Mutations in VP2 and VP1 capsid proteins increase infectivity and mouse lethality of enterovirus 71 by virus binding and RNA accumulation enhancement.

abstract：:The budded phenotype of Autograha californica nuclear polyhedrosis virus (AcNPV BV) has a 64K glycoprotein in its envelope which is important in the ability of the virus to functionally enter host cells. Tunicamycin (TM), an inhibitor of N-linked glycosylation, was used to determine whether the sugar moiety was essent...

journal_title：Virology

authors： Charlton CA,Volkman LE

更新日期：1986-10-15 00:00:00

abstract：:Transfusion of blood and blood products contaminated with the pathogenic form of prion protein Prp(sc), thought to be the causative agent of variant a Creutzfeldt-Jakob disease (vCJD), may result in serious consequences in recipients with a compromised immune system, for example, as seen in HIV-1 infection. In the pre...

journal_title：Virology

authors： Bacot SM,Feldman GM,Yamada KM,Dhawan S

更新日期：2015-02-01 00:00:00

abstract：:The yeast retrotransposon, Ty1, produces a macromolecular structure known as a virus-like particle (VLP) as an essential part of its replication cycle. The Ty1 Gag-like structural protein TYA, p1-440, alone is capable of directing assembly of the VLP. In order to determine the TYA sequences required for assembly, we h...

journal_title：Virology

authors： Brookman JL,Stott AJ,Cheeseman PJ,Adamson CS,Holmes D,Cole J,Burns NR

更新日期：1995-09-10 00:00:00

abstract：:The aim of this study was to establish a method that could differentiate antibodies against live and inactivated vaccines of porcine reproductive and respiratory syndrome virus (PRRSV). A blocking ELISA (b-ELISA) was established using the PRRSV non-structural protein, Nsp9, as the antigen and a monoclonal antibody, 2D...

journal_title：Virology

authors： Cong Y,Huang Z,Sun Y,Ran W,Zhu L,Yang G,Ding X,Yang Z,Huang X,Wang C,Ding Z

更新日期：2013-09-01 00:00:00

abstract：:The 30K protein of tobacco mosaic virus was recently confirmed to be involved in cell-to-cell movement of the virus. To characterize common structural features of the 30K protein, the nucleotide sequence of the 30K protein gene of cucumber green mottle mosaic virus (CGMMV, a member of the tobamoviruses) RNA has been d...

journal_title：Virology

authors： Saito T,Imai Y,Meshi T,Okada Y

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:When antiretroviral therapy does not fully suppress HIV replication, suboptimal levels of antiretrovirals can select for antiretroviral resistant variants of HIV. These variants may exhibit reduced replication capacity and result in lower viral loads in blood. Our study evaluated whether antiretroviral resis...

journal_title：Virology

authors： Hightower GK,Letendre SL,Cherner M,Gibson SA,Ellis RJ,Wolfson TJ,Gamst AC,Ignacio CC,Heaton RK,Grant I,Richman DD,Smith DM,HNRC Group.

更新日期：2009-11-25 00:00:00

abstract：:Efferocytosis, the phagocytic clearance of apoptotic cells, can provide host protection against certain types of viruses by mediating phagocytic clearance of infected cells undergoing apoptosis. It is known that HIV-1 induces apoptosis and HIV-1-infected cells are efferocytosed by macrophages, although its molecular m...

journal_title：Virology

authors： Chua BA,Ngo JA,Situ K,Ramirez CM,Nakano H,Morizono K

更新日期：2018-02-01 00:00:00

abstract：:Infection with bovine papillomavirus type 1 (BPV1) or BPV2 induces fibropapillomas in cows and skin sarcoids in horses. Prophylactic vaccination targeting BPV1 and BPV2 may reduce the incidence of these economically important diseases. The L1 major capsid proteins of BPV1 and BPV2 were expressed in Sf-9 insect cells a...

journal_title：Virology

authors： Shafti-Keramat S,Schellenbacher C,Handisurya A,Christensen N,Reininger B,Brandt S,Kirnbauer R

更新日期：2009-10-10 00:00:00

abstract：:Cell-to-cell and long-distance transport of some plant viruses requires coordinated action of three movement proteins encoded by triple gene block (TGB). The largest of TGB proteins, TGBp1, is a member of the superfamily I of DNA/RNA helicases and possesses a set of conserved helicase sequence motifs necessary for vir...

journal_title：Virology

authors： Kalinina NO,Rakitina DV,Solovyev AG,Schiemann J,Morozov SY

更新日期：2002-05-10 00:00:00

abstract：:Nuclear Matrix and MARs have been implicated in the transcriptional regulation of host as well as viral genes but their precise role in HIV-1 transcription remains unclear. Here, we show that >98% of HIV sequences contain consensus MAR element in their promoter. We show that SMAR1 binds to the LTR MAR and reinforces t...

