当前位置： SCI文献检索 > VIROLOGY期刊下所有文献 > Viral RNA load and histological changes in tissues following experimental infection with an arterivirus of possums (wobbly possum disease virus).

Viral RNA load and histological changes in tissues following experimental infection with an arterivirus of possums (wobbly possum disease virus).

Abstract：

:Tissues from Australian brushtail possums (Trichosurus vulpecula) that had been experimentally infected with wobbly possum disease (WPD) virus (WPDV) were examined to elucidate pathogenesis of WPDV infection. Mononuclear inflammatory cell infiltrates were present in livers, kidneys, salivary glands and brains of WPD-affected possums. Specific staining was detected by immunohistochemistry within macrophages in the livers and kidneys, and undefined cell types in the brains. The highest viral RNA load was found in macrophage-rich tissues. The detection of viral RNA in the salivary gland, serum, kidney, bladder and urine is compatible with transmission via close physical contact during encounters such as fighting or grooming, or by contact with an environment that has been contaminated with saliva or urine. Levels of viral RNA remained high in all tissues tested throughout the study, suggesting that on-going virus replication and evasion of the immune responses may be important in the pathogenesis of disease.

journal_name

Virology

journal_title

Virology

authors

Giles J,Perrott M,Roe W,Shrestha K,Aberdein D,Morel P,Dunowska M

doi

10.1016/j.virol.2018.07.003

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

73-80

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(18)30205-8

journal_volume

522

pub_type

杂志文章

相关文献

VIROLOGY文献大全
  • Friend murine leukemia virus and spleen focus-forming virus expression in highly malignant interferon-sensitive and interferon-resistant Friend leukemia cells.

    abstract：:Analysis of expression of the Friend murine leukemia virus (F-MuLV) and of the spleen focus forming virus (SFFV) has been undertaken in highly malignant interferon (IFN)-sensitive (745) and IFN-resistant (3Cl-8) Friend leukemia cells (FLC), serially passaged intraperitoneally in DBA/2 mice. In vivo passaged 745 cells,...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(86)90304-1

    authors： Oppi C,Fiorucci G,Ferrantini M,Battistini A,Belardelli F

    更新日期：1986-04-30 00:00:00

  • Promoter analysis of the Chilo iridescent virus DNA polymerase and major capsid protein genes.

    abstract：:The DNA polymerase (DNApol) and major capsid protein (MCP) genes were used as models to study promoter activity in Chilo iridescent virus (CIV). Infection of Bombyx mori SPC-BM-36 cells in the presence of inhibitors of DNA or protein synthesis showed that DNApol, as well as helicase, is an immediate-early gene and con...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2003.08.007

    authors： Nalçacioğlu R,Marks H,Vlak JM,Demirbaĝ Z,van Oers MM

    更新日期：2003-12-20 00:00:00

  • Double-stranded ribonucleic acid from carnation cryptic virus.

    abstract：:The nucleic acid of carnation cryptic virus has been identified as double-stranded RNA on the basis of (i) susceptibility to RNase in 0.1 x SSC (SSC = 0.15 M NaCl-0.015 M sodium citrate buffer, pH 7.0) and resistance to RNase in 2 x SSC and to DNase, (ii) reaction with an antiserum containing antibodies to dsRNA, and ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(81)90124-0

    authors： Lisa V,Boccardo G,Milne RG

    更新日期：1981-12-01 00:00:00

  • VP1 residues around the five-fold axis of enterovirus A71 mediate heparan sulfate interaction.

    abstract：:Enterovirus A71 (EV-A71) is a neurotropic enterovirus that uses heparan sulfate as an attachment receptor. The molecular determinants of EV-A71-heparan sulfate interaction are unknown. With In silico heparin docking and mutagenesis of all possible lysine residues in VP1, we identified that K162, K242 and K244 are resp...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2016.11.009

    authors： Tan CW,Sam IC,Lee VS,Wong HV,Chan YF

    更新日期：2017-01-15 00:00:00

  • Identification of the nuclear localization and export signals of high risk HPV16 E7 oncoprotein.

    abstract：:The E7 oncoprotein of high risk human papillomavirus type 16 (HPV16) binds and inactivates the retinoblastoma (RB) family of proteins. Our previous studies suggested that HPV16 E7 enters the nucleus via a novel Ran-dependent pathway independent of the nuclear import receptors (Angeline, M., Merle, E., and Moroianu, J....

