Cloning of SV40 genomes from human brain tumors.

Abstract:

:From two human brain tumors SV40 genomes were isolated by recombinant DNA techniques. The SV40 genome cloned from a human meningioma DNA was shown to be indistinguishable from wild-type SV40. In contrast, the SV40 genome cloned from a human astrocytoma proved to be a nonviable deletion mutant with a truncated early region removing most of the large T-coding region. In addition, this mutant also carries a tandem duplication of an intact origin of replication.

journal_name

Virology

journal_title

Virology

authors

Krieg P,Scherer G

doi

10.1016/0042-6822(84)90357-x

subject

Has Abstract

pub_date

1984-10-30 00:00:00

pages

336-40

issue

2

eissn

0042-6822

issn

1096-0341

journal_volume

138

pub_type

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