The eIF4AIII RNA helicase is a critical determinant of human cytomegalovirus replication.

abstract：:DNA obtained from New Zealand white rabbit oral papillomas was analyzed for the presence of papillomavirus DNA. The viral genome was cloned as three separate subclones, which were each mapped and oriented with respect to one another. Comparisons with other papillomavirus DNAs by Southern blot hybridization under vario...

journal_title：Virology

authors： O'Banion MK,Cialkowski ME,Reichmann ME,Sundberg JP

更新日期：1988-01-01 00:00:00

abstract：:3H-labelled complementary DNA (cDNA) was reverse transcribed from the RNA of three biologically distinct isolates of bean yellow mosaic virus (BYMV-G, Q, and S) by the random primer method of Taylor et al. [Biochim. Biophys. Acta 442, 324-330 (1976)]. Excess virus RNA was hybridized with each of the cDNAs and percenta...

journal_title：Virology

authors： Abu-Samah N,Randles JW

更新日期：1981-04-30 00:00:00

abstract：:Oral transmission of human immunodeficiency virus (HIV) in adult populations is rare. However, HIV spread across fetal/neonatal oropharyngeal epithelia could be important in mother-to-child transmission. Analysis of HIV transmission across polarized adult and fetal oral epithelial cells revealed that HIV transmigrates...

journal_title：Virology

authors： Tugizov SM,Herrera R,Veluppillai P,Greenspan D,Soros V,Greene WC,Levy JA,Palefsky JM

更新日期：2011-01-20 00:00:00

abstract：:We used a series of deletion mutations in the 5' untranslated region of the prototype D type retrovirus, Mason-Pfizer Monkey Virus (MPMV), to analyse RNA encapsidation. A region was identified upstream of the major splice donor which reduced particle production but had a proportionally greater effect on RNA packaging....

journal_title：Virology

authors： Guesdon FM,Greatorex J,Rhee SR,Fisher R,Hunter E,Lever AM

更新日期：2001-09-15 00:00:00

abstract：:cDNA clones of the St. Louis encephalitis (SLE) virus genome have been obtained and the nucleotide sequence of 4.7 kb corresponding to the 5' terminal half of the genome determined. The genome contains a 5' noncoding region of 98 nucleotides followed by a single continuous open reading frame that encodes three structu...

journal_title：Virology

authors： Trent DW,Kinney RM,Johnson BJ,Vorndam AV,Grant JA,Deubel V,Rice CM,Hahn C

更新日期：1987-02-01 00:00:00

abstract：:The bipartite genomic RNAs of red clover necrotic mosaic virus (RCNMV) lack a 5' cap and a 3' poly(A) tail. RNA1 encodes viral replication proteins, and RNA2 encodes a movement protein (MP). These proteins are translated in a cap-independent manner. We previously identified two cis-acting RNA elements that cooperative...

journal_title：Virology

authors： Tajima Y,Iwakawa HO,Hyodo K,Kaido M,Mise K,Okuno T

更新日期：2017-09-01 00:00:00

abstract：:An SH3-binding domain within the Nef protein of primate lentiviruses has been reported to be important to viral replication and infectivity and dispensable for CD4 downregulation, but its precise role remains unclear. This study investigates the effects of mutations in both the polyproline helix and in the hydrophobic...

journal_title：Virology

authors： Craig HM,Pandori MW,Riggs NL,Richman DD,Guatelli JC

更新日期：1999-09-15 00:00:00

abstract：:Virus infection may contribute to asthma pathogenesis. In turn, a Th2-polarized pulmonary environment may increase host susceptibility to infection. We used a cockroach antigen (CRA) model of allergic airway disease to test the hypothesis that Th2 cytokine overproduction increases susceptibility to mouse adenovirus ty...

journal_title：Virology

authors： Anderson VE,Nguyen Y,Weinberg JB

更新日期：2009-08-15 00:00:00

abstract：:A cDNA encoding the entire amino acid sequence of the G glycoprotein of respiratory syncytial virus (RSV) was inserted into a yeast-Escherichia coli shuttle vector such that expression of the virus gene was regulated by the yeast GAL1 promoter. Transformation of Saccharomyces cerevisiae with the vector led to the form...

journal_title：Virology

authors： Ding MX,Wen DZ,Schlesinger MJ,Wertz GW,Ball LA

更新日期：1987-08-01 00:00:00

abstract：:RSV is a major cause of severe lower respiratory infection in infants and young children. With no vaccine yet available, it is important to clarify mechanisms of disease pathogenesis. Since indoleamine-2,3-dioxygenase (IDO) is an immunomodulatory enzyme and is upregulated with RSV infection, we studied it in vivo duri...