journal_title：Virology

authors： Sreenath K,Pavithra L,Singh S,Sinha S,Dash PK,Siddappa NB,Ranga U,Mitra D,Chattopadhyay S

更新日期：2010-04-25 00:00:00

abstract：:The Chlorella virus PBCV-1 genome is a linear nonpermuted 333-kbp dsDNA molecule with covalently closed hairpin termini. The termini (minus the hairpin) are identical inverted repeats of at least 2185 bases after which the sequence diverges. The inverted repeats contain two small potential open reading frames and seve...

journal_title：Virology

authors： Strasser P,Zhang YP,Rohozinski J,Van Etten JL

更新日期：1991-02-01 00:00:00

abstract：:We have previously shown that the Edmonston strain of measles virus enters and is released preferentially at the apical surfaces of polarized epithelial cells. Small amounts of virus were found to be released at the basal surface. In the present study, we passaged the virus in polarized cells and characterized the pas...

journal_title：Virology

authors： Blau DM,Compans RW

更新日期：1997-05-12 00:00:00

abstract：:HIV-2 GH-1 is a molecular clone derived from an AIDS patient from Ghana. In contrast to the prototypic molecular clone ROD, GH-1 exhibits a narrow range of target cell specificity. By an infectious assay using HeLa-CD4 cells stably transfected with an HIV-1 LTR-beta-galactosidase reporter gene and transiently expressi...

journal_title：Virology

authors： Isaka Y,Sato A,Miki S,Kawauchi S,Sakaida H,Hori T,Uchiyama T,Adachi A,Hayami M,Fujiwara T,Yoshie O

更新日期：1999-11-10 00:00:00

abstract：:Turnip crinkle carmovirus (TCV) has a uniquely high recombination frequency and nonrandom cross-over site distribution among the recombining TCV-associated satellite RNAs. An in vitro system has been developed that includes a partially purified TCV replicase preparation (RdRp) and chimeric RNAs that resemble the putat...

journal_title：Virology

authors： Nagy PD,Simon AE

更新日期：1998-09-30 00:00:00

abstract：:While several studies have shown a role for autophagy in the replication of dengue virus (DENV), these studies have been performed in directly infected cells. However, in severe cases of DENV infection the critical cell in the disease is believed to be monocytes which are poorly infected directly, but are highly susce...

journal_title：Virology

authors： Panyasrivanit M,Greenwood MP,Murphy D,Isidoro C,Auewarakul P,Smith DR

更新日期：2011-09-15 00:00:00

abstract：:Ovarian cancer is the third most common female cancer, with poor survival in later stages of metastatic spread. We test a chimeric virus consisting of genes from Lassa and vesicular stomatitis viruses, LASV-VSV; the native VSV glycoprotein is replaced by the Lassa glycoprotein, greatly reducing neurotropism. Human ova...

journal_title：Virology

authors： van den Pol AN,Zhang X,Lima E,Pitruzzello M,Albayrak N,Alvero A,Davis JN,Mor G

更新日期：2020-11-12 00:00:00

abstract：:Lentiviral vectors have gained much attention in recent years mainly because they integrate into nondividing host-cell genomes. For clinical applications, a safe and efficient lentiviral vector system is required. Previously, we have established a human immunodeficiency virus type 1 (HIV-1)-derived three-plasmid lenti...

journal_title：Virology

authors： Iwakuma T,Cui Y,Chang LJ

更新日期：1999-08-15 00:00:00

abstract：:Revertants were isolated from the protease activation mutant of Sendai virus, F1-R, which causes a systemic infection in mice. The fusion (F) glycoprotein of F1-R is susceptible to activation cleavage by ubiquitous cellular proteases and is thus responsible for pantropism in mice (Tashiro et al., 1988. Virology 165, 5...

journal_title：Virology

authors： Tashiro M,James I,Karri S,Wahn K,Tobita K,Klenk HD,Rott R,Seto JT

更新日期：1991-09-01 00:00:00

abstract：:Piglets infected in utero with porcine reproductive and respiratory syndrome virus (PRRSV) are born severely immunocompromised. In this article we more closely examine the effects of in utero PRRSV infection on circulating and thymic T cell populations. Numbers of CD4+, CD8+, and dual-positive lymphocytes were quantit...

journal_title：Virology

authors： Feng WH,Tompkins MB,Xu JS,Brown TT,Laster SM,Zhang HX,McCaw MB

更新日期：2002-10-25 00:00:00

abstract：:Next generation sequence analyses were used to assess virus-derived small RNA (vsRNA) profiles for Homalodisca coagulata virus-1 (HoCV-1), family Dicistroviridae, and Homalodisca vitripennis reovirus (HoVRV), family Reoviridae, from virus-infected H. vitripennis, the glassy-winged sharpshooter. The vsRNA reads were ma...

