Abstract:
:From two human brain tumors SV40 genomes were isolated by recombinant DNA techniques. The SV40 genome cloned from a human meningioma DNA was shown to be indistinguishable from wild-type SV40. In contrast, the SV40 genome cloned from a human astrocytoma proved to be a nonviable deletion mutant with a truncated early region removing most of the large T-coding region. In addition, this mutant also carries a tandem duplication of an intact origin of replication.
journal_name
Virologyjournal_title
Virologyauthors
Krieg P,Scherer Gdoi
10.1016/0042-6822(84)90357-xsubject
Has Abstractpub_date
1984-10-30 00:00:00pages
336-40issue
2eissn
0042-6822issn
1096-0341journal_volume
138pub_type
杂志文章相关文献
VIROLOGY文献大全abstract::Cell-free extracts of Drosophila melanogaster cells infected with FHV (Flockhouse virus) have the capacity to synthesize FHV RNA. When such extracts are incubated appropriately, ss and ds FHV RNA 1, -2, and -3 can be detected as synthesis products. Pulse-chase analyses indicate that radioactivity, incorporated into ds...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(91)90153-3
更新日期:1991-07-01 00:00:00
abstract::Coordinated expression of viral genes in primary infection is essential for successful infection of host cells. We examined the expression profiles of Kaposi's sarcoma-associated herpesvirus (KSHV) transcripts in productive primary infection of primary human umbilical vein endothelial cells by whole-genome reverse-tra...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2005.08.018
更新日期:2005-12-05 00:00:00
abstract::Bombyx mori nucleopolyhedrovirus (BmNPV) orf11 (bm11) is a highly conserved gene with unknown function. It is homologous to AcMNPV orf19. In this study, a bm11 knockout virus was constructed and its role was investigated. Expression analysis indicated that bm11 is a late gene and confocal microscopy analysis demonstra...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2018.10.026
更新日期:2019-01-15 00:00:00
abstract::The mechanism by which lentivirus envelope (Env) glycoproteins are packaged into budding virions is poorly understood. Simian immunodeficiency virus (SIV) contains an Env protein with an unusually long cytoplasmic tail. To investigate the role of this domain in the incorporation of the SIV Env into virions, we generat...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2001.0869
更新日期:2001-05-10 00:00:00
abstract::Outbreaks of avian influenza virus H5N8 first occurred in 2014, and spread to poultry farms in Korea. Although there was no report of human infection by this subtype, it has the potential to threaten human public health. Therefore, we evaluated the pathogenesis of H5N8 viruses in ferrets. Two representative Korean H5N...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2015.02.042
更新日期:2015-07-01 00:00:00
abstract::A crucial step in the arenavirus life cycle is the proteolytic processing of the viral envelope glycoprotein precursor (GPC) by the cellular proprotein convertase (PC) subtilisin kexin isozyme-1 (SKI-1)/site-1 protease (S1P). Here we conducted a systematic and quantitative analysis of SKI-1/S1P processing of peptides ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2011.04.021
更新日期:2011-08-15 00:00:00
abstract::Methods currently used for HIV-1 viral load measurements are very sensitive, but cannot distinguish between infectious and noninfectious particles. Here we describe the development of a novel, sensitive, and highly reproducible method that allows rapid isolation and quantification of infectious particles from patient ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2004.05.022
更新日期:2004-08-15 00:00:00
abstract::Many viruses utilize molecular chaperone heat shock protein 90 (Hsp90) for protein folding and stabilization, however, the role of Hsp90 in herpesvirus lifecycle is obscure. Here, we provide evidence that Hsp90 participates in pseudorabies virus (PRV) replication. Viral growth kinetics assays show that Hsp90 inhibitor...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2020.10.013
更新日期:2021-01-15 00:00:00
abstract::In this study, we analyzed the replication and budding sites of severe acute respiratory syndrome coronavirus (SARS-CoV) at early time points of infection. We detected cytoplasmic accumulations containing the viral nucleocapsid protein, viral RNA and the non-structural protein nsp3. Using EM techniques, we found that ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2006.11.027