journal_title：Virology

authors： Rajan D,Chinnadurai R,O'Keefe EL,Boyoglu-Barnum S,Todd SO,Hartert TV,Galipeau J,Anderson LJ

更新日期：2017-12-01 00:00:00

abstract：:While some neurotropic viruses cause rapid central nervous system (CNS) disease upon entry into the brain parenchyma, other viruses that are cytolytic in the periphery either result in little neuropathology or are associated with a protracted course of CNS disease consistent with persistent infection. One such virus, ...

journal_title：Virology

authors： Daley JK,Gechman LA,Skipworth J,Rall GF

更新日期：2005-09-15 00:00:00

abstract：:The requirement for the herpes simplex virus type 1 (HSV-1) protein Vmw65 (VP16) for activation of immediate early (IE) gene expression was examined in synchronized HeLa cells. Analyses of IE RNA levels were conducted during infection with a viral Vmw65 mutant, in1814. The results revealed an increased requirement for...

journal_title：Virology

authors： Daksis JI,Preston CM

更新日期：1992-07-01 00:00:00

abstract：:Although defensins are known to inhibit the replication of human influenza A virus (IAV) in vitro, their in vivo expression during IAV infection is not known. Here we investigated mRNA and protein expression of several beta-defensins in the airways of IAV infected mice. Expression of murine beta-defensin (MBD)-3 and -...

journal_title：Virology

authors： Chong KT,Thangavel RR,Tang X

更新日期：2008-10-10 00:00:00

abstract：:The host innate response to viral infection includes the production of interferons, which is dependent on the coordinated activity of multiple transcription factors. Herpes simplex virus 1 (HSV-1) has been shown to block efficient interferon expression by multiple mechanisms. We and others have demonstrated that HSV-1...

journal_title：Virology

authors： Melroe GT,Silva L,Schaffer PA,Knipe DM

更新日期：2007-04-10 00:00:00

abstract：:In this study, we show that adenoviral infection induced accumulation of the sphingolipid ceramide in a dose- and time-dependent manner. This accumulation preceded cell lysis, occurred in the absence of biochemical evidence of apoptosis, and was derived from de novo synthesis of ceramide. An adenovirus mutant that lac...

journal_title：Virology

authors： Kanj SS,Dandashi N,El-Hed A,Harik H,Maalouf M,Kozhaya L,Mousallem T,Tollefson AE,Wold WS,Chalfant CE,Dbaibo GS

更新日期：2006-02-05 00:00:00

abstract：:Nectin-1 is a receptor for herpes simplex virus (HSV), a member of the immunoglobulin superfamily, and a cellular adhesion molecule. To study domains of nectin-1alpha involved in cell fusion, we measured the ability of nectin-1alpha/nectin-2alpha chimeras, nectin-1alpha/CD4 chimeras, and transmembrane domain and cytop...

journal_title：Virology

authors： Subramanian RP,Dunn JE,Geraghty RJ

更新日期：2005-09-01 00:00:00

abstract：:Glycoprotein B (gB, gpUL55) is a major antigen for the induction of neutralizing antibodies against human cytomegalovirus, making it an attractive antigen for active and passive immunoprophylaxis. The immunodominant region on gB is the antigenic domain 1 (AD-1), a complex structure which requires a minimal linear amin...

journal_title：Virology

authors： Schoppel K,Hassfurther E,Britt W,Ohlin M,Borrebaeck CA,Mach M

更新日期：1996-02-01 00:00:00

abstract：:In response to oncogenic insults, normal human cells execute a defense response that culminates in cellular suicide, apoptosis. Normal human diploid fibroblasts expressing the human papillomavirus type 16 (HPV-16) E7 oncoprotein are predisposed to apoptosis when they are deprived of growth factors. Even though a domin...

journal_title：Virology

authors： Eichten A,Rud DS,Grace M,Piboonniyom SO,Zacny V,Münger K

更新日期：2004-02-05 00:00:00

abstract：:We developed a positive selection method for recovering Marek's disease virus (MDV) recombinants. The Escherichia coli xanthine-guanine phosphoribosyltransferase gene (gpt), under the control of the major immediate-early promoter from cytomegalovirus, was inserted into the inverted repeats flanking the unique long (UL...

journal_title：Virology

authors： Marshall DR,Reilly JD,Liu X,Silva RF

更新日期：1993-08-01 00:00:00

abstract：:We recently developed an in vitro transcapsidation system in which infectivity of single-shelled (ss) rotavirus particles was successfully rescued (Chen and Ramig, Virology [1993]). Here, we report the rescue of infectivity of rotavirus core particles using virus strain B223 (G serotype 10) as the core donor and strai...