journal_title：Virology

authors： Nandety RS,Fofanov VY,Koshinsky H,Stenger DC,Falk BW

更新日期：2013-07-20 00:00:00

abstract：:The PBj14 isolate of simian immunodeficiency virus, SIVsmmPBj14, is an acutely pathogenic lentivirus that causes severe gastrointestinal disease in macaque monkeys. The studies reported here examine the basis for the enteropathic phenotype of SIVsmmPBj14, using flow cytometric analysis of cultured macaque lymphocytes ...

journal_title：Virology

authors： Gummuluru S,Novembre FJ,Seshi B,Dewhurst S

更新日期：1996-01-01 00:00:00

abstract：:Bovine cell lines individually expressing two related herpesviral proteins, pseudorabies virus glycoprotein 50 and herpes simplex virus type 1 glycoprotein D, were examined for their susceptibility/resistance to infection with several alphaherpesviruses. Cell lines expressing gp50 or gD-1 resisted plaque formation by ...

journal_title：Virology

authors： Chase CC,Lohff C,Letchworth GJ 3rd

更新日期：1993-05-01 00:00:00

abstract：:A clinical feature of Ross River virus disease (RRVD) is the periodic relapse of symptoms months after the initial onset of disease. The underlying mechanisms responsible for this relapse have not been determined. In a long-term (148 days) in vitro study of persistently infected murine macrophages we established that ...

journal_title：Virology

authors： Way SJ,Lidbury BA,Banyer JL

更新日期：2002-09-30 00:00:00

abstract：:Monoclonal antibody 1B4, previously shown to be protective in vivo and to cross-react with both virally encoded and normal host cell proteins, was used to screen a lambda gt11 cDNA derived from mRNA harvested from mouse embryo fibroblasts 24 hr after infection with murine cytomegalovirus (MCMV). A 700-bp cDNA was iden...

journal_title：Virology

authors： Dallas PB,Lyons PA,Hudson JB,Scalzo AA,Shellam GR

更新日期：1994-05-01 00:00:00

abstract：:Ovine pulmonary carcinoma, a contagious lung cancer of sheep, is caused by the oncogenic jaagsiekte sheep retrovirus (JSRV) that is closely related to a family of endogenous sheep retroviral sequences (ESRVs). By using exogenous virus-specific U3 oligonucleotide primers, the entire JSRV proviral genome or its 3' part ...

journal_title：Virology

authors： Bai J,Bishop JV,Carlson JO,DeMartini JC

更新日期：1999-06-05 00:00:00

abstract：:Syncytia formation has been considered important for cell-to-cell spread and pathogenesis of many viruses. As a syncytium forms, individual nuclei often congregate together, allowing close contact of nuclear membranes and possibly fusion to occur. However, there is currently no reported evidence of nuclear membrane fu...

journal_title：Virology

authors： Wang W,Yang L,Huang X,Fu W,Pan D,Cai L,Ye J,Liu J,Xia N,Cheng T,Zhu H

更新日期：2017-12-01 00:00:00

abstract：:To better understand the role of specific residues within the duck hepatitis B virus (DHBV) pre-S protein in neutralization and infectivity, we have selected and identified pre-S variants which escape neutralization. A highly neutralizing monoclonal antibody (Mab 900) which recognizes an epitope 83IPQPQWTP90 localized...

journal_title：Virology

authors： Sunyach C,Chassot S,Jamard C,Kay A,Trepo C,Cova L

更新日期：1997-08-04 00:00:00

abstract：:The requirement for the herpes simplex virus type 1 (HSV-1) protein Vmw65 (VP16) for activation of immediate early (IE) gene expression was examined in synchronized HeLa cells. Analyses of IE RNA levels were conducted during infection with a viral Vmw65 mutant, in1814. The results revealed an increased requirement for...

journal_title：Virology

authors： Daksis JI,Preston CM

更新日期：1992-07-01 00:00:00

abstract：:A range of deletion and other mutants in the coding region of the E1A gene of Ad5 has been assayed for transformation of baby rat kidney (BRK) cells in cooperation with ras, repression of the SV40 enhancer, and induction of proliferating cell nuclear antigen (PCNA). Transformation efficiency was drastically reduced by...

journal_title：Virology

authors： Jelsma TN,Howe JA,Mymryk JS,Evelegh CM,Cunniff NF,Bayley ST

更新日期：1989-07-01 00:00:00

abstract：:The equine herpesvirus 1 (EHV-1) immediate-early (IE) phosphoprotein is essential for the activation of transcription from viral early and late promoters and regulates transcription from its own promoter. The IE protein of 1487 amino acids contains a serine-rich tract (SRT) between residues 181 and 220. Deletion of th...

journal_title：Virology

authors： Kim SK,Buczynski KA,Caughman GB,O'Callaghan DJ

更新日期：2001-01-05 00:00:00