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Vaccination with herpes simplex virus type 1 glycoprotein K impairs clearance of virus from the trigeminal ganglia resulting in chronic infection.

Abstract：

:Following primary ocular infection, HSV-1 establishes a latent infection in the trigeminal ganglia with the complete absence of detectable infectious virus. Recently, we showed that vaccination of BALB/cJ with HSV-1 glycoprotein K (gK), but not other HSV-1 glycoproteins, significantly exacerbated the severity of HSV-1-induced ocular disease and herpetic dermatitis (H. Ghiasi et al. J. Virol. 68, 2347-2354, 1994). We now report that prior vaccination with gK blocked viral clearance from trigeminal ganglia until at least Day 56 postinfection, resulting in a chronic infection. The significance of this novel finding with respect to potential harmful complications associated with the immune response to gK is discussed.

journal_name

Virology

journal_title

Virology

authors

Ghiasi H,Cai S,Nesburn AB,Wechsler SL

doi

10.1006/viro.1996.0537

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

330-3

issue

1

eissn

0042-6822

issn

1096-0341

pii

S0042-6822(96)90537-1

journal_volume

224

pub_type

杂志文章

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