journal_title：Virology

authors： Chen D,Ramig RF

更新日期：1993-06-01 00:00:00

abstract：:Brain metastases occur commonly in the setting of a variety of human cancers. At present, such cases are invariably fatal and highlight a need for research on new therapies. We have developed a mouse brain tumor model utilizing the Harding-Passey melanoma cell line injected intracranially into C57Bl/6 mice. Tumors dev...

journal_title：Virology

authors： Randazzo BP,Kesari S,Gesser RM,Alsop D,Ford JC,Brown SM,Maclean A,Fraser NW

更新日期：1995-08-01 00:00:00

abstract：:Human adenovirus type 3 (HAdV-B3) has an apparently stable genome yet remains a major circulating and problematic respiratory pathogen. Comparisons of the prototype genome to genomes from three current field strains, including two isolated from epidemics, and a laboratory strain, yielded small-scale nucleotide variati...

journal_title：Virology

authors： Mahadevan P,Seto J,Tibbetts C,Seto D

更新日期：2010-02-05 00:00:00

abstract：:The mature flavivirus capsid protein (virion C) is commonly thought to be free in the cytoplasm of infected cells and to form a nucleocapsid-like complex with genomic RNA in mature virus particles. There is little sequence conservation among flavivirus virion C proteins, but they are similar in size (e.g., 99 amino ac...

journal_title：Virology

authors： Markoff L,Falgout B,Chang A

更新日期：1997-06-23 00:00:00

abstract：:Recently, cases of severe respiratory illness in military and civilian populations have been associated with a new genomic variant of adenovirus (Ad) serotype 14, designated Ad14a. Compared to the Ad14 reference strain (de Wit), this new virus had a deletion of two amino acid residues in the fiber protein knob. Here w...

journal_title：Virology

authors： Wang H,Tuve S,Erdman DD,Lieber A

更新日期：2009-05-10 00:00:00

abstract：:We describe the in vitro selection and characterisation of virus derived from B/Beijing/1/87 passaged in the presence of zanamivir. During zanamivir passage, the phenotype of virus isolates was either drug dependent or drug resistant in plaque reduction assays. The susceptibility of the neuraminidase of the drug-depen...

journal_title：Virology

authors： Barnett JM,Cadman A,Burrell FM,Madar SH,Lewis AP,Tisdale M,Bethell R

更新日期：1999-12-20 00:00:00

abstract：:Respiratory syncytial virus is a major cause of bronchiolitis in infants and pneumonia virus of mice (PVM) causes similar disease in mice. The impact of PVM infection in BALB/c and C57BL/6 neonates, and upon re-infection as elderly mice, was compared. As previously shown for adult mice, PVM caused more disease in BALB...

journal_title：Virology

authors： Shrivastava P,Atanley E,Sarkar I,Watkiss E,Gomis S,van Drunen Littel-van den Hurk S

更新日期：2015-11-01 00:00:00

abstract：:Ten human genital invasive squamous cell carcinomas and five human premalignant tissues were analyzed for the presence of selected sets of herpes simplex virus 2 (HSV-2) DNA sequences. Two vulvar tumors and one vulvar dysplastic tissue were found to contain DNA sequences homologous to the BglII O fragment (coordinates...

journal_title：Virology

authors： Manservigi R,Cassai E,Deiss LP,Di Luca D,Segala V,Frenkel N

更新日期：1986-11-01 00:00:00

abstract：:The parapoxvirus Orf virus (ORFV) encodes several immunomodulatory proteins (IMPs) that modulate host-innate and pro-inflammatory responses and has been proposed as a vaccine delivery vector for use in animal species. Here we describe the construction and characterization of two recombinant ORFV vectors expressing the...

journal_title：Virology

authors： Martins M,Joshi LR,Rodrigues FS,Anziliero D,Frandoloso R,Kutish GF,Rock DL,Weiblen R,Flores EF,Diel DG

更新日期：2017-11-01 00:00:00

abstract：:Viroids are small, nontranslatable pathogenic RNAs that replicate autonomously and traffic systemically in their host plants. We have used in situ hybridization to analyze the trafficking pattern of Potato spindle tuber viroid (PSTVd) in tomato and Nicotiana benthamiana. When PSTVd was inoculated onto the stem of a pl...

journal_title：Virology

authors： Zhu Y,Green L,Woo YM,Owens R,Ding B

更新日期：2001-01-05 00:00:00

abstract：:An ideal system to investigate individual determinants of the replication process of (+)-strand RNA viruses is a cell-free extract that supports viral protein and RNA synthesis in a synchronized manner. Here, we applied a translation/replication system based on cytoplasmic extracts of Nicotiana tabacum cells to Tomato...

journal_title：Virology

authors： Gursinsky T,Schulz B,Behrens SE

更新日期：2009-08-01 00:00:00