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2008.09.037

    authors： Knapp AA,McManus PM,Bockstall K,Moroianu J

    更新日期：2009-01-05 00:00:00

  • Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza H5N1 viruses.

    abstract：:Although H5N1 influenza viruses have been responsible for hundreds of human infections, these avian influenza viruses have not fully adapted to the human host. The lack of sustained transmission in humans may be due, in part, to their avian-like receptor preference. Here, we have introduced receptor binding domain mut...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2011.02.015

    authors： Maines TR,Chen LM,Van Hoeven N,Tumpey TM,Blixt O,Belser JA,Gustin KM,Pearce MB,Pappas C,Stevens J,Cox NJ,Paulson JC,Raman R,Sasisekharan R,Katz JM,Donis RO

    更新日期：2011-04-25 00:00:00

  • Identification and characterization of the repetitive DNA element in the genome of insect iridescent virus type 6.

    abstract：:The genome of the Chilo iridescent virus (CIV) was analyzed for existence of repetitive DNA sequences by DNA-DNA hybridization using a defined and complete gene library of the viral genome (209 kbp) and by heteroduplex mapping. These experiments revealed the presence of repetitive DNA elements in the CIV genome, which...

    journal_title：Virology

    pub_type： 杂志文章

    doi：

    authors： Fischer M,Schnitzler P,Delius H,Darai G

    更新日期：1988-12-01 00:00:00

  • The non-nucleoside reverse transcriptase inhibitor efavirenz stimulates replication of human immunodeficiency virus type 1 harboring certain non-nucleoside resistance mutations.

    abstract：:We measured the effects of non-nucleoside reverse transcriptase (RT) inhibitor-resistant mutations K101E+G190S, on replication fitness and EFV-resistance of HIV(NL4-3). K101E+G190S reduced fitness in the absence of EFV and increased EFV resistance, compared to either single mutant. Unexpectedly, K101E+G190S also repli...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2010.03.018

    authors： Wang J,Liang H,Bacheler L,Wu H,Deriziotis K,Demeter LM,Dykes C

    更新日期：2010-07-05 00:00:00

  • Assembly of influenza ribonucleoprotein in vitro using recombinant nucleoprotein.

    abstract：:The influenza A virus nucleoprotein previously expressed in Escherichia coli after fusion to 32 heterologous amino acids has now been purified and tested for its ability to form complexes with RNA in vitro. By using a simple filter binding assay, we show that ribonucleoprotein (RNP) complexes form readily with single-...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(87)90419-3

    authors： Kingsbury DW,Jones IM,Murti KG

    更新日期：1987-02-01 00:00:00

  • Sendai virus defective-interfering genomes and the activation of interferon-beta.

    abstract：:The ability of some Sendai virus stocks to strongly activate IFNbeta has long been known to be associated with defective-interfering (DI) genomes. We have compared SeV stocks containing various copyback and internal deletion DI genomes (and those containing only nondefective (ND) genomes) for their ability to activate...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2006.03.022

    authors： Strahle L,Garcin D,Kolakofsky D

    更新日期：2006-07-20 00:00:00

  • A stem-loop structure, sequence non-specific, at the origin of DNA replication of porcine circovirus is essential for termination but not for initiation of rolling-circle DNA replication.

    abstract：:A stem-loop structure, formed by a pair of inverted repeats during DNA replication, is a conserved feature at the origin of DNA replication among plant and animal viruses, bacteriophages and plasmids that replicate their genomes via the rolling-circle replication (RCR) mechanism. In this work, a head-to-tail tandem co...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2007.01.017

    authors： Cheung AK

    更新日期：2007-06-20 00:00:00

  • Activation of protein kinase R by hepatitis C virus RNA-dependent RNA polymerase.

    abstract：:Hepatitis C virus (HCV) was shown to activate protein kinase R (PKR), which inhibits expression of interferon (IFN) and IFN-stimulated genes by controlling the translation of newly transcribed mRNAs. However, it is unknown exactly how HCV activates PKR. To address the molecular mechanism(s) of PKR activation mediated ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2019.01.024

    authors： Suzuki R,Matsuda M,Shimoike T,Watashi K,Aizaki H,Kato T,Suzuki T,Muramatsu M,Wakita T

    更新日期：2019-03-01 00:00:00

  • The N-terminal domain of the vaccinia virus E3L-protein is required for neurovirulence, but not induction of a protective immune response.

    abstract：:Encephalitis is a rare, but serious complication from vaccination against smallpox using replication competent strains of vaccinia virus. In this report we describe mutants of vaccinia virus, containing N-terminal deletions of the vaccinia virus interferon resistance gene, E3L, that are attenuated for neuropathogenesi...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2005.01.006

    authors： Brandt T,Heck MC,Vijaysri S,Jentarra GM,Cameron JM,Jacobs BL

    更新日期：2005-03-15 00:00:00

  • Adenovirus interactions with CD46 on transgenic mouse erythrocytes.