更新日期:2007-05-10 00:00:00
abstract::CD8+ T lymphocytes are critical for the control of gammaherpesvirus latency. To determine how memory CD8+ T cells generated during latency differ from those primed during acute or chronic viral infection, we adoptively transferred naive P14 CD8+ T cells into uninfected recipients, and examined surface proteins, cytoki...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2017.06.018
更新日期:2017-09-01 00:00:00
abstract::Animal viruses profoundly modify the metabolism of lipids, the synthesis of new membranes, and membrane traffic. These alterations are related to the replication of viral genomes. Addition of oleic acid from the beginning of poliovirus infection inhibits the appearance of virus polypeptides at concentrations that do n...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(91)90802-i
更新日期:1991-11-01 00:00:00
abstract::High levels of nonfused chloramphenicol acetyltransferase, beta-galactosidase, and beta-glucuronidase expressed under the control of new vector constructs of the polyhedrin promoter in Spodoptera frugiperda cells infected with Autographa californica nuclear polyhedrosis virus were investigated by SDS-PAGE and RNA dot ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(89)90348-6
更新日期:1989-05-01 00:00:00
abstract::Among 167 rotavirus specimens collected from young children in a suburban area of Bissau, Guinea-Bissau, from 1996 to 1998, most identifiable strains belonged to the uncommon P[6], G2 type and approximately 50% remained incompletely typed. In the present study, 76 such strains were further characterized. Due to interp...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/s0042-6822(03)00153-3
更新日期:2003-06-20 00:00:00
abstract::The pathogenesis of two Californian strains of myxoma virus (MSW and MSD) was examined in European rabbits (Oryctolagus cuniculus) that were either susceptible to myxomatosis (laboratory rabbits) or had undergone natural selection for genetic resistance to myxomatosis (Australian wild rabbits). MSW was highly lethal f...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2005.12.007
更新日期:2006-04-25 00:00:00
abstract::Loss of T cell homeostasis usually precedes the onset of AIDS. We hypothesized that rapid progressors may be transmitted with HIV-1 that is particularly able to perturb T cell homeostasis. To this end, we have tested two transmitted, syncytium-inducing (SI) viral isolates from a rapid progressor in two thymus models. ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2004.07.019
更新日期:2004-10-10 00:00:00
abstract::HK97 is a temperate dsDNA bacteriophage of Escherichia coli that is structurally similar to phage lambda, with an icosahedral head of triangulation (7) number 7. Although the capsids of several large dsDNA phages have been studied extensively using a variety of biophysical approaches, no high-resolution structure is a...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1998.9040
更新日期:1998-03-30 00:00:00
abstract::The HSV-1 genome is composed of two unique regions (UL and US) flanked by inverted repeats. During the course of DNA replication the two unique regions UL and US invert relative to one another. In this report we present evidence that cleavage is not necessary for genomic inversion to occur. We isolated and characteriz...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1996.0668
更新日期:1996-12-15 00:00:00
abstract::Glycoproteins gB and gH/gL are required for entry of Epstein-Barr virus (EBV) into cells, but the role of each glycoprotein and how they function together to mediate fusion is unclear. Analysis of the functional homology of gB from the closely related primate gammaherpesvirus, rhesus lymphocryptovirus (Rh-LCV), showed...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2010.12.006
更新日期:2011-04-25 00:00:00
abstract::We have previously showed that equine arteritis virus (EAV), an arterivirus, induces apoptosis in vitro. To determine the caspase activation pathways involved in EAV-induced apoptosis, target cells were treated with peptide inhibitors of apoptosis Z-VAD-FMK (pan-caspase inhibitor), Z-IETD-FMK (caspase-8-specific inhib...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2007.05.023
更新日期:2007-10-10 00:00:00
