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Infection of mononucleated phagocytes with human cytomegalovirus.

Abstract：

:Human cytomegalovirus (HCMV) can be isolated from peripheral blood leukocytes; however, in vitro, only abortive infection of monocytes, lymphocytes, and granulocytes has been detected. These studies demonstrate that freshly isolated monocytes can be infected with HCMV. Infection of monocytes was not associated with loss of cell viability. The virus replication cycle in monocytes resembled that observed in fibroblasts but the virus yield was approximately 0.1% of that observed in fibroblasts. Transient phenotypical changes occurred in HCMV-infected monocytes. Virus persists in infected monocytes upon differentiation to macrophages, suggesting that monocytes may serve as a carrier of HCMV and a vector for viral dissemination. Differentiated mononuclear phagocytes appear to support a productive HCMV infection. Using a recombinant HCMV strain to express beta-galactosidase, we were able to transduce the bacterial beta-galactosidase gene into monocytes and macrophages.

journal_name

Virology

journal_title

Virology

authors

Maciejewski JP,Bruening EE,Donahue RE,Sellers SE,Carter C,Young NS,St Jeor S

doi

10.1006/viro.1993.1383

subject

Has Abstract

pub_date

1993-08-01 00:00:00

pages

327-36

issue

2

eissn

0042-6822

issn

1096-0341

pii

S0042682283713838

journal_volume

195

pub_type

杂志文章

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