    abstract：:Hemagglutination is an established method but has not been used previously to determine the efficacy of virus binding to a specific cellular receptor. Here we have utilized CD46-expressing erythrocytes from a transgenic mouse to establish whether and to what extent the species B adenoviruses (Ads) as well as Ad37 and ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2010.03.004

    authors： Andersson EK,Mei YF,Wadell G

    更新日期：2010-06-20 00:00:00

  • A point mutation in the coat protein abolishes aphid transmissibility of a potyvirus.

    abstract：:A nonaphid transmissible (NAT) variant of tobacco vein mottling virus (TVMV) was used to test the hypothesis that the viral coat protein (CP) plays a role in determining aphid transmissibility. Comparison of the nucleotide sequences in the coat protein cistron of an aphid transmissible isolate (TVMV-AT) with that of T...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(90)90389-9

    authors： Atreya CD,Raccah B,Pirone TP

    更新日期：1990-09-01 00:00:00

  • Infection with Langat Flavivirus or expression of the envelope protein induces apoptotic cell death.

    abstract：:Langat (LGT) flavivirus, derived from infectious full-length cDNA clone 636, was investigated for its apoptotic activities in mouse neuroblastoma (Neuro-2a) and simian kidney (Vero and LLC-MK(2)) cells. The hallmark of apoptosis, cleavage of cellular DNA, was observed 48 h after infection of Vero, LLC-MK(2), and Neuro...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2001.0980

    authors： Prikhod'ko GG,Prikhod'ko EA,Cohen JI,Pletnev AG

    更新日期：2001-08-01 00:00:00

  • Injection of the sciatic nerve with TMEV: a new model for peripheral nerve demyelination.

    abstract：:Demyelination of the human peripheral nervous system (PNS) can be caused by diverse mechanisms including viral infection. Despite association of several viruses with the development of peripheral demyelination, animal models of the condition have been limited to disease that is either autoimmune or genetic in origin. ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2006.09.009

    authors： Drescher KM,Tracy SM

    更新日期：2007-03-01 00:00:00

  • The ID proteins contribute to the growth of rodent fibroblasts during LMP1-mediated transformation.

    abstract：:LMP1 induces the expression of two members of the family of Id proteins, Id1 and Id3, and affects cell cycle regulation by decreasing the expression of the cyclin dependent kinase inhibitor, p27, and increasing levels and phosphorylation of cdk2 and Rb. In the present study, the contribution of the Id proteins to LMP1...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2007.12.003

    authors： Everly DN Jr,Mainou BA,Raab-Traub N

    更新日期：2008-07-05 00:00:00

  • Molecular evolution of West Nile virus in a northern temperate region: Connecticut, USA 1999-2008.

    abstract：:West Nile virus (WNV) has become firmly established in northeastern US, reemerging every summer since its introduction into North America in 1999. To determine whether WNV overwinters locally or is reseeded annually, we examined the patterns of viral lineage persistence and replacement in Connecticut over 10 consecuti...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2011.06.006

    authors： Armstrong PM,Vossbrinck CR,Andreadis TG,Anderson JF,Pesko KN,Newman RM,Lennon NJ,Birren BW,Ebel GD,Henn MR

    更新日期：2011-08-15 00:00:00

  • Enhanced production of morbillivirus gene-specific RNAs following induction of the cellular stress response in stable persistent infection.

    abstract：:Previous in vitro work demonstrated the incorporation of the major inducible 70k heat shock protein (i.e., 72k HSP) into the biologically active light nucleocapsid (L-NC) variant of canine distemper virus (CDV). Here, in vitro induction of the cellular stress response, characterized by elevated cytoplasmic and intranu...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1993.1072

    authors： Oglesbee MJ,Kenney H,Kenney T,Krakowka S

    更新日期：1993-02-01 00:00:00

  • Human importin alpha and RNA do not compete for binding to influenza A virus nucleoprotein.

    abstract：:Influenza virus has a segmented genome composed of eight negative stranded RNA segments. Each segment is covered with NP forming ribonucleoproteins (vRNPs) and carries a copy of the heterotrimeric polymerase complex. As a rare phenomenon among the RNA viruses, the viral replication occurs in the nucleus and therefore ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2010.10.001

    authors： Boulo S,Akarsu H,Lotteau V,Müller CW,Ruigrok RW,Baudin F

    更新日期：2011-01-05 00:00:00

  • Mutations in a satellite RNA of turnip crinkle virus result in addition of poly(U) in vivo.

    abstract：:Turnip crinkle virus (TCV) is associated with many subviral RNAs including satellite (sat-) RNAs which require a helper virus for infectivity. When plants were inoculated with TCV and transcripts of TCV sat-RNA C containing deletions of 3 to 8 nucleotides beginning at position 100 and extending toward the 5' end, some...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(91)90988-n

    authors： Carpenter CD,Cascone PJ,Simon AE

    更新日期：1991-08-01 00:00:00

  • Single oral immunization with replication deficient recombinant adenovirus elicits long-lived transgene-specific cellular and humoral immune responses.