abstract::The existence and genetic make-up of most primate retroviruses was revealed by studies of bushmeat and fecal samples from unhabituated primate communities. For these, detailed data on intra- and within-species contact rates are generally missing, which makes identification of factors influencing transmission a challen...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2014.05.012
更新日期:2014-07-01 00:00:00
abstract::A non-plaque-forming vaccine strain of NDV (NDV-B1) interferes with the infection of cultured chick embryo cells by the virulent plaque-forming NDV-L strain. The level of interference increases when the concentration of interfering virus is increased or when the time between infection and superinfection is increased. ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(67)90059-1
更新日期:1967-12-01 00:00:00
abstract::Guinea pig cytomegalovirus (GPCMV) immediate early proteins, IE1 and IE2, demonstrated structural and functional homologies with human cytomegalovirus (HCMV). GPCMV IE1 and IE2 co-localized in the nucleus with each other, the viral polymerase and guinea pig ND10 components (gpPML, gpDaxx, gpSp100, gpATRX). IE1 showed ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2017.01.023
更新日期:2017-04-01 00:00:00
abstract::The amino-terminal domain of influenza A virus matrix protein (residues 1-164) was crystallized at pH 7 into a new crystal form in space group P1. This packing of the protein implies that M1(1-164) was monomeric in solution when it crystallized. Otherwise, the structure of the M1 fragment in the pH 7 crystals was the ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2000.0727
更新日期:2001-01-20 00:00:00
abstract::Gene transfer approaches using viruses such human adenovirus (HAdV) may provide an alternative treatment for diseases involving hematopoietic cells. Better understanding of the cellular mechanisms by which the HAdV introduces DNA into these cells should help in vector design. We examined HAdV intracellular delivery in...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2003.09.043
更新日期:2004-03-01 00:00:00
abstract::Hepatitis C virus (HCV) is efficient in the establishment of persistent infection. We have previously shown that HCV core protein inhibits T cell proliferation through its interaction with the complement receptor, gC1qR. Here we show that HCV core-induced inhibition of T cell proliferation involves a G(0)/G(1) cell cy...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/s0042-6822(03)00419-7
更新日期:2003-09-15 00:00:00
abstract::The nucleic acid of carnation cryptic virus has been identified as double-stranded RNA on the basis of (i) susceptibility to RNase in 0.1 x SSC (SSC = 0.15 M NaCl-0.015 M sodium citrate buffer, pH 7.0) and resistance to RNase in 2 x SSC and to DNase, (ii) reaction with an antiserum containing antibodies to dsRNA, and ...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(81)90124-0
更新日期:1981-12-01 00:00:00
abstract::The LP-BM5 retrovirus, a complex containing ecotropic helper, recombinant MCF, and defective retroviruses, causes an immunodeficiency-termed mouse AIDS (MAIDS). Many disease features of MAIDS resemble those of AIDS, including terminal B cell lymphomas. Previously we generated from MAIDS-susceptible C57BL/6 mice cytoly...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.1994.1189
更新日期:1994-04-01 00:00:00
abstract::Purified preparations of the Helminthosporium victoriae 190S (Hv190S) virus contain two sedimenting components that differ in capsid structure. The slower sedimenting component (190S-1) contained p88 and p83 as the major capsid proteins; the faster component (190S-2) contained p88 and p78. Previous peptide-mapping stu...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/0042-6822(92)90520-y
更新日期:1992-06-01 00:00:00
abstract::The parapoxvirus Orf virus (ORFV) encodes several immunomodulatory proteins (IMPs) that modulate host-innate and pro-inflammatory responses and has been proposed as a vaccine delivery vector for use in animal species. Here we describe the construction and characterization of two recombinant ORFV vectors expressing the...
journal_title:Virology
pub_type: 杂志文章
doi:10.1016/j.virol.2017.08.027
更新日期:2017-11-01 00:00:00
abstract::To determine whether infection with HIV-1 strains of different tropisms would influence expression of the mucosa-associated integrins alpha 4 beta 7 and alpha E beta 7 or the lymph node homing receptor L-selectin on peripheral T lymphocytes, cells were infected with the CXCR4-tropic (X4)/syncytium-inducing (SI) HIV-1(...
journal_title:Virology
pub_type: 杂志文章
doi:10.1006/viro.2000.0781
更新日期:2001-02-15 00:00:00