAg should improve clinical outcome, as patients who effectively respond to current treatments...

journal_title：Virology

authors： Walsh R,Nuttall S,Revill P,Colledge D,Cabuang L,Soppe S,Dolezal O,Griffiths K,Bartholomeusz A,Locarnini S

更新日期：2011-03-01 00:00:00

abstract：:In order to establish whether the poor growth of the two fastidious adenoviruses types 40 and 41 (Ad40 and Ad41) in HeLa cells is due to a reduced trans-activation by the early region 1A (E1A), we have determined the trans-activating effect of this region on the expression of the chloramphenicol acetyltransferase (CAT...

journal_title：Virology

authors： van Loon AE,Gilardi P,Perricaudet M,Rozijn TH,Sussenbach JS

更新日期：1987-09-01 00:00:00

abstract：:The HIV-1 Nef protein causes a decrease in major histocompatibility complex (MHC) class I and CD4 molecule expression on the cell surface. To determine if Nef can affect components of the innate immune response, we assessed the ability of Nef to alter the cell surface expression of human CD1d. In cells co-expressing C...

journal_title：Virology

authors： Cho S,Knox KS,Kohli LM,He JJ,Exley MA,Wilson SB,Brutkiewicz RR

更新日期：2005-07-05 00:00:00

abstract：:A new type of retrovirus (Sm-MTV) released by cultured cells of a spontaneous mammary tumor from a house musk shrew, Suncus murinus, is described. The Sm-MTV is distinct morphologically from type C particles. In spite of certain morphological similarities to type B and type D retroviruses, the Sm-MTV is readily distin...

journal_title：Virology

authors： Tsutsui Y,Nagayoshi S,Saga S,Takahashi M,Aoyama A,Malavasi JY,Hayakawa S,Yokoi T,Oda S,Hoshino M

更新日期：1985-07-15 00:00:00

abstract：:The Pr76Gag and Pr180Gag-Pol polyprotein precursors of Rous sarcoma virus contain a 22-amino-acid spacer peptide, called p2, located between the amino acid sequences of the mature Gag proteins MA and p10. This spacer peptide is present in stoichiometric amounts in the virion, albeit cleaved into two parts, but its fun...

journal_title：Virology

authors： Bowles N,Bonnet D,Mulhauser F,Spahr PF

更新日期：1994-08-15 00:00:00

abstract：:Turnip crinkle carmovirus (TCV) has a uniquely high recombination frequency and nonrandom cross-over site distribution among the recombining TCV-associated satellite RNAs. An in vitro system has been developed that includes a partially purified TCV replicase preparation (RdRp) and chimeric RNAs that resemble the putat...

journal_title：Virology

authors： Nagy PD,Simon AE

更新日期：1998-09-30 00:00:00

abstract：:Infectious bronchitis has remained one of the most difficult to control diseases in poultry since it was first described in 1931. Previous studies demonstrated that primary CD8(+) T lymphocytes collected at 10 days post-infection (p.i.) are important in controlling acute infection. To further investigate the role of m...

journal_title：Virology

authors： Pei J,Briles WE,Collisson EW

更新日期：2003-02-15 00:00:00

abstract：:By employing two different buffer solutions for polyacrylamide gel electrophoresis, all genome segments of Fiji disease and maize rough dwarf virus were separated. Fiji disease virus contains ten genome segments with approximate genome molecular weights of 19.26 x 10(6) and 19.85 x 10(6), depending on the buffer emplo...

journal_title：Virology

authors： Reddy DV,Boccardo G,Outridge R,Teakle DS,Black LM

更新日期：1975-01-01 00:00:00

abstract：:N-tropic murine leukemia viruses have been observed in connection with radiation-induced osteosarcomagenesis in BALB/c mice. We have investigated the bone disease-inducing potential of molecularly cloned, BALB/c-derived N-tropic viruses in the random-bred NMRI mouse strain. The germ-line virus and an exogenous virus i...

journal_title：Virology

authors： Pedersen L,Strauss PG,Schmidt J,Luz A,Erfle V,Jørgensen P,Kjeldgaard NO,Pedersen FS

更新日期：1990-12-01 00:00:00

abstract：:In March 2017, a novel highly pathogenic avian influenza A(H7N9) virus was detected at two commercial broiler breeder facilities in Tennessee, United States. In this study, a wild bird low pathogenic avian influenza A virus, A/blue-winged teal/Wyoming/AH0099021/2016(H7N9), was shown to be the probable precursor of the...

journal_title：Virology

authors： Li L,DeLiberto TJ,Killian ML,Torchetti MK,Wan XF

更新日期：2018-12-01 00:00:00