Abstract:
:We have used a yeast two-hybrid system to show that human papillomavirus E7 proteins can form oligomeric complexes in vivo. The carboxyl-terminal cysteine-rich metal-binding domain is critical for this activity although amino-terminal sequences also contribute to oligomerization. Our experiments also reveal that E7 possesses an intrinsic transcription activation activity in yeast, which resides in the amino terminus of the protein.
journal_name
Virologyjournal_title
Virologyauthors
Clemens KE,Brent R,Gyuris J,Münger Kdoi
10.1006/viro.1995.9926subject
Has Abstractpub_date
1995-12-01 00:00:00pages
289-93issue
1eissn
0042-6822issn
1096-0341pii
S0042-6822(85)79926-6journal_volume
214pub_type
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