    abstract：:Oral-gastric delivery of vaccines is a preferred route of immunization and is particularly relevant to the development of vaccine-vector systems. We have investigated the ability of a replication deficient (E1-deleted) adenovirus construct (RAd68), which efficiently expresses the measles virus nucleocapsid (N) protein...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.2001.1281

    authors： Sharpe S,Fooks A,Lee J,Hayes K,Clegg C,Cranage M

    更新日期：2002-02-15 00:00:00

  • Murine leukemia virus recombinants that use phosphate transporters for cell entry induce similar spongiform encephalomyelopathies in newborn mice.

    abstract：:Amphotropic Moloney-murine leukemia virus recombinants (Mo-AmphoV) induce a severe spongiform encephalomyelopathy in newborn mice. We show here that a coisogenic recombinant with a 10A1-MuLV host range (Mo-10A1V) also induces a neurodegenerative disease, clinically characterized by mild tremor and ataxia. Spongiform l...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1006/viro.1998.9476

    authors： Münk C,Thomsen S,Stocking C,Löhler J

    更新日期：1998-12-20 00:00:00

  • Insertion and deletion mutants of vaccinia virus.

    abstract：:Thirteen viable insertion mutants of vaccinia virus have been constructed. These mutants, containing coding sequences of the herpes simplex virus thymidine kinase (HSV-TK) gene, were generated by marker transfer via in vivo recombination. The mutants were identified using a replica filter plating technique by in situ ...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(86)90132-7

    authors： Perkus ME,Panicali D,Mercer S,Paoletti E

    更新日期：1986-07-30 00:00:00

  • An EBNA-negative, EBV-genome-positive human lymphoblast cell line in which superinfecting EBV DNA is not maintained.

    abstract：:A human B-lymphoid cell line, designated TG8, which does not express detectable levels of the EBV (Epstein-Barr virus)-associated nuclear antigen (EBNA), yet carries an average of one to two plasmid copies of the P3HR-1 EBV genome has been identified. TG8 can be superinfected by B95-8 EBV, resulting in up to 60-70% of...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(84)90014-x

    authors： Reisman D,Sugden B

    更新日期：1984-08-01 00:00:00

  • TLR5 stimulation is sufficient to trigger reactivation of latent HIV-1 provirus in T lymphoid cells and activate virus gene expression in central memory CD4+ T cells.

    abstract：:When effector CD4+ T cells carrying integrated HIV-1 proviruses revert back to a resting memory state, the virus can remain silent in those cells for years. Following re-exposure to the nominal antigen or in response to other stimuli (e.g. pro-inflammatory cytokines), these cells can begin to produce virus. Here we de...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2009.04.019

    authors： Thibault S,Imbeault M,Tardif MR,Tremblay MJ

    更新日期：2009-06-20 00:00:00

  • The polarity suppression factor of bacteriophage P4 is also a decoration protein of the P4 capsid.

    abstract：:We show that the product of the polarity suppression (psu) gene from bacteriophage P4 associates with P4 capsids. This association can occur when Psu is (i) provided in vivo from the P4 genome or from a plasmid or (ii) provided in vitro by mixing viable phage particles with Psu protein. Psu is unable to associate with...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/0042-6822(92)90538-z

    authors： Isaksen ML,Rishovd ST,Calendar R,Lindqvist BH

    更新日期：1992-06-01 00:00:00

  • TGF-β regulation of gene expression at early and late stages of HPV16-mediated transformation of human keratinocytes.

    abstract：:In our in vitro model for HPV16-mediated transformation, HPV16-immortalized human keratinocytes (HKc/HPV16) give rise to differentiation resistant, premalignant cells (HKc/DR). HKc/DR, but not HKc/HPV16, are resistant to growth inhibition by transforming growth factor beta (TGF-β), due to a partial loss of TGF-β recep...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2013.08.034

    authors： Kowli S,Velidandla R,Creek KE,Pirisi L

    更新日期：2013-12-01 00:00:00

  • Amphibian (Xenopus laevis) tadpoles and adult frogs mount distinct interferon responses to the Frog Virus 3 ranavirus.

    abstract：:Infections of amphibians by Frog Virus 3 (FV3) and other ranavirus genus members are significantly contributing to the amphibian declines, yet much remains unknown regarding amphibian antiviral immunity. Notably, amphibians represent an important step in the evolution of antiviral interferon (IFN) cytokines as they ar...

    journal_title：Virology

    pub_type： 杂志文章

    doi：10.1016/j.virol.2017.01.001

    authors： Wendel ES,Yaparla A,Koubourli DV,Grayfer L

    更新日期：2017-03-01 00:00:00